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| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 2 | Effects of nitrogen level on yield and quality of japonica soft super rice显示文摘Although studies on the balance between yield and quality of japonica soft super rice are limited, they are crucial for super rice cultivation. In order to investigate the effects of nitrogen application rate on grain yield and rice quality, two japonica soft super rice varieties, Nanjing 9108(NJ 9108) and Nanjing 5055(NJ 5055), were used under seven N levels with the application rates of 0, 150, 187.5, 225, 262.5, 300, and 337.5 kg ha^(–1). With the increasing nitrogen application level, grain yield of both varieties first increased and then decreased. The highest yield was obtained at 300 kg ha^(–1). The milling quality and protein content increased, while the appearance quality, amylose content, gel consistency, cooking/eating quality, and rice flour viscosity decreased. Milling was significantly negatively related with the eating/cooking quality whereas the appearance was significantly positively related with cooking/eating quality. These results suggest that nitrogen level significantly affects the yield and rice quality of japonica soft super rice. We conclude that the suitable nitrogen application rate for japonica soft super rice, NJ 9108 and NJ 5055, is 270 kg ha^(–1), under which they obtain high yield as well as superior eating/cooking quality. | ZHU Da-wei ZHANG Hong-cheng GUO Bao-wei XU Ke DAI Qi-gen WEI Hai-yan GAO Hui HU Ya-jie CUI Pei-yuan HUO Zhong-yang | 2017 | Journal of Integrative Agriculture2017，16，5： | 31 |
| 3 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 4 | Water consumption in summer maize and winter wheat cropping system based on SEBAL model in Huang-Huai-Hai Plain, China显示文摘Crop consumptive water use is recognized as a key element to understand regional water management performance. This study documents an attempt to apply a regional evapotranspiration model(SEBAL) and crop information for assessment of regional crop(summer maize and winter wheat) actual evapotranspiration(ET a) in Huang-Huai-Hai(3H) Plain, China. The average seasonal ET a of summer maize and winter wheat were 354.8 and 521.5 mm respectively in 3H Plain. A high-ET a belt of summer maize occurs in piedmont plain, while a low ET a area was found in the hill-irrigable land and dry land area. For winter wheat, a high-ET a area was located in the middle part of 3H Plain, including low plain-hydropenia irrigable land and dry land, hill-irrigable land and dry land, and basin-irrigable land and dry land. Spatial analysis demonstrated a linear relationship between crop ET a, normalized difference vegetation index(NDVI), and the land surface temperature(LST). A stronger relationship between ET a and NDVI was found in the metaphase and last phase than other crop growing phase, as indicated by higher correlation coefficient values. Additionally, higher correlation coefficients were detected between ET a and LST than that between ET a and NDVI, and this significant relationship ran through the entire crop growing season. ET a in the summer maize growing season showed a significant relationship with longitude, while ET a in the winter wheat growing season showed a significant relationship with latitude. The results of this study will serve as baseline information for water resources management of 3H Plain. | YANG Jian-ying MEI Xu-rong HUO Zhi-guo YAN Chang-rong JU Hui ZHAO Feng-hua LIU Qin | 2015 | Journal of Integrative Agriculture2015，14，10： | 12 |
| 5 | Evaluation of surgical procedure selection based on intraoperative free portal pressure measurement in patients with portal hypertension显示文摘BACKGROUND:Various surgical procedures can be used to treat liver cirrhosis and portal hypertension.How to select the most appropriate procedure for patients with portal hypertension has become a difficult problem.This study aimed to analyze the relationship between the value of intraoperative free portal pressure(FPP)and postoperative complications,and to explore the significance of intraoperative FPP measurement with respect to surgical procedure selection.METHODS:The clinical data of 187 patients with portal hypertension who received pericardial devascularization and proximal splenorenal shunt combined with devascularization(combined operation)at the Department of General Surgery in our hospital from January 2001 to September 2008 were retrospectively analyzed.Among the patients who received pericardial devascularization,those with a postoperative FPP ≥22 mmHg were included in a high-pressure group(n=68), and those with FPP<22 mmHg were in a low-pressure group(n=49).Seventy patients who received the combined operation comprised a combined group.The intraoperative FPP measurement changes at different times,and the incidence of postoperative complications in the three groups of patients were compared.RESULTS:The postoperative FPP value in the high-pressure group was 27.5±2.3 mmHg,which was significantly higher than that of the low-pressure(20.9±1.8 mmHg)or combined groups(21.7±2.5 mmHg).The rebleeding rate in the high-pressure group was significantly higher than that in the low-pressure and combined groups.The incidence rates of postoperative hepatic encephalopathy and liver failure were not statistically different among the three groups.The mortality due to rebleeding in the low-pressure and combined groups(0.84%) was significantly lower than that of the high-pressure group.CONCLUSIONS:The study demonstrates that FPP is a critical measurement for surgical procedure selection in patients with portal hypertension.A FPP value≥22 mmHg after splenectomy and devascularization alone is an important indicator that an additional proximal splenorenal shunt needs to be performed. | Sun, Yong-Wei Chen, Wei Luo, Meng Hua, Rong Liu, Wei Huo, Yan-Miao Wu, Zhi-Yong Cao, Hui | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 9 |
| 6 | Fluorescent nanoparticles for chemical and biological sensing显示文摘Fluorescent nanoparticles (NPs), including quantum dots (QDs), dye-doped NPs, and rare earth-based NPs, etc., have been a major focus of research and development during the past decade. The impetus behind such endeavors can be attributed to their unique chemical and optical properties, such as bright fluorescence, high photostability, large Stocks shift and flexible processability. The introduction of fluorescent NPs into analytical chemistry has opened up new venues for fluorescent analysis. In this review, we focus on the developments and analytical applications of fluorescent NPs in the chemical and biological sensing of pH, ions, organic compounds, small biological molecules, nucleic acids, proteins, virus and bacteria. The review also points out the in vitro and in vivo imaging application of fluorescent NPs at the cell and body levels. Meanwhile, the ad- vantages of NPs brought field of sensing and signal transductions are also discussed. | LIU JianBo, YANG XiaoHai, HE XiaoXiao, WANG KeMin, WANG Qing, GUO QiuPing, SHI Hui, HUANG Jin & HUO XiQin State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, Institute of Biology, Hunan University Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, China | 2011 | Science China Chemistry2011，54，8： | 9 |
| 7 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 8 | Anti-inflammatory and Anti-oxidant Effects of Licorice Flavonoids on Ulcerative Colitis in Mouse Model显示文摘Licorice(Glycyrrhizae Radix or Liquiritiae Radix) is traditionally used to treat various diseases including inflammation and gastric ulcers. Licorice is rich in flavonoid compounds and possesses anti-inflammatory activities. To investigate the protective effects of licorice flavonoids(LFs) in both acetic acid-induced and dextran sulphate sodium(DSS)-induced ulcerative colitis(UC) mouse model and its underlying mechanism. Acute UC was induced by intra-rectal acetic acid(4% v/v) after pretreatment with LFs(100, 200, and 400 mg/kg, p.o.), 0.9% saline(20 mL/kg, p.o.) or Sulfasalazine(SASP)(600 mg/kg, p.o.) for 10 d. Quantitative analysis of chemical components of LFs was also conducted by HPLC. Our results showed that pre-treatment with LFs significantly reduced the wet weight/length ratio of colon, percentage of affected area, macroscopic and histological damage scores in acid-induced UC mice. LFs also significantly decreased the oxidative stress and pro-inflammatory cytokines, upregulated nuclear factor erythroid 2-related factor 2(Nrf2) pathway and downregulated nuclear transcription factor kappa B(NF-κB) pathway. At last, LFs also showed obvious antiulcer effect on the DSS-induced UC model. The major components of LFs were licochalcone A, glabrone, licoflavone, and licoflavone B. This study demonstrates that the protective effect of LFs may at least in part be due to its anti-oxidant activity through Nrf2 pathway and anti-inflammatory activity through NF-κB pathway. | Dong-yu Liu Li Gao Juan Zhang Xiao-wei Huo Hui Ni Li Cao | 2017 | Chinese Herbal Medicines2017，9，4： | 6 |
| 9 | Supercapacitor Performance of Hollow Carbon Spheres by Direct Pyrolysis of Melamine-formaldehyde Resin Spheres显示文摘 | MA Fang-wei SUN Li-ping ZHAO Hui LI Qiang HUO Li-hua XIA Tian GAO Shan | 2013 | Chemical Research in Chinese Universities2013，29，4： | 6 |
| 10 | Adaptive Fuzzy Control System of Servomechanism for Electro-Discharge Machining Combined with Ultrasonic Vibration显示文摘For electro-discharge machining, only in the optimum state could the highest material removal rate be realized. In practical machining process, the timely elevation of the tool electrode is needed to eliminate chipping, which ordinarily occupies quite a lot of time. Therefore, besides the control of the machining parameters, the control of the optimum discharge gap and the conversion of different machining states is also needed. In this paper, the adaptive fuzzy control system of servomechanism for EDM combined with ultrasonic vibration is studied, the servomechanism of which is composed of the stepping motor comprising variable steps and the inductive synchronizer. The fuzzy control technology is used to realize the control of the frequency and the step of the servomechanism. The adaptive fuzzy controller has three inputs and two outputs, which can well meet the actual control requirements. The constitution of the fuzzy control regulation for the step frequency is the key to the design of the whole fuzzy control system of the servomechanism. The step frequency is mainly determined by the position error and the change rate of the position error. When the value of the position error is high or medium, the controlled parameters are selected to eliminate the error; when the position error is lower, the controlled parameters are selected to avoid the over-orientation and thus keep the stability of the system. According to these, a fuzzy control table is established in advanced, which is used to express the relations between the fuzzy input parameters and the fuzzy output parameters. The input parameters and the output parameters are all expressed by the level-values in fuzzy field. Therefore, the output parameters used for control can be obtained for the fuzzy control table according to the detected actual input parameters, by which the EDM combined with ultrasonic vibration is improved and the machining efficiency is increased. In addition, a stimulation program is designed by means of Microsoft Visual Basic | ZHANG Jian-hua, ZHANG Hui, SU Da-shi, QIN Yong, HUO Meng-You, ZHANG Qin-he (College of Mechanical Engineering, Shandong University, Jinan 250061, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 6 |
| 11 | Monitoring the ionosphere based on the Crustal Movement Observation Network of China显示文摘The Global Navigation Satellite System(GNSS) is becoming important for monitoring the variations in the earth's ionosphere based on the total electron content(TEC) and ionospheric electron density(IED). The Crustal Movement Observation Network of China(CMONOC), which includes GNSS stations across China's Mainland, enables the continuous monitoring of the ionosphere over China as accurately as possible. A series of approaches for GNSS-based ionospheric remote sensing and software has been proposed and developed by the Institute of Geodesy and Geophysics(IGG) in Wuhan. Related achievements include the retrieval of ionospheric observables from raw GNSS data, differential code biases estimations in satellites and receivers, models of local and regional ionospheric TEC,and algorithms of ionospheric tomography. Based on these achievements, a software for processing GNSS data to determine the variations in ionospheric TEC and IED over China has been designed and developed by IGG. This software has also been installed at the CMONOC data centers belonging to the China Earthquake Administration and China Meteorological Administration. This paper briefly introduces the related research achievements and indicates potential directions of future work. | Yuan Yunbin Li Zishen Wang Ningbo Zhang Baocheng Li Hui Li Min Huo Xingliang Ou Jikun | 2015 | Geodesy and Geodynamics2015，6，2： | 5 |
| 12 | Comparison of agronomic performance between inter-sub-specific hybrid and inbred japonica rice under different mechanical transplanting methods显示文摘Mechanical transplanting has been applied to rice cultivation to save labor costs and ease labor shortages in Asian countries, especially in China. However, little information is available related to the characteristics of agronomic performance when comparing inter-sub-specific hybrid rice(IHR) and inbred japonica rice(IJR) under mechanical transplanting method. In 2013 and 2014, field experiments were conducted using IHR(Yongyou 2640) and IJR(Wuyunjing 24) under two cultivation patterns, that is, pot seedlings mechanically transplanted(PS) and carpet seedlings mechanically transplanted(CS). Grain yield, yield components, leaf area index(LAI), leaf area duration(LAD), aboveground biomass, crop growth rate(CGR), nitrogen(N) uptake, and N accumulation were investigated. When compared with CS, PS displayed significantly increased grain yield for both varieties because the larger sink size allowed higher N accumulation from panicle initiation to maturity. Moreover, total aboveground biomass under PS increased significantly compared with that under CS; that is, higher photosynthetic productivity resulted from a greater LAI and higher LAD during the grain filling stage. Higher N absorption capacity in the middle and late growth periods resulted in significantly enhanced total N uptake under PS. When compared with IJR for both treatments, IHR generated 75.2% more grain yield. However, the characteristics creating high yield of IHR were different from those of IJR. Greater aboveground biomass production as well as higher N uptake and accumulation created higher grain yield in IHR than in IJR. These results suggest higher yield could be achieved using PS with IHR, attributing to exploit both yield superiority and productive potential. | HU Ya-jie WU Pei ZHANG Hong-cheng DAI Qi-gen HUO Zhong-yang XU Ke GAO Hui WEI Hai-yan GUO Bao-wei CUI Pei-yuan | 2018 | Journal of Integrative Agriculture2018，17，4： | 4 |
| 13 | Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy显示文摘Objective To establish Surface-enhanced Raman Spectroscopy(SERS) can be used as a rapid and reliable method to distinguish virulent strain and mild strain of L. pneumophila. Methods We isolated and characterized of bacterial strains from ATCC and water samples strains, while we analyzed data from SERS technology using gold nanoparticles as a base and cell infections were employed to rapidly detect L. pneumophila strains. Origin 8.0 was used to collect Raman spectra, smooth and homogenize data, and to contrast spectra. Principal component analysis(PCA) was conducted to discriminate differences between groups using the multivariate analysis package Py Chem 3.0.5. Results Our results indicated that the peaks of high virulence strains reached ≥4000. This criterion was verified by subsequent cell experiments. In addition, we also conducted SERS rapid identification on the virulence of several collected clinical strains and obtained accurate results. Conclusion The present study indicates that the established SERS protocol can be used as a rapid and reliable method to distinguish virulent and mildly virulent strains of L. pneumophila, which can be further used in clinical samples. | LI Jing QIN Tian JIA Xiao Xiao DENG Ai Hua ZHANG Xu FAN Wen Hui HUO Shuai Dong WEN Ting Yi LIU Wen Jun | 2015 | Biomedical and Environmental Sciences2015，28，6： | 4 |
| 14 | Microstructure transformation of X70 pipeline steel welding heat-affected zone显示文摘The continuous cooling transformation curve of heat-affected zone(HAZ) of X70 pipeline steel was measured by Gleeble-3500 thermal mechanical simulator,optical microscope(OM) and hardness analysis. The microstructure transformation rule at different cooling rates and solution behaviors of microalloy carbonitride during heating process of simulated specimens were investigated.When the cooling rate changes from 10 to 20 °Cás-1,microstructures at HAZ are identified as granular bainite,lathy bainite, and quasi-polygonal ferrite. This microstructure is featured with fine ferrite grains, martensite/austenite islands dispersed, high-density dislocations, and fine carbonitride particles, resulting in improving the strength and toughness of HAZ. With the cooling rate increasing to above 40 °Cás-1, the microstructure is predominantly coarse lathy bainite with clear primary austenite grain boundary. While the cooling rate decreases to below 1 °Cás-1, a fairly small amount of pearlite can be observed at the boundaries. The strength and toughness of HAZ are deteriorated because of coarse grains among these microstructures. Most of microalloy carbonitrides in HAZ could be dissolved in the matrix during heating process. A few of TiN particles existing as residues in the matrix can prevent austenite grain from growing, and then improve the strength and toughness of HAZ. | Hui Li Jing-Long Liang Yun-Li Feng Dong-Xing Huo | 2014 | Rare Metals2014，33，4： | 4 |
| 15 | Optimization and evaluation of fish oil rnicrocapsules显示文摘 | Hui Liu Lia nyan Wang Tingyuan Yang Guifeng Zhang Jian Huang Jing Sun Junsheng Huo | 2016 | Particuology2016，14，6： | 4 |
| 16 | Feasibility study on expanded indication for endoscopic submucosal dissection of intramucosal poorly differentiated early gastric cancer显示文摘AIM: To identify clinicopathological factors predictive of lymph node metastasis(LNM) in intramucosal poorly differentiated early gastric cancer(EGC), and further to expand the possibility of using endoscopic submucosal dissection(ESD) for the treatment of intramucosal poorly differentiated EGC.METHODS: Data for 81 surgically treated patients with intramucosal poorly differentiated EGC were collected, and the association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. Odds ratios(ORs) with 95% confidence intervals(CIs) were calculated. Several clinicopathologic factors were investigated to identify predictive factors for lymph nodes metastasis, including gender, age, family history of gastric cancer, number of tumors, tumor location, ulceration, tumor size, macroscopic type, lymphatic vessel involvement, and signet-ring-cell component.RESULTS: Tumor size(OR = 7.273, 95%CI: 1.246-29.918, P = 0.042), lymphatic vessel involvement(OR = 42.219, 95%CI: 1.923-97.052, P = 0.018) and signet-ring-cell component(OR = 17.513, 95%CI: 1.647-77.469, P = 0.034) that were significantly associated with LNM by univariate analysis, were found to be significant and independent risk factors for LNM by multivariate analysis. However, gender, age, family history of gastric cancer, number, location, ulceration and macroscopic type of tumor were found not to be associated with LNM. Of these 81 patients diagnosed with intramucosal poorly differentiated EGC, 7(8.6%) had LNM. The LNM rates were 9.1%, 22.2% and 57.1%, respectively, in cases with one, two and three of the risk factors. There was no LNM in 54 patients without the three risk clinicopathological factors.CONCLUSION: Tumor size, lymphatic vessel involvement and signet-ring-cell component are independently associated with the presence of LNM in intramucosal poorly differentiated EGC. Thus, these three risk factors may be used as a simple criterion to expand the possibility of using ESD for the treatment of intramucosal poorly differentiated EGC. | Hua Li Zhi-Bin Huo Shu-Bo Chen Hui Li Dian-Chao Wu Tong-Shan Zhai Qi-Hai Xiao Shu-Xia Wang Li-Li Zhang | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 17 | A novel spectrophotometric determination of copper(Ⅱ) with bromosulphonazoⅢ显示文摘A novel chromogenic reaction involving copper(Ⅱ)and bromosulphonazoⅢ(Br-SAZⅢ)in hexamethylenetetramine- hydrochloric buffer solution was investigated.The results showed that a blue complex of copper(Ⅱ)and bromosulphonazoⅢwas formed with a molar ratio of 1:1.The apparent molar absorptivity was 3.3×10~5L mol^(-1)cm^(-1)and the maximum absorption peak was at 616.8 nm.The proposed procedure was used for quantitative estimation of Cu(Ⅱ)in the concentration range of 0-1.024μg/mL with the detection limit(3σ)of 7.03×10^(-4)μg/mL(n=20).The relative standard deviations(RSDs)were 0.56-4.68%.Under the optimized conditions,total copper in the vegetables and tea was successfully determined. | Li Yuan Shu Hui Huo Xiao Na Ren Hui Chen | 2008 | Chinese Chemical Letters2008，19，1： | 3 |
| 18 | Spin Transport in a Magnetic Superlattice with Broken Two-Fold Symmetry显示文摘我们理论上与破双重的对称在磁性的超点阵(MSL ) 调查纺纱依赖者电子运输性质。当它没在双重的对称中心被定位时,在 MSL 的一个反常障碍能打破系统的双重的对称。打破因素的双重的对称被介绍描述打破度的双重的对称。我们的数字计算证明传播,传导力和旋转极化非琐细地依赖于打破因素的双重的对称。当因素足够大时,极化几乎在一个合适的费密精力范围接近 100% 。为有一样的因素的二互相镜子对称的 MSL,然而,他们的极化可能类似或不同。这些特征提供一些线索给基于 MSL 的旋转过滤器或纺纱依赖者通道电子设备的设计和应用。[从作者抽象] | HUO Qiu-Hong WANG Ru-Zhi CHEN Si-Ying XUE Kun YAN Hui | 2010 | Chinese Physics Letters2010，27，6： | 3 |
| 19 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 20 | Kinematics analysis of a novel all-attitude flight simulator显示文摘To overcome the kinematic singularity limitation of simulator, which is unavoidable in a three-axis architecture, an all-attitude flight simulator in a four-axis architecture is proposed. The simulator can always provide 3DOF motion by applying redundant manipulator mechanism. For direct kinematics of the manipulator, a dual-Euler method is adopted to solve the expressions of attitude angles; thus computation singularity of all- attitude angles is overcome. For inverse kinematics of the manipulator, pseudo-inverse gradient projection method is used to obtain optimal velocity solution. Then, based on dynamic control method, optimal position solution is obtained. The proposed inverse kinematics algorithm can achieve desired attitudes, as well as can avoid kinematics singularity and axis angle limits. The simulation results show that the kinematic performance of the four-axis all-attitude flight simulator is superior to that of a three-axis simulator. | WANG XiaoChen , ZHAO Hui, MA KeMao, HUO Xin & YAO Yu Control and Simulation Center, Harbin Institute of Technology, Harbin 150080, China | 2010 | Science China(Information Sciences)2010，53，2： | 3 |
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