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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Geohazard Recognition and Inventory Mapping Using Airborne LiDAR Data in Complex Mountainous Areas显示文摘Geohazard recognition and inventory mapping are absolutely the keys to the establishment of reliable susceptibility and hazard maps. However, it has been challenging to implement geohazards recognition and inventory mapping in mountainous areas with complex topography and vegetation cover. Progress in the light detection and ranging(Li DAR) technology provides a new possibility for geohazard recognition in such areas. Specifically, this study aims to evaluate the performances of the Li DAR technology in recognizing geohazard in the mountainous areas of Southwest China through visually analyzing airborne Li DAR DEM derivatives. Quasi-3 D relief image maps are generated based on the sky-view factor(SVF), which makes it feasible to interpret precisely the features of geohazard. A total of 146 geohazards are remotely mapped in the entire 135 km^(2) study area in Danba County, Southwest China, and classified as landslide, rock fall, debris flow based on morphologic characteristics interpreted from SVF visualization maps. Field validation indicate the success rate of Li DAR-derived DEM in recognition and mapping geohazard with higher precision and accuracy. These mapped geohazards lie along both sides of the river, and their spatial distributions are related highly to human engineering activities, such as road excavation and slope cutting. The minimum geohazard that can be recognized in the 0.5 m resolution DEM is about 900 m^(2). Meanwhile, the SVF visualization method is demonstrated to be a great alternative to the classical hillshaded DEM method when it comes to the determination of geomorphological properties of geohazard. Results of this study highlight the importance of Li DAR data for creating complete and accurate geohazard inventories, which can then be used for the production of reliable susceptibility and hazard maps and thus contribute to a better understanding of the movement processes and reducing related losses. | Chen Guo Qiang Xu Xiujun Dong Weile Li Kuanyao Zhao Huiyan Lu Yuanzhen Ju | 2021 | Journal of Earth Science2021，32，5： | 6 |
| 3 | GLOBAL STABILITY IN TIME-DELAYED 3-DIMENSIONAL RICHARDS MODEL显示文摘We obtain the global attractivity and global asymptotical stability of positive equilibria to a 3-dimensional Richards model with delays. Our results do not depend on the size-asymmetry parameter which measures the degree of the curvature of size-growth among individuals over the entire growth curve, and the shape parameter which affects the shape of model curve. Lastly, we gave a numerical simulation to verify the feasibility of our main results. | Lifei Zheng (College of Science, Northwest A and F University, Yangling 712100, Shaan’xi) Huiyan Zhao (College of Plant Protection, Northwest A and F University, Yangling 712100, Shaan’xi) | 2010 | Annals of Differential Equations2010，26，1： | 3 |
| 4 | Properties and Structures of Bi_2O_3-B_2O_3-TeO_2 Glass显示文摘Glass formation range of Bi2O3—B2O3—TeO2 system has been investigated(B2O3 < 40 mol%).Four glasses with compositions xBi2O3—3OB2O3—(70—x)TeO2(x = 40,50,60 and 70 mol%) have been prepared by using melt quenching technique.The effect of Bi2O3 content on thermal stability,optical properties and structures of these four Bi2O3—B2O3—TeO2 glasses is systematically investigated by inductive coupled plasma emission spectrometer(ICP),differential scanning calorimetry(DSC),Raman spectra and X-ray photoelectron spectroscopy(XPS).It is found that the density,refractive index and optical basicity increase with increasing Bi2O3.The Raman spectra and XPS spectra show that the glass network is mainly constituted by the[BiO6] octahedron,[TeO4]trigonal bipyramidal,[TeO3]trigonal pyramid,[BO3]trigonal pyramid and[BO4]tetrahedron structural units.With increasing Bi2O3,the coordination number around B atom changes from 3 to 4 and [TeO4]units are converted to[TeO3]units.Bi5+ ions may exist in Bi2O3—B2O3—TeO2(BBT) system and their amount grows with increasing Bi2O3 content. | Guoying Zhao Ying Tian Huiyan Fan Junjie Zhang Lili Hu | 2013 | Journal of Materials Science & Technology2013，29，3： | 2 |
| 5 | Human visual system based adaptive digital image watermarking 显示文摘 | Qi Huiyan Zheng Dong Zhao Jiying | 2008 | Singal Processing2008，88，1： | 1 |
| 6 | APHIDSim: A population dynamics model for wheat aphids based on swallowtail catastrophe theory显示文摘 | M.K.D.K. Piyaratne Huiyan Zhao Qingxiang Meng | 2013 | Ecological Modelling2013，，： | 1 |
| 7 | A medical image 3 D recon- struction method based on improved MC and MT algorithms 显示文摘 | Huiyan Jiang Ye Zhang Yudong Zhao | 2009 | Industrial Electronics and Applications2009，，2527： | 1 |
| 8 | Human visual system based adaptive digital image watermarking显示文摘 | Huiyan Qi Dong Zheng Jiying Zhao | 2008 | Signal Processing2008，，88： | 1 |
| 9 | Human visual system basedadaptive digital image watermarking显示文摘 | Qi Huiyan Zheng Dong Zhao Jiying | | Signal Processing ElsevierNorth-Holland 200S0，1，： | 1 |
| 10 | Global attractivity of the predator-prey system for cotton aphid and seven-spot ladybird beetle with stage structure显示文摘 | Lifei Zheng Guixin Hu Huiyan Zhao M. K. D.K. Piyaratne Aying Wan | 2018 | International Journal of Biomathematics2018，11，1： | 1 |
| 11 | Investigations of strength and energy absorption of clinched joints 显示文摘 | He Xiaocong Zhao Lun Yang Huiyan | 2014 | Computational Materials Science2014，94，： | 1 |
| 12 | A population dynamics model for wheat aphids based on swallowtail catastrophe theory显示文摘 | Piyaratne M K D K Zhao Huiyan Meng Qingxiang | 2013 | Ecological Modeling2013，，253： | 1 |
| 13 | Butterfly catastrophe model for wheat aphid population dynamics:Construction,analysis and application显示文摘 | Wenqi Wu M K D K piyaratne Huiyan Zhao | 2014 | Ecological Model2014，288，： | 1 |
| 14 | Human visual system based adaptive digital image watermarking显示文摘 | QI HUIYAN ZHENG DONG ZHAO JIYING | 2008 | Signal Processing2008，88，1： | 1 |
| 15 | Interferon?γ and its pathway?associated gene expression in the vaginaltissue of premenopausal females with pelvic organ prolapse显示文摘 | Bing Zhao Jianguo Yan Huiyan Wu Yali Zhou Dongmei Xu Mengcai Hu Shihong Cui | 2014 | Experimental and Therapeutic Medicine2014，，4： | 1 |
| 16 | Human Visual SystemBased Adaptive Digital Image Watermarking显示文摘 | Qi Huiyan Zheng Dong Zhao Jiying | 2008 | Signal Processing2008，88，1： | 1 |
| 17 | Investigations ofstrength and energy absorption of clinched joints 显示文摘 | He Xiaocong Zhao Lun Yang Huiyan | 2014 | ComPuta- tional Materials Science2014，94，： | 1 |
| 18 | Human visual system based adaptive digital image watermarking 显示文摘 | Huiyan Qi Dong Zheng Jiying Zhao | 2008 | Signal Processing2008，88，1： | 1 |
| 19 | Key-insulated aggregate signature显示文摘为了最小化损坏,在总数签名由关键暴露引起了,一个绝缘钥匙的总数签名计划在这份报纸被建议。我们给定义和绝缘钥匙的总数签名的安全模型。我们也构造满足我们的定义的一个具体绝缘钥匙的总数签名计划。我们的计划有有效确认和短签名长度的性质。我们在计算 Diffie-Hellman 假设下面在随机的神谕模型证明我们的计划的安全。 | Huiyan ZHAO Jia YU Shaoxia DUAN Xiangguo CHENG Rong HAO | 2014 | Frontiers of Computer Science2014，8，5： | 1 |
| 20 | Dietary Epimedium extract supplementation improves intestinal functions and alters gut microbiota in broilers显示文摘Background Growth-promoting antibiotics have been banned by law in the livestock and poultry breeding industry in many countries.Various alternatives to antibiotics have been investigated for using in livestock.Epimedium(EM)is an herb rich in flavonoids that has many beneficial effects on animals.Therefore,this study was planned to explore the potential of EM as a new alternative antibiotic product in animal feed.Methods A total of 7201-day-old male broilers(Arbor Acres Plus)were randomly divided into six groups and fed basal diet(normal control;NC),basal diet supplemented with antibiotic(75 mg/kg chlortetracycline;CTC),and basal diet supplemented with 100,200,400 or 800 mg/kg EM extract for 6 weeks(EM100,EM200,EM400 and EM800 groups).The growth performance at weeks 3 and 6 was measured.Serum,intestinal tissue and feces were collected to assay for antioxidant indexes,intestinal permeability,lactic acid and short-chain fatty acids(SCFAs)profiles,microbial composition,and expression of intestinal barrier genes.Results The average daily feed intake in CTC group at 1-21 d was significantly higher than that in the NC group,and had no statistical difference with EM groups.Compared with NC group,average daily gain in CTC and EM200 groups increased significantly at 1-21 and 1-42 d.Compared with NC group,EM200 and EM400 groups had significantly decreased levels of lipopolysaccharide and D-lactic acid in serum throughout the study.The concentrations of lactic acid,acetic acid,propionic acid,butyric acid and SCFAs in feces of birds fed 200 mg/kg EM diet were significantly higher than those fed chlortetracycline.The dietary supplementation of chlortetracycline and 200 mg/kg EM significantly increased ileal expression of SOD1,Claudin-1 and ZO-1 genes.Dietary supplemented with 200 mg/kg EM increased the relative abundances of g_NK4A214_group and Lactobacillus in the jejunal,while the relative abundances of Microbacterium,Kitasatospora,Bacteroides in the jejunal and Gallibacterium in the ileum decreased.Conclusion Supplementation with 200 mg/kg EM extract improved the composition of intestinal microbiota by regulating the core bacterial genus Lactobacillus,and increased the concentration of beneficial metabolites lactic acid and SCFAs in the flora,thereby improving the antioxidant capacity and intestinal permeability,enhancing the function of tight junction proteins.These beneficial effects improved the growth performance of broilers. | Jiaqi Zhang Haitao Yu Huiyan Zhang Qingyu Zhao Wei Si Yuchang Qin Junmin Zhang | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 1 |
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