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| 1 | Salusins protect myocardium against ischemic injury by alleviating endoplasmic reticulum stress显示文摘Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-α and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery (LAD), salusin-α or -β was intravenously injected at 5 or 15 nmol kg 1 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD occlusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg 1 salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the activation of GRP78 and ER stress-specific apoptotic effectors caspase-12 and CHOP (C/EBP homologous protein), and attenuated the reduction of an ER stress-associated antiapoptotic protein Bcl-2 in ischemic cardiac tissue. The salusins also inhibited the ER stress induced by tunicamycin in cultured rat H9c2 cardiomyocytes. These results indicate that salusins protect myocardium against ischemic injury by inhibiting ER stress and ER stress-associated apoptosis. | WANG JianFei WANG Yin SHAN ShiFu HU TianTian CHEN HuYan TIAN Jing REN AnJing ZHOU Xu YUAN WenJun LIN Li | 2012 | Science China(Life Sciences)2012，55，4： | 11 |
| 2 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 3 | Orbit determination and time synchronization for BDS-3 satellites with raw inter-satellite link ranging observations显示文摘To provide competitive global positioning and timing services under the condition that monitoring stations are confined to Chinese territory,inter-satellite link(ISL)technology is used by the third-generation BeiDou Navigation Satellite System(BDS-3).The ISL,together with the dual one-way links between satellites and anchor stations,may enable autonomous navigation for BDS-3.In this paper,we propose a general observation model for orbit determination(OD)and time synchronization(TS)directly using non-simultaneous observations,such as raw ISL pseudoranges.With the proposed model,satellite orbits,clocks,and hardware delay biases of ISL equipment can be determined simultaneously by jointly processing inter-satellite one-way pseudorange data and observation data from ground monitoring stations.Moreover,autonomous OD and TS are also achievable with one-way pseudorange data from anchor stations and satellites.Data from eight BDS-3 satellites,two anchor stations,and seven monitoring stations located in China were collected to validate the proposed method.It is shown that by jointly processing data from the ISL and seven monitoring stations,the RMS of overlap orbit differences in radial direction is 0.019 m,the overlap clock difference(95%)is 0.185 ns,and the stability of the estimated hardware delay biases for each satellite is greater than 0.5 ns.Compared with the results obtained with the seven stations,the improvements of orbits in radial direction and clocks are 95.7%and 90.5%,respectively.When the hardware delay biases are fixed to predetermined values,the accuracies of orbits and clocks are further improved.By jointly processing pseudoranges from the satellites and the two anchor stations,the RMS of overlap orbit differences is 0.017 m in the radial direction,and the overlap clock difference(95%)is 0.037 ns.It has also been demonstrated that under the condition of one-way ranging links,the accuracies of orbits and clocks obtained by the above two modes are still significantly better than those obtained by using the data from the monitoring stations alone. | Rengui Ruan Xiaolin Jia Laiping Feng Jun Zhu Zongbo Huyan Jie Li Ziqing Wei | 2020 | Satellite Navigation2020，1，1： | 5 |
| 4 | Pt3Ag alloy wavy nanowires as highly effective electrocatalysts for ethanol oxidation reaction显示文摘Direct ethanol fuel cell(DEFC)has received tremendous research interests because of the more convenient storage and transportation of ethanol vs.compressed hydrogen.However,the electrocatalytic ethanol oxidation reaction typically requires precious metal catalysts and is plagued with relatively high over potential and low mass activity.Here we report the synthesis of Pt3Ag alloy wavy nanowires via a particle attachment mechanism in a facile solvothermal process.Transmission microscopy studies and elemental analyses show highly wavy nanowire structures with an average diameter of 4.6±1.0 nm and uniform Pt3Ag alloy formation.Electrocatalytic studies demonstrate that the resulting alloy nanowires can function as highly effective electrocatalysts for ethanol oxidation reactions(EOR)with ultrahigh specific activity of 28.0 mA/cm^2 and mass activity of 6.1 A/mg,far exceeding that of the commercial Pt/carbon samples(1.10 A/mg).The improved electrocatalytic activity may be partly attributed to partial electron transfer from Ag to Pt in the Pt3Ag alloy,which weakens CO binding and the CO poisoning effect.The one-dimensional nanowire morphology also contributes to favorable charge transport properties that are critical for extracting charge from catalytic active sites to external circuits.The chronoamperometry studies demonstrate considerably improved stability for long term operation compared with the commercial Pt/C samples,making the Pt3Ag wavy nanowires an attractive electrocatalyst for EOR. | Xiaoyang Fu Chengzhang Wan Aixin Zhang Zipeng Zhao Huaixun Huyan Xiaoqing Pan Shuaijing Du Xiangfeng Duan Yu Huang | 2020 | Nano Research2020，13，5： | 5 |
| 5 | Design of a Deterministic Interleaver for Turbo Codes and Its Applications in Self-Similar Traffic Streams显示文摘A new turbo interleaver is proposed and the proof of its mathematical completeness is provided.Our simulation results demonstrate that the BER performance of the associated turbo codec is similar to that of a random interleaver, despite the simple implementation of the proposed scheme. Even though the interleaver proposed here is a random one, the permuted results are deterministic, when the parameter h is set to a fixed integer. This characteristic is especially useful for reducing the hardware requirements imposed by the interleaving and deinterleaving operations. Finally, the interleaver contributes much to permuting self-similar traffic streams. | LIUXingcheng HUYan ZHANGLin | 2004 | Chinese Journal of Electronics2004，13，2： | 3 |
| 6 | Heterogeneous ZnO@CF structures and their excellent microwave absorbing properties with thin thickness and low filling显示文摘With the aim to obtain enhanced absorbing performance at small thickness and low filling,a robust strat-egy to fabricate zinc oxide(ZnO)modified carbon fiber(CF)structures have been successfully prepared by using low temperature hydrothermal method.Due to the multi-interface polarization caused by the high specific surface area of the complex heterostructures and the improvement of impedance matching,the composites show excellent electromagnetic wave absorption properties.Under the condition of low filling content(20 wt%)and ultra-thin thickness(1.5 mm),the excellent absorption performance of minimal reflection loss of−34.4 dB and an effective absorption bandwidth(RL≤−10 dB)of 4.94 GHz is achieved.In addition,the effective absorption bandwidth covers the whole 2-18 GHz band with the increase of thickness from 0.5 to 10 mm.This work provides an innovative method for designing the matching layer of carbon-based absorbing materials,and ZnO@CF heterostructure is expected to become a potential absorbing material. | Zibao Jiao Wenjun Huyan Junru Yao Zhengjun Yao Jintang Zhou Peijiang Liu | 2022 | Journal of Materials Science & Technology2022，，18： | 2 |
| 7 | Characterization and functionality of cell surface molecules on human mesendymal stem cells显示文摘 | Mojumdor MK keane-Moore M Huyaner U | 2003 | Biomed Sci2003，10，2： | 1 |
| 8 | Combined Treatment with Electrocauterization,Carbon Dioxide Laser,and Microneedle Fractional Radiofrequency for Facial Angiofibromas in Tuberous Sclerosis Complex:A Case Report and Literature Review显示文摘Tuberous sclerosis complex is a type of genetic multisystem disease that causes hamartomas in various organs.Facial angiofibromas commonly occur in 80%of patients and are prominently distributed over the cheek,chin,and nasolabial folds with severe disfigurement and emotional distress.Recently,photoelectric devices have been identified for the treatment of angiofibromas with great efficacy and fewer side effects.We report a case of a 42-year-old man with facial angiofibromas,who was treated with a combination of high-frequency electrocauterization,Ultrapulse CO_(2) laser,and microneedle fractional radiofrequency with 7 sessions and a 6-month follow-up.The patient showed great improvement in relation to the elevated lesions and nodules.A low recurrence rate was observed.This is the first study to investigate the efficacy of high-frequency electrocauterization and microneedle fractional radiofrequency in angiofibromas.It may provide an optimal approach for clinicians wherein a combined treatment of various lasers and electric devices is effective for complicated,protuberant,and firm angiofibromas of specific patients. | Jiying DONG Shen WANG Min YAN Jing MI Ying ZENG Huyan LIN Yiqiu ZHANG Min YAO | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，1： | 1 |
| 9 | Antioxidative activity and antidiscoloration efficacyof ergothioneine in mushroom (Flammulinavelutipes) extract added to beef and fish meats显示文摘 | Huyan N D B A O | 2008 | J Agric Food Chem2008，56，10： | 1 |
| 10 | Direct-writing Process and in vivo Evaluation of Prevascularized Composite Constructs for Muscle Tissue Engineering Application显示文摘Tissue engineered skeletal muscle is expected to treat muscle defects caused by trauma and disease.However,designing and manufacturing thick and complex tissue engineered skeletal muscle requires vascularization to ensure its internal cell viability and nutrient supply in vitro.In this article,we developed a set of Direct-Writing(DW)bio-printing procedure to manufacture a prevascularized composite construct with Human Umbilical Vein Endothelial Cell(HUVEC)and C2C12 cells for muscle tissue engineering application.We put the cells into the construct during the DW process to obtain the prevascularization and intend to promote its vascularization in vivo later.The constructs with cells or without cells were implanted respectively into nude mice back for 3 weeks,after which the mice healthily live for all the time and all the implants are tightly bonded to the host.From immunohistochemical analysis,CD31-positive blood vessels existed in the implanted samples with cells are more substantial than those without cells,but the implanted samples with HUVEC and C2C12 cells have much more number of small blood vessels distributing evenly.Moreover,the implants with cells,especially that with HUVEC and C2C12 cells,are able to get better fusion with the host skin and subcutaneous tissues.Histological analysis demonstrates that our DW-based constructs have the potential to be getting to vascularize the tissue engineered muscle. | Qin Lian Tingze Zhao Tian Jiao Yige Huyan Heng Gu Lin Gao | 2020 | Journal of Bionic Engineering2020，17，3： | 1 |
| 11 | Effects of simulated microgravity on primary human NK cells显示文摘 | Li O Mei Q Huyan T | 2013 | Astrobiology2013，13，8： | 1 |
| 12 | Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c mice显示文摘 | Huyan XH Lin YP Gao T | | 0，，09： | 1 |
| 13 | Structures and electronic properties of domain walls in Bi FeO3 thin films显示文摘Domain walls(DWs)in ferroelectrics are atomically sharp and can be created;erased,and reconfigured within the same physical volume of ferroelectric matrix by external electric fields.They possess a myriad of novel properties and functionalities that are absent in the bulk of the domains,and thus could become an essential element in next-generation nanodevices based on ferroelectrics.The knowledge about the structure and properties of ferroelectric DWs not only advances the fundamental understanding of ferroelectrics,but also provides guidance for the design of ferroelectric-based devices.In this article,we provide a review of structures and properties of DWs in one of the most widely studied ferroelectric systems,BiFeO3 thin films.We correlate their conductivity and photovoltaic properties to the atomic-scale structure and dynamic behaviors of DWs. | Huaixun Huyan Linze Li Christopher Addiego Wenpei Gao Xiaoqing Pan | 2019 | National Science Review2019，6，4： | 1 |
| 14 | Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c mice显示文摘 | Huyan XH Lin YP Gao T | 2011 | Int Immunopharmacol2011，11，9： | 1 |
| 15 | Assessment of runoff and sediment yield remote sensing,GIS,and AGNPS显示文摘 | HUYAN S J MARZEN L KOELLIKER J K | 2002 | Journal of Soil and Water Conservation2002，57，6： | 1 |
| 16 | Immunosuppressive effectof cyclophosphamide on white blood cells and lymphocytesubpopulations from peripheral blood of Balb/c mice 显示文摘 | Huyan XH Lin YP Gao T | 2011 | IntImmunopharmacol^2011，11，9： | 1 |
| 17 | Immunosuppressive effect of cy- clophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of BALB/c mice 显示文摘 | Huyan XH Lin YP Gao T | 2011 | Int Immunopharmaco12011，11，9： | 1 |
| 18 | In situ construction of a stable composite solid electrolyte interphase for dendrite-free Zn batteries显示文摘Building a stable solid electrolyte interphase(SEI)has been regarded to be highly effective for mitigating the dendrite growth and parasitic side reactions of Zn anodes.Herein,a robust inorganic composite SEI layer is in situ constructed by introducing an organic cysteine additive to achieve long lifetime Zn metal batteries.The chemisorbed cysteine derivatives are electrochemically reduced to trigger a local alkaline environment for generating a gradient layered zinc hydroxide based multicomponent interphase.Such a unique interphase is of significant advantage as a corrosion inhibitor and Zn^(2+)modulator to enable reversible plating/stripping chemistry with a reduced desolvation energy barrier.Accordingly,the cells with a thin glass fiber separator(260μm)deliver a prolonged lifespan beyond 2000 h and enhanced Coulombic efficiency of 99.5%over 450 cycles.This work will rationally elaborate in situ construction of a desirable SEI by implanting reductive additives for dendrite-free Zn anodes. | Yiming Zhao Huanyan Liu Yu Huyan Da Lei Na Li Shan Tian Jian-Gan Wang | 2023 | Journal of Energy Chemistry2023，，4： | 1 |
| 19 | Modulation of Pglycoprotein-mediated doxorubicin resistance in canine cell lines显示文摘 | PAGE R L HUGHES C S HUYAN S | 2000 | Anticancer Res2000，20，5： | 1 |
| 20 | Achieving Ultra-Wideband and Elevated Temperature Electromagnetic Wave Absorption via Constructing Lightweight Porous Rigid Structure显示文摘Realizing ultra-wideband absorption,desirable attenuation capability at high temperature and mechanical requirements for real-life applications remains a great challenge for microwave absorbing materials.Herein,we have constructed a porous carbon fiber/polymethacrylimide(CP)structure for acquiring promising microwave absorption performance and withstanding both elevated temperature and high strength in a low density.Given the ability of porous structure to induce desirable impedance matching and multiple reflection,the absorption bandwidth of CP composite can reach ultra-wideband absorption of 14 GHz at room temperature and even cover the whole X-band at 473 K.Additionally,the presence of imide ring group in polymethacrylimide and hard bubble wall endows the composite with excellent heat and compressive behaviors.Besides,the lightweight of the CP composite with a density of only 110 mg cm^(−3) coupled with high compressive strength of 1.05 MPa even at 453 K also satisfies the requirements in engineering applica-tions.Compared with soft and compressible aerogel materials,we envision that the rigid porous foam absorbing material is particularly suitable for environmental extremes. | Zibao Jiao Wenjun Huyan Feng Yang Junru Yao Ruiyang Tan Ping Chen Xuewei Tao Zhengjun Yao Jintang Zhou Peijiang Liu | 2022 | Nano-Micro Letters2022，14，11： | 1 |
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