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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus(HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters.Elevated expression of HCMV pp65 protein and DNA was observed in 88.5%(23/26) and 69.2%(18/26) of RE cases, respectively. In the non-RE group, HCMV pp65 antigen was detected only in two cases(10%), both of which were negative for DNA staining. Additionally, the intensity of HCMV pp65 staining was correlated with a shorter duration of the prodromal stage, younger age of seizure onset, and more severe unilateral cortical atrophy. Elevated expression of HCMV pp65 was observed in RE brain tissue and was correlated with the clinical features of RE disease. In summary, our results suggested that HCMV infection may be involved in the occurrence and progression of RE disease. Thus, further studies are needed to determine whether early treatment with anti-HCMV antibodies could modulate the course of RE. | Yao Zhang Yisong Wang Sichang Chen Shuai Chen Yuguang Guan Changqing Liu Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，2： | 9 |
| 3 | Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis显示文摘Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis,intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8?T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8?T cells are involved in the pathogenesis of RE. | Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan | 2018 | Virologica Sinica2018，33，5： | 4 |
| 4 | Microstructural evolution and tensile properties of low-carbon steel with martensitic microstructure during warm deforming and annealing显示文摘For preparing large-scale nano-grained and ultrafine-grained steel sheets by warm rolling and annealing,the effects of de- forming temperature on both the flow stress and the microstructure evolution of 09MnNiD steel with lath martensitic microstructure were studied by warm-compression test and transmission electron microscopy(TEM)observation.Thereafter,the steel with the lath martensitic structure was multi-pass warm-rolled and then annealed.TEM results indicate that nano-grained and ultrafine-grained steel sheets are formed by warm rolling at 400℃and annealing at 400-600℃.In comparison with the as-warm-rolled specimen,the tensile strength at room temperature changes a little when the rolled samples are annealed below 450℃,and the tensile strength is greatly lowered as the annealing temperature increases to above 550℃. | Yuwei Gao Tianfu Jing Guiying Qiao Jinku Yu Tiansheng Wang Qun Li Xinyu Song Shuqiang Wang Hong Gao | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 4 |
| 5 | Elevated expression of EBV and TLRs in the brain is associated with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare pediatric neurological disorder, the etiology of which remains unclear. It has been speculated that the immunopathogenesis of RE involves damage to neurons, which eventually leads to the occurrence of RE. Viral infection may be a critical factor in triggering RE immunopathogenesis. In this study, we analyzed the expression of Epstein-Barr virus(EBV) antigens as well as of Toll-like receptor 3(TLR3), TLR9, and downstream adapter TIRdomain-containing adapter-inducing interferon-β(TRIF) in the brain tissues of 26 patients with RE and 16 control individuals using immunohistochemistry(IHC). In the RE group, EBV antigens were detected in 53% of individuals at various expression levels. In contrast, there was no detectable EBV antigen expression in control brain tissues. Moreover, we found marked increases in the expression of TLR3, TLR9, and TRIF in the brain tissues of RE patients compared with levels in the control group. Furthermore, among RE cases, EBV expression and high TLR3 expression were associated with more severe brain atrophy. Our results suggest that the elevated expression of EBV and TLRs may be involved in RE occurrence through the activation of downstream molecules. | Xin Wang Yisong Wang Dong Liu Peigang Wang Dongying Fan Yuguang Guan Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，5： | 3 |
| 6 | High-speed jet electrodeposition and microstructure of nanocrystalline Ni-co alloy显示文摘 | Qiao Guiying Jing Tianfu Wang Nan | 2005 | Electrochimica Acta2005，51，1： | 1 |
| 7 | High-speed jet electrodeposition and microstructure of nanocrystalline Ni-Co alloy显示文摘 | Qiao Guiying Jing Tianfu Wang Nan | 2005 | Electrochimica Acta2005，51，1： | 1 |
| 8 | High-speedjet elec- trodeposition and microstructure of nanocrystalline Ni-Co alloys 显示文摘 | Qiao Guiying Jing Tianfu Wang Nan | 2005 | Electrochimica Acta2005，，51： | 1 |
| 9 | High-speed jet electrodeposition and microstructure of nanocrystalline Ni-co alloy显示文摘 | Jing Tianfu Wang Nan | 2005 | Electrochimica Acta2005，51，1： | 1 |
| 10 | Determination of ac-tivation of energy for crystallizations in Ni-Sn-P amorphous al-loys 显示文摘 | Jinku Yu Tianfu jing Jun Yang | 2009 | Journal of Materials processing Technology2009，，： | 1 |
| 11 | High performance steel plates with micro-laminated layer structure produced by plastic deformation显示文摘 | JING TIANFU ZHANG JINGWU FU WANTANG GAO MING | 1997 | Journal of Materials Science Letters1997，，6： | 1 |
| 12 | High-speed jet electrodeposition and mierostructure of nanocrystalline Ni- Co alloys 显示文摘 | Qiao Guiying Jing Tianfu Wang Nan | 2005 | Electrochim Acta2005，51，1： | 1 |
| 13 | Investigation on the Mechanical Carbon Steel Prepared Properties of an Ultrafine Plain by Warm Deformation显示文摘 | LI Qun JING Tianfu GAO Yuwei YU Jinku WANG Jinyang LI Hongbiao | 2008 | 金属材料研究2008，34，3： | 0 |
| 14 | Warm Deformation Behavior of High Carbon Steel with Martensite Starting Structure显示文摘 | LI Qun JING Tianfu DU Tongxun YIN Minggui ZHAI Xiangtian | 2007 | 金属材料研究2007，33，4： | 0 |
| 15 | Identification of transgene insertions in two genetically modified soybeans using high throughput next generation sequencing显示文摘Genetically modified(GM) organisms are widely adopted. However, their safety assessments and control are still of special concern to the public. Identifying and localizing transgene insertion is an essentially prerequisite step. In this study, 2 independent transgene soybean lines were selected(LB4-AtDCGS-1-20-5-2 and CGS-ZG11) as typical cases. Both lines contained expression cassette of At-DCGS that encoding a feedback-insensitive cystathionine gamma-synthase to produce higher level methionine(Met). LB4-AtDCGS-1-20-5-2 was whole genome sequenced with one paired-end 500 bp library and two mate-paired 1 kb and 2 kb libraries using Illumina HiSeq sequencing platform. CGS-ZG11 was sequenced with only one paired-end 500 bp library. Both genomes were assembled,and 2 scaffold sequences(1 for each line) were screened out by aligning with transgene.Then the transgene insertion and its flanking regions in soybean genome were further identified and confirmed by PCR cloning and Sanger sequencing. Results showed that these 2 transgene lines had single copy of inserted transgene. Their transgene insertion contents were identified, which facilitates further safety assessment. These results indicated that genome assembly using high throughput sequencing is a powerful tool for identifying transgene insertions, even with limited knowledge. | Shouwei Zhang Shi Sun Jing Sun Xiujie Liu Wensheng Hou Tingting Wu Cunxiang Wu Tianfu Han Bingjun Jiang | 2018 | Oil Crop Science2018，3，2： | 0 |
| 16 | Effect of Additive on the Microstructure of Electro-deposited Nanocrystalline Ni-Fe Alloy显示文摘 | YU Jinku JING Tianfu LI Qun YANG Jun ZHANG Falun SONG Hao WEN Ruisheng | 2008 | 金属材料研究2008，34，2： | 0 |
| 17 | Chelating Metal Ions in a Metal-Organic Framework for Constructing a Biomimetic Catalyst Through Post-modification显示文摘Crystal engineering,as a burgeoning technology,has been widely used to construct metalloporphyrins biomimetic catalysts.Herein,a bimetallic metal-organic framework(MOF)was constructed by 4-(4-carboxyphenyl)-1,2,4-triazole ligand,Co2+and Zr4+metal ions by solvothermal reaction(named PFC-88).A N,N-chelation site was found between the two adjacent ligands in PFC-88,consequently a porphyrin-like structure was obtained through chelating Fe^(3+) in this site by post-modification,named PFC-88-Fe.The result of a single crystal X-ray technology verified that Fe ions were successfully metalated in the N,N-chelation site of PFC-88,which is assisted by the X-ray absorption near-edge structure(XANES)spectra.An o-phenylenediamine oxidation reaction was applied to assessing the catalytic activity of PFC-88-Fe,in which the absorbance increases of phenazine-2,3-diamine atλ=418 nm were recorded by absorption spectroscopy in kinetic mode,exhibiting the application potential as a biomimetic catalyst. | PANG Kuan XUE Huan LIU Haixiong SUN Jing LIU Tianfu | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
| 18 | Investigation of Preparing the Ultrafine Grained Low-carbon Steel by Warm Deformation显示文摘 | LI Qun JING Tianfu GAO Yuwei LI Hongbiao YU Jinku | 2011 | 金属材料研究2011，37，3： | 0 |
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