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| 1 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 2 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis显示文摘 | Guruprasad P. Aithal James A. Thomas Philip V. Kaye Adam Lawson Stephen D. Ryder Ian Spendlove Andrew S. Austin Jan G. Freeman Linda Morgan Jonathan Webber | 2008 | Gastroenterology2008，，4： | 2 |
| 3 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 4 | Micro- and nanofluidics for DNA analysis显示文摘 | Jonas O. Tegenfeldt Christelle Prinz Han Cao Richard L. Huang Robert H. Austin Stephen Y. Chou Edward C. Cox James C. Sturm | 2004 | Analytical and Bioanalytical Chemistry2004，，7： | 1 |
| 5 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis显示文摘 | Guruprasad P. Aithal James A. Thomas Philip V. Kaye Adam Lawson Stephen D. Ryder Ian Spendlove Andrew S. Austin Jan G. Freeman Linda Morgan Jonathan Webber | 2008 | Gastroenterology2008，，4： | 1 |
| 6 | teaching notes: communicating the teacher's wisdom显示文摘 | Austin James E | | Harvard Business school0，9，： | 1 |
| 7 | Microbiological and bio-chemical origins of human axillary odour 显示文摘 | James AG Austin C J Cox DS | 2013 | FEMS Microbiol Ecol2013，83，3： | 1 |
| 8 | Social and Commercial Entrepreneurship:Same,Different,or Both?显示文摘 | James Austin Howard Stevenson and Jane Wei-Skillern | 2006 | Entrepreneurship Thoery & Practice2006，，1： | 1 |
| 9 | Genetic Mechanisms in Interval Colon Cancers显示文摘 | James M. Richter Maria Simona Pino Thomas R. Austin Emily Campbell Jackie Szymonifka Andrea L. Russo Theodore S. Hong Darrell Borger A. John Iafrate Daniel C. Chung | 2014 | Digestive Diseases and Sciences2014，，9： | 1 |
| 10 | Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFNbeta during acute ocular herpes simplex virus type 1 infection 显示文摘 | Austin BA James C Silverman RH | 2005 | JImmunol2005，175，2： | 1 |
| 11 | Stratospheric equatorial QBO influences on Sudden Warming显示文摘 | James R Holton and Austin J | 1991 | Journal of Atmospheric Sciences1991，48，4： | 1 |
| 12 | Treatment recommendations for primary extradural meningionms 显示文摘 | Austin M Betsy H James O | 2011 | Caneer2011，117，： | 1 |
| 13 | 有效防治害虫,捍卫食品安全显示文摘某些害虫不仅可以导致媒介疾病,如昏睡病、黑热病以及伤寒等,还可以传播腹泻病菌,与肠道传染病的发生也密切相关。因此,由媒介生物传播的疾病是整个食品加工过程中非常值得关注的一个问题。 | James Austin Dawn Calibeo-Hayes | 2009 | 食品安全导刊2009，，5： | 1 |
| 14 | Mathematical modeling of the forces between an intraocular lens and the capsule显示文摘 | James F. Boyce Gurpreet Saab Bhermi David J. Spalton Austin R. El-Osta | 2002 | Journal of Cataract & Refractive Surgery2002，，10： | 1 |
| 15 | Admixture of ephedrine to offset side effects of propofol : a randomized, controlled trial 显示文摘 | James D Austin FR Camrcp CH | 2009 | J Clin Anesth2009，21，： | 1 |
| 16 | The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups显示文摘 | Michael T. Jaklitsch Francine L. Jacobson John H.M. Austin John K. Field James R. Jett Shaf Keshavjee Heber MacMahon James L. Mulshine Reginald F. Munden Ravi Salgia Gary M. Strauss Scott J. Swanson William D. Travis David J. Sugarbaker | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 17 | Theory of Raman Gain Spectrum Transformations 显示文摘 | James Murray T William Austin L | 1999 | Optical Materials1999，11，： | 1 |
| 18 | The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups显示文摘 | Michael T. Jaklitsch Francine L. Jacobson John H.M. Austin John K. Field James R. Jett Shaf Keshavjee Heber MacMahon James L. Mulshine Reginald F. Munden Ravi Salgia Gary M. Strauss Scott J. Swanson William D. Travis David J. Sugarbaker | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 19 | Estimating source location using normalized magnetic source strength calculated from magnetic gradient tensor data显示文摘 | Majid Beiki Clark A David Austin R James | 2012 | Geophysics2012，77，6： | 1 |
| 20 | Energy Use and Transport Correlation Linking Permnal and Travel Related Energy Uses to the Urban Structure显示文摘 | James Cooper Tim Ryley Austin Smyth | 2001 | Environmental Science & Policy2001，，4： | 1 |
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