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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | Myocardialnecrosis induced by temporary occlusion of coronary atery in the dog 显示文摘 | Jennings R B Sommers H M Smyth G A | 1960 | Arch Pathol1960，70，1： | 1 |
| 4 | Enzymatic, mechanical and thermal pre-treatment of surplus sludge 显示文摘 | BAP JEN B M KOPPLOW O | 2003 | Advances in Environmental Research2003，7，3： | 1 |
| 5 | Resveratrol in metabolic health: an overview of the current evidence and perspectives显示文摘 | Morten M?ller Poulsen Jens Otto Lunde J?rgensen Niels Jessen Bj?rn Richelsen Steen B?nl?kke Pedersen | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 6 | MR imaging of synovial sarcoma with radiologic-pathologic correlation显示文摘 | Murphey M D Gibson M S Jenning B T | 2006 | Radiologics2006，26，5： | 1 |
| 7 | Effect of the amount of adhesive on the bending fatigue strength of adhesively bonded aluminum honeycomb sandwich beams 显示文摘 | JEN Y M KO C W LIN H B | 2009 | Int J Fatigue2009，31，3： | 1 |
| 8 | Microtopographic cues for settlement of zoospores of the green fouling alga Enteromorpha显示文摘 | Callow M E Jennings A R Brennan A B | 2002 | Bio- fouling2002，18，3： | 1 |
| 9 | Iontophoresis of monomeric insulin analogues in vitro: Effects of insulin charge and skin pretreatment 显示文摘 | Lotte L Jens B Gerold M G | 1998 | J Control Release1998，51，： | 1 |
| 10 | Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog显示文摘 | Jennings R B Sommers H M Smyth G A | 1960 | Arch Pathol1960，6，70： | 1 |
| 11 | Comparison of measured and calculated permeabilities for hardened cement pastes显示文摘 | Christensen B J Mason T O Jennings H M | 1996 | Cement and Concrete Research1996，26，13： | 1 |
| 12 | Camel and bovine chymosin: the relationship between their structures and cheese‐making properties显示文摘 | Jesper Langholm Jensen Anne M?lgaard Jens‐Christian Navarro Poulsen Marianne Kirsten Harboe Jens B?k Simonsen Andrea Maria Lorentzen Karin Hjern? Johannes M. van den Brink Karsten Bruun Qvist Sine Larsen | 2013 | Acta Cryst. D2013，，5： | 1 |
| 13 | A study of Internet instant messaging and chat protocols显示文摘 | Jennings III R B Nahum E M | 2006 | Network IEEE2006，20，4： | 1 |
| 14 | Expression of the hantaan virus M genome segment by using a vaccinia virus recombinant 显示文摘 | Pensiero M N Jennings G B Sehmajohn C S | 1988 | J Virol1988，62，3： | 1 |
| 15 | Mechanism of elevated plasma noradrenaline in the course of essential hypertension显示文摘 | Esler M Jennings G Biviano B | 1986 | J Cardiovasc Pharmacol1986，8，5： | 1 |
| 16 | Trends in transparency: Nursing performance measurement and reporting显示文摘 | Kurtzman E T Jennings B M | 2008 | Journal of Nursing Adminst ration2008，38，78： | 1 |
| 17 | Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition12345显示文摘 | Martine M Ros H Bas Bueno-de-Mesquita Ellen Kampman Katja KH Aben Frederike L Büchner Eugene HJM Jansen Carla H van Gils Lars Egevad Kim Overvad Anne Tj?nneland Nina Roswall Marie Christine Boutron-Ruault Marina Kvaskoff Florence Perquier Rudolf Kaaks Jen | 2012 | American Journal of Clinical Nutrition2012，，4： | 1 |
| 18 | Natural frequencies and mode shapes of beam carrying a two degree of freedom spring mass system显示文摘 | Jen M U Magrab E B | 1993 | Journal of Sound and Vibration1993，115，2： | 1 |
| 19 | Assessing Time-to-Failure Due to Conductive Filament Formation in Multi-Layer Organic Laminates显示文摘 | Rudra B Pecht M Jennings D | 1994 | IEEE Trans On CPMT-PartB1994，17，3： | 1 |
| 20 | Early growth determines longevity in male rats and may be related to telomere shortening in the kidney 显示文摘 | JENNINGS B J OZANNE S E DORLING M W | 1999 | FEBS Letters1999，448，1： | 1 |
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