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| 1 | Detection of RASSF1A promoter hypermethylation in serum from gastric and colorectal adenocarcinoma patients显示文摘AIM:To evaluate the diagnostic role of serum RASSF1A promoter hypermethylation in gastric and colorectal ad- enocarcinoma. METHODS:Methylation-specific polymerase chain reac- tion (MSPCR) was used to examine the promoter meth- ylation status of the serum RASSF1A gene in 47 gastric adenocarcinoma patients, 45 colorectal adenocarcinoma patients, 60 patients with benign gastrointestinal dis- ease (30 with benign gastric disease and 30 with benign colorectal disease), and 30 healthy donor controls. Apaired study of RASSF1A promoter methylation status in primary tumor, adjacent normal tissue, and postopera- tive serum were conducted in 25 gastric and colorectal adenocarcinoma patients who later were underwent sur- gical therapy. RESULTS:The frequencies of detection of serum RASSF1A promoter hypermethylation in gastric (34.0%) and colorectal (28.9%) adenocarcinoma patients were significantly higher than those in patients with benign gastric (3.3%) or colorectal (6.7%) disease or in healthy donors (0%) (P < 0.01). The methylation status of RASSF1A promoter in serum samples was consistent with that in paired primary tumors, and the MSPCR results for RASSF1A promoter methylation status in paired preoperative samples were consistent with those in postoperative serum samples. The serum RASSF1A promoter hypermethylation did not correlate with patient sex, age, tumor differentiation grade, surgical therapy, or serum carcinoembryonic antigen level. Although the serum RASSF1A promoter hypermethylation frequency tended to be higher in patients with distant metastases, there was no correlation between methylation status and metastasis. CONCLUSION:Aberrant CpG island methylation within the promoter region of RASSF1A is a promising biomark- er for gastric and colorectal cancer. | Yu-Cai Wang Zheng-HongYu Chang Liu Li-Zhi Xu Wen Yu Jia Lu Ren-Min Zhu Guo-Li Li Xin-Yi Xia Xiao-Wei Wei Hong-Zan Ji Heng Lu Yong Gao Wei-Min Gao Long-Bang Chen | 2008 | World Journal of Gastroenterology2008，14，19： | 26 |
| 2 | Self-supported high-entropy alloy electrocatalyst for highly efficient H_(2) evolution in acid condition显示文摘Developing non-precious catalysts as Pt substitutes for electrochemical hydrogen evolution reaction(HER)with superior stability in acidic electrolyte is of critical importance for large-scale,low-cost hydrogen production from water.Herein,we report a CoCrFeNiAl high-entropy alloy(HEA)electrocatalyst with self-supported structure synthesized by mechanical alloying and spark plasma sintering(SPS)consolidation.The HEA after HF treatment and in situ electrochemical activation for 4000 cycles of cyclic voltammetry(HF-HEAa2)presents favourable activity with overpotential of 73 mV to reach a current density of 10 mA cm^(2) and a Tafel slope of 39.7 mV dec1.The alloy effect of Al/Cr with Co/Fe/Ni at atomic level,high-temperature crystallization,as well as consolidation by SPS endow CoCrFeNiAl HEA with high stability in 0.5 M H2SO4 solution.The superior performance of HF-HEAa2 is related with the presence of metal hydroxides/oxides groups on HEA. | Peiyan Ma Mingming Zhao Long Zhang Heng Wang Junfeng Gu Yuchen Sun Wei Ji Zhengyi Fu | 2020 | Journal of Materiomics2020，6，4： | 8 |
| 3 | Degradation of p-nitrophenol(PNP) in aqueous solution by mFe/Cu-air-PS system显示文摘In this study,batch experiments were conducted to investigate the performance of microscale Fe/Cu bimetallic particles-air-persulfate system(mFe/Cu-air-PS)for p-nitrophenol(PNP)treatment in aqueous solution.First,the optimal operating parameters(i.e.,aeration rate of 1.0 L/min,theoretical Cu mass loading(TMLCu)of 0.110 g Cu/g Fe,mFe/Cu dosage of 15 g/L,PS total dosage of 15 mmol/L,feeding times of PS of 5,initial pH 5.4)were obtained successively by single-factor experiments.Under the optimal conditions,high COD and TOC removal efficiencies(71.0%,65.8%)were obtained after 60 min treatment.Afterword,compared with control experiments(i.e.,mFe/Cu,air,PS,mFe/Cu-air,mFe/Cu–PS,air-PS and mFe-air-PS),mFe/Cu-air-PS system exerted superior performance for pollutants removal due to the synergistic effect between mFe/Cu,air and PS.In addition,the results of control experiments and radical quenching experiments indicate this reinforcement by feeding of PS was greater than by aeration in m Fe/Cu-air-PS system.Furthermore,the degradation intermediates of PNP in mFe/Cu-air-PS process were identified and measured by HPLC.Based on the detected intermediates,the degradation pathways of PNP were proposed comprehensively,which revealed that toxic and refractory PNP in aqueous solution could be decomposed effectively and transformed into lower toxicity intermediates.As a result,m Fe/Cu-air-PS system with the performance of oxidation combined reduction can be also a potential technology for the treatment of toxic and refractory PNP contained wastewater. | Heng Zhang Qingqing Ji Leiduo Lai Gang Yao Bo Lai | 2019 | Chinese Chemical Letters2019，30，5： | 7 |
| 4 | IGHG1 promotes motility likely through epithelial-mesenchymal transition in ovarian cancer显示文摘Objective: Ovarian cancer(OC) is one of the leading causes of death for female cancer patients. COC166-9 is an OC-specific monoclonal antibody and we have identified immunoglobulin γ-1 heavy chain constant region(IGHG1) as its antigen. We explore the function of IGHG1 in proliferation, apoptosis and motility of OC cells further in this research.Methods: IGHG1 expression in OC specimens was detected through immunohistochemistry. Real-time quantitative polymerase chain reaction(RT-q PCR) or western blotting assay was used to test IGHG1 expression in OC cells. Viability of OC cells was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay. Flow cytometry or western blotting assay was used to detect cell cycle and apoptosis. Cellular motility was analyzed by using transwell assay and the markers of epithelial-mesenchymal transition(EMT) were tested through immunoblots.Results: Although it exerts negligible effect on the viability and apoptosis of OC cells, IGHG1 could promote migration and invasion of malignant cells in vitro. Mechanistically, IGHG1 increases the expression of N-cadherin and Vimentin while decreases E-cadherin expression. Additionally, IGHG1 expression in OC specimens is higher relative to the paired normal counterparts. Further analysis demonstrates that the increased IGHG1 expression correlates positively with the lymph node metastasis of OC.Conclusions: IGHG1 promotes the motility of OC cells likely through executing the EMT program. Increased IGHG1 expression in OC specimens is associated with the lymph node metastasis. | Jingfeng Qian Fangxing Ji Xue Ye Hongyan Cheng Ruiqiong Ma Xiaohong Chang Chengchao Shou Heng Cui | 2018 | Chinese Journal of Cancer Research2018，30，2： | 6 |
| 5 | High Prevalence and Factors Contributing to Hyperhomocysteinemia, Folate Deficiency, and Vitamin B_(12) Deficiency among Healthy Adults in Shanghai, China显示文摘Elevated plasma or serum total homocysteine (tHcy) level has been established as a risk factor for cardiovascular disease[1], as well as dementia and cognitive decline[2]. Plasma or serum folate and vitamin B12 influence homocysteine (Hcy) metabolism as a co-substrate and cofactor respectively, so that low concentrations of folate and vitamin B12 are also associated with high Hcy levels[1]. However, not much information is available describing serum tHcy, folate, and vitamin B12 status in Shanghai adults, especially in a healthy population. Therefore, we hypothesize that low serum folate and vitamin B12 is associated with high Hcy in healthy adults in Shanghai. The aim of this study was to determine the status of serum tHcy, folate, and vitamin B12, and the prevalence and factors contributing to HHcy, folate deficiency, and vitamin B12 deficiency among healthy adults in Shanghai, China. | WANG Yu Heng YAN Qing Hua XU Ji Ying LI Xin Jian CHENG Min Na | 2019 | Biomedical and Environmental Sciences2019，32，1： | 6 |
| 6 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 7 | Joint Entity and Event Extraction with Generative Adversarial Imitation Learning显示文摘We propose a new framework for entity and event extraction based on generative adversarial imitation learning-an inverse reinforcement learning method using a generative adversarial network(GAN).We assume that instances and labels yield to various extents of difficulty and the gains and penalties(rewards)are expected to be diverse.We utilize discriminators to estimate proper rewards according to the difference between the labels committed by the ground-truth(expert)and the extractor(agent).Our experiments demonstrate that the proposed framework outperforms state-of-the-art methods. | Tongtao Zhang Heng Ji Avirup Sil | 2019 | Data Intelligence2019，1，2： | 6 |
| 8 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 9 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 10 | A method to Estimate Dynamic Responses of VLFS Based on Multi-Floating-Module Model Connected by Elastic Hinges显示文摘Based on the elastic foundation beam theory and the multi-floating-module hydrodynamic theory,a novel method is proposed to estimate the dynamic responses of VLFS(Very Large Floating Structure).In still water,a VLFS can be simplified as an elastic foundation beam model or a multi-floating-module model connected by elastic hinges.According to equivalent displacement of the two models in static analysis,the problem of rotation stiffness of elastic hinges can be solved.Then,based on the potential flow theory,the dynamic responding analysis of multi-floatingmodule model under wave loads can be computed in ANSYS-AQWA software.By assembling the time domain analysis results of each module,the dynamic responses of the VLFS can be obtained.Validation of the method is conducted through a series of comparison calculations,which mainly includes a continuous structure and a three-part structure connected by hinges in regular waves.The results of this paper method show a satisfactory agreement with the experiment and calculation data given in relative references. | HUANG Heng CHEN Xu-jun LIU Jun-yi MIAO Yu-ji JI Song | 2021 | China Ocean Engineering2021，35，5： | 4 |
| 11 | Mycophenolic acid inhibits SLE-associated cytokine expression and promotes apoptosis of peripheral blood mononuclear cells from patients with systemic lupus erythematosus显示文摘瞄准:在 cytokine 生产和外部血的 apoptosis 上调查新奇抑制免疫力的药 mycophenolic (MPA ) 的效果有全身性红斑狼疮(SLE ) 的病人的单音的原子房间(PBMC ) 。方法:在从 41 个 SLE 病人的有教养的 PBMC 的上层清液的 IL-10, IL-12, IFN-gamma, sFas 和 sFasL 的层次被 ABC-ELISA 方法决定。IFN-gamma (+) IL-10 (-) , IFN-gamma (-) IL-10 (+) ,和 IFN-gamma (+) IL-10 (+) 的百分比在 CD4+ 房间的子集被三色的流动血细胞计数检测。apoptotic Th 房间的百分比被 AV-FITC/PI 流动血细胞计数检测。从 22 个性可比较、年龄可比较的健康的人的样品被用作正常控制。结果:IL-10, IL-12,和 IFN-gamma 的层次都显著地从 SLE 样品在有教养的 PBMC 的上层清液被提高,与正常控制相比。自发地从 SLE 由 PBMC 提高了 IL-10, IL-12,和 IFN-gamma 的生产并且由 phytohaemagglutinin (公众房产管理局) 刺激了被 MPA 显著地减少。当 MPA 被增加进文化时,在从 SLE 的有教养的 PBMC 的 CD4 (+) IFN-gamma (-) IL-10 (+) 和 CD4 (+) IFN-gamma (+) IL-10 (+) 房间子集的百分比显著地被增加,但是减少。在是为 48 h 的有教养的在试管内以后, SLE 病人的 PBMC 象 apoptosis 的一个更高的百分比一样显示出 sFasL 的更高的分泌物。MPA 显著地增加了 SLE PBMC 的 apoptotic 百分比,但是减少了 sFasL 和 sFas 的分泌物。结论:MPA 减少联系 SLE 的 cytokines 的反常生产,例如 IL-10, IL-12,和 IFN-gamma;禁止 CD4 (+) IFN-gamma (+) IL-10, CD4 (+) IFN-gamma (-) IL-10 (+) 和 CD4 (+) IFN-gamma (+) IL-10 (+) 子集的增加;并且在 SLE 支持 PBMC 的 apoptosis 病人,它可以为 SLE 与 MPA 的治疗学的机制被联系。 | Ding-lei SU Hui-juan WANG Xiao-hui JI Yuan-yuan LI Heng-bao XUAN Chun HENG Yu-feng LI | 2006 | Acta Pharmacologica Sinica2006，27，8： | 4 |
| 12 | The lifestyle transition of Arthrobotrys oligospora is mediated by microRNA-like RNAs显示文摘The lifestyle transition of fungi,defined as switching from taking organic material as nutrients to pathogens,is a fundamental phenomenon in nature.However,the mechanisms of such transition remain largely unknown.Here we show microRNA-like RNAs(milRNAs)play a key role in fungal lifestyle transition for the first time.We identified milRNAs by small RNA sequencing in Arthrobotrys oligospora,a known nematode-trapping fungus.Among them,7 highly expressed milRNAs were confirmed by northern-blot analysis.Knocking out two milRNAs significantly decreased A.oligospora’s ability to switch lifestyles.We further identified that two of these milRNAs were associated with argonaute protein QDE-2 by RNA-immunoprecipitation(RIP)analysis.Three of the predicted target genes of milRNAs were found in immunoprecipitation(IP)products of QDE-2.Disruption of argonaute gene qde-2 also led to serious defects in lifestyle transition.Interestingly,knocking out individual milRNAs or qde-2 lead to diverse responses under different conditions,and qde-2 itself may be targeted by the milRNAs.Collectively,it indicates the lifestyle transition of fungi is mediated by milRNAs through RNA interference(RNAi)machinery,revealing the wide existence of miRNAs in fungi kingdom and providing new insights into understanding the adaptation of fungi from scavengers to predators and the mechanisms underlying fungal infections. | Xinglai Ji Heng Li Weihua Zhang Jiai Wang Lianming Liang Chenggang Zou Zefen Yu Shuqun Liu Ke-Qin Zhang | 2020 | Science China(Life Sciences)2020，63，4： | 4 |
| 13 | Cratering process and morphological features of the Xiuyan impact crater in Northeast China显示文摘By using crater impact morphological theory and mathematics modeling,the paper studies the cratering process and morphological features of the Xiuyan Crater in Northeast China based on remote sensing imagery,digital elevation model(DEM)and drilling and measuring data.The results show that:1)Simulated calculation indicates the diameter of the transient crater was1406±12 m and the depth was 497±4 m.The diameter of the final crater was 1758±15 m and the depth was 374.5±3.5 m;the thickness of the breccia lens was 188.5±0.5 m.The data is basically the same as previous drilling data.2)Preliminary determination of the size of Xiuyan impactor:The diameter at about 55 m for an iron meteorite,and about 115 m for a stony meteorite.3)The depth-to-diameter ratio is 0.143,similar to the typical simple crater.The circularity index of the Xiuyan Crater is0.884,indicating erosion and degradation.4)The distribution pattern of radial fractures has priority in NW-SE and WNW-ESE and these fractures control the development and evolution of drainage inside the crater. | WANG XinYuan LUO Lei GUO HuaDong MU LingLi LI Chao JI Wei CAI Heng | 2013 | Science China Earth Sciences2013，56，10： | 4 |
| 14 | Clinical outcome of treating intractable hematospermia using holmium laser incision through a ureteroscope显示文摘 | Xiao-Jun Wu Heng Zhang Yong-Quan Wang Yi Zhi Ji Zheng Peng He Wei-Bing Li Zhan-Song Zhou | 2016 | Asian Journal of Andrology2016，18，1： | 4 |
| 15 | Efficacy and safety of anlotinib plus S-1as thirdly-line or later-line treatmentin advanced non-small cell lung cancer显示文摘Objective Anlotinib,an oral vascular endothelial growth factor receptor 2(VEGFR2)inhibitor,has confirmed antitumor activity in lung cancer in both in vitro and in vivo assays,and has been recommended as third-line treatment agent in non-oncogene driven non-small cell lung cancer(NSCLC).This prospective study aimed to investigate the efficacy and safety of anlotinib plus S-1 for third-or later-line treatment in patients with advanced NSCLC.Methods Patients with histologically or cytologically confirmed NSCLC,and documented disease progression following second-line chemotherapy,and/or epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI)treatment were enrolled in this study.The patients were treated anlotinib(8 mg daily d 1–14)and S-1(60 mg/m^2 d 1–14)and the treatment was repeated every 3 weeks.Treatment was continued until disease progression or unacceptable toxicity occurred.The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),and adverse events(AEs)were reviewed and evaluated.Results Forty-one patients were enrolled in the study between June 2018 and December 2018.The total ORR and DCR were 26.8%and 80.5%,respectively.The median PFS was 5.2 months[95%confidence interval(CI),3.9 to 6.6 months].In the univariate analysis,there was a significant difference in the median PFS between patients with brain metastases and those without brain metastases(4.8 months vs 5.9 months,respectively;P=0.039).The Eastern Cooperative Oncology Group(ECOG)performance status(P=0.002),lines of therapy(P=0.015),and therapeutic evaluation(P=0.014)were independent factors that influenced PFS.The most common AEs were hypertension,proteinuria,myelosuppression,gastrointestinal reactions,fatigue,and mucositis.Conclusion Anlotinib plus S-1 is an effective and safe regimen for advanced NSCLC as third-or later-line therapy. | Heng Cao Kai Liang Peng Liu Jing Wang Yuanyuan Ji Lujuan Xu Weilong Wu Shengnan Guo Xuekun Song Yonggui Hong | 2020 | Oncology and Translational Medicine2020，6，1： | 4 |
| 16 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 17 | Kongsheng Zhenzhong pill's effect on the learning and memory ability and its neuroprotective effects in vascular dementia rats显示文摘Clinical reports have demonstrated that the Kongsheng Zhenzhong pill (KSZZP),a classical prescription deriving from Valuable Prescription for Emergencies,has good therapeutic effects on vascular dementia.However,the mechanisms that mediate its effects remain unclear.In this study,the expression of N-methyl-D-aspartate receptor 1 mRNA,the content of nitric oxide,and the concentration of calcium in neurons was determined with in situ hybridization,spectrophotometry and flow cytometry,respectively.In addition,the expressions of N-methyl-D-aspartate receptor 1,nerve growth factor protein,and glial cell line-derived neurotrophic factor protein were detected with immunohistochemistry.We found that KSZZP could significantly decrease the expression of N-methyl-D-aspartate receptor 1 mRNA and protein,the content of nitric oxide,and the concentration of calcium in neurons.KSZZP also increased the expression of nerve growth factor and glial cell line-derived neurotrophic factor protein in the hippocampus CA1 region and in the cerebral cortex.Morris water maze and passive avoidance tests verified that KSZZP ameliorated the cognitive impairments of vascular dementia rats.Moreover,the KSZZP-induced improvements in the cognitive functions of vascular dementia rats were correlated with both inhibition of N-methyl-D-aspartate-induced excitable neurotoxicity and elevation of neurotrophic factor expression. | Xuming Ji Huayun Yu Bin Ouyang Guowei Liu Zhichun Wu Heng Liu Fang Du | 2011 | Neural Regeneration Research2011，6，30： | 3 |
| 18 | A Perspective:the Technical Barriers of Zn Metal Batteries显示文摘Energy storage will witness a leap of understanding of new battery chemistries.Considering the safety that cannot be compromised,new aqueous batteries may surface as the solutions to meet the immense market needs,where the growth of renewables is no longer limited by the lack of storage.Aqueous Zn-metal batteries are intriguing candidates to deliver the desirable properties and exhibit competitive levelized energy cost.However,the fact that most commercial Zn batteries are primary batteries states the difficulty of reversibility for the reactions of electrodes in such batteries.This article will highlight the practical needs that guide the development of storage batteries.The causes of irreversibility for both cathode and zinc metal anode are discussed,and the potential solutions for these challenges are summarized.Zn metal batteries may one day address the storage needs,and there exists a vast potential to further improve the properties of reactions in this battery. | JI Xiulei JIANG Heng | 2020 | Chemical Research in Chinese Universities2020，36，1： | 3 |
| 19 | Counter-ion insertion of chloride in Mn3O4 as cathode for dual-ion batteries: A new mechanism of electrosynthesis for reversible anion storage显示文摘Irreversible reductive insertion of Zn2+transforms Mn3O4 such that the resulting Zn0.2Mn3O4 exhibits highly reversible storage properties of chloride ions,thus rendering Zn0.2Mn3O4 an excellent cathode of aqueous dual-ion batteries.With Zn2+trapped,Zn0.2Mn3O4 delivers the chloride-storage capacity over 200 mAh/g at an average potential of 1.6 V vs Zn2+/Zn by reversibly forming a new ionic compound equivalent to Zn0.2Mn3O4Cl1.7.Electrochemical quartz crystal microbalance results suggest chloride as the primary charge carrier in the reversible oxidative anion insertion.The Mn3O4 anion-hosting cathode couples with Zn metal anode in a full-cell dual-ion battery,demonstrating stable cycling in practical pouch cells with an energy density of 150 Wh/kg based on the mass of both electrodes. | Heng Jiang Xiulei Ji | 2020 | Carbon Energy2020，2，3： | 3 |
| 20 | Global detection of large lunar craters based on the CE-1 digital elevation model显示文摘坑,月亮的表面的最重要的特征之一,因为他们为我们提供表面单位以及关键地质的信息的相对年龄,广泛地被研究了。关于月亮和另外的行星的身体的算法(CDA ) 专注于从形象数据检测他们的坑察觉的研究,而是检测使用的大坑的计算费用想象使这些 CDA 不切实际。这篇论文介绍一条新途径给利用一个数字举起模型而不是图象的坑察觉;这启用大坑的充分自动的全球察觉。坑被地面属性,然后 thresholding 描出地面属性的地图被用来把地志的数据转变成一幅二进制图象,最后,坑被从二进制图象使用 Hough 变换检测。由使用建议算法,我们生产了所有坑的一个目录在月亮的表面上的直径的 10 km 并且分析了他们的分发和人口特征。 | Lei LUO Lingli MU Xinyuan WANG Chao LI Wei JI Jinjin ZHAO Heng CAI | 2013 | Frontiers of Earth Science2013，7，4： | 3 |
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