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| 1 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 2 | 食品中磷的检测方法显示文摘磷是人体内的重要元素之一,对人体生命活动有十分重要的作用,如何快速、简便、准确、灵敏地检测食品中磷的含量已经引起了世界各国的重视.本文总结了前人的研究工作,概述了近年来食品中总磷及有机磷农药的检测研究进展,分析了各种检测方法的优势和局限性,展望了未来该领域研究的发展趋势. | 卫敏 LIU RuiHai DING Liang CHENG WenLong XU JianFeng LUO Dan 刘钟栋 | 2010 | 中国科学:化学2010，40，7： | 24 |
| 3 | Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography显示文摘[-2]proPSA (p2PSA ) 和它的衍生物, p2PSA-to-free PSA 比率(% p2PSA ) ,和前列腺健康索引(PHI ) 极大地在前列腺活体检视有或没有前列腺癌症(PCa ) 改进了在人之间的辨别。然而,很少在数字直肠的考试(DRE ) 和 transrectal ultrasonography (TRUS ) 是否定的情况中对他们的表演被知道。在有否定 DRE 和 TRUS 的中国的 261 个连续病人的一个未来的队被招募并且经历前列腺活体检视。在活体检视被用来测量各种各样的 PSA 衍生物以前,一件浆液样品收集了,包括总数前列腺特定的抗原(tPSA ) ,免费 PSA,和 p2PSA。为每个病人, free-to-total PSA 比率(% fPSA ) , PSA 密度(PSAD ) , p2PSA-to-free PSA 比率(% p2PSA ) ,和 PHI 是计算的。歧视的性能在在 91% 敏感操作典型曲线(AUC ) 和活体检视率的接收装置下面用区域被估计。在关于年龄, tPSA, % fPSA, PSAD, p2PSA, % p2PSA,和 PHI 的全部队以内的 AUC 分数分别地是 0.598, 0.751, 0.646, 0.789, 0.814, 0.808,和 0.853。PHI 是前列腺活体检视结果的最好的预言者,特别在有 10.1-20 ng ml −1 的 tPSA 的病人。与另外的标记相比,在 91% 的敏感, PHI 为决定哪个人不需要经历活体检视是最有用的,从而避免不必要的过程。PHI 的使用能由在中国与否定 DRE 和 TRUS 在人之中预言前列腺活体检视结果改进 PCa 察觉的精确性。 | Guo-Peng Yu Rong Na Ding-Wei Ye Jun Qi Fang Liu Hai-Tao Chen Yi-Shuo Wu Gui-Ming Zhang Jie-Lin Sun Yao Zhu Li-Qun Huang Shan-Cheng Ren De-Ke Jiang S Lilly Zheng Hao-WenJiang Ying-Hao Sun Qiang Ding Jianfeng Xu | 2016 | Asian Journal of Andrology2016，18，4： | 10 |
| 4 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 5 | Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population显示文摘Risk prediction models including the Prostate Health Index(phi)for prostate cancer have been well established and evaluated in the Western population.The aim of this study is to build phi-based risk calculators in a prostate biopsy population and evaluate their performanee in predicting prostate cancer(PCa)and high-grade PCa(Gleason score 27)in the Chinese population.We developed risk calculators based on 635 men who underwent initial prostate biopsy.Then,we validated the performance of prostate-specific antigen(PSA),phi,and the risk calculators in an additional observational cohort of 1045 men.We observed that the phi-based risk calculators(risk calculators 2 and 4)outperformed the PSA-based risk calculator for predicting PCa and high-grade PCa in the training cohort.In the validation study,the area under the receiver operating characteristic curve(AUC)for risk calculators 2 and 4 reached 0.91 and 0.92,respectively,for predicting PCa and high-grade PCa,respectively;the AUC values were better than those for risk calculator 1(PSA-based model with an AUC of 0.81 and 0.82,respectively)(all P<0.001).Such superiority was also observed in the stratified population with PSA ranging from 2.0 ng ml^-1 to 10.0 ng ml^-1.Decision curves confirmed that a considerable proportion of unnecessary biopsies could be avoided while applying phi-based risk calculators.In this study,we showed that,compared to risk calculators without phi,phi-based risk calculators exhibited superior discrimination and calibration for PCa in the Chinese biopsy population.Applying these risk calculators also considerably reduced the number of unnecessary biopsies for PCa. | Yi-Shuo Wu Xiao-Jian Fu Rong Na Ding-Wei Ye Jun Qi Xiao-Ling Lin Fang Liu Jian Gong Ning Zhang Guang-Liang Jiang Hao-Wen Jiang Qiang Ding Jianfeng Xu Ying-Hao Sun | 2019 | Asian Journal of Andrology2019，21，6： | 6 |
| 6 | 溃疡性结肠炎内镜下严重度指数(UCEIS评分)与Mayo内镜评分(MES)用于预测急性重症结肠炎患者行肠切除术的比较研究显示文摘背景溃疡性结肠炎内镜下严重度指数(UCEIS)和Mayo内镜评分(MES)都是溃疡性结肠炎(UC)内镜下严重程度的客观评估方法,然而,对于这两种评分方法能否用于筛选出需要行结肠切除术的急性重症结肠炎患者,目前仍不明了。方法:对2012年1月至2016年5月间连续收治的ASC患者进行回顾性分析。提取并分析入组患者的人口统计资料、既往治疗史、疾病特征资料、实验室指标、药物治疗及内镜评估等资料。主要结局指标是住院和随访期间需行结肠切除术的患者比例。结果:92例患者纳入研究,其中37例(40.2%)需行结肠切除术。多因素分析显示,UCEIS评分是需行结肠切除术的独立预测因素(OR=3.25,95%CI:1.77~5.97;P<0.001)。UCEIS评分的ROC曲线下面积为0.85;以7分作为最佳阈值,其预测需行结肠切除术的敏感度为60.3%,特异度为85.5%。UCEIS评分对于需要行结肠切除术的预测价值优于MES评分,后者曲线下面积仅为0.65。当UCEIS评分≥7分时,有80%的ASC患者最终需行结肠切除术。结论:预测ASC患者的肠切除风险,UCEIS评分优于MES评分。对于USEIS≥7分的患者,由于其药物治疗失败风险较高,因此,可考虑早期行结肠切除术。 | Tingbin Xie Tenghui Zhang Chao Ding Xujie Dai Yi Li Zhen Guo Yao Wei Jianfeng Gong Weiming Zhu Jieshou Li | 2018 | Gastroenterology Report2018，6，1： | 6 |
| 7 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 8 | Design of a C-band polarization rotator-splitter based on a mode-evolution structure and an asymmetric directional coupler显示文摘A C-band polarization rotator-splitter based on a mode-evolution structure and an asymmetric directional coupler is proposed. The mode-evolution structure is designed in a bi-level taper through which the TM_0 mode can evolve into the TE_1 mode. Then the TE_1 mode is coupled to the TE_0 mode at the cross port using the asymmetric directional coupler. The input TE_0 mode propagates along the waveguide without mode conversion and output at the through port. From the experimental results, the extinction ratio is lower than 30 dB and the excess loss is less than 1 dB for input TE_0 mode at the whole C-band. For input TM_0 mode, the ER and the EL are, respectively,lower than-10 and 1.5 dB. | Chen Yuan Jincheng Dai Hao Jia Jianfeng Ding Lei Zhang Xin Fu Lin Yang | 2018 | Journal of Semiconductors2018，39，12： | 4 |
| 9 | Heat Transfer Characteristics of Printed Circuit Heat Exchanger with Supercritical Carbon Dioxide and Molten Salt显示文摘Molten salt and supercritical carbon dioxide(S-CO_(2))are important high temperature heat transfer media,but molten salt/S-CO_(2) heat exchanger has been seldom reported.In present paper,heat transfer in printed circuit heat exchanger(PCHE)with molten salt and S-CO_(2) is simulated and analyzed.Since S-CO_(2) can be drove along passage wall by strong buoyancy force with large density difference,its heat transfer is enhanced by natural convection.In inlet region,natural convection weakens along flow direction with decreasing Richardson number,and the thermal boundary layer becomes thicker,so local heat transfer coefficient of S-CO_(2) significantly decreases.In outlet region,turbulent kinetic energy gradually increases,and then heat transfer coefficient increases for turbulent heat transfer enhancement.Compared with transcritical CO_(2) with lower inlet temperature,local heat transfer coefficient of S-CO_(2) near inlet is lower for smaller Richardson number,while it will be higher for larger turbulent kinetic energy near outlet.Performance of PCHE is mainly determined by the pressure drop in molten salt passage and the heat transfer resistance in S-CO_(2) passage.When molten salt passage width increases,molten salt pressure drop significantly decreases,and overall heat transfer coefficient slightly changes,so the comprehensive performance of PCHE is improved.As a result,PCHE unit with three semicircular passages and one semi-elliptic passage has better performance. | LAO Jiewei FU Qianmei WANG Weilong DING Jing LU Jianfeng | 2021 | Journal of Thermal Science2021，30，3： | 4 |
| 10 | Research Progress and the Main Achievements of The Regional Geology of China Preface显示文摘Introduction to The Regional Geology of China In 2008, a new project concerning the recompilation of The Regional Geology of China (RGC) was assigned by the Chinese Geological Survey (CGS) and undertaken by the Institute of Geology, Chinese Academy of Geological Sciences (CAGS). Li Tingdong, an academician of the Chinese Academy of Sciences (CAS), is the chief leader and chief scientist of the project. The last time The Regional Geology of China was compiled was in the 1980s (Cheng, 1994). | DING Xiaozhong ZHANG Kexin GAO Linzhi LU Songnian PAN Guitang XIAO Qinghui LIU Yong PANG Jianfeng | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 3 |
| 11 | Digital Geological Mapping of Sinus Iridum Area of the Moon Based on the Chang'E-I Data显示文摘Based on the CCD images,IIM data and DEM data of China’s lunar exploration project(Chang’E-I)and related processed and analytic results,an integrated study of regional geology of Sinus Iridum and its adjacent area was conducted,and a series of relevant researches and analyses were carried out,including analysis of impact craters and their extrusive and accumulative materials,division of stratigraphic and tectonic units and classification of rock types,integrated analysis of chronology and lunar evolution history.In consideration of crater’s shape features,quantity and preserving status of filling materials,the lunar impact craters can be divided into 7 types and 11 subtypes,and the accumulative materials of craters are divided into 6 types and 9 accumulative groups.According to the content and distribution of TiO2and image characteristics,the basalts are divided into high-TiO2,medium-TiO2and low-TiO2basalts.Discussion was made on division of tectonic units and evolution features in the study area.The geological map of the Sinus Iridum Quadrangle(LQ-4)at a scale of 1:2.5 M was preliminarily compiled with the ArcGIS system,and the spatial database of the map was established.Related technical specification,procedure and method for lunar geological mapping have been worked out,so as to lay a foundation for the forthcoming geological mapping of the global Moon in China by using the data of Chang’E-II and also for comprehensive study and geological mapping of other celestial bodies in the future. | DING Xiaozhong HAN Kunying PANG Jianfeng WANG Liang HAN Tonglin JU Yuanjing DING Weicui | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 3 |
| 12 | Clinically available RNA profiling tests of prostate tumors: utility and comparison显示文摘在 postscreening 时代,医生们需要方法区别从 nonaggressive 前列腺癌症(PCa ) 好攻击减少 overdiagnosis 和 overtreatment。然而,研究显示出那预测(例如,前进和死亡) 与类似的临床、病理学的特征甚至在个人之中不同。存在风险分类器(TMN 分级系统,格利森分数,等等) 不是精确地足够的代表 PCa 的生物特征。用新 genomic 技术,新奇 biomarkers 和分类器被开发了并且出现为预言好攻击的疾病把价值加到临床或病理学的风险因素。在他们之中,因为它不能仅仅反映基因变化而且反映 epigenetic 规定,测试的 RNA (基因表示分析) 是有用的。商业地可得到的 RNA 介绍测试(Oncotype Dx, Prolaris,并且译解) 表明了强壮的能力从不太好攻击的疾病与差的预后区别 PCa。例如,介绍测试的这些 RNA 能在激进的治疗以后在活跃监视病人或早复发预言疾病前进。这些测试可以提供更可靠的方法让 PCa 预后预言做更精确、个人的医药决定。 | Rong Na Yishuo Wu Qiang Ding Jianfeng Xu | 2016 | Asian Journal of Andrology2016，18，4： | 2 |
| 13 | The Gβy-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation显示文摘 | Lisheng Li Wanze Chen Yaoji Liang Huabin Ma Wenjuan Li Zhenru Zhou Jie Li Yan Ding Junming Ren Juan Lin Felicia Han Jianfeng Wu Jiahuai Han | 2014 | Cell Research2014，24，4： | 2 |
| 14 | Preparation and characterization of porous hollow silica nanoparticles for drug delivery application显示文摘 | CHEN Jianfeng DING Haomin WANG Jiexin | 2004 | Biomaterials2004，25，4： | 1 |
| 15 | Wear Surface Studies on Coal Water Slurry Nozzles in Industry Boilers显示文摘 | Ding Zeliang Deng Jianxin Li Jianfeng | | 0，，05： | 1 |
| 16 | Zircon U–Pb Ages and Lu–Hf Isotope of the Dongchuan Group in Central Yunnan, China, and their Geological Significance显示文摘On the southwestern margin of the Yangtze Block, the Dongchuan Group consists of slightly metamorphosed sedimentary rocks, including silty slate, argillaceous slate, clayey slate, arkose, dolomite, and minor volcanic rocks. To date, it is still a controversy over the depositional age and stratigraphic sequence of the Dongchuan Group. In this study, we analyzed five samples of meta-sedimentary rocks and one sample of meta-tuff from the Yinmin, Luoxue and Etouchang Formations of the Dongchuan Group in the Yuxi region for detrital zircon U-Pb ages and Lu-Hf isotope. The detrital zircon ages of the meta-sediments vary from 3073 to 1703 Ma, mainly clustered at three periods, from 1889 to 1840, 2490 to 2008 and 2878 to 2844 Ma. The youngest age peak of all the samples is ~1859 Ma, with the εHf(t) values of the zircons ranging from-20.3 to +4.3 and more than 90% being negative, indicating that the Paleoproterozoic crustal accretion on the southwestern margin of the Yangtze Block was dominated by reworking of the ancient crustal materials involved in the assembly and breakup of the Columbia supercontinent. Another important age range is between 2490 Ma and 2008 Ma, with εHf(t) values from-14.7 to +8.9 and 70% of them are negative, suggesting that the magmatism in the source area was also dominated by reworking and recycling of the ancient crustal materials, with minor juvenile mantle substances added. The detritus was probably derived from the Paleoproterozoic crystalline basement in the southern Yuxi region. The oldest peak age is ~2847 Ma and the εHf(t) values are from-7.7 to +7.0 with 50% of both positive and negative values, demonstrating a possible ~2.85 Ga ancient continental nucleus on the southwestern margin of the Yangtze Block and substantial growth in juvenile crust materials during this period. Besides, the weighted average age of the zircons from the meta-tuff of the Etouchang Formation is 1677 ± 14 Ma. Combining the previous research data and this study, we can constrain the depositional age of the Dongchuan Group in central Yunnan Province to the period from the late Paleoproterozoic to early Mesoproterozoic, slightly earlier than that of the Dongchuan Group in the Dongchuan area near to the southwestern Sichuan Province. The depositional age of the Dongchuan Group is older than that of the Kunyang Group. | HAN Kunying ZHANG Heng DING Xiaozhong REN Liudong SHI Chenglong PANG Jianfeng | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 1 |
| 17 | Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms显示文摘 | HuiJuan Wu Yang Cao Danhui Weng Hui Xing Xiaohong Song Jianfeng Zhou Gang Xu Yunping Lu Shixuan Wang Ding Ma | 2008 | Cancer Letters2008，，2： | 1 |
| 18 | Coordinated Control Strategy for Harmonic Compensation of Multiple Active Power Filters显示文摘In order to minimize the harmonic distortion rate of the current at the common coupling point,this paper proposes a coordinated allocation strategy of harmonic compensation capacity considering the performance of active power filters(APF).On the premise of proportional distribution of harmonic compensation capacity,the harmonic compensation rate of each APF is considered,and the harmonic current value of each APF to be compensated is obtained.At the same time,the communication topology is introduced.Each APF takes into account the compensation ability of other APFs.Finally,three APFs with different capacity and performance are configured at the harmonic source to suppress the same harmonic source,and the harmonic distortion rate is reduced to 1.73%.The simulation results show that the strategy can effectively improve the compensation capability of the multiple APF cascaded system to the power grid without increasing the installed capacity. | Jianfeng Yang Rende Qi Yang Liu Yu Ding | 2022 | Energy Engineering2022，119，2： | 1 |
| 19 | Mullite fibres prepared by sol–gel method using polyvinyl butyral显示文摘 | Yabin Zhang Yaping Ding Jiqiang Gao Jianfeng Yang | 2008 | Journal of the European Ceramic Society2008，，6： | 1 |
| 20 | Mullite fi-bers prepared from an inorganic sol-gel precursor显示文摘 | Tan Hongbin Ding Yaping Yang Jianfeng | 2010 | Journal of Sol-Gel Science and Technology2010，53，2： | 1 |
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