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| 1 | Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis显示文摘 | Zhen Zhang Na Jiang Zhaohui Ni | 2017 | Frontiers of Medicine2017，11，3： | 14 |
| 2 | ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome显示文摘OBJECTIVES:Anti-citrullinated protein antibodies(ACPAs)are a group of autoantibodies targeted against citrullinated proteins/peptides and are informative rheumatoid arthritis(RA)biomarkers.ACPAs also play a crucial role in RA pathogenesis,and their underlying mechanism merits investigation.METHODS:Immunohistochemical(IHC)assays were carried out to determine IL-1βlevels in ACPA+and ACPA−RA patients.PBMCderived monocytes were differentiated into macrophages before stimulation with ACPAs purified from RA patients.The localization and interaction of molecules were analyzed by confocal microscopy,co-IP,and surface plasmon resonance.RESULTS:In our study,we found that IL-1βlevels were elevated in ACPA+RA patients and that ACPAs promoted IL-1βproduction by PBMC-derived macrophages.ACPAs interacted with CD147 to enhance the interaction between CD147 and integrinβ1 and,in turn,activate the Akt/NF-κB signaling pathway.The nuclear localization of p65 promoted the expression of NLRP3 and pro-IL-1β,resulting in priming.Moreover,ACPA stimulation activated pannexin channels,leading to ATP release.The accumulated ATP bound to the P2X7 receptor,leading to NLRP3 inflammasome activation.CONCLUSIONS:Our study suggests a new hypothesis regarding IL-1βproduction in RA involving ACPAs,which may be a potential therapeutic target in RA treatment. | Xiwen Dong Zhaohui Zheng Peng Lin Xianghui Fu Fanni Li Jianli Jiang Ping Zhu | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 3 | Seasonal,diurnal and nocturnal variations of carbonyl compounds in the semi-urban environment of Orléans,France显示文摘Atmospheric carbonyls were measured at a semi-urban site in Orléans, France, from October 2010to July2011. Formaldehyde, acetaldehyde and acetone were found to be the most abundant carbonyls, with average concentrations of 3.1, 1.0, 2.0 ppb, respectively in summer, 2.3, 0.7, 2.2 ppb, respectively in autumn, 2.2, 1.0, 2.1 ppb, respectively in spring,and 1.5, 0.7, 1.1 ppb, respectively in winter. Photo-oxidation of volatile organic compounds(VOCs) was found to make a remarkable contribution to atmospheric carbonyls in the semi-urban site based on the distinct seasonal and diurnal variations of the carbonyls, as well as the significantly positive correlations between the carbonyls and ozone. The significantly negative correlations between NO x and O_3 as well as the carbonyls and the positive correlations between wind speed and O_3 as well as the carbonyls implied that the carbonyls and O_3 at the semi-urban site were probably formed during air mass transport from neighboring cities. | Zhaohui Jiang Benoit Grosselin Véronique Daele Abdelwahid Mellouki Yujing Mu | 2016 | Journal of Environmental Sciences2016，28，2： | 10 |
| 4 | Experimental investigation on drag reduction in turbulent boundary layer over superhydrophobic surface by TRPIV显示文摘This study aims at the mechanism of drag reduction in turbulent boundary layer(TBL) with superhydrophobic surface.Comparing the time-resolved particle image velocimetry(TRPIV) measurement results with that of hydrophilic surface,the drag reduction rate over a superhydrophobic surface is approximately10%.To investigate the characteristics of coherent structure in a drag-reduced TBL with superhydrophobic surface,a modified multi-scale spatial locally-averaged structure function is proposed for detecting coherent structure.The conditional sampling and spatial phase-lock average methods are employed to obtain the topology of physical quantities like the velocity fluctuation,spanwise vorticity,and Reynolds stress during eject and sweep process.The results indicate that the suppression of coherent structure burst in the near-wall region is the key mechanism in reducing the skin friction drag for TBL over superhydrophobic surface. | Haiping Tian Jingxian Zhang Erdan Wang Zhaohui Yao Nan Jiang | 2015 | Theoretical & Applied Mechanics Letters2015，5，1： | 7 |
| 5 | Decentralized robust H-infinity descriptor output feedback control for value-bounded uncertain descriptor large-scale systems显示文摘为围住值的不明确的描述符的一个类大规模互连的系统,分散的柔韧的 H_ ∞描述符输出反馈控制问题被调查。Adesign 方法为一个分散的描述符基于围住的真实词根被开发动态输出反馈控制器,它为非线性的矩阵不平等(NLMI ) 被归结为一个可行性问题。由 homotopy 的想法反复地解决 NLMI 被建议,在一些变量在把 NLMI 归结为线性矩阵不平等(LMI ) 的每次重复或者被修理的地方。 | Yongfang XIE Weihua GUI Zhaohui JIANG | 2006 | 控制理论与应用(英文版)2006，4，2： | 6 |
| 6 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 7 | Spatial heterogeneity and source apportionment of soil metal(loid)s in an abandoned lead/zinc smelter显示文摘Metal smelting have brought severe metal(loid)s contamination to the soil.Spatial distribution and pollution source analysis for soil metal(loid)s in an abandoned lead/zinc smelter were studied.The results showed that soil was contaminated heavily withmetal(loid)s.The mean of lead(Pb),arsenic(As),cadmium(Cd),mercury(Hg)and antimony(Sb)content in topsoil is 9.7,8.2,5.0,2.3,and 1.2 times higher than the risk screening value for soil contamination of development land of China(GB36600-2018),respectively.Cd ismainly enriched in the 0–6mdepth of site soil while As and Pbmainly deposited in the 0–4mlayer.The spatial distribution of soil metal(loid)s is significantly correlated with the pollution source in the different functional areas of smelter.As,Hg,Sb,Pb and copper(Cu)were mainly distributed in pyrometallurgical area,while Cd,thallium(Tl)and zinc(Zn)was mainly existed in both hydrometallurgical area and raw material storage area.Soil metal(loid)s pollution sources in the abandoned smelter are mainly contributed to the anthropogenic sources,accounting for 84.5%.Specifically,Pb,Tl,As,Hg,Sb and Cumainly from atmospheric deposition(55.9%),Cd and Zn mainly from surface runoff(28.6%),While nickel(Ni)mainly comes from parent material(15.5%).The results clarified the spatial distribution and their sources in different functional areas of the smelter,providing a new thought for the risk prevention and control of metal(loid)s in polluted site soil. | Yunxia Zhang Tianshuang Li Zhaohui Guo Huimin Xie Zhihao Hu Hongzhen Ran Changzhou Li Zhichao Jiang | 2023 | Journal of Environmental Sciences2023，，5： | 5 |
| 8 | Flow Instability of a Centrifugal Pump Determined Using the Energy Gradient Method显示文摘The stability of the centrifugal pump has not been well revealed because of the complexity of internal flow. To analyze the flow characteristics of a centrifugal pump operating at low capacity, methods of numerical simulation and experimental research were adopted in this paper. Characteristics of the inner flow were obtained. Standard k–ε turbulence models were used to calculate the inner flow of the pump under off-design conditions. The distribution of the energy gradient function K was obtained by three-dimensional numerical simulation at different flow rates. The relative velocity component was acquired from the absolute velocity obtained in particle image velocimetry. By comparing with experimental results, it was found that flow instability occurs at the position of maximum K. The flow stability reduces with an increasing flow rate. The research results provide a theoretical basis for the optimization design of a centrifugal pump. | Li Yi Dong Wenlong He Zhaohui Huang Yuanmin Jiang Xiaojun | 2015 | Journal of Thermal Science2015，24，1： | 5 |
| 9 | Gene Expression and Activity of Enzymes Involved in Sugar Metabolism and Accumulation During “Huangguan” and “Yali” Pear Fruit Development显示文摘Since the carbohydrate content affects pear flavor during the process of growth, it is necessary to determine the sugar components that accumulate in the fruit. We analyzed the fruit carbohydrate content, and the gene expression and activity ofacid invertase(AI), neutral invertase(NI), sucrose synthase(SS), and sucrose phosphate synthase(SPS) during the development of 'Huangguan' and 'Yali' pears. The results demonstrate that during development, the fruit sugar metabolism of the 'Huangguan' pear follows a typical sorbitol–starch-soluble sugars middle model, whereas the 'Yali' pear fruit follows a typical sorbitol–sucrose–starch-soluble sugars middle model. In the 'Huangguan' pear, we found the AI and NI gene expressions, as well as AI( P < 0.05) and NI( P < 0.01) enzyme activities, to be positively correlated, whereas we found the NI gene expression and NI enzyme activity of 'Yali' pear to be negatively correlated( P < 0.01). We observed the high levels oflate-stage AI and early-stage SS during development to roughly correspond with the gene expression found in the late and early stages, respectively, suggesting their potential regulatory roles in 'Huangguan' pear fruit development. Our results indicate that the primary function of SPS during the early developmental stage is to accumulate sucrose, whereas the primary function of AI is to promote hexose accumulation during the late developmental stage ofmature 'Yali' pear fruit. | Xiaohong Kou Yunfei Li Ying Zhang Bianling Jiang Zhaohui Xue | 2018 | Transactions of Tianjin University2018，24，2： | 4 |
| 10 | LncRNA HOTAIR promotes endometrial fibrosis by activating TGF-β1/Smad pathway显示文摘Homeobox transcript antisense RNA(HOTAIR)is a long non-coding RNA associated with a number of fibrosis-related diseases.The aim of this study was to investigate the specific role of HOTAIR in the development of endometrial fibrosis and to identify the molecular mechanisms underlying this process.Reverse transcription-quantitative polymerase chain reaction(RT-qPCR)was used to determine the expression levels of HOTAIR in samples of intrauterine adhesion(lUA)tissue and in endometrial stromal cells(ESCs)that had been treated with transforming growth factor beta 1(TGF-β1).Additionally,we transfected ESCs with either overexpression plasmid(pcDNA-HOTAIR)or silencing construct(si-HOTAIR)and then treated these cells with TGF-β1.We then performed RTqPCR and western blot analysis,along with cell proliferation and apoptosis assays,to investigate the effects of HOTAIR on the transdifferentiation of ESCs into myofibroblasts.The results showed that the expression levels of HOTAIR were significantly elevated in IUA tissue and in ESCs that had been treated with TGF-β1.The overexpression of HOTAIR had a pro-fibrotic effect on ESCs,while the silencing of HOTAIR exerted an anti-fibrotic effect.Most importantiy,the protein expression levels of p-Smad2 and p-Smad3 were significantly upregulated in TGF-β1.treated ESCs transfected with pcDNA-HOTAIR and were downregulated after transfection with si-HOTAIR constructs.These data indicate that HOTAIR promotes endometrial fibrosis by activating the TGF-β1/Smad signaling pathway,suggesting that the inhibition of HOTAIR may represent a promising therapeutic option for suppressing endometrial fibrosis. | Jianhong Wu Lingge Jin Yudi Zhang Aihong Duan Juhong Liu Ziwen Jiang Liang Huang Jing Chen Zhaohui Liu Dan Lu Yinmei Dai | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 3 |
| 11 | Separation-and-Recovery Technology for Organic Waste Liquid with a High Concentration of Inorganic Particles显示文摘 | Hualin Wang Pengbo Fu Jianping Li Yuan Huang Ying Zhao Lai Jiang Xiangchen Fang Tao Yang Zhaohui Huang Cheng Huang | 2018 | Engineering2018，4，3： | 3 |
| 12 | Isogeometric topology optimization based on energy penalization for symmetric structure显示文摘We present an energy penalization method for isogeometric topology optimization using moving morphable components(ITO–MMC),propose an ITO–MMC with an additional bilateral or periodic symmetric constraint for symmetric structures,and then extend the proposed energy penalization method to an ITO–MMC with a symmetric constraint.The energy penalization method can solve the problems of numerical instability and convergence for the ITO–MMC and the ITO–MMC subjected to the structural symmetric constraint with asymmetric loads.Topology optimization problems of asymmetric,bilateral symmetric,and periodic symmetric structures are discussed to validate the effectiveness of the proposed energy penalization approach.Compared with the conventional ITO–MMC,the energy penalization method for the ITO–MMC can improve the convergence rate from 18.6%to 44.5%for the optimization of the asymmetric structure.For the ITO–MMC under a bilateral symmetric constraint,the proposed method can reduce the objective value by 5.6%and obtain a final optimized topology that has a clear boundary with decreased iterations.For the ITO–MMC under a periodic symmetric constraint,the proposed energy penalization method can dramatically reduce the number of iterations and obtain a speedup of more than 2. | Xianda XIE Shuting WANG Ming YE Zhaohui XIA Wei ZHAO Ning JIANG Manman XU | 2020 | Frontiers of Mechanical Engineering2020，15，1： | 3 |
| 13 | Adsorption of ciprofloxacin on 2:1 dioctahedral clay minerals显示文摘 | Chih-Jen Wang Zhaohui Li Wei-Teh Jiang | 2011 | Applied Clay Science2011，，4： | 2 |
| 14 | A C2-symmetric triple [5]helicene based on N-annulated triperylene hexaimide for chiroptical electronics显示文摘Two diastereoisomers(NTPH-P and NTPH-T1) as a C2-symmetric triple [5]helicene based on N-annulated triperylene hexaimide were synthesized.Aided by nuclear magnetic resonance spectroscopy(NMR) and theoretical calculations,NTPH-P was assigned to three-blade propeller conformation while NTPH-T1 tended to exhibit twisted conformation with pyrrole ring fusing on a bowl-shaped PDI foil.Characterized by circular dichroism(CD) and circular polarized luminescence(CPL) measurements,the enantiomerically pure NTPH-P exhibited fairly good chiral activities both in the absorption and emission range with dissymmetry factors |gabs| of 4.1×10^-3 and |glum| of 1.2×10^-3.The diastereoisomers were further employed as acceptors for organic solar cells with distinct PCEs of 8.11% and 5.24% for NTPH-P and NTPH-T1 based devices,respectively,signifying the prospects in chiroptical electronics by designing molecularly defined aromatics. | Zetong Ma Thorsten Winands Ningning Liang Dong Meng Wei Jiang Nikos L.Doltsinis Zhaohui Wang | 2020 | Science China Chemistry2020，63，2： | 2 |
| 15 | Tea picking point detection and location based on Mask-RCNN显示文摘The accurate identification,detection,and segmentation of tea buds and leaves are important factors for realizing intelligent tea picking.A tea picking point location method based on the region-based convolutional neural network(R-CNN)Mask-RCNN is proposed,and a tea bud and leaf and picking point recognition model is established.First,tea buds and leaf pictures are collected in a complex environment,the Resnet50 residual network and a feature pyramid network(FPN)are used to extract bud and leaf features,and preliminary classification and preselection box regression training-performed on the feature maps through a regional proposal network(RPN).Second,the regional feature aggregation method(RoIAlign)is used to eliminate the quantization error,and the feature map of the preselected region of interest(ROI)is converted into a fixed-size feature map.The output module of the model realizes the functions of classification,regression and segmentation.Finally,through the output mask image and the positioning algorithm the positioning of the picking points of tea buds and leaves is determined.One hundred tea tree bud and leaf pictures in a complex environment are selected for testing.The experimental results show that the average detection accuracy rate reaches 93.95%and that the recall rate reaches 92.48%.The tea picking location method presented in this paper is more versatile and robust in complex environments. | Tao Wang Kunming Zhang Wu Zhang Ruiqing Wang Shengmin Wan Yuan Rao Zhaohui Jiang Lichuan Gu | 2023 | Information Processing in Agriculture2023，10，2： | 2 |
| 16 | Calculation model of AC loss for CICC(cable-in-conduit conductor) based on strain显示文摘The CICC (cable-in-conduit conductor) in ITER (International Thermal-nuclear Experimental Reactor) will run in high-current, fast transient magnet field and complex environment. In response to the impact of magnet fields above 10 T, the Nb3Sn conductor has been introduced. However, the AC (alternating current) loss mechanism of Nb3Sn conductor on strain has not been explored. So, it is necessary to study the AC loss calculation method with transient electromagnetic field and wide range of strain, the coupling current in complex field and current signal of field is simplified to the spectrum effects of coil excitation, and calculation technology of AC loss, which contains the frequency, magnet field, coil characteristics and other parameters, is constructed to meet the discrete Fourier transform (DFT). By comparative analysis of simulation, it is found that the AC loss calculation of the conductor with spectrum algorithm is closer to the actual project value than the traditional algorithm. For the rapid excitation, in particular plasma discharge and burst, spectrum algorithm and the traditional algorithm are consistent. For the relative error calculation of hysteresis loss and coupling loss, it is found that the coupling loss is cumulative linearly, where the hysteresis loss is not so. As a function of the amplitude, frequency and phase angle, the relative error is less than 40%. The results showed that the method of Fourier restructuring is satisfactory. | JIANG HuaWei WU SongTao ZHANG DeXian XU ZhaoHui ZHEN Tong | 2012 | Science China(Technological Sciences)2012，55，4： | 2 |
| 17 | Sensor fault-tolerant observer applied in satellite attitude control显示文摘The observing failure and feedback instability might happen when the partial sensors of a satellite attitude control sys- tem (SACS) go wrong. A fault diagnosis and isolation (FDI) method based on a fault observer is introduced to detect and isolate the fault sensor at first. Based on the FDI result, the object system state-space equation is transformed and divided into a corresponsive triangular canonical form to decouple the normal subsystem from the fault subsystem. And then the KX fault-tolerant observers of the system in different modes are designed and embedded into online monitoring. The outputs of all KX fault-tolerant observers are selected by the control switch process. That can make sense that the SACS is part-observed and in stable when the partial sensors break down. Simulation results demonstrate the effectiveness and superiority of the proposed method. | Jiaolong Wei Zhaohui Cen Rui Jiang | 2012 | Journal of Systems Engineering and Electronics2012，23，1： | 2 |
| 18 | Laboratory investigation into the oil diffusion from submarine pipeline under water flow显示文摘A physical model test has been conducted to study the oil diffusion from the submarine pipeline under water flow.The crude oil in the flume is spilled from a leakage point of the pipeline and diffused from the seabed to the surface. By the non-contact optical measuring technology, an image acquisition and data analysis system is designed to explore the spilled mechanism and characteristic. The oil trajectory, velocity and the rising time to the surface are obtained through this system. The influence of the water flow and the spilled discharge on the behavior of the spilled oil are analyzed from both qualitative and quantitative perspectives. The sensitivity study of the characteristic physical quantities to various factors are presented afterward. The spilled oil under water is mainly distributed in the form of the scattered particles with different sizes. The rising process of the oil can be divided into three stages: full, dispersion and aggregation period. The spilled discharge is the primary factor affecting the rising time of the oil particles. In the rising process of the oil particles, the vertical velocity of the oil is mainly affected by the spilled discharge, and the transverse velocity is more dependent on the water velocity. The deviation of the transverse oil velocity is much larger than that of the rising time and the vertical oil velocity. The study can provide a theoretical reference for the prediction system of oil spill emergency. | JIANG Meirong YU Jianxing LI Zhigang ZHONG Wenjun WU Zhaohui YU Yang | 2018 | Acta Oceanologica Sinica2018，37，11： | 2 |
| 19 | Adsorption and intercalation of tetracycline by swelling clay minerals显示文摘 | Po-Hsiang Chang Zhaohui Li Wei-Teh Jiang Jiin-Shuh Jean | 2009 | Applied Clay Science2009，，1： | 1 |
| 20 | Neuroprotective effect of heat shock protein 70 Inhibition of Tau protein expression显示文摘BACKGROUND: Previous studies have shown that heat shock protein 70 (HSP70) hasneuroprotective effects by decreasing phosphorylation of Tau protein, thereby reducing theexpression of Tau protein and proper aggregation.OBJECTIVE: To observe and verify expressional changes of HSP70 and Tau in retinal ganglioncells following stretch injury to the right optic nerve in rats, and to determine the effect of heat stresspretreatment on HSP70 and Tau protein expressions.DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at theLaboratory of Neurology Research Institute of the First Affiliated Hospital of Chongqing MedicalUniversity from March to June 2006.MATERIALS: Instant SABC immunohistochemistry kit, as well as mouse anti-HSP70 and rabbitanti-Tau polyclonal antibodies, were purchased from Wuhan Boster Bioengineering Limited, China.METHODS: A total of 57 male, Wistar rats were randomly assigned to 4 groups: control (n = 3);150-180 g stretch force was induced in the right optic nerves in stretch-only group (n = 18) toestablish optic nerve stretch injury model; heat stress was applied to 18 animals in heat-stresstreatment group; 18 rats in the heat-stress pretreatment plus stretch group were subjected toidentical stretch injury as stretch-only group after 24-hour heat-stress pretreatment. According tosacrifice time, the groups were assigned to 6 subgroups at different time points of 4, 8, and 16 hours,and 1,3, and 5 days, with 3 rats in each subgroup. No treatment was performed in the control groupexcept anesthesia.MAIN OUTCOME MEASURES: Morphological changes of optic nerves and retinal ganglion cellsfollowing stretch injury were observed by light microscopy following hematoxylin-eosin staining.HSP70 and Tau protein expression levels were observed in retinal ganglial cells from each groupusing im munohistochemistry.RESULTS: (1) Compared with the control group, morphological axonal and retinal ganglial cellchanges, as well as a decreased number of retinal ganglial cells, were identified in the stretch-onlygroup (P< 0.01). Pathological damage in optical nerve and retinal ganglial cells were not remarkablein the heat-stress pretreatment plus stretch group, with no statistical difference in the number ofretinal ganglial cells compared with the control group (P > 0.05). (2) Compared with the control groupsignificantly increased HSP70 expression in retinal ganglial cells occurred in the stretch-only,heat-stress treatment, and heat-stress pretreatment plus stretch groups (P < 0.05 or P < 0.01). Thepeak of HSP70 expression was earlier in the heat-stress pretreatment plus stretch group comparedwith the stretch-only and heat-stress treatment groups, and was expressed over a longer period oftime compared with the heat-stress treatment group. Compared with the control group, Tauexpression in the retinal ganglial cells rapidly increased 4-16 hours following stretch injury in thestretch-only group (P < 0.05 or P < 0.01), and obviously decreased in the heat-stress pretreatmentplus stretch group (P < 0.05 or P < 0.01).CONCLUSION: Tau expression increased following stretch injury, with an earlier expression peakthan HSP70, which indicated that stretch injury-induced HSP70 expression was not strong or quickenough to sufficiently protect the nerve. A much more enhanced HSP70 expression, with an earlierpeak and longer expression period, was observed in rats subjected to stretch injury following heatstress, which demonstrated that HSP70 exhibited neuroprotective functions by reducing abnormalaggregation of Tau. | Zhaohui He Xiaochuan Sun Feng Li Yong Jiang Haitao Wu Luping Zheng | 2009 | Neural Regeneration Research2009，4，12： | 1 |
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