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| 1 | Quantitative prediction of mining subsidence and its impact on the environment显示文摘This study is focused on the prediction of mining subsidence and its impact on the environment in the Hongqi mining area. The study was carried out by means of a probability integral model based, in first instance based on field surveys and the analysis of data collected from this area. Isolines of mining subsidence were then drawn and the impact caused by mining subsidence on the environment was analyzed quantitatively by spatial analysis with Geographic Information System (GIS). The results indicate that the subsidence area of the first working-mine can be as large as 2.54 km 2 , the maximum subsidence is 3440 mm which will cause 1524 houses to be relocated. The entire subsidence area of the mine can reach 8.09 km 2 , with a maximum subsidence of 3590 mm. Under these circumstances the value of the loss of ecosystem services will reach 5.371 million Yuan and the cost of relocating buildings will increase to 6.858 million Yuan. | Jianjun Song Chunjian Han Ping Li Junwei Zhang Deyuan Liu Minde Jiang Lin Zheng Jingkai Zhang Jianying Song | 2012 | International Journal of Mining Science and Technology2012，22，1： | 13 |
| 2 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 3 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 4 | Collinear holographic data storage technologies显示文摘In the era of information explosion,the demand of data storage is increased dramatically.Holographic data storage technology is one of the most promising next-generation data storage technologies due to its high storage density,fast data transfer rate,long data life time and less energy consumption.Collinear holographic data storage technology is the typical solution of the holographic data storage technology which owns a more compact,compatible and practical system.This paper gives a brief review of holographic data storage,introduces collinear holographic data storage technology and discusses phase modulation technology being used in the holographic data storage system to achieve higher storage density and higher data transfer rate. | Xiao Lin Jinpeng Liu Jianying Hao Kun Wang Yuanying Zhang Hui Li Hideyoshi Horimai Xiaodi Tan | 2020 | Opto-Electronic Advances2020，3，3： | 8 |
| 5 | Transgenic breeding of anti-Bombyx mori L. nuclear polyhedrosis virus silkworm Bombyx mori显示文摘对 Bombyx 粗腐殖质 i L 抵抗的蚕紧张。原子 polyhedrosis 病毒通过转基因的实验被获得。与一个 A3 倡导者一起的小猪用绳子拖的平底渡船 transposon 随机被插入到蚕,驾驶进蚕染色体的提高的绿荧光灯的蛋白质(EGFP ) 记者基因。聚合酶链反应结果证实体外的 EGFP 基因的插入,和荧光显微镜学证明 EGFP 在中间的内脏织物被表示。原子 polyhedrosis 的病态比率在转基因的蚕紧张在原来的蚕紧张从 90% 减少了到 66.7% 。与到 Bombyx 粗腐殖质 i L 的抵抗相比。在 Qiufeng 紧张的原子 polyhedrosis 病毒,通常在生产被使用,有在转基因的蚕的 33 个百分的点的增加。在 ChunhuaxQiuyue 紧张的 antivirotic 特性,从一个不同转基因的家庭被引起,比在 QiufengxBaiyu,另一个生气品种在生产使用了高是大约 10 个百分的点。我们的结果在繁殖 anti-BmNPV 蚕紧张显示了插入 transposon 的变化的好申请价值。 | Huijuan Yang Wei Fan Hao Wei Jinwei Zhang Zhonghua Zhou Jianying Li Jianrong Lin Nong Ding Boxiong Zhong | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 6 |
| 6 | Andrographolide and Its Derivative Potassium Dehydrographolide Succinate Suppress PRRSV Replication in Primary and Established Cells via Differential Mechanisms of Action显示文摘Porcine reproductive and respiratory syndrome virus(PRRSV) continues to cause significant economic loss worldwide and remains a serious threat to the pork industry. Currently, vaccination strategies provide limited protection against PRRSV infection, and consequently, new antiviral strategies are urgently required. Andrographolide(Andro) and its derivative potassium dehydrographolide succinate(PDS) have been used clinically in China and other Asian countries as therapies for inflammation-related diseases, including bacterial and viral infections, for decades. Here, we demonstrate that Andro and PDS exhibit robust activity against PRRSV replication in Marc-145 cells and primary porcine alveolar macrophages(PAMs). The two compounds exhibited broad-spectrum inhibitory activities in vitro against clinically circulating type 2 PRRSV GD-HD, XH-GD, and NADC30-like HNhx strains in China. The EC_(50)values of Andro against three tested PRRSV strain infections in Marc-145 cells ranged from 11.7 to 15.3 lmol/L, with selectivity indexes ranging from 8.3 to10.8, while the EC_(50)values of PDS ranged from 57.1 to 85.4 lmol/L, with selectivity indexes ranging from 344 to 515.Mechanistically, the anti-PRRSV activity of the two compounds is closely associated with their potent suppression on NFj B activation and enhanced oxidative stress induced by PRRSV infection. Further mechanistic investigations revealed that PDS, but not Andro, is able to directly interact with PRRSV particles. Taken together, our findings suggest that Andro and PDS are promising PRRSV inhibitors in vitro and deserves further in vivo studies in swine. | Lizhan Su Yarou Gao Mingxin Zhang Zexin Liu Qisheng Lin Lang Gong Jianying Guo Lixia Chen Tongqing An Jianxin Chen | 2021 | Virologica Sinica2021，36，6： | 4 |
| 7 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 8 | Recombinant protein expression in Pichia pastoris显示文摘 | James M. Cregg Joan Lin Cereghino Jianying Shi David R. Higgins | 2000 | Molecular Biotechnology2000，，1： | 3 |
| 9 | Recombinant protein expression in Pichia pastoris显示文摘 | James M. Cregg Joan Lin Cereghino Jianying Shi David R. Higgins | 2000 | Molecular Biotechnology2000，，1： | 3 |
| 10 | Anion recognition with porphyrin-bottomed tetraurea receptors显示文摘Three tetraurea-appended porphyrin derivatives were synthesized and applied as anion receptors to complex with various anions, including F^-,Cl^-, Br^-,I, NO_3^-, HSO_4^-, and AcO^-. The binding stoichiometries were all measured to be 1:1 and high binding abilities of these receptors toward the anions were demonstrated with the association constants of up to 1.1 × 10~8 L/mol. The complexation of the receptors with anions was further unambiguously confirmed by single-crystal X-ray | Wei Lin Tian-Yong Cen Shu-Ping Wang Zibin Zhang Jing Wu Jianying Huang Shijun Li | 2018 | Chinese Chemical Letters2018，29，9： | 3 |
| 11 | Energy dissipation mechanism and experiment of particle dampers for gear transmission under centrifugal loads显示文摘 | Wangqiang Xiao Yuxiang Huang Hong Jiang Hong Lin Jiani Li | 2016 | Particuology2016，14，4： | 2 |
| 12 | Revisiting the effects of Co_(2)O_(3)on multiscale defect structures and relevant electrical properties in ZnO varistors显示文摘Element doping is an effective method to improve the performance of ZnO varistors.Previous studies mainly focused on the variation of microstructures and Schottky barriers.In this study,the effects of Co dopant on electrical properties are investigated from the aspect of multiscale defect structures,including intrinsic point defects,the heterogeneous interface of depletion/intergranular layers,and interface states at grain boundaries.Combining with analysis of phase composition and energy dispersive spectroscopy,it is found that Co tends to dissolve into ZnO grains when slightly doped.It substitutes Zn2+with the same valence and affects little on densities of donors.Segregation of Co at grain boundaries would result in the formation of spinel phase Co(Co4/3Sb2/3)O4 and transformation of the intergranular phase fromα-Bi2O3 toδ-Bi2O3.Meanwhile,densities of point defects are indirectly affected by oxygen ambient during sintering,resulting in abnormal variation of grain resistivity.And interface states are enhanced,leading to improved barriers at grain boundaries.Therefore,reduced leakage current,enhanced grain resistivity,and improved non-linear coefficient in Co-doped ZnO varistor blocks are understood from the underlying multiple defect structures.This presents a potential approach to explore short-term performance and long-term stability of ZnO varistors from the aspect of defect responses. | Men Guo Yao Wang Kangning Wu Lei Zhang Xia Zhao Ying Lin Jianying Li | 2020 | High Voltage2020，5，3： | 2 |
| 13 | Red fluorescent protein (DsRed2), an ideal reporter for cotton genetic transformation and molecular breeding显示文摘Genes encoding reporter proteins are used as visual marker-assisted tools in genetic transformation as well as plant breeding. In this study, the red fluorescent protein identified in Discosoma sp. coral(DsRed2) was successfully used as a visual marker for cotton genetic engineering. DsRed2 was successfully expressed in two cotton cultivars,JIN668 and YZ1, driven by the Ca MV-35 S promoter via the Agrobacterium-mediated transformation. Our results suggest that DsRed2 expression provides an early-stage selection tool for the transgenic calli via visual observation. Red fluorescence can be detected not only in callus and somatic embryos but also in most tissues and organs of mature plants. The transgenic line Yz-2-DsRed2 was crossed with four different cotton cultivars to assess the transgene heritability and stability in different genetic backgrounds.The heritability of the red color was highly stable when Yz-2-DsRed2 was used as a male parent. The DsRed2 gene expressed 100% in the F_1 hybrids. To investigate the relationship between DsRed2 transcription and DNA methylation, a methylation-specific PCR approach was applied to the Ca MV-35 S promoter region. The results showed a negative association between DNA methylation level in the promoter region and the transgene transcription.Taken together, these findings suggest DsRed2 a visual reporter gene for cotton genetic transformation and molecular breeding programs. | Lin Sun Muna Alariqi Yi Zhu Jianying Li Zelin Li Qing Wang Yajun Li Hangping Rui Xianlong Zhang Shuangxia Jin | 2018 | The Crop Journal2018，6，4： | 2 |
| 14 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 15 | Recombinant protein expression in Pichia pastoris显示文摘 | James M. Cregg Joan Lin Cereghino Jianying Shi David R. Higgins | 2000 | Molecular Biotechnology2000，，1： | 1 |
| 16 | Recombinant protein expression in Pichia pastoris显示文摘 | James M. Cregg Joan Lin Cereghino Jianying Shi David R. Higgins | 2000 | Molecular Biotechnology2000，，1： | 1 |
| 17 | Controlled chitosan coated Prussian blue nanoparticles with the mix- ture of graphene nanosheets and carbon nanoshperes as a redox mediator for the electrochemical oxidation of nitrite 显示文摘 | Cui Lin Zhu Jianying Meng Xiaomeng | 2012 | Sensors and Actuators B : Chemical2012，161，1： | 1 |
| 18 | Electrospun nanofiber reinforced and toughened composites through in situ nano-interface formation 显示文摘 | LIN Song CAI Qing JI Jianying | 2008 | Composites Science and Technology2008，68，1516： | 1 |
| 19 | Recombinant protein expression in Pichia pastoris显示文摘 | James M. Cregg Joan Lin Cereghino Jianying Shi David R. Higgins | 2000 | Molecular Biotechnology2000，，1： | 1 |
| 20 | T-cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications显示文摘T cells,which are involved in adaptive immunity,are essential in the elimination of tumor cells.Mature T cells can specifically recognize the antigen on the major histocompatibility complex(MHC)molecule through T-cell receptors(TCR).The unique rearrangement mechanisms during T-cell maturation provide great diversity to TCR,ensuring specific recognition between T cells and antigens.Thus,TCR repertoire analysis occupied an important position in T-cell regarding research.Nowadays,next-generation sequencing technology allows the simultaneous detection of TCR sequences with high throughput,and several evaluation indexes facilitate the measure of TCR repertoire.Based on this new methodology,discoveries are made across a range of tumor types.Results have shed light on the TCR repertoire differences between cancer patients and healthy control as well as between individual’s lesions,paracancer,and peripheral blood samples.The potential of TCR repertoire as a biomarker for immunotherapy efficacy is also widely studied as TCR repertoire represents different baseline within individuals and shows dynamic change during treatment.Accurate delineation of the T-cell repertoire can further the understanding of the immune system response to tumorigenesis.Still,existing researches are insufficient to clarify the specific clinical implications of TCR dynamic change and the definite role of TCR repertoire diversity during the treatment process.The results of some studies are even contrary.In this article,we reviewed TCR rearrangement mechanisms and analysis methods.Recent progress of TCR sequencing technology in tumor research is also discussed.In conclusion,intensive studies over an extended range of cancer types and a broadened group of subjects should be carried to solidify the TCR repertoire’s position as an immunotherapy biomarker. | Na Li Jiani Yuan Wenjia Tian Lin Meng Yongyu Liu | 2020 | Cancer Communications2020，40，10： | 1 |
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