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| 1 | Response regimes of nonlinear energy harvesters with a resistorinductor resonant circuit by complexification-averaging method显示文摘In this paper, the steady-state response regimes of nonlinear energy harvesters with a resistor-inductor resonant circuit are theoretically investigated. The complexification averaging(CA) method is used to theoretically analyze the energy harvesting performance and reduce the motion equations into a set of first-order differential equations. The amplitudes and phases of both the response displacement and the output voltage are derived, and the corresponding stability conditions are determined. The response regimes are studied with the variation of nonlinear stiffness coefficients and coupling parameters, which are verified by the time domain analysis. The frequency island phenomenon is found and analyzed. Additionally, the backbone curve for deducing the extreme vibration frequency and amplitude is derived. Simultaneously, the analytical expressions of the switching points(critical amplitude and frequency) to identify the hardening and softening properties are established. Accordingly, a criterion is given to determine the occurrence of the jump phenomenon, and its effectiveness is verified. Overall, this paper presents an in-depth theoretical analysis of nonlinear energy harvesters with a resistor-inductor resonant circuit. It presents the theoretical framework and guidance for more extensive evaluations and understanding the theoretical analysis of nonlinear energy harvesters with external circuits. | HUANG DongMei CHEN JiaYi ZHOU ShengXi FANG XueLai LI Wei | 2021 | Science China(Technological Sciences)2021，64，6： | 6 |
| 2 | Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic response.Increasing evidence suggests that microbes influence the efficacy of cancer therapies.Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)statuses.Here,we investigated the effect of F.nucleatum on anti-PD-L1 therapy in CRC.We found that high F.nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC.Additionally,F.nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival.Combining F.nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade.Furthermore,F.nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 blockade.Finally,patient-derived organoid models demonstrated that increased F.nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade.These findings suggest that F.nucleatum may modulate immune checkpoint therapy for CRC. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 3 |
| 3 | Lysophosphatidic acid increases SLC26A3 expression in inflamed intestine and reduces diarrheal severity in C57BL/6 mice with dextran-sodium-sulfate-induced colitis显示文摘 | Xu Lihong Xiao Fang He Jiayi Lan Xiaoqin Ding Qiang Li Junhua Ursula Seidler Zheng Yong Tian Dean | 2014 | Chinese Medical Journal2014，，9： | 2 |
| 4 | A novel frequency offset estimation method for OFDM systems with large estimation range 显示文摘 | Chunlin Yah Shaoqian Li Youxi Tang Jiayi Fang | 2006 | IEEE Transaction on Broadcasting (S0018-9316)2006，52，1： | 1 |
| 5 | Link level performance comparison between LTE V2X and DSRC显示文摘Applications of VANETs(Vehicular Ad hoc Networks)have their own requirements and challenges in wireless communication technology.Although regarded as the rst standard for VANETs,IEEE 802.11p is still in the eld-trial stage.Recently,LTE V2X(Long-Term Evolution Vehicular to X)appeared as a systematic V2X solution based on TD-LTE(Time Division Long-Term Evolution)4G.It is regarded as the most powerful competitor to 802.11p.We conduct link level simulations of LTE V2X and DSRC(Dedicated Short-Range Communication)for several di erent types of scenarios.Simulation results show that LTE V2X can achieve the same BLER(Block Error Ratio)with a lower SNR(Signal Noise Ratio)than DSRC.A more reliable link can be guaranteed by LTE V2X,which can achieve the same BLER with lower receiving power than DSRC.The coverage area of LTE V2X is larger than that of DSRC. | Jinling Hu Shanzhi Chen Li Zhao Yuanyuan Li Jiayi Fang Baozhu Li Yan Shi | 2017 | Journal of Communications and Information Networks2017，2，2： | 1 |
| 6 | Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential显示文摘Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array of regulators,including the multi-functional protein Rif1,has been reported to influence the switch of fate potential,how they act in concert to achieve this cellular plasticity remains elusive.Here,by modularizing the known totipotency regulatory factors,we identify an unprecedented functional connection between Rif1 and the non-canonical polycomb repres-sive complex PRC1.6.Downregulation of the expression of either Rif1 or PRC1.6 subunits imposes similar impacts on the transcriptome of mESCs.The LacO-LacI induced ectopic colocalization assay detects a specific interaction between Rif1 and Pcgf6,bolstering the intactness of the PRC1.6 complex.Chromatin immunoprecipitation followed by sequencing(ChIP-seq)analysis further reveals that Rif1 is required for the accurate targeting of Pcgf6 to a group of genomic loci encompassing many genes involved in the regulation of the 2C-like state.Depletion of Rif1 or Pcgf6 not only activates 2C genes such as Zscan4 and Zfp352,but also derepresses a group of the endogenous retroviral element MERVL,a key marker for totipotency.Collectively,our findings discover that Rif1 can serve as a novel auxiliary component in the PRC1.6 complex to restrain the genetic circuit underlying totipotent fate potential,shedding new mechanistic insights into its function in regulating the cellular plasticity of embryonic stem cells. | Lu Li Pishun Li Jiale Chen Li Li Yunfan Shen Yangzixuan Zhu Jiayi Liu Lu Lv Song Mao Fang Chen Guang Hu Kai Yuan | 2022 | Cell Regeneration2022，11，1： | 1 |
| 7 | The sulfolane-based liquid electrolyte with LiClO_(4)additive for the wide-temperature operating high nickel ternary cathode显示文摘An adequate wide temperature electrolyte for high nickel ternary cathode is urgent to further develop high energy density batteries.Herein,a comprehensive double-salt local high-concentration sulfolane-based electrolyte(DLi)is proposed with specific sheath structure to build stable interface on the LiNi_(0.8)Co_(0.1)Mn_(0.1O2)(NCM811)cathode at wide operating temperature between−60 and 55℃.Lithium perchlorate(LiClO_(4))in combination with high concentration lithium bis-(trifluoromethanesulfonyl)imide(LiTFSI)strengthens the internal interaction between anion and cation in the solvation structure,increasing Li+transference number of the electrolyte to 0.61.Moreover,the structure and component characteristics of the passive interface layer on NCM811 are modulated,decreasing desolvation energy of Li+ions,benefiting Li+transport dynamics especially at low temperature,and also ensuring the interfacial stability at a wide operating temperature range.As a result,the cathode with DLi exhibits excellent high-temperature storage performance and high capacity retention of 80.5%in 100 cycles at 55℃.Meanwhile,the Li||NCM811 cells can deliver high discharge capacity of 160.1,136.1,and 110.3 mAh·g^(−1)under current density of 0.1 C at−20,−40,and−60℃,maintaining 84.5%,71.8%,and 58.2%of the discharge capacity at 30℃,respectively.Moreover,it enables NCM811 cathode to achieve a reversible capacity of 142.8 mAh·g^(−1)in 200 cycles at−20℃and 0.2 C.Our studies shed light on the molecular strategy of wide operational temperature electrolyte for high nickel ternary cathode. | Yixin Zhu Shuang He Jiayi Ding Guangyu Zhao Fang Lian | 2023 | Nano Research2023，16，3： | 0 |
| 8 | Pan-cancer analysis of DNA epigenetic modifications by hydrophilic interaction liquid chromatography-tandem mass spectrometry显示文摘Accumulating evidence in recent years indicates that DNA methylation(5-methyl-2-deoxycytidine,5-mdC) and hydroxymethylation(5-hydroxymethyl-2-deoxycytidine, 5-hmd C) have been implicated in various biological processes, and the aberrations of these DNA cytosine modifications is tightly associated with cancer. N6-methyl-2-deoxyadenosine(m~6dA), as a newly discovered epigenetic modification in genome of mammals, has been demonstrated to play vital regulatory roles in tumorigenesis. However, the content information of m~6dA in human tumor tissues is still limited and pan-cancer analysis of these DNA epigenetic modifications is lacked. Herein, we developed a sensitive and robust stable isotopediluted hydrophilic interaction liquid chromatography-tandem mass spectrometry(HILIC-MS/MS) method for accurate quantification of m~6dA, 5-mdC and 5-hmdC in genomic DNA from 82 pairs of human tumor tissues and matched tumor-adjacent normal tissues. The types of tumors included esophagus cancer, lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, stromal tumor and colorectal cancer.Compared to the normal tissues, we revealed the level of m6dA was increased in tumor tissues of esophagus cancer, lung cancer and liver cancer, whereas the level of m~6dA was diminished in tumor tissues of pancreatic cancer and gastric cancer;while the contents of 5-mdC and 5-hmdC exhibited significant decrease in tumor tissues of most types of cancer. It is worth noting that we revealed, for the first time,the content of genomic m~6dA in pancreatic cancer, stromal tumor and colorectal cancer. The significant changes of these DNA epigenetic modifications indicate they may serve as indicators of cancers. In addition, this study will benefit for better understanding of the regulatory roles of these DNA epigenetic modifications in cancers. | Yiqiu Hu Xiujuan Hong Zhijun Yuan Jiayi Mu Xiaoxiao Zhang Zhihao Fang Ying Yuan Shu Zheng Cheng Guo | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 9 | Dynamic changes in urban land spatial inequality under the core-periphery structure in urban agglomerations显示文摘Relatively coordinated development among cities can typically promote the integration of the whole urban agglomeration,while urbanization of land has been found important to economic development in developing countries.Numerous studies have measured the urban land expansion in urban agglomerations.However,urban land spatial inequality under a specific spatial structure remains poorly understood.Here,we combined theβ-convergence model and the core-periphery structure to explore the dynamic changes in urban land spatial inequality in urban agglomerations.The Yangtze River Delta Urban Agglomeration(YRDUA)in China was selected as the study area.Indicators of urban land have been applied in conjunction with a modified conditionalβ-convergence model,while the existence of the core-periphery structure was tested by analyzing coefficients of the control variable.The results show that although the spatial inequality of urban land area had decreased during 2000–2020,the whole YRDUA had still shown an obvious core-periphery structure.Compared with urban land area,the spatial inequality of urban land economic density and population density had decreased more rapidly,and the core-periphery structure was less obvious.Our findings can help to improve our current understanding of urban agglomeration and serve as a scientific reference for the coordinated development of urban agglomerations. | FANG Xiaoqian SU Dan WU Qing WANG Jiayi ZHANG Yangjian LI Guoyu CAO Yu | 2023 | Journal of Geographical Sciences2023，33，4： | 0 |
| 10 | Correction To: Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfsxbpqfobffkox65uq.ffgz.tsg.suse.edu.cn/10.1038/S41392-021-00795-x,published online 19 November 2021 In this article^(1) Qing Wei should have been denoted as a corresponding author along with Huanlong Qin,but was inadvertently removed during the production process.The original article has been corrected. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 11 | The Importance of Digital Elevation Model Selection in Flood Simulation and a Proposed Method to Reduce DEM Errors:A Case Study in Shanghai显示文摘Digital Elevation Models(DEMs)play a critical role in hydrologic and hydraulic modeling.Flood inundation mapping is highly dependent on the accuracy of DEMs.Various vertical differences exist among open access DEMs as they use various observation satellites and algorithms.The problem is particularly acute in small,flat coastal cities.Thus,it is necessary to assess the differences of the input of DEMs in flood simulation and to reduce anomalous errors of DEMs.In this study,we first conducted urban flood simulation in the Huangpu River Basin in Shanghai by using the LISFLOOD-FP hydrodynamic model and six open-access DEMs(SRTM,MERIT,CoastalDEM,GDEM,NASADEM,and AW3D30),and analyzed the differences in the results of the flood inundation simulations.Then,we processed the DEMs by using two statistically based methods and compared the results with those using the original DEMs.The results show that:(1)the flood inundation mappings using the six original DEMs are significantly different under the same simulation conditions—this indicates that only using a single DEM dataset may lead to bias of flood mapping and is not adequate for high confidence analysis of exposure and flood management;and(2)the accuracy of a DEM corrected by the Dixon criterion for predicting inundation extent is improved,in addition to reducing errors in extreme water depths—this indicates that the corrected datasets have some performance improvement in the accuracy of flood simulation.A freely available,accurate,high-resolution DEM is needed to support robust flood mapping.Flood-related researchers,practitioners,and other stakeholders should pay attention to the uncertainty caused by DEM quality. | Kepeng Xu Jiayi Fang Yongqiang Fang Qinke Sun Chengbo Wu Min Liu | 2021 | International Journal of Disaster Risk Science2021，12，6： | 0 |
| 12 | Preparation Process of Hydroxypropyl Tetrahydropyrantriol Liposomes显示文摘[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Using particle size distribution and encapsulation rate as evaluation indicators, the effects of hydration time, ratio of organic phase to aqueous phase, granulation method, as well as thin film dispersion and reverse evaporation methods on liposomes preparation were investigated, and the optimal preparation method was selected. Single factor experiments were used to screen the drug phospholipid ratio, ultrasound time, and phospholipid cholesterol ratio, and the preparation process was optimized through orthogonal experiments. [Results] The optimal process of preparing hydroxypropyl tetrahydropyrantriol liposomes was as below: 1 : 10 of drug phospholipid ratio, 6 min of ultrasound time, 4 : 1 of phospholipid cholesterol ratio, (60.94%±7.24%) of entrapment efficiency, (86.44±6.08) nm of particle size, (0.195±0.077) of PDI. [Conclusions] The optimal preparation process of hydroxypropyl tetrahydropyrantriol liposomes selected by orthogonal experiment could effectively improve the encapsulation efficiency of hydroxypropyl tetrahydropyranotriol and reduce particle size. Moreover, the method was stable and reliable. | Chun BAI Xin ZHANG Jiayi DING Jing XIONG Tingting LIU Hua JIN Fang YANG Peijue CHEN Lili HE | 2023 | Medicinal Plant2023，14，4： | 0 |
| 13 | Chinese Built-up Land in Floodplains Moving Closer to Freshwaters显示文摘Human proximity to water and its dynamics are important to understanding the socio-hydrological dilemma between using floodplains and avoiding flood risk.However,previous studies have not distinguished between the water proximity of built-up land in floodplains(BLF)and the water proximity of built-up land outside floodplains(BLOF).This article provides a new and spatiotemporal perspective of the BLF water proximities for understanding the changing flood risk in China.The results show that China’s BLFs had an average water proximity of 5.41 km in 2014.Most of the BLFs(62%,25.889103 km2)were located within 3 km of waterbodies.From 1990 to 2014,China’s BLFs increased rapidly by 81%from23.069103 km2 to 41.749103 km2,of which a large portion(57%)was concentrated in water surroundings(≤km),shortening the distance between BLFs and waterbodies by 169 m.The BLF growth concentrated in water surroundings even in areas where BLFs have an overall increasing distance from waterbodies.Both the increases in the BLFs and their proximity to waterbodies can increase flood exposure and exacerbate flood risk.The scientific community and policymakers should pay attention not only to the volume of BLF growth,but also its spatial relationship with waterbodies. | Yongqiang Fang Shiqiang Du Jiahong Wen Min Zhang Jiayi Fang Min Liu | 2021 | International Journal of Disaster Risk Science2021，12，3： | 0 |
| 14 | ARTICLE OPEN Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection显示文摘Over 40% of the coronavirus disease 2019(COVID-19)COVID-19 patients were asymptomatically infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the immune responses of these asymptomatic individuals is a critical factor for developing the strategy to contain the COVID-19 pandemic.Here,we determined the viral dynamics and antibody responses among 143 asymptomatic individuals identified in a massive screening of more than 5 million people in eight districts of Wuhan in May 2020.Asymptomatic individuals were admitted to the government-designated centralized sites in accordance with policy.The incidence rate of asymptomatic infection is〜2.92/100,000.These individuals had low viral copy numbers(peaked at 315 copies/mL)and short-lived antibody responses with the estimated diminish time of 69 days.The antibody responses in individuals with persistent SARS-CoV-2 infection is much longer with the estimated diminish time of 257 days.These results imply that the immune responses in the asymptomatic individuals are not potent enough for preventing SARS-CoV-2 re-infection,which has recently been reported in recovered COVID-19 patients.This casts doubt on the efficacy of forming'herd-immunity'through natural SARS-CoV-2 infection and urges for the development of safe and effective vaccines. | Zhiwei Sui Xinhua Dai Qingbin Lu Yulan Zhang Min Huang Shufen Li Tao Peng Jie Xie Yongzhuo Zhang Chunchen Wu Jianbo Xia Lianhua Dong Jiayi Yang Wenfeng Huang Siyuan Liu Ziquan Wang Ke Li Qingfang Yang Xi Zhou Ying Wu Wei Liu Xiang Fang Ke Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 0 |
| 15 | Broadening the genetic base of Brassica juncea by introducing genomic components from B.rapa and B.nigra via digenomic allohexaploid bridging显示文摘A narrow genetic base has hindered improvement of Brassica juncea(A^(j)A^(j)B^(j)B^(j)).In this study,large-scale genomic components were introduced from diploid ancestor species into modern B.juncea using a digenomic hexaploid strategy.The hexaploids A^(j)A^(j)A^(r)A^(r)B^(j)B^(j) and A^(j)A^(j)B^(j)B^(j)B^(n)B^(n) were first developed from B.juncea×B.rapa(A^(r)A^(r))and B.juncea×B.nigra(B^(n)B^(n)),and then crossed with dozens of B.nigra and B.rapa,respectively.Both types of hexaploid showed high pollen fertility and moderate seed set throughout the S_(1) to S_(3) generations,and could be crossed with diploid progenitor species under field conditions,in particular for the combination of A^(j)A^(j)B^(j)B^(j)B^(n)B^(n)×B.rapa.Thirty A^(j)A^(r)B^(n)B^(j)-type and 31 A^(j)A^(r)B^(n)B^(j)-type B.juncea resources were generated,of which the A^(j)A^(r)B^(n)B^(j) type showed higher fertility.Of these new-type B.juncea resources,97 individual plants were genotyped with 42 simple sequence repeat markers,together with 16 current B.juncea accessions and 30 hexaploid plants.Based on 180 polymorphic loci,the new-type B.juncea resources and current B.juncea were separated clearly into distinct groups,with large genetic distance between the new-type B.juncea resources and current B.juncea.Our study provides a novel approach to introducing large-scale genomic components from diploid ancestor species into B.juncea. | Jiaqin Mei Jin Liu Fang Yue Yangui Chen Jiayi Ming Zhiyong Xiong Fengqun Yu Jiana Li Wei Qian | 2022 | The Crop Journal2022，10，3： | 0 |
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