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| 1 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 2 | High-efficiency extraction synthesis for high-purity copper nanowires and their applications in flexible transparent electrodes显示文摘Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance and conductivity of the electrodes.Therefore,highly purified Cu NWs without oxidation are vital for high-performance FTEs.Herein,a facile and effective purification process is introduced to purify Cu NWs in a water and n-hexane system,which takes advantage of the differences in hydrophilicity between Cu NWs and Cu NPs caused by their different adsorption affinities to octadecylamine(ODA).At the same sheet resistance,the transmittance of the purified Cu NW-based FTEs improved approximately 2%compared to that of non-purified Cu NW-based FTEs.Immersion of the electrode in glacial acetic acid removed the surface organics and oxides.After only 40 s of treatment,the sheet resistance dramatically decreased from 10^5 Ohm/sq to 31 Ohm/sq with a transmittance of 85%.In addition,the Cu NW-based FTE conductors showed excellent flexibility(remaining stable after 1000 bending cycles).The Cu NW-based FTEs were further applied to fabricate a flexible transparent heater.At a voltage of 10 V,the temperature of the heater reached 73℃,demonstrating the potential applications of this material in various fields. | He Zhang Shang Wang Yanhong Tian Jiayue Wen Chunjin Hang Zhen Zheng Yilong Huang Su Ding Chenxi Wang | 2020 | Nano Materials Science2020，2，2： | 4 |
| 3 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 4 | Flight Safety System Evaluation and Optimal Linear Prediction显示文摘The complexity of flight safety system is usually affected by a variety of uncertainties.The uncertainty of overall security situation of flight safety system are hardly determined.In this work,flight safety assessment index system is firstly established based on software hardware environment liveware management(SHELM)model.And flight safety assessment is also carried out with matter-element theory algorithm to obtain safety state.According to correlation degree values of each evaluation index,key indexes affected flight safety are obtained.Under the assumption that the flight safety system is a linear dynamic system and combining the above evaluation analysis,Kalman filter algorithm is used to carry out prediction analysis on security situation.A simulation analysis is carried out based on an actual flight safety situation of an airline.The results show that the security state of airline flight safety system in a short period of time can be obtained,and main factors affecting flight safety are found out.This provides a viable way for airlines to further strengthen flight safety management. | DING Songbin GU Qianqian LIU Jiayu | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，2： | 1 |
| 5 | Validation of a rice specific gene,sucrose phosphate synthase,used as the endogenous reference gene for qualitative and real-time quantitative PCR detection of transgenes显示文摘 | DING Jiayu JIA Junwei YANG Litao | 2004 | Journal of Agricultural and Food Chemistry2004，52，11： | 1 |
| 6 | Unmodified methodologies in target discovery for small molecule drugs:A rising star显示文摘Target discovery,involving target identification and validation,is the prerequisite for drug discovery and screening.Novel methodologies and technologies for the precise discovery and confirmation of drug targets are powerful tools in understanding the disease,looking for a drug and elucidating the mechanism of drug treatment.Among the common target identification and confirmation methods,the modified method is time-consuming and laborious,which may reduce or change the activity of natural products.The unmodified methods developed in recent years without chemical modification have gradually become an important means of studying drug targets.A wide range of unmodified approaches have been reported,introducing and analyzing the recent emerging methodologies and technologies.This review highlights the advantages and limitations of these methods for the application of drug target discovery and presents an overview of their contributions to the target discovery of small molecule drugs.The application and future development trends of methodologies in target discovery are also prospected to provide a reference for drug target research. | Jiayue Tang Meng Ou Qiuling Zheng Ya Ding | 2022 | Chinese Chemical Letters2022，33，12： | 1 |
| 7 | Validation of a rice specific gene sucrose phosphate synthase used as the endogenous reference gene for qualitative and real-time quantitative PCR detection of transgenes显示文摘 | DING Jiayu JIA Junwei YANG Litao | 2004 | Journal of Agricultural and Food Chemistry2004，52，11： | 1 |
| 8 | True complete left bundle branch block morphology strongly predicts good response to cardiac resynchronization therapy显示文摘 | Yun Tian Ping Zhang Xuebin Li Ying Gao Tiangang Zhu Long Wang Ding Li Jiayu Wang Cuizhen Yuan Jihong Guo | 2013 | Europace2013，，10： | 1 |
| 9 | Presence of notched QRS on paced electrocardiographs as a predictor of poor response to cardiac resynchronization therapy显示文摘 | Wang Jiayu Zhang Ping Li Xuebin Zhu Tiangang Li Hua Wang Long Li Ding Wu Cuncao Gao Ying Tian Yun Guo Jihong | 2014 | Chinese Medical Journal2014，，15： | 1 |
| 10 | Dimensional Analysis and Physical Similarity of Lossy Electromagnetic Systems显示文摘The dimensional analysis is applied to the model measurements of lossy electromagnetic systems.The physical similarity between prototype and model system is given.By this theory,it is predictable that which conditions for the model system should be satisfied in order to get a result similar to the prototype of lossy electromagnetic phenomenon. | SHI Zhendong DING Chunsheng CHEN Jiayu | 1993 | Chinese Physics Letters1993，10，6： | 1 |
| 11 | Bridgman Growth and Defects of Nd^3+: Sr3 Ga2 Ge4O14 Laser Crystals 显示文摘 | Ding Jiaxuan Wu Anhua Xu Jiayue | 2004 | Bulletin of Materials Science2004，27，： | 1 |
| 12 | Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell显示文摘Hematopoietic stem cell(HSC) transplantation is the only curative therapy for many diseases.HSCs from umbilical cord blood(UCB) source have many advantages over from bone marrow.However,limited HSC dose in a single CB unit restrict its widespread use.Over the past two decades,ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs.Till now,several small-molecule compounds have entered the phase Ⅰ/Ⅱ trials,showing safe and favorable pharmacological profiles.As HSC expansion has become a hot topic over recent years,many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue.Here,we will give an overview of HSC biology,discovery and medicinal chemistry development of small molecules,natural products targeting for HSC expansion,and their recent clinical progresses,as well as potential protein targets for HSC expansion. | Jiaxing Li Xiao Wang Jiayu Ding Yasheng Zhu Wenjian Min Wenbing Kuang Kai Yuan Chengliang Sun Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 0 |
| 13 | Pan-cancer analysis of DNA methyltransferase family with potential implications in prognosis and immunology in human cancer显示文摘DNA methylation,as a key epigenetic modification affecting gene expression,is catalyzed by DNA methyl-transferase(DNMT).DNMT1,DNMT3A,and DNMT3B are the main members of the DNMT family,which have been found to regulate many biological processes.^(1)Aberrant DNA methylation in the promoter of tumor suppressor genes is considered a biomarker in cancer.However,no evidence of regulatory mechanisms and pathways relating to DNMTs and immune abnormalities has been provided. | Jiayu Ding Hao Shen Dawei Wang Wenbin Kuang Liping Wang Xiao Wang Peng Yang | 2023 | Genes & Diseases2023，10，4： | 0 |
| 14 | Control of lupus activity during pregnancy via the engagement of IgG sialylation:novel crosstalk between IgG sialylation and pDC functions显示文摘Immunoglobulin(IgG)glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases,including systemic lupus erythematosus(SLE),thus underlining the pathogenic role of glycosylation aberration in autoimmunity.This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy.Relative to that in serum samples from the control cohort,IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages(from preconception to the third trimester of pregnancy)and was significantly associated with lupus activity and fetal loss during lupus pregnancy.The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation.The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells(pDCs).RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase(SYK)signaling pathway significantly differed between IgG-and deSia-IgG-treated pDCs.This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG.Finally,the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG.Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner. | You Wang Sihan Lin Jiayue Wu Meng Jiang Jianhua Lin Yu Zhang Huihua Ding Haibo Zhou Nan Shen Wen Di | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 15 | SALL4A蛋白与TET家族双加氧酶协同调节5-甲基胞嘧啶的逐级氧化显示文摘哺乳动物DNA的胞嘧啶甲基化(5mC)修饰被认为是最稳定的表观遗传修饰。近年研究发现,TET家族蛋白能够将5mC逐步氧化成5-羟甲基胞嘧啶(5hmC)、5-醛基胞嘧啶(5fC)和5-羧基胞嘧啶(5caC),并走向最终的去甲基化。 | Jun Xiong 张珠强 Jiayu Chen Hua Huang Yali Xu Xiaojun Ding Yong Zheng Ryuichi Nishinakamura Guo-Liang Xu Hailin Wang She Chen Shaorong Gao 朱冰 | 2017 | 科学新闻2017，19，4： | 0 |
| 16 | Synthesis and Antioxidant Activity of(E)ω-Formylcamphene-Based Thiazole Hydrazone Derivatives显示文摘(E)ω-formylcamphene was synthesized fromα-pinene,the main component of turpentine,and then reacted with thiosemicarbazide to obtain(E)ω-formylcamphene thiosemicarbazide 3,which was reacted with 14α-bromoace-tophenone compounds to obtain 14(E)ω-formylcamphene thiazole hydrazone compounds 5a–5n;the yields were all above 80%.The structures of the target compounds were characterized by IR,^(1)H-NMR,^(13)C-NMR,and HR-MS analyses.Then,500,250,125,62.5,and 31.25 mg/L drug solutions were prepared.Free radical scavenging experi-ments of 1,1-diphenyl-2-picrylhydrazyl(DPPH)and 2,2-bis(3-ethyl-benzothiazole-6-sulfonic acid)diammonium salt(ABTS)were carried out with Trolox and L-ascorbic acid as the control samples.The scavenging rates of 14 compounds for DPPH and ABTS free radicals were obtained;the IC_(50) values of scavenging free radicals were fitted using SPSS software.The results show that 14(E)ω-formylcamphene-based thiazole hydrazone compounds exhibited good scavenging effects on the two free radicals,especially when the concentration of the drug solution was 125 and 62.5 mg/L;most compounds exceeded the scavenging efficiency of Trolox and L-ascorbic acid. | Jiayu Chang Qingying Ding Chong Zhong Yao Long Zhuanquan Xiao Hai Luo Yuling Yang Zongde Wang Shengliang Liao Jinzhu Chen Shangxing Chen Ji Zhang | 2023 | Journal of Renewable Materials2023，11，1： | 0 |
| 17 | Entity set expansion in knowledge graph:a heterogeneous information network perspective显示文摘Entity set expansion(ESE)aims to expand an entity seed set to obtain more entities which have common properties.ESE is important for many applications such as dictionary con-struction and query suggestion.Traditional ESE methods relied heavily on the text and Web information of entities.Recently,some ESE methods employed knowledge graphs(KGs)to extend entities.However,they failed to effectively and fficiently utilize the rich semantics contained in a KG and ignored the text information of entities in Wikipedia.In this paper,we model a KG as a heterogeneous information network(HIN)containing multiple types of objects and relations.Fine-grained multi-type meta paths are proposed to capture the hidden relation among seed entities in a KG and thus to retrieve candidate entities.Then we rank the entities according to the meta path based structural similarity.Furthermore,to utilize the text description of entities in Wikipedia,we propose an extended model CoMeSE++which combines both structural information revealed by a KG and text information in Wikipedia for ESE.Extensive experiments on real-world datasets demonstrate that our model achieves better performance by combining structural and textual information of entities. | Chuan SHI Jiayu DING Xiaohuan CAO Linmei HU Bin WU Xiaoli LI | 2021 | Frontiers of Computer Science2021，15，1： | 0 |
| 18 | NIR-Ⅱ photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities显示文摘Rational design and exploitation of nanomaterials with superior treatment properties for suitable indications is a way out to relieve cost constraint of therapy and solve the unsatisfactory efficacy for cancer patients.In this work,we propose a greatly facile approach to produce heterogeneous Pd-Au nanorods(Pd-Au NRs)that solve the current bottleneck problems of photothermal thermal therapy(PTT)as well as completely eliminate tumors in animal models without toxic side effects.Depositing Pd clusters on both tips of Au NRs offers Pd-Au NRs three novel functions,i.e.,the extension of the absorption into NIR-Ⅱ region,the activation of prodrug of 5-fluorouracil(5-Fu)via the bioorthogonal reaction,and the peroxidase-mimic activity to produce·OH.The heterogeneous nanorods showed a high and stable photothermal conversion efficiency(52.07%)in a safer NIR-Ⅱ irradiation region(1,064 nm),which not only eliminate most of tumor cells at only one dose of the irradiation for 5 min but also improve the in situ conversion of 5-fluoro-1-propargyluracil and H2O2 into active 5-Fu and·OH to eradicate residual tumors for inhibiting tumor metastasis.This dual catalytic activity-synergistic mechanism of PTT demonstrates the importance of material design in solving current bottleneck problem of tumor therapy. | Linghua Zhang Wenjie Wang Meng Ou Xiaoxiao Huang Yu Ma Jiayue Tang Ting Hou Sheng Zhang Li Yin Huan Chen Yanglong Hou Ya Ding | 2022 | Nano Research2022，15，5： | 0 |
| 19 | PHB介导的HIRA复合物调控人胚胎干细胞的表观--代谢环路显示文摘文章简介染色质地貌和细胞代谢对细胞命运决定有着重要的作用,但人们对它们之间的相互作用却了解甚少。课题组运用基因组范围的si RNA筛选,发现PHB对于维持人胚胎干细胞的自我更新具有重要的作用。 | Huanhuan Li Ping Lai Jinping Jia Yawei Song Qing Xia Kaimeng Huang Na He Wangfang Ping Jiayu Chen Zhongzhou Yang Jiao Li Mingze Yao Xiaotao Dong Jicheng Zhao Chunhui Hou Miguel A.Esteban Shaorong Gao Duanqing Pei Andrew P.Hutchins 姚红杰 Zhexin Zhu Chunliang Li Yanwu Zeng Jianyi Ding Zepeng Qu Junjie Gu Laixiang Ge Fan Tang Xin Huang Chenlin Zhou Ping Wang Deyou Zheng 金颖 | 2018 | 科学新闻2018，0，4： | 0 |
| 20 | Gut microbiota,immunity,and bile acid metabolism:decoding metabolic disease interactions显示文摘In recent decades,the global prevalence of metabolic syndrome has surged,posing a significant public health challenge.Metabolic disorders,encompassing diabetes,obesity,nonalcoholic fatty liver disease,and polycystic ovarian syndrome,have been linked to alterations in the gut microbiota.Nonetheless,the connection between gut microbiota and host metabolic diseases warrants further investigation.In this review,we delve into the associations between various metabolic disorders and the gut microbiota,focusing on immune responses and bile acid(BA)metabolism.Notably,T helper cells,innate lymphoid cells,macrophages,and dendritic cells have been shown to modulate host metabolism through interactions with intestinal microorganisms and the release of cytokines.Furthermore,secondary BA metabolites,derived from the microbiota,are involved in the pathogenesis of metabolic diseases via the farnesoid X receptor and Takeda G protein-coupled receptor 5.By covering both aspects of this immune system-microorganism axis,we present a comprehensive overview of the roles played by the gut microbiota,microbiota-derived BA metabolites,and immune responses in metabolic diseases,as well as the interplay between these systems. | Qixiang Zhao Jiayu Wu Yong Ding Yanli Pang Changtao Jiang | 2023 | Life Metabolism2023，2，6： | 0 |
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