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| 1 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 2 | Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer显示文摘Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response. | Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan | 2021 | Cancer Biology & Medicine2021，18，3： | 11 |
| 3 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 4 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 5 | PERFORMANCE IMPROVEMENT OF CENTRIFUGAL FAN BY MEANS OF NUMERICAL SIMULATION显示文摘数字模拟被用来在一台模型离心通风机调查流动地让蒸气发电站以便改进表演。在测试模型扇子期间,效率仅仅与入口盒子是 62.5% ,这被发现,没有它效率是 83% 。另外,测试钻塔的强壮的颤动与入口盒子被观察。如果扇子的气体动力学能被学习,它将是高度合乎需要的。因此,数字模拟被执行与入口盒子调查一把模型扇子的内部流动特征。从入口的整个区域关的 CFD 分析表演的结果被作为转子的方向相反地旋转的一个螺线旋涡占据,它显著地在扇子内影响大多数流动区域。为这个原因,一个哑巴盘子在入口盒子中被安排阻碍螺线旋涡的产生,从在改革以后的 CFD 的结果证明修正是安静的有效,以前的大螺线顶点有效地被破坏了,大的被代替赞成二个小旋涡。然而,二个小旋涡在转子和下列部分的内部流动上有小效果。最后,模型扇子的效率被测试改进,测试钻塔的强壮的颤动消失。这类修正尽最大努力被使用了车站,扇子效率成功地涨到 84% 。 | ZHANG Bo HUANG Shujuan SUN Zhongwei HUI Shien LIU Jiayu QI Chunsong | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 8 |
| 6 | The 2020 Summer Floods and 2020/21 Winter Extreme Cold Surges in China and the 2020 Typhoon Season in the Western North Pacific显示文摘China experienced significant flooding in the summer of 2020 and multiple extreme cold surges during the winter of 2020/21.Additionally,the 2020 typhoon season had below average activity with especially quiet activity during the first half of the season in the western North Pacific(WNP).Sea surface temperature changes in the Pacific,Indian,and Atlantic Oceans all contributed to the heavy rainfall in China,but the Atlantic and Indian Oceans seem to have played dominant roles.Enhancement and movement of the Siberian High caused a wavier pattern in the jet stream that allowed cold polar air to reach southward,inducing cold surges in China.Large vertical wind shear and low humidity in the WNP were responsible for fewer typhoons in the first half of the typhoon season.Although it is known that global warming can increase the frequency of extreme weather and climate events,its influences on individual events still need to be quantified.Additionally,the extreme cold surge during 16–18 February 2021 in the United States shares similar mechanisms with the winter 2020/21 extreme cold surges in China. | Chunzai WANG Yulong YAO Haili WANG Xiubao SUN Jiayu ZHENG | 2021 | Advances in Atmospheric Sciences2021，38，6： | 8 |
| 7 | Identifying the major fluorescent components responsible for ultrafiltration membrane fouling in different water sources显示文摘Three-dimensional fluorescence excitation–emission matrix(EEM) coupled with parallel factor analysis(PARAFAC) was performed for a total of 18 water samples taken from three water sources(two lakes and one wastewater treatment plant(WWTP) secondary effluent),with the purpose of identifying the major ultrafiltration(UF) membrane foulants in different water sources. Three fluorescent components(C1, C2 and C3) were identified,which represented terrestrially derived humic-like substances(C1), microbially derived humic-like substances(C2), and protein-like substances(C3). The correlations between the different fluorescent components and UF membrane fouling were analyzed. It was shown that for the WWTP secondary effluent, all three components(C1, C2 and C3) made a considerable contribution to the irreversible and total fouling of the UF membrane.However, for the two lakes, only the C3 exhibited a strong correlation with membrane fouling, indicating that the protein-like substances were the major membrane foulants in the lake waters. Significant attachment of C1, C2 and C3 to the UF membrane was also confirmed by mass balance analyses for the WWTP secondary effluent; while the attachment of C1 and C2 was shown to be negligible for the two lakes. The results may provide basic formation for developing suitable fouling control strategies for sustainable UF processes. | Weiguang Sun Jun Nan Jia Xing Jiayu Tian | 2016 | Journal of Environmental Sciences2016，28，7： | 5 |
| 8 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 9 | Machine-learning-based high-resolution DOA measurement and robust directional modulation for hybrid analog-digital massive MIMO transceiver显示文摘At hybrid analog-digital(HAD)transceiver,an improved HAD estimation of signal parameters via rotational invariance techniques(ESPRIT),called I-HAD-ESPRIT,is proposed to measure the direction of arrival(DOA)of a desired user,where the phase ambiguity due to HAD structure is dealt with successfully.Subsequently,a machine-learning(ML)framework is proposed to improve the precision of measuring DOA.Meanwhile,we find that the probability density function(PDF)of DOA measurement error(DOAME)can be approximated as a Gaussian distribution by the histogram method in ML.Then,a slightly large training data set(TDS)and a relatively small real-time set(RTS)of DOA are formed to predict the mean and variance of DOA/DOAME in the training stage and real-time stage,respectively.To improve the precisions of DOA/DOAME,three weight combiners are proposed to combine the-maximum-likelihood-learning outputs of TDS and RTS.Using the mean and variance of DOA/DOAME,their PDFs can be given directly,and we propose a robust beamformer for directional modulation(DM)transmitter with HAD by fully exploiting the PDF of DOA/DOAME,especially a robust analog beamformer on RF chain.Simulation results show that:(1)the proposed I-HAD-ESPRIT can achieve the HAD Cramer-Rao lower bound(CRLB);(2)the proposed ML framework performs much better than the corresponding real-time one without training stage;(3)the proposed robust DM transmitter can perform better than the corresponding non-robust ones in terms of secrecy rate. | Zhihong ZHUANG Ling XU Jiayu LI Jinsong HU Linlin SUN Feng SHU Jiangzhou WANG | 2020 | Science China(Information Sciences)2020，63，8： | 5 |
| 10 | Identification of Rice QTLs for Important Agronomic Traits with Long-Kernel CSSL-Z741 and Three SSSLs显示文摘Rice kernel shape affects kernel quality(appearance) and yield(1000-kernel weight) and therefore is an important agronomic trait, but its inheritance is complicated. We identified a long-kernel rice chromosome segment substitution line(CSSL), Z741, derived from Nipponbare as a recipient and Xihui 18 as a donor parent. Z741 has six substitution segments distributed on rice chromosomes 3, 6, 7, 8 and 12 with an average replacement length of 5.82 Mb. Analysis of a secondary F2 population from a cross between Nipponbare and Z741 identified 20 QTLs for important agronomic traits. The kernel length of Z741 is controlled by a major QTL(qKL3) and a minor QTL(qKL7). Candidate gene prediction and sequencing indicated that qKL3 may be an allele of OsPPKL1, which encodes a protein phosphatase implicated in brassinosteroid signaling, and qKL7 is an unreported QTL. Finally, we validated eight QTLs(qKL3, qKL7, qRLW3-1, qRLW7, qPH3-1, qKWT3, qKWT7 and qNPB6) using three selected singlesegment substitution lines(SSSLs), S1, S2 and S3. Also, we detected five QTLs(qKL6, qKW3, qKW7, qKW6 and qRLW6) in S1, S2 and S3, which were not found in the Nipponbare/Z741 F2 population. However, qNPB3, qNPB7 and qPL3 QTLs were not validated by the three SSSLs in 2019, suggesting that minor QTLs are susceptible to environmental factors. These results lay the foundation for studying the biodiversity of kernal length and molecular breeding of different kernel types. | Wang Hui Zhang Jiayu Naz Farkhanda Li Juan Sun Shuangfei He Guanghua Zhang Ting Ling Yinghua Zhao Fangming | 2020 | Rice science2020，27，5： | 5 |
| 11 | The telomere-to-telomere genome of Fragaria vesca reveals the genomic evolution of Fragaria and the origin of cultivated octoploid strawberry显示文摘Fragaria vesca,commonly known as wild or woodland strawberry,is the most widely distributed diploid Fragaria species and is native to Europe and Asia.Because of its small plant size,low heterozygosity,and relative ease of genetic transformation,F.vesca has been a model plant for fruit research since the publication of its Illumina-based genome in 2011.However,its genomic contribution to octoploid cultivated strawberry remains a long-standing question.Here,we de novo assembled and annotated a telomere-to-telomere,gap-free genome of F.vesca‘Hawaii 4’,with all seven chromosomes assembled into single contigs,providing the highest completeness and assembly quality to date.The gap-free genome is 220785082 bp in length and encodes 36173 protein-coding gene models,including 1153 newly annotated genes.All 14 telomeres and seven centromeres were annotated within the seven chromosomes.Among the three previously recognized wild diploid strawberry ancestors,F.vesca,F.iinumae,and F.viridis,phylogenomic analysis showed that F.vesca and F.viridis are the ancestors of the cultivated octoploid strawberry F.×ananassa,and F.vesca is its closest relative.Three subgenomes of F.×ananassa belong to the F.vesca group,and one is sister to F.viridis.We anticipate that this high-quality,telomere-to-telomere,gap-free F.vesca genome,combined with our phylogenomic inference of the origin of cultivated strawberry,will provide insight into the genomic evolution of Fragaria and facilitate strawberry genetics and molecular breeding. | Yuhan Zhou Jinsong Xiong Ziqiang Shu Chao Dong Tingting Gu Pengchuan Sun Shuang He Mian Jiang Zhiqiang Xia Jiayu Xue Wasi Ullah Khan Fei Chen Zong-Ming Cheng | 2023 | Horticulture Research2023，10，4： | 4 |
| 12 | Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes显示文摘Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell labeling, and can be detectable by both magnetic resonance and near infrared (NIR) fluorescence imaging. Multiple hydrophobic superparamagnetic iron oxide (SPIO) nanocrystals are self-assembled into nanocomposites in water phase with the help of partially alkylated hyperbranched polycation, polyethylenimine (PEI), which already conjugated with the indocyanine dye Cy5.5 and can be used for cell imaging under NIR fluorescence imaging. The amphiphilic PEI/SPIO nanocomposites have a strong T 2 relaxivity. The iron uptake process in MCF-7/Adr displays a time dependent behavior. Confocal laser scanning microscopy reveals that the nanoprobes are internalized into the cytoplasm of MCF-7/Adr after 24 h labeling. Both MR and NIR fluorescence imaging showed strong image contrast against unlabeled cells. Under a clinical MRI scanner, labeled cells in gelatin phantom present much darker images than controlled ones. The T2 relaxation rate of the labeled cells is 98.2 s 1 , significantly higher than that of the control ones of 2.3 s 1 . This study provides an important alternative to label MCF-7/Adr at optimized low dosages with high efficiency, and may be useful to label other biologically important cells and track their behaviors in vivo. | WANG Dan SU HongYing LIU yanHong WU ChangQiang XIA ChunChao SUN JiaYu GAO FaBao GONG QiYong SONG Bin AI Hua | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 13 | Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia显示文摘Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological features.Rare variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD development.It is still unknown whether TREM2 is related to cognitive impairment in T2DM.Here,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed mice.Male C57BL/6J mice were maintained on HFD for 50 weeks.TREM2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene delivery.The results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and memory.Compared with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD mice.The overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic transmission.Dendritic complexity and spine density in the CA1 region were rescued after TREM2 overexpression.Furthermore,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial activation.In sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory phenotype.Our study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline. | Min Wu Maolin Liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu Li Jibin Li Yuxiang Sun Chaodong Wu Qifu Li Xiaoqiu Xiao | 2022 | Genes & Diseases2022，9，2： | 4 |
| 14 | Comparative analysis of four essential Gracilariaceae species in China based on whole transcriptomic sequencing显示文摘Three Gracilaria species,G.chouae,G.blodgettii,G.vermiculophylla and a close relative species,Gracilariopsis lemaneiformis which is now nominated as Gracilaria lemaneiformis,are the typically indigenous species which are important resources for the production of special proteins,phycobilisomes,special carbohydrates,and agar in China.In this study,de novo transcriptome sequencing on these four species using the next generation sequencing technology was performed for the first time.Functional annotations on assembled sequencing reads showed that the transcriptomic profiles were quite different between G.lemaneiformis and other three Gracilaria species.Comparative analysis of differential gene expression related to carbohydrate and phycobiliprotein metabolisms also showed that the expression profiles of these essential genes were different in four species.The genes encoding allophycocyanin,phycocyanin and phycoerythrin were further examined in four species and their deduced amino acid sequences were used for phylogenetic analysis to confirm that G.lemaneiformis had close relationship to genus Gracilaria,as well as that within genus Gracilaria,G.chouae had closer relationship to G.vermiculophylla rather than to G.blodgettii.The de novo transcriptome study on four species provided a valuable genomic resource for further understanding and analysis on biological and evolutionary study among marine algae. | XU Jiayue SUN Jing YIN Jinlong WANG Liang WANG Xumin LIU Tao CHI Shan LIU Cui REN Lufeng WU Shuangxiu YU Jun | 2014 | Acta Oceanologica Sinica2014，33，2： | 3 |
| 15 | Recent advances in hydrothermal modification of calcium phosphorus coating on magnesium alloy显示文摘Magnesium(Mg) and its alloys have emerged as a favored candidate for bio-regenerative medical implants due to their superior biocompatibility, biodegradability and the elastic modulus close to that of human bone. Unfortunately, the rapid and uncontrollable degradation rate of Mg alloys in chloride-rich body microenvironments limits their clinical orthopedic applications. Recently, Calcium Phosphate(Ca-P)biomaterials, especially Hydroxyapatite(HA), have been broadly applied in the surface functional modification of metal-based biomaterials attributed to their excellent bioactivity and biocompatibility. Hydrothermal modification of Ca-P coatings on Mg alloys has been extensively exploited by researchers for its significant superiorities in controlling coating structure and improving interfacial bonding strength for better osseointegration and corrosion resistance. This work focuses on the up-to-the-minute advances in Ca-P coatings on the surface of Mg and its alloys via hydrothermal methods, including the strategies and mechanisms of hydrothermal modification. Herein, we are inclined to share some feasible and attractive hydrothermal surface modification strategies. From the perspectives of hydrothermal manufacturing technique innovation and coating structure optimization, we evaluate how to foster the corrosion resistance, coating bonding strength, osseointegration and antibacterial properties of Mg alloys with Ca-P coatings synthesized by hydrothermal method. The challenges and future perspectives on the follow-up exploration of Mg alloys for orthopedic applications are also elaborately proposed. | Lei Ling Shu Cai Qianqian Li Jiayue Sun Xiaogang Bao Guohua Xu | 2022 | Journal of Magnesium and Alloys2022，10，1： | 2 |
| 16 | The Second Type Singularities of Symplectic and Lagrangian Mean Curvature Flows显示文摘This paper mainly deals with the type II singularities of the mean curvature flow from a symplectic surface or from an almost calibrated Lagrangian surface in a K¨ahler surface.The relation between the maximum of the Kahler angle and the maximum of |H|2 on the limit flow is studied.The authors also show the nonexistence of type II blow-up flow of a symplectic mean curvature flow which is normal flat or of an almost calibrated Lagrangian mean curvature flow which is flat. | Xiaoli HAN Jiayu LI Jun SUN | 2011 | Chinese Annals of Mathematics,Series B2011，32，2： | 2 |
| 17 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 18 | Contact parameter analysis and calibration in discrete element simulation of rice straw显示文摘Discrete element method was used to study and analyze the interaction between rice straws and between rice straw and agricultural machinery parts,thereby providing a scientific basis for post-harvest paddy field processing.Calibrations of rice straw-rice straw,rice straw-agricultural machinery part contact parameters(collision recovery coefficient,static friction coefficient and rolling friction coefficient)constitute an important prerequisite for the discrete element research process.In this study,the collision recovery coefficients of rice straw-steel and rice straw-rice straw were 0.230 and 0.357,respectively,which were calibrated by the collision method.The static friction coefficient and rolling friction coefficient of rice straw-steel were 0.363 and 0.208 respectively,which were calibrated by the inclined plate method and the slope method.The static friction coefficient and rolling friction coefficient of rice straw-rice straw were 0.44 and 0.07,respectively,which were calibrated by the split cylinder method.The paired t-test showed insignificant differences between calibration parameter simulation results and the physical test values(p>0.05).Taking the angle of repose that reflecting rice straw flow and friction characteristics as the evaluation index,the verification tests of the above calibration values indicated that the simulated angle of repose has no significant difference from the physical test value(p>0.05).The side plate lifting test on rice straw of different lengths showed no significant difference between the simulated angle of repose and the physical test value(p>0.05).This study can provide a basis for contact parameters choice in discrete element simulation analysis with rice straw-rice straw and rice straw-agricultural machinery parts as the research object.The calibration method can provide a reference for the contact parameter calibration of other crop straws. | Honglei Jia Jiayu Deng Yanling Deng Tianyou Chen Gang Wang Zaijin Sun Hui Guo | 2021 | International Journal of Agricultural and Biological Engineering2021，14，4： | 2 |
| 19 | A new luminescent material: Li 2 CaSiO 4 :Eu 2+显示文摘 | Jie Liu Jiayue Sun Chunshan Shi | 2006 | Materials Letters2006，，23： | 2 |
| 20 | Synthesis and luminescence properties of Na,z Ba2 Si2 07 : Eu2 + phosphor显示文摘 | Sun Jiayue Cui Dianpeng Du Haiyan | 2013 | Appl Phys B2013，111，4： | 1 |
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