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| 1 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 2 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 3 | Low frequency oscillation characteristics of East China Power Grid after commissioning of Huai-Hu ultra-high voltage alternating current project显示文摘The low frequency oscillation characteristics of East China Power Grid after commissioning of the first ultra-high voltage alternating current(UHVAC)project-the Huai-Hu UHVAC project are studied.Several low frequency oscillation cases occurred in East China Power Grid in the past few years are reviewed and summarized.Based on the analysis of the different typical operation modes,the main low frequency oscillation modes in East China Power Grid in the early stages of development of ultra-high voltage(UHV)are summarized,and the impacts of the significant power grid maintenance on low frequency oscillation characteristics are analyzed.Besides,the oscillation mode of UHV generators to East China Power Grid is researched,and the importance of the power system stabilizator(PSS)is emphasized.Furthermore,the comparative analysis between the time domain and the frequency domain is carried out,and the influences of the governing system on low frequency oscillation characteristics are revealed.Finally,both the focus and the direction of low frequency oscillation research are presented. | Chao WANG Yang LV Hongyang HUANG Jing ZHANG Jihong LI Yingyi LI Weizhen SUN Yong CHANG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 6 |
| 4 | Molecular genetic studies of familial Meniere’s disease显示文摘Dear Editor.Meniere's disease(MD,MIM 156000),a chronic clinical illness affecting the inner ear,presents as episodes of spontaneous vertigo,fluctuating sensorineural hearing loss,tinnitus,and aural fullness.Endolymphatic hydrops in the cochlear duct and vestibular organs is considered the underlying histopathologic characteristic of MD.Most MD cases are sporadic(sporadic Meniere's disease,SMD),and approximately 4%-20%of patients with MD have a familial history. | Jing Zhang Jing Guan Hongyang Wang Dayong Wang Lidong Zhao Huifang Zhou Qiuju Wang | 2019 | Science China(Life Sciences)2019，62，11： | 2 |
| 5 | Evaluation on Fracture Toughness at Dynamic Loading for Welded Joint Based on the Local Approach显示文摘The changes in mechanical properties and fracture toughness by dynamic loading were investigated with experiments.The parameter R, which can reflect the effect of the loading rate and the temperature rising during the high loading rate, could be employed to describe the constituent relation for the typical structure steel and its weld metal. The dynamic loading effect on the stress/strain fields and the temperature variation in the vicinity of the crack tip was analyzed by the finite element method, the dynamic fracture behavior was evaluated based on the local approach. It has been found that the Weibull stress is an effective fracture parameter, independent of the temperature and the loading rate. | Hongyang JING, Lianyong XU, Lixing HUO and Yufeng ZHANGSchool of Materials Science and Engineering, Tianjin University, Tianjin 300072, China | 2004 | Journal of Materials Science & Technology2004，20，1： | 2 |
| 6 | Fusion boundary evolution, precipitation behaviour, and interaction with dislocations in an Fe–22Cr–15Ni steel weldment during long-term creep显示文摘A tungsten inert gas welded joint between a novel heat-resistant austenitic steel and ERNiCrCoMo-1 weld metal was investigated before and after creep in this study. The evolution of the microstructures in the base and weld metals was discussed based on the electron back-scatter diffraction(EBSD) and transmission electron microscopy(TEM) analyses. The preferred orientations of the fusion boundary after creep revealed the influence of the applied stress on creep deformation mechanism. A cooperative nucleation process of M23C6 carbides in the base metal was proposed. The finely distributed Cu-rich phase was cut off by the dislocations during creep, leading to increased mean size and reduced amount of the nano-Cu phase. A modified triple-precipitate hardening model was constructed based on TEM observations of the interactions between the particles and the dislocations in the base metal after creep at 200 MPa. The evolution of a μ phase in the weld metal involved epitaxial growth and dissolving into the matrix. | Yu Zhang Hongyang Jing Lianyong Xu Yongdian Han Lei Zhao Xishan Xie Zhengxin Tang | 2019 | Progress in Natural Science:Materials International2019，29，1： | 2 |
| 7 | Study on the Basic Mechanical Behaviors of High Density Polyethylene Electrofusion Welded Joints at Different Temperature显示文摘The basic mechanical behaviors of high density polyethylene electrofusion welded joint at different temperatures were studied by using differently designed specimens in this paper. The results show that the strength of weld bonding plane is higher than that of the pipe and socket materials at room temperature. In order to get the shear strength of electrofusion welded joint,the effective bond lengths were reduced by cutting artificial groove through the socket. The effective bonding length of welded joint to get the shear strength is decreased with decreasing testing temperature. The shear strength and the sensibility to sharp notch of HDPE material increased with decreasing temperature. | Lixing HUO, Fangjuan QI, Yufeng ZHANG, Hongyang JING and Xinqi YANGSchool of Materials Science and Engineering, Tianjin University, Tianjin 300072, China | 2003 | Journal of Materials Science & Technology2003，19，6： | 2 |
| 8 | Organoid Technology and Clinical Applications in Digestive System Cancer显示文摘Cancers of the digestive system(DS),including esophageal,gastric,colorectal,liver,and pancreatic can-cers,have a high incidence and mortality worldwide.Current cancer models cannot faithfully recapitu-late the critical features of the original tumor,resulting in the failure of translation from basic research into clinical practice.More advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine development.Organoids are in vitro cultured three dimensional(3D)self-organizing organotypic structures derived from tissues and pluripotent stem cells,which faithfully mimic the histological features and preserve the genetic heterogeneity of the original tissues.Both normal and malignant organoids can now be efficiently established from the DS tissues of patients.In this review,we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research,preclinical medical practice,and precision medicine. | Xiaofang Zhao Youhai Jiang Chunliang Liu Minghui Hou Hongyang Wang Jing Fu | 2022 | Engineering2022，8，2： | 2 |
| 9 | J-integral of interfacial crack between metal-base ceramic coating and steel显示文摘 | Xu Lianyong Jing Hongyang He Ying | | 0，，01： | 1 |
| 10 | Young's modulus and stress intensity factor determination of high velocity electric arc sprayed metal-based ceramic coatings显示文摘 | Xu Lianyong Jing Hongyang Huo Lixing | 2006 | Surf Coat Techn2006，201，6： | 1 |
| 11 | Preparation and characterization of hollow glass microspheres/ZnO composites显示文摘 | Yongming Sui Haibin Yang Wuyou Fu Jing Xu Lianxia Chang Hongyang Zhu Qingjiang Yu Minghui Li Guangtian Zou | 2008 | Journal of Alloys and Compounds2008，，1： | 1 |
| 12 | Synthesis and characterization of hollow glass microspheres coated by SnO 2 nanoparticles显示文摘 | Jing Xu Haibin Yang Qingjiang Yu Lianxia Chang Xiaofen Pang Xiang Li Hongyang Zhu Minghui Li Guangtian Zou | 2006 | Materials Letters2006，，6： | 1 |
| 13 | Growth optical and thermal properties ofYb,Tm:KLu (WO4)2显示文摘 | ZHAO Hongyang WANG Jiyang LI Jing | 2006 | J Cryst Growth2006，293，： | 1 |
| 14 | Numerical investigation of factors affecting creep damage accumulation in ASME P92 steel welded joint显示文摘 | Lei Zhao Hongyang Jing Lianyong Xu Junchao An Guangchun Xiao | 2011 | Materials and Design2011，，： | 1 |
| 15 | Experimental study on creep damage evolution process of Type IV cracking in 9Cr–0.5Mo–1.8W–VNb steel welded joint显示文摘 | Lei Zhao Hongyang Jing Lianyong Xu Yongdian Han Junjie Xiu | 2011 | Engineering Failure Analysis2011，，： | 1 |
| 16 | Tracking Tonoplast Protein Behaviors in Intact Vacuoles Isolated from Arabidopsis Leaves显示文摘 | Lv, Xueqin Jing, Yanping Wu, Hongyang Lin, Jinxing | 2017 | Molecular Plant2017，10，2： | 1 |
| 17 | Experimental investigation of specimen size effect on creep crack growth behavior in P92 steel welded joint显示文摘 | Lei Zhao Hongyang Jing Junjie Xiu Yongdian Han Lianyong Xu | 2014 | Materials and Design2014，，： | 1 |
| 18 | Effects ofstrength mis-matching on the fracture behavior of nuclear pressuresteel A508-III welded joint显示文摘 | Zhu Zhengqiang Jing Hongyang Ge Jingguo | 2005 | Materials Science And Engineer-ing A2005，390，12： | 1 |
| 19 | Young's modulus and stress intensity factor determination of high velocity dectric arc sprayed metal - based ceramic coating 显示文摘 | Xu Lianyong Jing Hongyang Huo Lixing | 2006 | Surface and Coatings Technology2006，201，6： | 1 |
| 20 | Understanding auditory neuropathy spectrum disorder: a system- atic review in transgenic mouse models显示文摘Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future. | Li Wang Jing Guan Hongyang Wang Lan Lan Qiujing Zhang Liang Zong Wan Du Wenping Xiong Fengjiao Li Kaiwen Wu Dayong Wang Qiuju Wang | 2016 | Science China(Life Sciences)2016，59，5： | 1 |
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