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| 1 | Fabricated temperature sensitive photocatalyst of PNIPAM@ZnO/C for controllable photocatalytic activity显示文摘PNIPAM@ZnO/C composite photocatalyst was prepared by cross-linking polymerization technology with N-isopropylacrylamide used as functional monomer, N,N'-methylenebis(acrylamide) used as crosslinking agent, ammonium persulfate used as initiator, and 3-(trimethoxysilyl) propyl methacrylate used as surface modification reagent. The morphology, structure, electrochemical and photocatalytic properties of as-prepared samples were characterized via the serial tests. The temperature-response performances of PNIPAM@ZnO/C were evaluated by the photocatalytic degradation of tetracycline(TC)under different temperatures. The results show that the synthesized composite photocatalysts possess the excellent and switchable photocatalytic activity. The photocatalytic degradation activity of PNIPAM@ZnO/C is suppressed above the lower critical solution temperature(LCST), and it is enhanced below the LCST. | Pengwei Huo Jinze Li Zhefei Ye Huiqin Wang Xinlin Liu Xiuying Li Yongsheng Yan | 2017 | Chinese Chemical Letters2017，28，12： | 2 |
| 2 | Integrated microdevice with a windmill-like hole array for the clog-free,efficient,and self-mixing enrichment of circulating tumor cells显示文摘Circulating tumor cells(CTCs)have tremendous potential to indicate disease progression and monitor therapeutic response using minimally invasive approaches.Considering the limitations of affinity strategies based on their cost,effectiveness,and simplicity,size-based enrichment methods that involve low-cost,label-free,and relatively simple protocols have been further promoted.Nevertheless,the key challenges of these methods are clogging issues and cell aggregation,which reduce the recovery rates and purity.Inspired by the natural phenomenon that the airflow around a windmill is disturbed,in this study,a windmill-like hole array on the SU-8 membrane was designed to perturb the fluid such that cells in a fluid would be able to self-mix and that the pressure acting on cells or the membrane would be dispersed to allow a greater velocity.In addition,based on the advantages of fluid coatings,a lipid coating was used to modify the membrane surface to prevent cell aggregation and clogging of the holes.Under the optimal conditions,recovery rates of 93%and 90%were found for A549 and HeLa cells in a clinical simulation test of our platform with a CTC concentration of 20-100 cells per milliliter of blood.The white blood cell(WBC)depletion rate was 98.7%(n=15),and the CTC detection limit was less than 10 cells per milliliter of blood(n=6).Moreover,compared with conventional membrane filtration,the advantages of the proposed device for the rapid(2 mL/min)and efficient enrichment of CTCs without clogging were shown both experimentally and theoretically.Due to its advantages in the efficient,rapid,uniform,and clog-free enrichment of CTCs,our platform offers great potential for metastatic detection and therapy analyses. | Hao Li Jinze Li Zhiqi Zhang Zhen Guo Changsong Zhang Zixu Wang Qiuquan Guo Chao Li Chuanyu Li Jia Yao Anran Zheng Jingyi Xu Qingxue Gao Wei Zhang Lianqun Zhou | 2022 | Microsystems & Nanoengineering2022，8，1： | 1 |
| 3 | Preparation of biomorpic SiC ceramic by carbothermal reduction of oak wood charcoal 显示文摘 | QIAN J M Wang J P JinZ H | 2004 | Mater Sci Eng A2004，371，22： | 1 |
| 4 | Isolated ultrasmall Bi nanosheets for efficient CO_(2)-to-formate electroreduction显示文摘Electrochemical reduction of CO_(2) to valuable formate as liquid fuel is a promising way to alleviate the greenhouse effect.The edge active sites in bismuth(Bi)nanosheets play a critical role in the electrochemical reduction of CO_(2) into formate,which enable the operation of CO_(2) reduction with high cathodic energy efficiency,especially under large current densities of≥200 mA/cm^(2).However,the undesirable reconstruction of small Bi nanosheets into large nanosheets leads to the decreasing of edge active sites during electrocatalysis.Here we report stable isolated ultrasmall bismuth nanosheets-synthesized by in-situ electrochemical transformation of ligands covered bismuth vanadate-on silver nanowires as an efficient electrocatalyst for CO_(2)-to-formate reduction.The cooperative electrocatalyst achieves a formate current density of 186 mA/cm^(2) and a cathodic energy efficiency of 75%for formate,which is the only best compared to the literature results.Operand。Raman and morphologic measurements demonstrate that the excellent energy utilization of the electrocatalyst is originated from the rich edge active sites with Bi-O species of the ultrasmall Bi nanosheets. | Jinze Liu Yuhang Li Yating Wang Chuqian Xiao Miaomiao Liu Xiaodong Zhou Hao Jiang Chunzhong Li | 2022 | Nano Research2022，15，2： | 1 |
| 5 | Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway显示文摘Background Salmonella typhimurium(S.T),as an important foodborne bacterial pathogen,can cause diarrhea and gastroenteritis in humans and animals.Numerous studies have confirmed that exopolysaccharides(EPSs)have various biological functions,but the mechanism through which EPSs improve the immunity of animals against the invasion of pathogenic bacteria is unclear.Here,we explored the protective effect of EPSs of Lactobacillus rhamnosus GG(LGG)on the S.T-infected intestine.Methods Mice received adequate food and drinking water for one week before the start of the experiment.After 7 d of prefeeding,2×108 CFU/mL S.T solution and an equivalent volume of saline(control group)were given orally for 1 d.On the fourth day,the mice were treated with 0.5 mg/mL EPSs,1.0 mg/mL EPSs,2.0 mg/mL EPSs,or 2.0 mg/mL penicillin for 7 d.Finally,the body and relative organ weight,histological staining,and the levels of antioxidant enzyme activity and inflammatory cytokines were determined.Results The S.T-infected mice exhibited symptoms of decreased appetite,somnolence,diarrhea and flagging spirit.Treatment with EPSs and penicillin improved the weight loss of the mice,and the high dose of EPSs showed the best therapeutic effect.EPSs significantly ameliorated S.T-induced ileal injury in mice.High-dose EPSs were more effective than penicillin for alleviating ileal oxidative damage induced by S.T.The mRNA levels of inflammatory cytokines in the ileum of mice showed that the regulatory effects of EPSs on inflammatory cytokines were better than those of penicillin.EPSs could inhibit the expression and activation of key proteins of the TLR4/NF-κB/MAPK pathway and thereby suppress the level of S.T-induced ileal inflammation.Conclusions EPSs attenuate S.T-induced immune responses by inhibiting the expression of key proteins in the TLR4/NF-κB/MAPK signaling pathway.Moreover,EPSs could promote bacterial aggregation into clusters,which may be a potential strategy for reducing the bacterial invasion of intestinal epithelial cells. | Jinze Li Qiuke Li Qianhui Wu Nan Gao Zhihua Wang Yang Yang Anshan Shan | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 0 |
| 6 | Siamese single object tracking algorithm with natural language prior显示文摘1 Introduction Visual tracking has long been considered as a fundamental mission in computer vision,and it has been widely used for many applications.Siamese trackers[1]utilize Siamese network to do template matching and achieve state-of-the-art performance recently.However,the Siamese trackers fail to distinguish the target from the distractors with the same category and perform unstably in complicated environment.We find there are three reasons which affect the robustness and stability of the tracker. | Qianli ZHOU Rong WANG Jinze LI Naiqian TIAN Wenjin ZHANG | 2021 | Frontiers of Computer Science2021，15，5： | 0 |
| 7 | Microstructure and thermoelectric properties of nanoparticled copper selenide alloys synthesized using a microwave-assisted hydrothermal method显示文摘With the fabrication of high-performance thermoelectric(TE)materials,developments are being made in enhanc-ing the figure of merit,zT,of TE materials.Liquid-like binary copper selenide(Cu_(2) Se)chalcogenides recently gained significant recognition because of their anomalous but fascinating electrical and thermal transport perfor-mances.In this study,a facile synthesis technique was adopted in fabricating Cu_(2) Se nanoparticles using a rapid microwave-assisted hydrothermal route at different reaction times.The results were compared with those of the Cu_(2) Se solid-state(SS)sample synthesized using the traditional melting and annealing technique.X-ray diffrac-tion patterns revealed successful synthesis of nanoparticles and a phase transition from orthorhombic��-phase and cubic��-phase to a single orthorhombic structure after hot-pressing.Scanning electron microscopic images revealed that although the grain sizes of the nanoparticle(NP)bulk samples increased with the reaction time of the microwave hydrothermal process,the grain sizes were significantly smaller than that of the SS sample.Additionally,NP bulk samples exhibited plenty of nano-grains and pores that are absent in the SS sample.The size and distribution of the grains and pores were measured to study their effects on the transport of carriers and phonons.The NP30 sample exhibited the highest power factor of 983.3μW K−2 m at 673 K among the NP samples,exhibiting intermediate values of resistivity and Seebeck coefficient that are close to those of the SS sample.Moreover,the NP samples exhibited appreciably lower thermal conductivity than the SS sample that is attributed to strengthened phonon scattering.The minimum thermal conductivity of the NP05 sample,0.78 WK−1 m−1 at 348 K,is 1.7 times lower than that of the SS sample.Finally,a maximum zT of 0.56 at 673 K,being approximately 1.3 times higher than that of the SS sample owing to the optimized thermal conductivity,was achieved for the NP30 sample.This value is comparable to or higher than that reported for Cu_(2) Se synthesized using the traditional SS method.Investigations revealed that the proposed microwave hydrothermal synthesis technique is a facile,rapid,and reliable method that results in Cu_(2) Se alloys with excellent TE performance. | Mahwish Khan Jinze Zhai Wenbin Su Fahad Mehmood Tingting Chen Juanjuan Feng Hongchao Wang Chunlei Wang | 2023 | ChemPhysMater2023，2，3： | 0 |
| 8 | Efficient Simultaneous Detection of Metabolites Based on Electroenzymatic Assembly Strategy显示文摘Objective and Impact Statement:We describe an electroenzymatic mediator(EM)sensor based on an electroenzymatic assembly peak separation strategy,which can efficiently realize the simultaneous detection of 3 typical cardiovascular disease(CVD)metabolites in 5μl of plasma under one test.This work has substantial implications toward improving the efficiency of chronic CVD assessment.Introduction:Monitoring CVD of metabolites is strongly associated with disease risk.Independent and time-consuming detection in hospitals is unfavorable for chronic CVD management.Methods:The EM was flexibly designed by the cross-linking of electron mediators and enzymes,and 3 EM layers with different characteristics were assembled on one electrode.Electrons were transferred under tunable potential;3 metabolites were quantitatively detected by 3 peak currents that correlated with metabolite concentrations.Results:In this study,the EM sensor showed high sensitivity for the simultaneous detection of 3 metabolites with a lower limit of 0.01 mM.The linear correlation between the sensor and clinical was greater than 0.980 for 242 patients,and the consistency of risk assessment was 94.6%.Conclusion:Metabolites could be expanded by the EM,and the sensor could be a promising candidate as a home healthcare tool for CVD risk assessment. | Anran Zheng Chao Li Shengkai Xu Zhen Guo Chuanyu Li Changsong Zhang Jia Yao Zhiqi Zhang Jinze Li Lutao Du Shasha Zhao Chuanxin Wang Wei Zhang Lianqun Zhou | 2023 | Biomedical Engineering Frontiers2023，4，1： | 0 |
| 9 | Emergent leader-follower relationship in networked multiagent systems显示文摘Understanding the collective dynamics of leader-follower systems is a crucial and challenging issue.Previous studies have a priori designated leaders.However,the leaderfollower relationship is self-organized in human society over time and social interactions[1]. | Jinzhuo LIU Chenyou FAN Yunchen PENG Jinze DU Zhen WANG Chen CHU | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 10 | Current insights into the oncogenic roles of lncRNA LINC00355显示文摘Long noncoding RNAs(lncRNAs)are a class of nonprotein-coding transcripts that are longer than 200 nucleotides.LINC00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various cancers.It regulates the expression of downstream genes at both transcriptional and posttranscriptional levels,including eight microRNAs(miR-15a-5p,miR-34b-5p,miR-424-5p,miR-1225,miR-217-5p,miR-6777-3p,miR-195,and miR-466)and three protein-coding genes(ITGA2,RAD18,and UBE3C).LINC00355 plays a role in regulating various biological processes such as cell cycle progression,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and metastasis of cancer cells.It is involved in the regulation of the Wnt/β-catenin signaling pathway and p53 signaling pathway.Upregulation of LINC00355 has been identified as a high-risk factor in cancer patients and its increased expression is associated with poorer overall survival,recurrence-free survival,and disease-free survival.LINC00355 upregulation has been linked to several unfavorable clinical characteristics,including advanced tumor node metastasis and World Health Organization stages,reduced Karnofsky Performance Scale scores,increased tumor size,greater depth of invasion,and more extensive lymph node metastasis.LINC00355 induces chemotherapy resistance in cancer cells by regulating five downstream genes,namely HMGA2,ABCB1,ITGA2,WNT10B,and CCNE1 genes.In summary,LINC00355 is a potential oncogene with great potential as a diagnostic marker and therapeutic target for cancer. | Jinze Shen Xinming Su Ming Pan Zehua Wang Yufei Ke Qurui Wang Jingyin Dong Shiwei Duan | 2023 | Cancer Innovation2023，2，6： | 0 |
| 11 | Analysis of Subcellular Localization and Pathogenicity of Plum Bark Necrosis Stem-Pitting Associated Virus Protein P6显示文摘Infection of plum bark necrosis stem pitting associated virus(PBNSPaV)has been reported in many Prunus species in several countries,causing significant economic losses.The very small proteins encoded by plant viruses are often overlooked due to their short sequences and uncertain significance.However,numerous studies have indicated that they might play important roles in the pathogenesis of virus infection.The role of small hydrophobic protein P6,encoded by the open reading frame 2 of PBNSPaV,has not been well explored.In this study,we amplified the P6 fragment from a PBNSPaV isolate by RT-PCR using specific primers and found that it is 174 bp long and encodes a protein of approximately 6.3 kD with a transmembrane domain.Subcellular localization analysis of P6 proteins in tobacco leaves showed that P6 localizes to the cytomembrane and nuclear membrane.To further clarify the pathogenicity of P6 proteins,we constructed a PVX-P6 expression vector by inserting the p6 fragment into a potato virus X(PVX)-based vector and transformed it into Agrobacterium tumefaciens GV3101.Infiltration of Nicotiana benthamiana(N.benthamiana)with the PVX vector-transformed A.tumefaciens led to slight mosaic symptoms at 14 days of post-inoculation.Meanwhile,infiltration with the PVX-P6 vector-transformed A.tumefaciens resulted in no significant symptoms.These results demonstrated that heterologous expression of P6 in N.benthamiana could not enhance the pathogenicity of PVX.Our study indicates that P6 may not be a potential pathogenic factor associate with the causing of symptoms,and the mode of action of PBNSPaV-P6 protein remains to be further studied. | Yuanyuan Li Jinze Mu Qingliang Li Huabing Liu Xuefeng Yuan Deya Wang | 2023 | Phyton-International Journal of Experimental Botany2023，92，7： | 0 |
| 12 | Targeted mutagenesis in rabbit using an engineered BhCas12b variant显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeat(CRISPR)and CRISPR-associated protein(CRISPR–Cas)system has exhibited powerful abilities to manipulate genomes of animals and plants(Knott and Doudna,2018).Up to now,numerous Cas nucleases have been harnessed for genome editing in human cells,such as Cas9,Cas12a(also known as Cpf1),and Cas12b(also termed C2c1).Cas12b,a Class 2 type V-B CRISPR system,generates staggered double-strand breaks(DSBs)in the target DNA(Stella et al.,2017)and recognizes a distal 5′-T-rich protospacer adjacent motif(PAM)sequence(Shmakov et al.,2015),making it a complement to Cas9(recognizing 5′-NGG-3′PAM)in genome editing.Three Cas12b nucleases have been engineered for targeted genome editing in mammals or plants:BhCas12b v4(Strecker et al.,2019),BvCas12b(Strecker et al.,2019),and AaCas12b(Teng et al.,2018).However,they have not been compared parallelly with each other.In this study,we compared the three Cas12b proteins for genome editing in mammalian cells. | Yingqi Jia Tian Wang Ding Zhao Zhiquan Liu Tingting Sui Siyu Chen Jinze Li Liangxue Lai Zhanjun Li | 2022 | Journal of Molecular Cell Biology2022，14，12： | 0 |
| 13 | An Interpretable Depression Prediction Model for the Elderly Based on ISSA Optimized LightGBM显示文摘Depression is one of the most severe mental health illnesses among senior citizens.Aiming at the low accuracy and poor interpretability of traditional prediction models,a novel interpretable depression predictive model for the elderly based on the improved sparrow search algorithm(ISSA)optimized light gradient boosting machine(LightGBM)and Shapley Additive exPlainations(SHAP)is proposed.First of all,to achieve better optimization ability and convergence speed,various strategies are used to improve SSA,including initialization population by Halton sequence,generating elite population by reverse learning and multi-sample learning strategy with linear control of step size.Then,the ISSA is applied to optimize the hyper-parameters of light gradient boosting machine(LightGBM)to improve the prediction accuracy when facing massive high-dimensional data.Finally,SHAP is used to provide global and local interpretation of the prediction model.The effectiveness of the proposed method is validated by a series of comparative experiments based on a real-world dataset. | Jie Wang Zitong Wang Jinze Li Yan Peng | 2023 | Journal of Beijing Institute of Technology2023，32，2： | 0 |
| 14 | Particulate Amines in the Background Atmosphere of the Yangtze River Delta,China:Concentration,Size Distribution,and Sources显示文摘Amines are important for new particle formation and subsequent growth in the atmosphere.Consequently,the processes involved are receiving more attention in recent years.Here,we conduct a field observation in order to investigate the atmospheric particulate amines at a background site in the Yangtze River Delta(YRD)during the summer of 2018.Four amines in PM_(2.5),i.e.,methylamine(MA),dimethylamine(DMA),diethylamine(DEA),and trimethylamine(TMA),were collected,twice daily and analyzed.During the campaign,our measurements found the concentrations of MA,DMA,DEA,and TMA of 15.0±15.0,6.3±6.9,20.4±30.1,and 4.0±5.9 ng m^-(3),respectively,and the four amines correlated well with each other.The concentration of amines appear to be independent of whether they were collected during the day or night.Both MA and DMA exhibited a bimodal size distribution that had peaks at 0.67 and 1.1μm,suggesting amines preferably distribute on submicron particles.Boundary layer height(BLH),relative humidity,and pH of aerosols were found have a negative relationship with amines,while aerosol liquid water content(ALWC)was found to have a positive relationship with amines.The PMF(positive matrix factorization)source apportionment results showed that the main source of amines in Chongming Island was of anthropogenic origin such as industrial and biomass emission,followed by marine sources including sea salt and marine biogenic sources.Given that the YRD region is still suffering from complex atmospheric pollution and that the knowledge on aerosol amines is still limited,more field studies are in urgent need for a better understanding of the pollution characteristics of amines. | Wei DU Xinpei WANG Fengqin YANG Kaixu BAI Can WU Shijie LIU Fanglin WANG Shaojun LV Yubao CHEN Jinze WANG Wenliang LIU Lujun WANG Xiaoyong CHEN Gehui WANG | 2021 | Advances in Atmospheric Sciences2021，38，7： | 0 |
| 15 | Evaluating students' learning situations using “Four-quadrant law”显示文摘Evaluation is widely acknowledged as a powerful means of improving the quality of education and it is a very important component of the education system. However, the current mainstream evaluation method is based on the examination as the common way, which has very limited help to instructors' teaching. In this paper, based on an online learning platform named 'educoder', we design an evaluation method by using 'Four-quadrant law', which divides students' learning situations into four types. In addition, we provide some suggestions for instructors about how to give targeted teaching to different students in each type. We verify that our method is useful by setting up experiments. The experiment results show that our method can effectively improve the quality of instructors' teaching. | Jinze Liu Dongyang Hu Xunhui Zhang Tao Wang Yue Yu Gang Yin | 2018 | 计算机教育2018，，12： | 0 |
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