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| 1 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 2 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 3 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 4 | Hierarchical hollow Li4Ti5O12 urchin-like microspheres with ultra-high specific surface area for high rate lithium ion batteries显示文摘 | Jin Cheng Renchao Che Chongyun Liang Jiwei Liu Min Wang Junjie Xu | 2014 | Nano Research2014，7，7： | 11 |
| 5 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 6 | Hierarchical magnetic core-shell nanostructures for microwave absorption:Synthesis,microstructure and property studies显示文摘Core-shell nanostructures have attracted considerable attention in the past decades because of their fundamental scientific significance and many technological applications.Recently,it has been reported that the core-shell nanostructures with advanced compositions and complicated morphologies show great potential as high-performance microwave absorbers due to their unique properties,such as large surface areas,multi-functionalities and synergistic effects between the interior core and outer shell.This review article focuses on the recent progress in synthesis and characterization of hierarchical magnetic core-shell nanostructures for microwave absorption applications based on our own work.In addition,several future trends in this field for next-generation microwave absorbers are discussed. | LIU JiWei XU JunJie LIU ZhengWang LIU XiaLin CHE RenChao | 2014 | Science China Chemistry2014，57，1： | 8 |
| 7 | MCP-1-induced protein-1,an immune regulator显示文摘MCP-1-induced protein-1(MCPIP1)is a newly identified protein that is crucial to immune regulation.Mice lack-ing MCPIP1 gene suffer from severe immune disorders,and most of them cannot survive longer than 12 weeks.Considerable progress has been made in revealing the mechanism underlying the immune regulatory function of MCPIP1.MCPIP1 can act as an RNase to promote the mRNA degradation of some inflammatory cytokines,such as IL-6 and IL-1.Pre-microRNAs are also confirmed to be the substrate of MCPIP1 RNase.The structure of MCPIP1 N-terminal conserved domain shows a PilT N-terminus-like RNase structure,further supporting the notion that MCPIP1 has RNase activity.MCPIP1 can also deubiquitinate TNF receptor-associated factor family proteins,which are known to mediate immune and inflammatory responses.In this review,we summarize recent progress on the immune regulatory role of MCPIP1 and discuss the mechanisms underlying its function. | Jiwei Xu Sheng Fu Wei Peng Zihe Rao | 2012 | Protein & Cell2012，3，12： | 6 |
| 8 | A Randomized Trial Comparing Radiofrequency Ablation and Surgical Resection for HCC Conforming to the Milan Criteria显示文摘 | Jiwei Huang Lvnan Yan Zheyu Cheng Hong Wu Liang Du Jinzhou Wang Yinglong Xu Yong Zeng | 2010 | Annals of Surgery2010，，6： | 5 |
| 9 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 3 |
| 10 | Electrochemical Lithium Storage Performance of Molten Salt Derived V_(2)SnC MAX Phase显示文摘MAX phases are gaining attention as precursors of two-dimensional MXenes that are intensively pursued in applications for electrochemical energy storage.Here,we report the preparation of V_(2)SnC MAX phase by the molten salt method.V_(2)SnC is investigated as a lithium storage anode,showing a high gravimetric capacity of 490 mAh g−1 and volumetric capacity of 570 mAh cm^(−3) as well as superior rate performance of 95 mAh g^(−1)(110 mAh cm^(−3))at 50 C,surpassing the ever-reported performance of MAX phase anodes.Sup-ported by operando X-ray diffraction and density functional theory,a charge storage mechanism with dual redox reaction is proposed with a Sn-Li(de)alloying reaction that occurs at the edge sites of V_(2)SnC particles where Sn atoms are exposed to the electrolyte followed by a redox reaction that occurs at V_(2)C layers with Li.This study offers promise of using MAX phases with M-site and A-site elements that are redox active as high-rate lithium storage materials. | Youbing Li Guoliang Ma Hui Shao Peng Xiao Jun Lu Jin Xu Jinrong Hou Ke Chen Xiao Zhang Mian Li Per OÅPersson Lars Hultman Per Eklund Shiyu Du Zhifang Chai Zhengren Huang Na Jin Jiwei Ma Ying Liu Zifeng Lin Qing Huang | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 11 | Distributed Intrusion Monitoring System With Fiber Link Backup and On-Line Fault Diagnosis Functions显示文摘与聪明的纤维连接备份和联机差错诊断函数监视系统的新奇多信道的分布式的光纤维侵入被建议。1?? | Jiwei XU Huijuan WU Shunkun XIAO | 2014 | Photonic Sensors2014，4，4： | 2 |
| 12 | Learning generalizable deep feature using triplet-batch-center loss for person re-identification显示文摘Dear editor,Metric learning loss functions are important for deep learning-based person re-identification(re-ID).Several loss functions,such as triplet loss,center loss,and sphere loss,have been proposed.However,there are a few discussions on the generalization ability of these loss functions.In this study,we proposed a novel metric-learning loss function,triplet-batch-center loss(TBCL),to learn more generalizable deep features than the previous loss functions.TBCL averages features from the same class within a batch to get a center and requires each sample to be close to its corresponding center and far from the other centers.We carried out extensive experiments on the following datasets:CUHK03,DukeMTMC-re-ID,and Market1501.TBCL leads to state-of-the-art results on these datasets without the image re-ranking post-processing.For instance,our methods achieved 75.9%Rank-1 accuracy and 73.3%mean average precision(mAP)on CUHK03 for the setting of having labelled person using only global features,remarkable better than the previous state-of-the-art person re-ID methods by at least+6.9%/+7.6%. | Bin HU Jiwei XU Xinggang WANG | 2021 | Science China(Information Sciences)2021，64，2： | 2 |
| 13 | Neural circuit control of innate behaviors显示文摘All animals possess a plethora of innate behaviors that do not require extensive learning and are fundamental for their survival and propagation.With the advent of newly-developed techniques such as viral tracing and optogenetic and chemogenetic tools,recent studies are gradually unraveling neural circuits underlying different innate behaviors.Here,we summarize current development in our understanding of the neural circuits controlling predation,feeding,male-typical mating,and urination,highlighting the role of genetically defined neurons and their connections in sensory triggering,sensory to motor/motivation transformation,motor/motivation encoding during these different behaviors.Along the way,we discuss possible mechanisms underlying binge-eating disorder and the pro-social effects of the neuropeptide oxytocin,elucidating the clinical relevance of studying neural circuits underlying essential innate functions.Finally,we discuss some exciting brain structures recurrently appearing in the regulation of different behaviors,which suggests both divergence and convergence in the neural encoding of specific innate behaviors.Going forward,we emphasize the importance of multi-angle and cross-species dissections in delineating neural circuits that control innate behaviors. | Wei Xiao Zhuo-Lei Jiao Esra Senol Jiwei Yao Miao Zhao Zheng-Dong Zhao Xiaowei Chen Peng Cao Yu Fu Zhihua Gao Wei L Shen Xiao-Hong Xu | 2022 | Science China(Life Sciences)2022，65，3： | 2 |
| 14 | Theoretical analysis of a method for segmented heat exchanger design显示文摘In the process of the design of heat exchangers,it is difficult to establish the factors governing the optimal points of the design objective functions due to the contradictions and uncertainties of the design objectives.The variation of fluid properties is one of the main factors causing this type of uncertainty.Conventional design methods have not completely solved these problems.In the present work,based on the logarithmic mean temperature difference,a new heat exchanger design method(called the segmented design method) is proposed which takes into account the variation of fluid properties with respect to the temperature.In this method,the whole heat exchanger is first divided into several segments.Then by applying the principle of the conservation of energy and taking into account the initial conditions as well as the connecting conditions of the adjacent segments,the inlet and outlet temperatures of each segment are determined.Finally,the application of the logarithmic mean temperature difference method on each segment defines the heat transfer area. | SONG JiWei XU MingTian CHENG Lin | 2011 | Chinese Science Bulletin2011，56，20： | 2 |
| 15 | Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas显示文摘Due to the special physiological and pathological characteristics of gliomas,most therapeutic drugs are prevented from entering the brain.To improve the poor prognosis of existing therapies,researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy.Although these strategies can be used clinically to overcome the blood-brain barrier(BBB),the accurate delivery of drugs to the glioma lesions cannot be ensured.Nano-drug delivery systems(NDDS)have been widely used for precise drug delivery.In recent years,researchers have gathered their wisdom to overcome barriers,so many well-designed NDDS have performed prominently in preclinical studies.These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions,drug release in response to the glioma microenvironment,biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein,and carriers created according to the active ingredients of traditional Chinese medicines.We reviewed these well-designed NDDS in detail.Furthermore,we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy,and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 16 | Surface Modification of Multi-walled Carbon Nanotubes by O2 Plasma 显示文摘 | Tao Xu Jinghui Yang Jiwei Liu | 2007 | Applied Surface Science2007，253，： | 1 |
| 17 | Quantitative Evaluation of Fatigue Crack Size Using Eddy Current Pulsed Thermography显示文摘A set of metallic specimens containing fatigue cracks with different sizes were tested using eddy current pulsed thermography(ECPT),therefore the relations between heating response of the crack area and the crack length was studied.The numerical and experimental results both showed that the increase of the crack length enhanced the crack heating response under specific test conditions.A particular form of calculated response signal,which is linearly related to the crack length,was introduced to provide a quantitative evaluation of crack length. | Feng Fuzhou Xu Chao Zhu Junzhen Min Qingxu Sun Jiwei | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，3： | 1 |
| 18 | A Randomized Trial Comparing Radiofrequency Ablation and Surgical Resection for HCC Conforming to the Milan Criteria显示文摘 | Jiwei Huang Lvnan Yan Zheyu Cheng Hong Wu Liang Du Jinzhou Wang Yinglong Xu Yong Zeng | 2010 | Annals of Surgery2010，，6： | 1 |
| 19 | DOA estimation of incoherently distributed sources using importance sampling maximum likelihood显示文摘In this paper, an importance sampling maximum likelihood(ISML) estimator for direction-of-arrival(DOA) of incoherently distributed(ID) sources is proposed. Starting from the maximum likelihood estimation description of the uniform linear array(ULA), a decoupled concentrated likelihood function(CLF) is presented. A new objective function based on CLF which can obtain a closed-form solution of global maximum is constructed according to Pincus theorem. To obtain the optimal value of the objective function which is a complex high-dimensional integral,we propose an importance sampling approach based on Monte Carlo random calculation. Next, an importance function is derived, which can simplify the problem of generating random vector from a high-dimensional probability density function(PDF) to generate random variable from a one-dimensional PDF. Compared with the existing maximum likelihood(ML) algorithms for DOA estimation of ID sources, the proposed algorithm does not require initial estimates, and its performance is closer to CramerRao lower bound(CRLB). The proposed algorithm performs better than the existing methods when the interval between sources to be estimated is small and in low signal to noise ratio(SNR)scenarios. | WU Tao DENG Zhenghong HU Xiaoxiang LI Ao XU Jiwei | 2022 | Journal of Systems Engineering and Electronics2022，33，4： | 1 |
| 20 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 1 |
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