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| 1 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 2 | CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6显示文摘睫是毛一般的细胞器从房间表面延长与重要感觉并且活动性功能。睫的缺点能导致作为 ciliopathies 知道的大量人的疾病。然而,控制 ciliogenesis 的分子的机制仍然保持糟糕定义。这里,我们显示出那 cylindromatosis (CYLD ) ,怀有 deubiquitinase 活动的肿瘤 suppressor 蛋白质,在多重机关在主要、能动的睫的集会起一个关键作用。CYLD 猛烈老鼠 polydactyly 展出并且各种各样的睫的缺点,例如在基础身体抛锚和基础身体和 axenomes 的组织的破坏的失败。CYLD 的睫的功能部分从 70 kDa (Cep70 ) 的 centrosomal 蛋白质被归因于它 polyubiquitin 链的 deconjugation,为 Cep70 到的一个要求与 γ 交往;导管素并且在中心体本地化。另外, histone deacetylase 的调停 CYLD 的抑制 6 (HDAC6 ) ,它支持导管素 acetylation,为 CYLD 的睫的功能组成另一机制。HDAC6 的小分子的禁止者能部分在 CYLD 猛烈老鼠救睫的缺点。这些调查结果在 ciliogenesis 的调整强调蛋白质 ubiquitination 的重要性,作为这个过程的一个关键管理者识别 CYLD,并且建议在 ciliopathies 的 CYLD 缺乏的参与。 | Yunfan Yang Jie Ran Min Liu Dengwen Li Yuanyuan Li Xingjuan Shi Dan Meng Junmin Pan Guangshuo Ou Rim Aneja Sbao-Cong Sun Jun Zhou | 2014 | Cell Research2014，24，11： | 8 |
| 3 | Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment显示文摘Heat shock protein 90(Hsp90)is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers.Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones resulting in the degradation of Hsp90-dependent client proteins through the ubiqui tina tion-proteasome pathway,thereby leading to the growth inhibition of tumor cells.This review will briefy discuss the molecular structure and biological function of Hsp90,and focus on a summary of recent progress in the development and testing of natural Hsp90 inhibitors and their different means by which they interact with Hsp90. | Yong Li Dongmei Zhang Jun Xu Junmin Shi Lei Jiang Nan Yao Wencai Ye | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 7 |
| 4 | Bi_(2)S_(3) for Aqueous Zn Ion Battery with Enhanced Cycle Stability显示文摘Aqueous Zn ion batteries(ZIBs)are promising in energy storage due to the low cost,high safety,and material abundance.The development of metal oxides as the cathode for ZIBs is limited by the strong electrostatic forces between O2−and Zn2+which leads to poor cyclic stability.Herein,Bi2S3 is proposed as a promising cathode material for rechargeable aqueous ZIBs.Improved cyclic stability and fast diffusion of Zn2+is observed.Also,the layered structure of Bi2S3 with the weak van der Waals interaction between layers offers paths for diffusion and occupancy of Zn2+.As a result,the Zn/Bi2S3 battery delivers high capacity of 161 mAh g−1 at 0.2 A g−1 and good cycling stability up to 100 cycles with ca.100%retention.The battery also demonstrates good cyclic performance of ca.80.3%over 2000 cycles at 1 A g−1.The storage mechanism in the Bi2S3 cathode is related to the reversible Zn ion intercalation/extraction reactions and the capacitive contribution.This work indicates that Bi2S3 shows great potential as the cathode of ZIBs with good performance and stability. | Ting Xiong Yinming Wang Bosi Yin Wen Shi Wee Siang Vincent Lee Junmin Xue | 2020 | Nano-Micro Letters2020，12，1： | 3 |
| 5 | Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice显示文摘Transposable elements(TEs)constitute the most abundant portions of plant genomes and can dramatically shape host genomes during plant evolution.They also play important roles in crop domestication.However,whether TEs themselves are also selected during crop domestication has remained unknown.Here,we identify an active long terminal repeat(LTR)retrotransposon,HUO,as a potential target of selection during rice domestication and breeding.HUO is a low-copy-number LTR retrotransposon,and is active under natural growth conditions and transmitted through male gametogenesis,preferentially inserting into genomic regions capable of transcription.HUO exists in all wild rice accessions and about half of the archaeological rice grains(1200–7000 years ago)and landraces surveyed,but is absent in almost all modern varieties,indicating its gradual elimination during rice domestication and breeding.Further analyses showed that HUO is subjected to strict gene silencing through the RNA-directed DNA methylation pathway.Our results also suggest that multiple HUO copies may trigger genomic instability through altering genome-wide DNA methylation and small RNA biogenesis and changing global gene expression,resulting in decreased disease resistance and yield,coinciding with its elimination during rice breeding.Together,our study suggests that negative selection of an active retrotransposon might be important for genome stability during crop domestication and breeding. | Yu Peng Yingying Zhang Yijie Gui Dong An Junzhong Liu Xun Xu Qun Li Junmin Wang Wen Wang Chunhai Shi Longjiang Fan Baorong Lu Yiwen Deng Sheng Teng Zuhua He | 2019 | Molecular Plant2019，12，10： | 2 |
| 6 | Assessing the genetic diversity of the critically endangered Chinese sturgeon Acipenser sinensis using mitochondrial markers and genome-wide single-nucleotide polymorphisms from RAD-seq显示文摘As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2006, for economic purposes.The natural population of Chinese sturgeon has declined since then, as these dams block its migratory route to the original spawning grounds in the middle reaches of the Yangtze River. In 2013 and 2014, there was an absence of spawning where it typically happened near the Gezhouba Dam. Nevertheless, from April to June in 2015, over 1,000 larvae with different body lengths(10–35 cm) were detected along the Shanghai Yangtze Estuary; but only little is currently known about the population genetic structure of the Chinese sturgeon. Herein, we inferred population genetic parameters from 462 available Chinese sturgeon specimens based on a 421-bp fragment of the mitochondrial DNA(mtDNA) D-loop region and 1,481,620 SNPs(singlenucleotide polymorphisms) generated by restriction site-associated DNA sequencing(RAD-seq). For the D-loop dataset, 15 haplotypes were determined. Randomly picked 23 individuals, representing the 15 D-loop haplotype groups, were subsequently used for further RAD-seq validation. The average nucleotide diversity calculated from the mtDNA and RAD datasets was 0.0086 and 0.000478, respectively. The overall effective female population size was calculated to be 1,255 to 2,607, and the long-term effective population size was estimated to range from 11,950 to 119,500. We observed that the genetic variability and the effective female population size of the current population in the Yangtze River are severely low, which are similar to the data reported over 10 years ago. The deduced relatively small effective population of female fish, limiting the genetic connectivity among Chinese sturgeon, should be considered a serious threat to this endangered species. | Jian Liu Xinxin You Pao Xu Ping Zhuang Yueping Zheng Kai Zhang Min Wang Yunyun Lv Gangchun Xu Feng Zhao Jianhui Wu Houyong Fan Jianan Xu Zhiqiang Ruan Chao Bian Kai Liu Dongpo Xu Jinhui Chen Junmin Xu Qiong Shi | 2018 | Science China(Life Sciences)2018，61，9： | 2 |
| 7 | A TDOA location algorithm based on data fusion显示文摘 | LIU Junmin ZHANG Chen LIU Shi | | 0，，03： | 1 |
| 8 | Double-layer silica core-shell nanospheres with superparamagnetic and fluorescent functionalities显示文摘 | Ling Li Eugene Shi Guang Choo Junmin Xue | 2008 | Chemical Physics Letters2008，461，： | 1 |
| 9 | Research on Impro- ving TDOA Location Accuracy Based on Data Fusion显示文摘 | Zhang Chen Liu Junmin Liu Shi | 2004 | Pro- ceedings of the IEEE 6th Circuits and Systems Symposium on Emerging Technologies: Frontiers of Mobile and Wireless Com- munication2004，2，： | 1 |
| 10 | Colon hydrotherapy plus Traditional Chinese Medicine to treat non-alcoholic fatty liver disease:a pilot study显示文摘OBJECTIVE: To demonstrate the potential to treat non-alcoholic fatty liver disease(NAFLD) with colon hydrotherapy(CHT) plus Traditional Chinese Medicine(TCM).METHODS: A total of 20 patients were enrolled into the study and received CHT with TCM for 2 weeks.Body mass index(BMI) and levels of serum triglycerides(TG) and total cholesterol(TC) were compared between pre-treatment and post-treatment.RESULTS: Two-week treatment with CHT plus TCM significantly lowered BMI and reduced blood lipids.BMI decreased from 29.5 ± 4.3 to 25.4 ± 1.0, while mean TG levels decreased by 0.70 mmol/L on average from baseline and mean TC levels decreased by0.37 mmol/L. Forty-five percent of patients exhibited TC decreasing by more than 10% from baseline and25%ofpatientsexhibited TCdecreasingbymore than 20%. Sixty percent of patients exhibited TG decreasing by more than 20% and 20% of patients exhibited TG decreasing by more than 40%. However,high-density and low-density lipoprotein cholester-ol levels did not change significantly after intervention. No serious adverse events were reported.CONCLUSION: Our findings suggest that CHT plus TCM to treat NAFLD is promising and it might be a new treatment strategy for management of NAFLD. | Xiao Huanming Jiang Junmin Xie Yubao Shi Meijie Tian Guangjun Zhao Pengtao Zhang Chaozhen Chen Huijun Xu Chanyuan Chi Xiaoling | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 1 |
| 11 | Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study显示文摘Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)vs.rituximab plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in China.Methods:Patients were randomized to G-chemo or R-chemo.Responders received maintenance therapy for 2 years or until disease progression.The primary endpoint was investigator(INV)-assessed PFS.Secondary endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and safety.Results:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,respectively.INV-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the R-chemo.Median OS was not reached in either arm.Grade 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with FL.Trial registration:ClinicalTrials.gov,No.NCT01332968. | Xiaonan Hong Yuqin Song Yuankai Shi Qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 12 | Perpendicular magnetic clusters with configurable domain structures via dipole-dipole interactions显示文摘 | Weimin Li Seng Kai Wong Tun Seng Herng Lee Koon Yap Cheow Hin Sim Zhengchun Yang Yunjie Chen Jianzhong Shi Guchang Han Junmin Xue Jun Ding | 2015 | Nano Research2015，8，11： | 1 |
| 13 | Genomic selection of orange-spotted grouper(Epinephelus coioides)based on multiplex PCR enrichment capture sequencing显示文摘Orange spotted grouper(Epinephelus coioides)is an important mariculture fish,and genomic breeding of this grouper species has been hindered due to lack of efficient genotyping tools.Here,we developed a single nucleotide polymorphism(SNP)genotyping technology based on multiplex PCR enrichment capture sequencing,which mainly aims at target area for high-throughput sequencing,and 741 SNPs were designed for genomic selection(GS)of growth and ammonia tolerance traits at the same time.The multiplex PCR enrichment capture sequencing assay showed that the genotyping efficiency was more than 99%in the orange-spotted grouper and the predictive accuracy of body weight and ammonia tolerance traits was 82%and 96%,respectively.More importantly,the average identity of the sequences with these SNPs aligned to the genomes of giant grouper(E.lanceolatus)and brown-marbled grouper(E.fuscoguttatus)were both over 96%.Test data showed that the SNP genotyping efficiency was more than 94%in both giant grouper and brown-marbled grouper.In summary,these results indicated that the development of SNP loci and genotyping approach based on the multiple PCR enrichment capture sequencing are suitable for GS of growth and ammonia tolerance traits in various grouper species,and it would provide technical support for practical grouper breeding. | Xinxin Shan Xinhui Zhang Zhiqiang Ruan Jieming Chen Qiong Shi Junmin Xu Xinxin You | 2023 | Aquaculture and Fisheries2023，8，6： | 0 |
| 14 | Electrohydrodynamic lithography of metallic mesh for optically transparent flexible and conformal antennas显示文摘The optically transparent antenna is becoming a very attractive proposition for various applications, such as wearable devices and vehicle radars. The fabrication of transparent flexible/conformal antennas is a long-lasting interest in academia and industry.However, the preparation of radio-frequency radiators with excellent conductivity and optical transmittance is still quite challenging. Herein, we introduce a facile approach to directly fabricate optically transparent flexible and conformal coplanar waveguide-fed antennas using programmable electrohydrodynamic lithography. Metallic meshes with transmittance above 90%have been successfully created based on the conformal electrohydrodynamic printing of high-viscosity photoresist masks, and the corresponding sheet resistance can be tuned down to ~2 Ω/□. Then, the geometrical structure of the proposed transparent antenna has been systematically optimized because of the basic radio frequency components, including the radiator, feeder line,ground plane, and size of metallic meshes. Optically transparent flexible and conformal antennas are finally obtained, presenting an optical transmittance of 92% and 55%, respectively. The simulated and measured results demonstrate that the transparent antennas with a good optoelectronic performance indeed exhibit a nice electromagnetic behavior. We believe that this newly developed conformal electrohydrodynamic lithography method can be utilized to fabricate a variety of other transparent electronic devices, such as transparent electromagnetic shielding meshes on aircraft canopies, in the future. | YE Dong XIE Han TIAN Yu WEN JunMin SHI ZeYing AN Kang ZHANG YuPeng HUANG YongAn | 2023 | Science China(Technological Sciences)2023，66，1： | 0 |
| 15 | Surveillance of Multidrug-Resistant Bacterial Infections in Non-Adult Patients-Zhejiang Province,China,2014-2019显示文摘ABSTRACT Introduction:Antimicrobial resistance has become a major public health threat globally.The prevalence of multidrug-resistant(MDR)bacterial infections increased substantially among inpatients under 18 years of age in recent years.In Zhejiang Province,China,the trends of drug-resistance in non-adult patients from 2014 to 2019 were monitored,aiming to determine the variation patterns and epidemiological features of MDR strains. | Yuchen Wu Shi Chen Jiaping Li Chang Cai Hanyu Wang Mingming Zhou Junmin Cao Qiang Wang Shenghai Wu Shibiao Ding Xiaofei Zhao Long Sun Qingfeng Hu Hongwei Zhou Xiang Qian Qing Yang Sheng Chen Rong Zhang | 2021 | China CDC weekly2021，3，47： | 0 |
| 16 | An intelligent control method based on artificial neural network for numerical flight simulation of the basic finner projectile with pitching maneuver显示文摘In this paper,an intelligent control method applying on numerical virtual flight is proposed.The proposed algorithm is verified and evaluated by combining with the case of the basic finner projectile model and shows a good application prospect.Firstly,a numerical virtual flight simulation model based on overlapping dynamic mesh technology is constructed.In order to verify the accuracy of the dynamic grid technology and the calculation of unsteady flow,a numerical simulation of the basic finner projectile without control is carried out.The simulation results are in good agreement with the experiment data which shows that the algorithm used in this paper can also be used in the design and evaluation of the intelligent controller in the numerical virtual flight simulation.Secondly,combined with the real-time control requirements of aerodynamic,attitude and displacement parameters of the projectile during the flight process,the numerical simulations of the basic finner projectile’s pitch channel are carried out under the traditional PID(Proportional-Integral-Derivative)control strategy and the intelligent PID control strategy respectively.The intelligent PID controller based on BP(Back Propagation)neural network can realize online learning and self-optimization of control parameters according to the acquired real-time flight parameters.Compared with the traditional PID controller,the concerned control variable overshoot,rise time,transition time and steady state error and other performance indicators have been greatly improved,and the higher the learning efficiency or the inertia coefficient,the faster the system,the larger the overshoot,and the smaller the stability error.The intelligent control method applying on numerical virtual flight is capable of solving the complicated unsteady motion and flow with the intelligent PID control strategy and has a strong promotion to engineering application. | Yiming Liang Guangning Li Min Xu Junmin Zhao Feng Hao Hongbo Shi | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 17 | Surface Passivation Toward Efficient and Stable Perovskite Solar Cells显示文摘Although metal halide perovskites are increasingly popular for the next generation of efficient photovoltaic devices,the inevitable defects from the preparation process have become the notorious barrier to further improvement of performance,which increases non-radiative recombination and lowers the power conversion efficiency of solar cells.Surface passivation strategies have been affirmed as one of the most practical approaches to suppress these defects.Therefore,it is necessary to have a detailed review on the surface passivation to reveal the improvements of the devices.Herein,the mechanism and recent advances of surface passivation have been systematically summarized with respect to various passivation approaches,including the Lewis acid–base,the low-dimensional perovskite,inorganic molecules,and polymers.Finally,the review also offers the research trend and prospects of surface passivation. | Junmin Xia Chao Liang Hao Gu Shiliang Mei Shengwen Li Nan Zhang Shi Chen Yongqing Cai Guichuan Xing | 2023 | Energy & Environmental Materials2023，6，1： | 0 |
| 18 | China is initiating the Aquatic 10-100-1,000 Genomics Program显示文摘On June 17 of 2016,a group of scientists from Chinese Academy of Fishery Sciences(CAFS)and Shenzhen BGI Fisheries Sci&Tech Co.Ltd.(BGI Fisheries)met together in Shenzhen,China to launch a novel project,the China Aquatic 10-100-1,000 Genomics Program,to conduct molecular breeding of^10 aquaculture species and sequence genomes of^100 and transcriptomes of^1,000 aquatic species.The main objective of this project is to build | Yingjie Liu Pao Xu Junmin Xu Yu Huang Yongxin Liu Hui Fang Yinchang Hu Xinxin You Chao Bian Min Sun Ruobo Gu Lifeng Cui Xianliang Zhang Peng Xu Qiong Shi | 2017 | Science China(Life Sciences)2017，60，3： | 0 |
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