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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 3 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 4 | Model predictive control for hybrid vehicle ecological driving using traffic signal and road slope information显示文摘This paper presents development of a control system for ecological driving of a hybrid vehicle. Prediction using traffic signal and road slope information is considered to improve the fuel economy. It is assumed that the automobile receives traffic signal information from intelligent transportation systems(ITS). Model predictive control is used to calculate optimal vehicle control inputs using traffic signal and road slope information. The performance of the proposed method was analyzed through computer simulation results. Both the fuel economy and the driving profile are optimized using the proposed approach. It was observed that fuel economy was improved compared with driving of a typical human driving model. | Kaijiang YU Junqi YANG Daisuke YAMAGUCHI | 2015 | Control Theory and Technology2015，13，1： | 9 |
| 5 | The Rice RMR1 Associates with a Distinct Prevacuolar Compartment for the Protein Storage Vacuole Pathway显示文摘从到液泡的 Golgi 仪器或 trans-Golgi 网络(TGN ) 的 vacuolar 蛋白质的运输在植物房间是经由中间的膜界限 prevacuolar 分隔空间(PVC ) 的一个调停受体的过程。排序受体(VSR ) 和受体相同 region-transmembrane domain-RING-H2 (RMR ) 蛋白质的两 vacuolar 被显示了在把存储蛋白质搬运到蛋白质存储液泡(PSV ) 工作,但是很少为 PSV 小径对 PVC 的性质被知道。这里,我们把米饭 RMR1 (OsRMR1 ) 用作一根探针在植物学习 PSV 小径。有特定的 OsRMR1 抗体的 Immunogold 电子显微镜学(他们)证明 OsRMR1 蛋白质在两个大米文化房间和发展中的大米种子与 PVC 的特征在 Golgi 仪器, TGN ,和一个不同细胞器被发现,象蛋白质身体类型 II ( PBII )或在开发大米种子的 PSV 一样。这个细胞器,也在烟草 BY-2 和 Arabidopsis 暂停发现有教养的房间,从 VSR 积极的 multivesicular 是词法上不同的 lysin 的 PVC 或 multivesicular 身体(MVB ) 并且因此为我们说出存储 PVC (sPVC ) 的 PSV 小径代表 PVC。进一步,在 vivo 并且在 vitro,相互作用用蛋白质分泌了进暂停房间表明了的转基因的 BY-2 的文化媒介的截断的 OsRMR1 学习那 OsRMR1 在搬运象 vicilin 一样存储蛋白质作为排序的受体工作。 | Yun Shen Junqi Wang Yu Ding Sze Wan Lo Guillaume Gouzerh Jean-Marc Neuhau Liwen Jiang | 2011 | Molecular Plant2011，4，5： | 5 |
| 6 | Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice显示文摘 | Jizheng Chen Yang Zhao Chao Zhang Hairong Chen Jin Feng Xiumei Chi Yu Pan Jun Du Min Guo Huang Cao Honghe Chen Zilong Wang Rongjuan Pei Qian Wang Lei Pan Junqi Niu Xinwen Chen Hong Tang | 2014 | Cell Research2014，24，9： | 5 |
| 7 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 8 | Overwhelming low ammonia escape and low temperature denitration efficiency via MnOx-decorated two-dimensional MgAl layered double oxides显示文摘Low temperature catalysts are attracting increasing attention in the selective catalytic reduction(SCR)of NO with NH3.Mn Ox-decorated Mg Al layered double oxide(Mn/Mg Al-LDO)was synthesized via a facile fast pour assisted co-precipitation(FP-CP)process.Compared to the Mn/Mg Al-LDO obtained via slow drop assisted coprecipitation(SD-CP)method,the Mn/Mg Al-LDO(FP-CP)has excellent activity.The Mn/Mg Al-LDO(FP-CP)catalyst was shown to possess a high NO conversion rate of 76%-100%from 25 to 150℃,which is much better than the control Mn/Mg Al-LDO(SD-CP)(29.4%-75.8%).In addition,the Mn/Mg Al-LDO(FP-CP)offered an enhanced NO conversion rate of 97%and a N2selectivity of 97.3%at 100℃;the NO conversion rate was 100%and the N2selectivity was 90%at 150℃with a GHSV of 60,000 h^-1.The Mn/Mg Al-LDO(FP-CP)catalyst exhibited a smaller fragment nano-sheet structure(sheet thickness of 7.23 nm).An apparent lattice disorder was observed in the HRTEM image confirming the presence of many defects.The H2-TPR curves show that the Mn/Mg Al-LDO(FP-CP)catalyst has abundant reducing substances.Furthermore,the enhanced surface acidity makes the NH3concentration of the Mn/Mg Al-LDO(FP-CP)catalyst lower than 100 ml·m^-3after the reaction from 25 to 400℃.This can effectively reduce the ammonia escape rate in the SCR reaction.Thus,the Mn/Mg Al-LDO(FP-CP)catalyst has potential applications in stationary industrial installations for environmentally friendly ultra-low temperature SCR. | Junqi Tian Yanqin Li Xia Zhou Yongbin Yao DenghaoWang Jianming Dan Bin Dai Qiang Wang Feng Yu | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 4 |
| 9 | Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer显示文摘Electroactive bacteria could perform bi-directional extracellular electron transfer(EET)to exchange electrons and energy with extracellular environments,thus playing a central role in microbial electro-fermentation(EF)process.Unbalanced fermentation and microbial electrosynthesis are the main pathways to produce value-added chemicals and biofuels.However,the low efficiency of the bi-directional EET is a dominating bottleneck in these processes.In this review,we firstly demonstrate the main bi-directional EET mechanisms during EF,including the direct EET and the shuttle-mediated EET.Then,we review representative milestones and progresses in unbalanced fermentation via anode outward EET and microbial electrosynthesis via inward EET based on these two EET mechanisms in detail.Furthermore,we summarize the main synthetic biology strategies in improving the bi-directional EET and target products synthesis,thus to enhance the efficiencies in unbalanced fermentation and microbial electrosynthesis.Lastly,a perspective on the applications of microbial electro-fermentation is provided. | Ziying Gong Huan Yu Junqi Zhang Feng Li Hao Song | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 4 |
| 10 | Enhanced selective catalytic reduction of NO with NH3 via porous micro-spherical aggregates of Mn–Ce–Fe–Ti mixed oxide nanoparticles显示文摘We rationally designed a high performance denitration(De-NOx) catalyst based on a micrometer-sized spherical Mn–Ce–Fe–Ti(CP-SD)catalyst for selective catalytic reduction(SCR). This was prepared by a co-precipitation and spray drying(CP-SD) method. The catalyst was systematically characterized, and its morphological structure and surface properties were identified. Compare with conventional Mn–Ce–Fe–Ti(CP) catalysts, the Mn–Ce–Fe–Ti(CP-SD) catalyst had superior surface-adsorbed oxygen leading to enhanced 'fast NH3-SCR' reaction. The asobtained Mn–Ce–Fe–Ti(CP-SD) catalyst offered excellent NO conversion and N2 selectivity of 100.0% and 84.8% at 250℃, respectively, with a gas hourly space velocity(GHSV) of 40,000 h-1. The porous micro-spherical structure provides a larger surface area and more active sites to adsorb and activate the reaction gases. In addition, the uniform distribution and strong interaction of manganese, iron, cerium, and titanium oxide species improved H2O and SO2 resistance. The results showed that the Mn–Ce–Fe–Ti(CP-SD) catalyst could be used prospectively as a denitration(De-NOx) catalyst. | Junqi Tian Ke Zhang Wei Wang Fu Wang Jianming Dan Shengchao Yang Jinli Zhang Bin Dai Feng Yu | 2019 | Green Energy & Environment2019，4，3： | 4 |
| 11 | InAs-based interband cascade lasers at 4.0 μm operating at room temperature显示文摘InAs-based interband cascade lasers(ICLs) with InAs plasmon waveguides or InAs/AlSb superlattice(SL) waveguides were demonstrated at emission wavelengths below 4.1 μm. The threshold current densities of the lasers with SL waveguides were 37 A/cm^2 at 77 K in continuous wave mode. The operation temperature of these lasers reached room temperature in pulsed mode. Compared with the thick InAs n++ plasmon cladding layer, the InAs/AlSb superlattice cladding layers have greater advantages for ICLs with wavelengths less than 4 μm even in InAs based ICLs because in the short-wavelength region they have a higher confinement factor than InAs plasmon waveguides. | Tian Yu Shuman Liu Jinchuan Zhang Bo Xu Lijun Wang Junqi Liu Ning Zhuo Shenqiang Zhai Xiaoling Ye Yonghai Chen Fengqi Liu Zhanguo Wang | 2018 | Journal of Semiconductors2018，39，11： | 3 |
| 12 | Needling at the Waiguan (SJ5) in healthy limbs deactivated functional brain areas in ischemic stroke patients A functional magnetic resonance imaging study显示文摘Deactivation is common in cerebral functional imaging. However, the physiological mechanisms responsible for this phenomenon remain poorly understood. The present study analyzed 12 ischemic stroke patients, who were randomly assigned to two groups: one group underwent sham needling and true needling at the Waiguan (SJ 5) in the healthy upper limb and the other group underwent sham and true needling at a sham point. Functional magnetic resonance imaging results showed no activation points in brain tissues following needling at SJ 5. However, compared with sham needling at SJ 5, true needling at SJ 5 deactivated Broadmann 4, 6, 24, and 32 areas. In addition, compared to needling at the sham point, true needling at SJ 5 deactivated bilateral hypothalamus. Results demonstrated that SJ 5 needling in the healthy upper limb resulted in specific directional brain action, as manifested by deactivation of cerebral areas related to motor (Broadmann 4 and 6), emotion (hypothalamus), and cognition (Broadmann 24, 32). | Yong Huang Huiling Xiao Junqi Chen Shanshan Qu Yu Zheng Yangjia Lu Xinsheng Lai | 2011 | Neural Regeneration Research2011，6，36： | 2 |
| 13 | Systematic Full-Cycle Engineering Microbial Biofilms to Boost Electricity Production in Shewanella oneidensis显示文摘Electroactive biofilm plays a crucial rule in the electron transfer efficiency of microbial electrochemical systems(MES).However,the low ability to form biofilm and the low conductivity of the formed biofilm substantially limit the extracellular electron transfer rate of microbial cells to the electrode surfaces in MES. | Feng Li Rui Tang Baocai Zhang Chunxiao Qiao Huan Yu Qijing Liu Junqi Zhang Liang Shi Hao Song | 2023 | Research2023，，2： | 2 |
| 14 | Probing deactivation by coking in catalyst pellets for dry reforming of methane using a pore network model显示文摘Dry reforming of methane(DRM) is an attractive technology for utilizing the greenhouse gases(CO_(2) and CH_(4)) to produce syngas. However, the catalyst pellets for DRM are heavily plagued by deactivation by coking, which prevents this technology from commercialization. In this work, a pore network model is developed to probe the catalyst deactivation by coking in a Ni/Al_(2)O_(3) catalyst pellet for DRM. The reaction conditions can significantly change the coking rate and then affect the catalyst deactivation. The catalyst lifetime is higher under lower temperature, pressure, and CH_(4)/CO_(2) molar ratio, but the maximum coke content in a catalyst pellet is independent of these reaction conditions. The catalyst pellet with larger pore diameter, narrower pore size distribution and higher pore connectivity is more robust against catalyst deactivation by coking, as the pores in this pellet are more difficult to be plugged or inaccessible.The maximum coke content is also higher for narrower pore size distribution and higher pore connectivity, as the number of inaccessible pores is lower. Besides, the catalyst pellet radius only slightly affects the coke content, although the diffusion limitation increases with the pellet radius. These results should serve to guide the rational design of robust DRM catalyst pellets against deactivation by coking. | Yu Wang Qunfeng Zhang Xinlei Liu Junqi Weng Guanghua Ye Xinggui Zhou | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 2 |
| 15 | Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation显示文摘To improve the osteointegration property of biomedical titanium,nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole.The highly binding affinity of Ca2t to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions.The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid.The PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant. | Zhengao Wang Jinquan Zeng Guoxin Tan Jingwen Liao Lei Zhou Junqi Chen Peng Yu Qiyou Wang Chengyun Ning | 2018 | Bioactive Materials2018，3，1： | 1 |
| 16 | Sustainability assessment indicators and methodology for intelligent buildings显示文摘 | Yu Junqi Dang Bo Clements-Croome D | 2012 | Advanced Materials Research2012，368，373： | 1 |
| 17 | Construction of hybrid constructed wetlands for phosphorus chemical industry tailwater treatment in the middle Yangtze river basin:Responses of plant growth and root-associated microbial communities显示文摘Constructed wetlands are commonly utilized to treat industrial wastewater due to their effectiveness,affordability,and environmental benefits.Many phosphorus chemical enterprises in the middle Yangtze River basin are facing high pollution load challenges and efforts are needed to improve removal efficiency of pollutants.This work was the first to use constructed wetlands for phosphorus chemical industry tailwater(PCITW)treatment.The new hybrid constructed wetlands(CWs)proposed were the aeration horizontal subsurface flow constructed wetland(AHSCW)and the integrated vertical flow constructed wetland(IVCW),which were constructed on a pilot scale.Here,the effectiveness of pollutant removal along hybrid CWs,wetland plant growth,and rootassociated microbial community responses to the PCITW were investigated.The results showed that there was spatial variation in removal of carbon,nitrogen,and phosphorus in the hybrid CWs,and that the AHSCW and the IVCW played synergistic roles in the removal of pollutants.Compared with influent,the toxic effect of effluent to embryos of a rare minnow(Gobiocypris rarus)was alleviated.Exposure to the effluent resulted in no malformation or death for embryos.Plants and microorganisms in the wetland system of the phosphate chemical tailwater were then compared with the control system of municipal tailwater.Plants in the former system had lower root density,and higher average root diameter,root shoot ratio,specific root length,and specific surface area.Plant roots also had decreased NH_(4)^(+)uptake ability but increased Ca^(2+)uptake to adapt to the high load and complex pollution stress.Unlike the control system,stochastic mechanisms had a more important role than deterministic processes in shaping the microbial community assembly associated with the PCITW.Meanwhile,analysis of microbial network-level topological characteristics demonstrated substantial reduction in network interactions complexity and microbiome stability in the treatment system.Findings from this study suggest wetlands will be helpful for efficient purification of phosphorus chemical industry wastewater in the Yangtze River basin. | Qianzheng Li Yao Guo Junqi Yu Lu Yao Shun Liu Yahua Li Disong Chen Fei Peng Dong Xu Zhenbin Wu Qiaohong Zhou | 2023 | Water Biology and Security2023，2，3： | 1 |
| 18 | Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients显示文摘 | Juan Lv Qinglong Jin Haibo Sun Xiumei Chi Xiaoli Hu Hongqing Yan Yu Pan Weihua Xiao Zhigang Tian Jinlin Hou Damo Xu Zhengkun Tu Junqi Niu Alex Kleinjan | 2012 | Mediators of Inflammation2012，，： | 1 |
| 19 | Impeller inlet geometry effect on performance improvement for centrifugal pumps显示文摘 | Xianwu Luo Yao Zhang Junqi Peng Hongyuan Xu Weiping Yu | 2008 | Journal of Mechanical Science and Technology2008，，10： | 1 |
| 20 | Histological observation on unique phenotypes of malformation induced in Xenopus tropicalis larvae by tributyltin显示文摘Tributyltin(TBT),a biocide used in antifouling paints,has shown strong teratogenic effects on Xenopus tropicalis embryos at environmentally relevant concentrations.X.tropicalis embryos were exposed to 50,100 and 200 ng/L tributyltin chloride for 72 hr.The histological changes were further observed on abnormal eyes,enlarged trunks,enlarged proctodaeums and absence of fins induced by TBT.The lens and the retinal layers of abnormal eyes were slightly or barely differentiated,and that the pigment epithelium was neither continuous nor smooth.The abdomens were full of undifferentiated gut tissue with yolk-rich inclusions in the tadpoles with enlarged trunks.The proctodaeums formed a bump-like or columnar structure.The mass of yolk-rich cells occupied the lumen,blocked the opening and even turned inside out of the proctodaeum.Both the ventral and dorsal fins in trunks and tails became narrow or even disappeared totally.Our results suggest that great changes of histology took place corresponding to the unique phenotypes.The gut tissue was poorly differentiated,which led to the failed elongation of the guts and subsequently the enlarged trunks.The enlarged proctodaeums were due to the undifferentiation of inner layer,the expansion of outer epidermal part and the absence of fins around them.In brief,the histological observations provided insights into the reason of the unique external malformations in some degree. | Junqi Liu Qinzhen Cao Jing Yuan Xiaoli Zhang Lin Yu Huahong Shi | 2012 | Journal of Environmental Sciences2012，24，2： | 1 |
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