|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase Ⅱ trial显示文摘Objective: The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy(NAC) using oxaliplatin plus capecitabine(Cap OX) for patients with operable locally advanced colon cancer(CC).Methods: Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m2 oxaliplatin on d 1,plus 1,000 mg/m2 capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy. Radiological response was evaluated after 2 cycles of NAC. Tumor response, treatment toxicity, and surgical complications were recorded. The pathological response to therapy was evaluated according to the tumor regression grade(TRG) score. The primary endpoint was pathologic tumor response. This trial is registered in Clinical Trials.gov(No: NCT02415829).Results: Forty-seven patients were enrolled in the study. Forty-two patients completed the planned treatments.The total radiological response rate was 68%(32/47), including complete and partial response rates of 2%(1/47)and 66%(31/47), respectively. Stable disease was observed in 32%(15/47) and progressive disease was observed in none. Complete pathologic response, major regression, and at least moderate regression were achieved in 1(2%), 2(4%), and 29(62%) patients, respectively. Four patients developed grade 3 treatment toxicities. One patient with wound infection occurred after operation(1/47, 2%). There was no treatment-related death.Conclusions: Our results suggest that NAC with Cap OX is an effective and safe treatment option for patients with locally advanced CCs. | Fangqi Liu Li Yang Yuchen Wu Cong Li Jiang Zhao Adili Keranmu Hongtu Zheng Dan Huang Lei Wang Tong Tong Junyan Xu Ji Zhu Sanjun Cai Ye Xu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 14 |
| 2 | Effects of Land Use Change on Ecosystem Services in Arid Area Ecological Migration显示文摘Ecological migration is the process of increasing the population density in the immigration area and transferring the ecological pressure from emigration area to immigration area. This process may result in significant changes in land use and land cover in the area of immigration and have an important effect on ecosystem services. Therefore, scientifically revealing the effects and differentiation mechanisms of ecological migration on ecosystem services is becoming an important issue related to the implementation of the national ecological migration strategy in China. This study employed the Hongsibu District as a typical example of ecological migration. Hongsibu District is located in the central Ningxia steppe and desert steppe areas. Remote sensing data covering five periods from the period before ecological migration in 1995 and after migration in 2000, 2005, 2010, and 2015 was used to measure the value of ecosystem services(ESV). A geographical detector model and the value of ecosystem services model were used to diagnose the dynamic mechanism of the effects of land use change on ecosystem services. The results showed that: 1) The development of large-scale ecological resettlement has caused the area of cultivated land and urbanized land area to increase significantly in the area of immigration, while the grass area decreased significantly. 2) The overall value of the Hongsibu ecosystem services increased in a form of a ‘V'. Among them, during the period of 1995–2005, the overall ESV decreased and had an annual rate of change of-0.67%. During the period of development 2005–2015, the ESV increased steadily, with an annual rate of change of 0.79%. 3) The proportion and total ESV in soil formation and protection, waste treatment, and biodiversity conservation of the Hongsibu District decreased from 57.61% in 1995 to 56.17% in 2015, indicating that the region's ecological regulation function slightly decreased. 4) The ESV in the Hongsibu District, showed a low distribution pattern of ecosystem services increasing from northeast to southwest, and the capacity of three townships, Hongsibu, Taiyangshan, and Liuquan, to provide ecosystem services gradually declined over time. The ecological service function of Xinzhuangji Township and Dahe Township gradually improved. 5) The sensitivity index of the ESV of each land use type was less than 1, indicating that the environment lacks flexibility in providing a strong ESV index in Hongsibu, which shows that the research results are reliable and believable. 6) During the study period, the decisive force of the change of land use on ecosystem services in Hongsibu District was: grassland(0.9934), climate regulation(0.9413), soil formation and protection(0.9321) and waste treatment(0.9241). | LIU Xiaopeng CHEN Xiao HUA Kaiping WANG Yajuan WANG Peng HAN Xiaojia YE Junyan WEN Shengqiang | 2018 | Chinese Geographical Science2018，28，5： | 9 |
| 3 | A study of S-xdialkyldithiophosphates as novel additives in liquid paraffin显示文摘 | ZHANG Junyan YE Shengrong LIU Weiming | 2000 | Wear2000，237，12： | 1 |
| 4 | Flavipin in Chaetomium globosum CDW7, an endophytic fungus from Ginkgo biloba , contributes to antioxidant activity显示文摘 | Yonghao Ye Yu Xiao Liang Ma Hongxia Li Zhenglu Xie Minghua Wang Haitian Ma Huaiwu Tang Junyan Liu | 2013 | Applied Microbiology and Biotechnology2013，，16： | 1 |
| 5 | An Anti-Quantum Authentication Protocol for Space Information Networks Based on Ring Learning with Errors显示文摘With the continuous development of satellite communication and Internet of things technology,more and more devices can access space information networks(SIN)and enjoy satellite services everywhere in the world.However,due to the openness of the air-to-ground channel,the device will face a series of security threats when accessing SIN,such as replay attacks,eavesdropping attacks,impersonation attacks,and man-in-the-middle attacks.These security threats will lead to illegal entity access and further endanger the reliability and availability of the system.Although scholars have proposed many enhanced security access authentication protocols,most of them have been proved to have security vulnerabilities.In addition,with the development of quantum computing,the previous authentication protocols based on some asymmetric cryptographic mechanisms such as discrete logarithm and elliptic curve cryptographic mechanisms may face new security challenges.In this context,this paper proposes a novel antiquantum access authentication protocol based on ring learning with errors(RLWE),which meets more security requirements and greatly reduces the authentication delay through prenegotiation.Through the security analysis and performance analysis,it is shown that our protocol can be more suitable for delaysensitive IoT devices to access SIN while ensuring higher security. | Junyan Guo Ye Du Xuesong Wu Meihong Li | 2021 | Journal of Communications and Information Networks2021，6，3： | 0 |
| 6 | High-performance liquid-phase catalytic purification of phosphine in tail gas using Pd(Ⅱ)/Cu(Ⅱ)composite显示文摘Pd/Cu liquid-phase composite was utilized as the catalyst in this study to remove PH_(3) at low temperatures.The anti-heterotoxicity of catalysts in the PH_(3) catalytic oxidation purification process was carefully explored and pioneered.The catalytic performance,thermodynamics,kinetics,and catalytic oxidation mechanism of Pd/Cu liquid-phase catalyst catalytic oxidation of PH_(3) were thoroughly investigated.The results showed that Pd/Cu has a superior catalytic effect on the removal of PH_(3) in the gas mixture under low temperature.With CO as the carrier gas,the removal efficiency of PH_(3) could be maintained at 100%for nearly 450 min,indicating that the Pd/Cu liquid phase catalyst has good resistance to heterotoxicity.According to the thermodynamic,kinetic,and related characterization results of the PH_(3) purification process,the kinetic region of the gas–liquid reaction of PH_(3) absorption by Pd/Cu solution was an interfacial reaction.Pd was the primary catalyst and Cu was the secondary catalyst,and the adsorption of PH_(3)was a primary reaction.PH_(3) was spontaneously oxidized to H_(3)PO_(4) in the Pd/Cu catalytic system during the removal process.Pd was regenerated by O_(2) and Cu,increasing the activity and stability of the Pd/Cu catalyst in the sustain and efficient purification of PH_(3) in tail gas. | Chenyang Zhao Yinhan Cheng Guangfei Qu Yongheng Yuan Fenghui Wu Ye Liu Shan Liu Junyan Li Ping Ning | 2023 | Chinese Journal of Chemical Engineering2023，57，5： | 0 |
| 7 | A monolithic K-band phase-locked loop for microwave radar application显示文摘A monolithic K-band phase-locked loop(PLL) for microwave radar application is proposed and implemented in this paper. By eliminating the tail transistor and using optimized high-Q LC-tank, the proposed voltage-controlled oscillator(VCO) achieves a tuning range of 18.4 to 23.3 GHz and reduced phase noise. Two cascaded current-mode logic(CML) divide-by-two frequency prescalers are implemented to bridge the frequency gap, in which inductor peaking technique is used in the first stage to further boost allowable input frequency.Six-stage TSPC divider chain is used to provide programmable division ratio from 64 to 127, and a second-order passive loop filter with 825 kHz bandwidth is also integrated on-chip to minimize required external components.The proposed PLL needs only approximately 18.2 μs settling time, and achieves a wide tuning range from 18.4 to 23.3 GHz, with a typical output power of –0.84 dBm and phase noise of 91:92 d Bc/Hz @ 1 MHz. The chip is implemented in TSMC 65 nm CMOS process, and occupies an area of 0.56 mm^2 without pads under a 1.2 V single voltage supply. | Guangyao Zhou Shunli Ma Ning Li Fan Ye Junyan Ren | 2017 | Journal of Semiconductors2017，38，2： | 0 |
| 8 | Convolution neural network and 77 GHz millimeter wave radar based intelligent liquid classification system显示文摘An intelligent liquid classification system based on 77 GHz millimeter wave radar and convolution neural network are proposed in this paper.The data are collected by the AWR1843 radar platform and processed by the neural network on the host PC in real-time.The doppler heatmap generated by radar signal processing is tried for the first time as the input of the system.The information carried by the heatmap in 2 dimensions is analyzed and the reason why the doppler heatmap could be used for classification is explained.The feasible experiment proved that the proposed method can successfully classify 8 kinds of common liquid with high accuracy.The result of the experiment is explained and the limitations of the experiment are discussed.It can be drawn that the combination of FMCW millimeter wave radar and convolution neural network is a method with great potential for liquid classification.The advantages of real time,non-invasive and unilateral measurement can also be used for the detection of dangerous liquids. | Jiayu Chen Xinhuai Wang Yin Xu Ye Peng Wen Wang Junyan Xiang Qihang Xu | 2023 | Journal of Information and Intelligence2023，1，4： | 0 |
| 9 | Advances of nanoparticles in transmucosal drug delivery显示文摘Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site.However,many challenges still remain in its clinical application,including low drug availability and limited retention time in the mucosa.The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations,leveraging their distinct advantages of high drug-loading capacity and strong permeability.In this review,the latest developments of nanoparticles(NPs)in transmucosal drug delivery as well as their clinical applications are discussed. | Li Zhang Changwei Yang Yingxiang Song Tao Sheng Junyan Li Jicheng Yu Xiaohong Wu Xiao Ye | 2024 | Nano Research2024，17，4： | 0 |
| 10 | Innate immune imprints in SARS-CoV-2 Omicron variant infection convalescents显示文摘SARS-CoV-2 Omicron variant infection generally gives rise to asymptomatic to moderate COVID-19 in vaccinated people.The immune cells can be reprogrammed or“imprinted”by vaccination and infections to generate protective immunity against subsequent challenges.Considering the immune imprint in Omicron infection is unclear,here we delineate the innate immune landscape of human Omicron infection via single-cell RNA sequencing,surface proteome profiling,and plasma cytokine quantification.We found that monocyte responses predominated in immune imprints of Omicron convalescents,with IL-1β-associated and interferon(IFN)-responsive signatures with mild and moderate symptoms,respectively.Low-density neutrophils increased and exhibited IL-1β-associated and IFN-responsive signatures similarly.Mild convalescents had increased blood IL-1β,CCL4,IL-9 levels and PI3+neutrophils,indicating a bias to IL-1βresponsiveness,while moderate convalescents had increased blood CXCL10 and IFN-responsive monocytes,suggesting durative IFN responses.Therefore,IL-1β-or IFN-responsiveness of myeloid cells may indicate the disease severity of Omicron infection and mediate post-COVID conditions. | Zhiqing Li Xiaosu Chen Junyan Dan Tianju Hu Ye Hu Shuxun Liu Yangyang Chai Yansong Shi Jian Wu Hailai Ni Jiaqi Zhu Yanfeng Wu Nan Li Yizhi Yu Zhongfang Wang Jincun Zhao Nanshan Zhong Xianwen Ren Zhongyang Shen Xuetao Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
| 11 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员