|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma显示文摘气喘是在多重基因、环境的因素之中包含复杂相互影响的普通过敏混乱。最近的研究作为一个新奇气喘危险性因素识别了人的 GAB1 的基因变体。然而,在肺的 Gab1 的功能仍然保持大部分未经勘探。在这研究,我们首先在尖锐恶化期间从气喘的病人在外部血 mononuclear 房间观察了 Gab1 水平的举起与康复相比。有在 myeloid 的有选择地破坏的 Gab1 的老鼠树枝状的房间(mDCs ) 更加在气喘的试验性的模型稀释了过敏发炎。进一步的调查在 Gab1 缺乏的 mDCs 的调停 CCL19 的移植揭示了突出的减小到排干淋巴节点和驾驶 Th2 的适应激活的随后的缺陷。机械学地, Gab1 是在气喘的回答期间调整 mDC 移植的 CCL19/CCR7 chemokine 轴的一个必要部件。一起,这些调查结果在肺为 Gab1 的角色提供第一条证据,给我们气喘的致病的更深的理解。 | Yun Zhang Yun Xu Shuwan Liu Xiaohong Guo Dong Cen Jiaqi Xu Heyuan Li Kaijun Li Chunlai Zeng Linrong LU Yiting Zhou Huahao Shen Hongqiang Cheng Xue Zhang Yuehai Ke | 2016 | Cell Research2016，26，11： | 3 |
| 2 | Visible Raman and Brillouin lasers from a microresonator/ZBLAN-fiber hybrid system显示文摘Raman and Brillouin lasers based on a high-quality(high-Q) whispering gallery mode microresonator(WGMR)are usually achieved by employing a tunable single-frequency laser as a pump source. Here, we experimentally demonstrate visible Raman and Brillouin lasers using a compact microresonator/ZrF4-BaF2-LaF3-AlF3-NaF(ZBLAN)-fiber hybrid system by incorporating a WGMR with a fiber-compatible distributed Bragg reflector/fiber Bragg grating to form a Fabry–Perot(F-P) fiber cavity and using a piece of Pr:ZBLAN fiber as gain medium.The high-Q silica-microsphere not only offers a Rayleigh-scattering-induced backreflection to form the ~635 nm red laser oscillation in the F-P fiber cavity, but also provides a nonlinear gain in the WGMR itself to generate either stimulated Raman scattering or stimulated Brillouin scattering. Up to six-order cascaded Raman lasers at0.65 μm, 0.67 μm, 0.69 μm, 0.71 μm, 0.73 μm, and 0.76 μm are achieved, respectively. Moreover, a Brillouin laser at 635.54 nm is clearly observed. This is, to the best of our knowledge, the first demonstration of visible microresonator-based lasers created by combining a Pr:ZBLAN fiber. This structure can effectively extend the laser wavelength in the WGMR to the visible waveband and may find potential applications in underwater communication, biomedical diagnosis, microwave generation, and spectroscopy. | SHUISEN JIANG CHANGLEI GUO KAIJUN CHE ZHENGQIAN LUO TUANJIE DU HONGYAN FU HUIYING XU ZHIPING CAI | 2019 | Photonics Research2019，7，5： | 1 |
| 3 | Involvement of ERK1/2 signalling and growth-related molecules’ expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells显示文摘 | Jin Yu Peng Yin Jingdong Yin Fenghua Liu Xiaoyu Zhu Guiling Cheng Kaijun Guo Yulong Yin Jianqin Xu | 2010 | International Journal of Hyperthermia2010，，6： | 1 |
| 4 | Effect of heat stress on the porcine small intestine: A morphological and gene expression study显示文摘 | Jin Yu Peng Yin Fenghua Liu Guilin Cheng Kaijun Guo An Lu Xiaoyu Zhu Weili Luan Jianqin Xu | 2010 | Comparative Biochemistry and Physiology, Part A2010，，1： | 1 |
| 5 | Effect of heat stress on the porcine small intestine: A morphological and gene expression study显示文摘 | Jin Yu Peng Yin Fenghua Liu Guilin Cheng Kaijun Guo An Lu Xiaoyu Zhu Weili Luan Jianqin Xu | 2010 | Comparative Biochemistry and Physiology Part A2010，，1： | 1 |
| 6 | Chiral mesoporous silica nano-screws as an efficient biomimetic oral drug delivery platform through multiple topological mechanisms显示文摘In the microscale, bacteria with helical body shapes have been reported to yield advantages in many bio-processes. In the human society, there are also wisdoms in knowing how to recognize and make use of helical shapes with multi-functionality. Herein, we designed atypical chiral mesoporous silica nano-screws(CMSWs) with ideal topological structures(e.g., small section area, relative rough surface,screw-like body with three-dimension chirality) and demonstrated that CMSWs displayed enhanced bioadhesion, mucus-penetration and cellular uptake(contributed by the macropinocytosis and caveolaemediated endocytosis pathways) abilities compared to the chiral mesoporous silica nanospheres(CMSSs)and chiral mesoporous silica nanorods(CMSRs), achieving extended retention duration in the gastrointestinal(GI) tract and superior adsorption in the blood circulation(up to 2.61-and 5.65-times in AUC).After doxorubicin(DOX) loading into CMSs, DOX@CMSWs exhibited controlled drug release manners with pH responsiveness in vitro. Orally administered DOX@CMSWs could efficiently overcome the intestinal epithelium barrier(IEB), and resulted in satisfactory oral bioavailability of DOX(up to 348%).CMSWs were also proved to exhibit good biocompatibility and unique biodegradability. These findings displayed superior ability of CMSWs in crossing IEB through multiple topological mechanisms and would provide useful information on the rational design of nano-drug delivery systems. | Yumei Wang Jia Ke Xianmou Guo Kaijun Gou Zhentao Sang Yanbu Wang Yan Bian Sanming Li Heran Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 7 | Effect of office-based brief high-impact exercise on bone mineraldensity in healthy premenopausal women: the Sendai Bone HealthConcept Study 显示文摘 | Kaijun Niu Riikka Ahola Hui Guo | 2010 | Bone Miner Metab2010，28，5： | 1 |
| 8 | Exosomal miR-218 regulates the development of endometritis in dairy cows by targeting TGIF2/TGF-βpathway显示文摘Endometritis affects the reproductive capacity of dairy cows and leads to serious economic losses in dairy farming.Clarification of the pathogenesis of endometritis is necessary to improve the reproductive efficiency of dairy cows.Exosomes and their miRNAs have been proven to play an important role in inflammatory regulation.Exosomal miR-218 is a differentially expressed miRNA found in endometrial epithelial cells(EECs)under endometrial inflammation.Therefore,we investigated the expression of miR-218 in the uterine tissue of dairy cows,lipopolysaccharide(LPS)treated EECs,exosomal vesicles,and regulation of exosomal miR-218 by targeting TGIF-2 inducible factor homology frame 2(TGIF2)/transforming growth factor-beta(TGF-β).The expression of miR-218 was suppressed in inflammatory uterine tissues and LPS treated EECs.The expression of TGIF2 and TGF-βin inflammatory uterine tissues and LPS treated EECs was significantly higher than those in healthy uterine tissues and EECs(p<0.01).Interestingly,miR-218 derived from donor cells was found to regulate the expression of the target gene TGIF2 in recipient cells through the fusion of exosomes.Concurrently,the expression of its target gene TGIF2 was also suppressed by miR-218 in donor cells resulting in fewer TGIF2 being transported into recipient cells with exosomal fusion.This may be a novel mechanism of miRNAs-mediated regulation and provides a new reference for analyzing the pathogenesis of endometritis in dairy cows. | CHANG CHEN LIMIN QIAO KAIJUN GUO YINGQIU WANG MENGYI YUAN BOFAN FU XIAOBO GAO HEMIN NI LONGFEI XIAO XIANGGUO WANG | 2022 | BIOCELL2022，46，11： | 0 |
| 9 | Experimental research of a thermoacoustic prime mover and a refrigerator显示文摘Thermoacoustic engine has been concerned recently because of its advantages of no moving parts and no pollution. A prime mover is built and its characteristics of onset temperature difference, frequency and output acoustic power are measured and analyzed. A thermoacoustic refrigerator driven by this prime mover had been tested. It may develop a temperature difference of 25 K across the regenerator and a lowest temperature of -8℃ was achieved with the frequency, input power and the static pressure 81.7 Hz, 800 W and 1 Mpa respectively. | DONG Kaijun, LI Qing, GUO Fangzhong (Cryogenic Laboratory, Huazhong University of Science and Technology Wuhan) | 2001 | Chinese Journal of Acoustics2001，20，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员