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| 1 | Diagnosis and management of insulinoma显示文摘Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general population.Common autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and coma.Diagnosis of suspected cases is based on standard endocrine tests,especially the prolonged fasting test.Non-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion.Invasive modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques.The range of techniques available for the localization of insulinomas means thatblind resection can be avoided.Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with surgery.In patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of life.In patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life. | Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi Ito Yasuhiro Ogawa Michiya Kobayashi Kazuhiro Hanazaki | 2013 | World Journal of Gastroenterology2013，19，6： | 78 |
| 2 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 3 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 4 | Appleby Operation for Pancreatic Body-Tail Carcinoma: Report of Three Cases显示文摘 | Koji Yamaguchi Kenji Nakano Kiichiro Kobayashi Yasuhiro Ogura Hiroyuki Konomi Atsushi Sugitani Masao Tanaka | 2003 | Surgery Today2003，，11： | 2 |
| 5 | The mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid显示文摘 | Takahiro Kobayashi Atsushi Okada Yasuhiro Fujii Kazuhiro Niimi Shuzo Hamamoto Takahiro Yasui Keiichi Tozawa Kenjiro Kohri | 2010 | Urological Research2010，，2： | 2 |
| 6 | Preoperative Ultrasonographic Examination for Lymph Node Metastasis: Usefulness when Designing Lymph Node Dissection for Papillary Microcarcinoma of the Thyroid显示文摘 | Yasuhiro Ito M.D. Ph.D. Chisato Tomoda M.D. Takashi Uruno M.D. Yuuki Takamura M.D. Akihiro Miya M.D. Kaoru Kobayashi M.D. Fumio Matsuzuka M.D. Kanji Kuma M.D. Akira Miyauchi M.D | 2004 | World Journal of Surgery2004，，5： | 1 |
| 7 | Impairment of PI3K/AKT pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model显示文摘 | Kobayashi T Taguchi K Yasuhiro T | 2004 | Hypertension2004，44，6： | 1 |
| 8 | Free jejunal graft for hypopharyngeal and esophageal reconstruction显示文摘 | Yasuhiro Shirakawa Yoshio Naomoto Kazuhiro Noma Ryoko Ono Tetsuji Nobuhisa Masahiko Kobayashi Toshiya Fujiwara Hirofumi Noguchi Takaomi Ohkawa Tomoki Yamatsuji Minoru Haisa Junji Matsuoka Mehmet Gunduz Noriaki Tanaka | 2004 | Langenbeck’s Archives of Surgery2004，，5： | 1 |
| 9 | Postoperative adjuvant chemotherapy with S-1 alters recurrence patterns and prognostic factors among patients with stage II/III gastric cancer: A propensity score matching analysis显示文摘 | Mitsuro Kanda Kenta Murotani Daisuke Kobayashi Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | Surgery2015，，6： | 1 |
| 10 | Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer显示文摘 | Mitsuro Kanda Dai Shimizu Shuji Nomoto Soki Hibino Hisaharu Oya Hideki Takami Daisuke Kobayashi Suguru Yamada Yoshikuni Inokawa Chie Tanaka Tsutomu Fujii Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2014 | J. Surg. Oncol2014，，2： | 1 |
| 11 | Excellent Prognosis of Patients with Solitary T1N0M0 Papillary Thyroid Carcinoma Who Underwent Thyroidectomy and Elective Lymph Node Dissection Without Radioiodine Therapy显示文摘 | Yasuhiro Ito Hiroo Masuoka Mitsuhiro Fukushima Hiroyuki Inoue Minoru Kihara Chisato Tomoda Takuya Higashiyama Yuuki Takamura Kaoru Kobayashi Akihiro Miya Akira Miyauchi | 2010 | World Journal of Surgery2010，，6： | 1 |
| 12 | A large-scale multicenter study of long-term outcomes after endoscopic resection for submucosal invasive colorectal cancer显示文摘 | Yusuke Yoda Hiroaki Ikematsu Takahisa Matsuda Yuichiro Yamaguchi Kinichi Hotta Nozomu Kobayashi Takahiro Fujii Yasuhiro Oono Taku Sakamoto Takeshi Nakajima Madoka Takao Tomoaki Shinohara Takahiro Fujimori Kazuhiro Kaneko Yutaka Saito | 2013 | Endoscopy2013，，： | 1 |
| 13 | Prognotic impact of serum follistatin in patients with hepatocellular carcinoma显示文摘 | Takeshi Tomoda Kazuhiro Nouso Koji Miyahara Sayo Kobayashi Hideaki Kinugasa Junki Toyosawa Hiroaki Hagihara Kenji Kuwaki Hideki Onishi Shinichiro Nakamura Fusao Ikeda Yasuhiro Miyake Hidenori Shiraha Akinobu Takaki Kazuhide Yamamoto | 2013 | J Gastroenterol Hepatol2013，，8： | 1 |
| 14 | Impairment of PI3K/Akt pathway underlies attenuated endothelial function in aorta of type2 diabetic mouse model显示文摘 | Kobayashi T Taguchi K Yasuhiro T eta | 2004 | Hyperlension2004，44，6： | 1 |
| 15 | Lodging in rice can be alleviated by atmospheric CO 2 enrichment显示文摘 | Hiroyuki Shimono Masumi Okada Yasuhiro Yamakawa Hirofumi Nakamura Kazuhiko Kobayashi Toshihiro Hasegawa | 2006 | Agriculture Ecosystems and Environment2006，，1： | 1 |
| 16 | Formation and breakdown of surface films on magnesium and its alloys in aqueous solutions 显示文摘 | Nobuyoshi Hara Yasuhiro Kobayashi Daisuke Kagaya | 2007 | Corrosion and Science2007，49，1： | 1 |
| 17 | Impairment of PI3 - K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model显示文摘 | KOBAYASHI T TAGUCHI K YASUHIRO T | 2004 | Hypertension2004，44，6： | 1 |
| 18 | New Pancreas-preserving Total Duodenectomy Technique显示文摘 | Masayuki Imamura M.D. Izumi Komoto M.D. Ryuichiro Doi M.D. Hisashi Onodera M.D. Hiroyuki Kobayashi M.D. Yasuhiro Kawai M.D | 2005 | World Journal of Surgery2005，，2： | 1 |
| 19 | Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer显示文摘 | Mitsuro Kanda Dai Shimizu Shuji Nomoto Soki Hibino Hisaharu Oya Hideki Takami Daisuke Kobayashi Suguru Yamada Yoshikuni Inokawa Chie Tanaka Tsutomu Fujii Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2014 | Oncol2014，，2： | 1 |
| 20 | Formation and breakdown of surface films on magnesium and its alloys in aqueous solutions 显示文摘 | Nobuyoshi Hara Yasuhiro Kobayashi Daisuke Kagaya | 2007 | Corrosion Science2007，49，7： | 1 |
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