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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2显示文摘新兴的证据与肿瘤开发和前进显示出异常地表示的 microRNAs (miRNAs ) 的协会。然而,很少在胃的 carcinogenesis 对 miRNAs 的潜在的角色被知道。这里,我们执行了 miRNA microarray 屏蔽在配对的胃的癌症和他们的邻近的 nontumor 纸巾表示并且发现 miR-375 是的 miRNAs 差别极大地在胃的癌症纸巾的 downregulated。量的即时 PCR 分析证实那 miR-375 表情显著地从经历胃的切除术的病人与他们的 nontumor 对应物相比在超过 90% 主要胃的癌症被减少。miR-375 的 Overexpression 显著地在 vitro 并且在 vivo 禁止了胃的癌症房间增长。在胃的癌症房间的 miR-375 的强迫的表示显著地减少了 Janus kinase 的蛋白质水平 2 ( JAK2 )并且镇压带 JAK2 的 3 鈥? untranslated 区域的一个酶记者的活动,被预言的 miR-375-binding 地点的变化废除,显示那 JAK2 可以是 miR-375 目标基因。由由 RNAi 的 JAK2 的 AG490 或 silencing 的 JAK2 活动的任何一个抑制压制了类似于 miR-375 overexpression 的胃的癌症房间增长。而且, JAK2 的宫外的表示能部分颠倒 miR-375 引起的房间增长的抑制。最后,我们在胃的癌症发现了在 miR-375 表示和 JAK2 蛋白质水平之间的重要反的关联。因此,这些数据建议 miR-375 可以作为肿瘤 suppressor 工作由指向 JAK2 oncogene 潜在地调整胃的癌症房间增长,含有在胃的癌症的致病的 miR-375 的一个角色。 | Ling Ding Yanjun Xu Wei Zhang Yujie Deng Misi Si Ying Du Haomi Yao Xuyan Liu Yuehai Ke Jianmin Si Tianhua Zhou | 2010 | Cell Research2010，20，7： | 59 |
| 3 | Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer显示文摘AIM:To investigate the impact of prognostic nutritional index(PNI)on the postoperative complications and long-term outcomes in gastric cancer patients undergoing total gastrectomy.METHODS:The data for 386 patients with gastric cancer were extracted and analyzed between January2003 and December 2008 in our center.The patients were divided into two groups according to the cutoff value of the PNI:those with a PNI≥46 and those with a PNI<46.Clinicopathological features were compared between the two groups and potential prognostic factors were analyzed.The relationship between postoperative complications and PNI was analyzed by logistic regression.The univariate and multivariate hazard ratios were calculated using the Cox proportional hazard model.RESULTS:The optimal cutoff value of the PNI was set at 46,and patients with a PNI≥46 and those with a PNI<46 were classified into PNI-high and PNI-low groups,respectively.Patients in the PNI-low group were more likely to have advanced tumor(T),node(N),and TNM stages than patients in the PNI-high group.The low PNI is an independent risk factor for the incidence of postoperative complications(OR=2.223).The 5-year overall survival(OS)rates were 54.1%and21.1%for patients with a PNI≥46 and those with a PNI<46,respectively.The OS rates were significantly lower in the PNI-low group than in the PNI-high group among patients with stagesⅡ(P=0.001)andⅢ(P<0.001)disease.CONCLUSION:The PNI is a simple and useful marker not only to identify patients at increased risk for postoperative complications,but also to predict long-term survival after total gastrectomy.The PNI should be included in the routine assessment of advanced gastric cancer patients. | Nan Jiang Jing-Yu Deng Xue-Wei Ding Bin Ke Ning Liu Ru-Peng Zhang Han Liang | 2014 | World Journal of Gastroenterology2014，20，30： | 41 |
| 4 | Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan,China:a retrospective study显示文摘Background:The 2019 novel coronavirus has caused the outbreak of the acute respiratory disease in Wuhan,Hubei Province of China since December 2019.This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease(COVID-19).Methods:Clinical data were collected from two tertiary hospitals in Wuhan.A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19(death group)and we compare them with recovered patients(recovered group).Continuous variables were analyzed using the Mann-WhitneyU test.Categorical variables were analyzed byχ2 test or Fisher exact test as appropriate.Results:Our study enrolled 109 COVID-19 patients who died during hospitalization and 116 recovered patients.The median age of the death group was older than the recovered group(69[62,74]vs.40[33,57]years,Z=9.738,P<0.001).More patients in the death group had underlying diseases(72.5%vs.41.4%,χ2=22.105,P<0.001).Patients in the death group had a significantly longer time of illness onset to hospitalization(10.0[6.5,12.0]vs.7.0[5.0,10.0]days,Z=3.216,P=0.001).On admission,the proportions of patients with symptoms of dyspnea(70.6%vs.19.0%,χ2=60.905,P<0.001)and expectoration(32.1%vs.12.1%,χ2=13.250,P<0.001)were significantly higher in the death group.The blood oxygen saturation was significantly lower in the death group(85[77,91]%vs.97[95,98]%,Z=10.625,P<0.001).The white blood cell(WBC)in death group was significantly higher on admission(7.23[4.87,11.17]vs.4.52[3.62,5.88]×109/L,Z=7.618,P<0.001).Patients in the death group exhibited significantly lower lymphocyte count(0.63[0.40,0.79]vs.1.00[0.72,1.27]×109/L,Z=8.037,P<0.001)and lymphocyte percentage(7.10[4.45,12.73]%vs.23.50[15.27,31.25]%,Z=10.315,P<0.001)on admission,and the lymphocyte percentage continued to decrease during hospitalization(7.10[4.45,12.73]%vs.2.91[1.79,6.13]%,Z=5.242,P<0.001).Alanine transaminase(22.00[15.00,34.00]vs.18.70[13.00,30.38]U/L,Z=2.592,P=0.010),aspartate transaminase(34.00[27.00,47.00]vs.22.00[17.65,31.75]U/L,Z=7.308,P<0.001),and creatinine levels(89.00[72.00,133.50]vs.65.00[54.60,78.75]μmol/L,Z=6.478,P<0.001)were significantly higher in the death group than those in the recovered group.C-reactive protein(CRP)levels were also significantly higher in the death group on admission(109.25[35.00,170.28]vs.3.22[1.04,21.80]mg/L,Z=10.206,P<0.001)and showed no significant improvement after treatment(109.25[35.00,170.28]vs.81.60[27.23,179.08]mg/L,Z=1.219,P=0.233).The patients in the death group had more complications such as acute respiratory distress syndrome(ARDS)(89.9%vs.8.6%,χ2=148.105,P<0.001),acute cardiac injury(59.6%vs.0.9%,χ2=93.222,P<0.001),acute kidney injury(18.3%vs.0%,χ2=23.257,P<0.001),shock(11.9%vs.0%,χ2=14.618,P<0.001),and disseminated intravascular coagulation(DIC)(6.4%vs.0%,χ2=7.655,P=0.006).Conclusions:Compared to the recovered group,more patients in the death group exhibited characteristics of advanced age,pre-existing comorbidities,dyspnea,oxygen saturation decrease,increased WBC count,decreased lymphocytes,and elevated CRP levels.More patients in the death group had complications such as ARDS,acute cardiac injury,acute kidney injury,shock,and DIC. | Yan Deng Wei Liu Kui Liu Yuan-Yuan Fang Jin Shang Ling Zhou Ke Wang Fan Leng Shuang Wei Lei Chen Hui-Guo Liu | 2020 | Chinese Medical Journal2020，，11： | 29 |
| 5 | Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease显示文摘目的:调查在 aquaporin-5 ( AQP5 )之间的关系在有长期的妨碍的肺的疾病( COPD )和与肺的功能 change.Methods 的关联的中国病人的航线的表示和粘液生产过剩:支气管的纸巾从纤维被获得到 July2004.Twenty 的从4月的韦斯特中国医院里的眼的 bronchoscopy 和支气管的活体检视--五病人们作为 COPD 病人,和另外一个被诊断 20 作为控制病人被诊断。 AQP5 ,粘蛋白 5AC ( MUC5AC ),和在支气管的纸巾的粘蛋白的表情被半检测量的 RT-PCR 在 situ 杂交,和组织化学的免疫和染色的alcianblue周期的 acid-Schiff (AB舞步), respectively.Results :与控制组相比, AQP5 的稀释表情从病人 withCOPD 在整个支气管的纸巾被检测( P < 0.01 ),但是没有差别在肺纸巾存在( P > 0.05 )。同时,增加了 MUC5AC 染色,在 submucosal 腺的粘液被注意(P < 0.01,分别地) 。吸烟稀释了 AQP5 的表情并且增加了在 COPDgroups 在 submucosal 腺染色 MUC5AC 和粘液( P < 0.01 ),当有时,没有重要差别在控制组观察了( P > 0.05 ) AQP5 mRNA 的 .Thedecreased 表示在 1 s ( FEV1 )与强迫的吐气的体积被相关 /forcedvital 能力( FVC )( r=0.60 , P < 0.01 ),FEV1%预言了值( r=0.60 , P < 0.01 ),重要能力( V50 )%预言了的最大的吐气的流动in50%值( r=0.55 , P < 0.01 ),并且在25%重要能力( V25 )的最大的吐气的流动%预言了值( r=0,45 , P < 0.01 )。减少的表达式否定地与上皮航线的 MUC5AC mRNA 被相关(r=-0.45, P < 0.01 ) 并且 submucosalglands 的 AB-PAS-stained 区域(r=-0.61, P < 0.01 ) 。起来 MUC5AC mRNA 的规定相关与断然 submucosal 腺的 AB-PAS-stainedarea 并且与 FEV1/FVC 否定地相关( r=-0.53 ; P < 0.01 ),FEV1%预言了值( r=-0.53 ; P < 0.01 ),V50%预言了值( r=-0.48 ; P < 0.01 ),并且V25%预言了值( r=-0.43 ; P < 0.01 ) .Conclusion : AQP5 的稀释基因表达式在中国 COPD 病人的航线存在,它由粘液分泌过盛是复杂的。AQP5mRNA 的减少的表达式可能与气流阻塞的严厉有关。 | Ke WANG Yu-lin FENG Fu-qiang WEN Xue-rong CHEN Xue-mei OU Dan XU Jie YANG Zhi-ping DENG | 2007 | Acta Pharmacologica Sinica2007，28，8： | 24 |
| 6 | Laboratory culture of the freshwater benthic gastropod Bellamya aeruginosa (Reeve) and its utility as a test species for sediment toxicity显示文摘This study aimed to develop original laboratory culture and sediment toxicity testing protocols for the freshwater gastropod Bellamya aeruginosa(Reeve),a new potential species for sediment toxicity testing.B.aeruginosa was successfully cultured with an effective culture system under proposed laboratory conditions.Optimal ad libitum feeding levels for larvae,juveniles,and adults were 2.0,6.0,and 16.0 mg fish food/(snail·day),respectively.Mean survival rates of juveniles were higher than 90%.The snails could be sexed at 9 weeks of age,and their generation time is approximately 4 months.Reproduction continued all year around;the mean fecundity was 0.55 newborn/(female·day).The utility of this species for bioassays was evaluated in both 10-day and 28-day case studies with artificial sediments.The 10-day LC50 of Cu for larvae was 480 μg/g dry weight(dw),and the lowest observed effects concentration of Cu for survival and growth of larvae was 195 μg/g dw.Survival and growth are reliable indicators of acute toxicity.Larvae accumulated more Cu than adults.B.aeruginosa exhibited a higher sensitivity to Cu exposure than standard test species(Hyalella azteca and Chironomus tentans).The 28-day test of sediment toxicity with adults showed that fecundity was a robust endpoint indicator of reproductive toxicity,and the biochemical endpoints of superoxide dismutase,catalase,and glutathione could be used as sensitive biomarkers for Cu-induced oxidative damage.B.aeruginosa can be therefore recommended as a candidate for the standardization of the freshwater sediment toxicity test protocol. | Taowu Ma Shuangjiao Gong Ke Zhou Cheng Zhu Kaidong Deng Qinghua Luo Zijian Wang | 2010 | Journal of Environmental Sciences2010，22，2： | 22 |
| 7 | Intracoronary arterial retrograde thrombolysis with percutaneous coronary intervention: a novel use of thrombolytic to treat acute ST-segment elevation myocardial infarction显示文摘Background Clearance of coronary arterial thrombosis is necessary in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing urgent percutaneous coronary intervention (PCI). There is currently no highly-recommended method of thrombus removal during interventional procedures. We describe a new method for opening culprit vessels to treat STEMI: intracoronary arterial retrograde thrombolysis (ICART) with PCI. Methods & Results Eight patients underwent ICART. The guidewire was advanced to the distal coronary artery through the occlusion lesion. Then, we inserted a microcatheter into the distal end of the occluded coronary artery over the guidewire. Urokinase (5–10 wu) mixed with contrast agents was slowly injected into the occluded section of the coronary artery through the microcatheter. The intracoronary thrombus gradually dissolved in 3–17 min, and the effect of thrombolysis was visible in real time. Stents were then implanted according to the characteristics of the recanalized culprit lesion to achieve full revascularization. One patient experienced premature ventricular contraction during vascular revascularization, and no malignant arrhythmias were seen in any patient. No reflow or slow flow was not observed post PCI. Thrombolysis in myocardial infarction flow grade and myocardial blush grade post-primary PCI was 3 in all eight patients. No patients experienced bleeding or stroke. Conclusions ICART was accurate and effective for treating intracoronary thrombi in patients with STEMI in this preliminary study. ICART was an effective, feasible, and simple approach to the management of STEMI, and no intraprocedural complications occurred in any of the patients. ICART may be a breakthrough in the treatment of acute STEMI. | Jin-Wen TIAN Mei ZHU Feng-Qi WANG Ke LI Chao-Fei ZHOU Bo LI Min WANG Jue-Lin DENG Bo JIANG Jing BAI Yi GUO Rong-Jie JIN Zhao ZHANG Ying LIN Ji-Hang WANG Shi-Hao ZHAO Ming-Zhi SHEN | 2019 | Journal of Geriatric Cardiology2019，16，6： | 22 |
| 8 | A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε显示文摘类型我发信号的干扰素(IFN ) 是调停的主要反应抗病毒的天生的免疫。IFN 抄写依赖于抄写因素 IRF3/IRF7 和 NF-B 的激活。许多病毒的蛋白质作为能够防碍 IFN 发信号从主人便于避免被显示出天生的有免疫力的反应。这里,我们报导那病毒的 miRNA, miR-K12-11,由 Kaposi 的联系肉瘤的 herpesvirus (KSHV ) 编码了为 IFN 通过指向 I-kappa-B kinase epsilon (IKK ) 发信号和行为的调整是批评的。miR-K12-11 的宫外的表示导致了减少的 IKK 表示,当 miR-K12-11 的抑制被发现在感染 KSHV 的房间恢复 IKK 表示时。重要地, miR-K12-11 的表示稀释了由减少的调停 IKK 的 IRF3/IRF7 phosphorylation 并且由禁止刺激基因(ISG ) 的 IKK 依赖的 IFN 的激活发信号的 IFN,允许抗病毒的免疫的 miR-K12-11 抑制。我们的数据建议由 miR-K12-11 指向的 IKK 是 KSHV 利用调制在 KSHV 生命周期期间发信号的 IFN 的重要策略,特别在潜伏。我们也证明 IKK 能与 12-O-tetradecanoylphorbol 13 醋酸盐的处理 synergistically 提高 KSHV 复活。而且, miR-K12-11 的抑制提高了小囊的口炎病毒感染导致的 KSHV 复活。一起拿,我们的调查结果也建议 miR-K12-11 能由指向 IKK 贡献 KSHV 潜伏的维护。 | Deguang Liang Yuan Gao Xianzhi Lin Zhiheng He Qinglan Zhao Qiang Deng Ke Lan | 2011 | Cell Research2011，21，5： | 15 |
| 9 | Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality显示文摘Severe fever with thrombocytopenia syndrome (SFTS),an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the World Health Organization due to its high fatality of 12%-50% and possibility of pandemic transmission. Currently, effective anti-SFTSV intervention remains unavailable. Here, by screening a library of FDA-approved drugs, we found that benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication. Further experiments showed that a broad panel of CCBs, including nifedipine, inhibited SFTSV infection. The anti-SFTSV effect of these two CCBs was further an a lyzed in a humanized mouse model in which CCB treatment resulted in reduced viral load and decreased fatality rate. Importantly, by performing a retrospective clinical investigation on a large cohort of 2087 SFTS patients, we revealed that nifedipine administration enhaneed virus clearance, improved clinical recovery, and remarkably reduced the case fatality rate by >5-fold. These findings are highly valuable for developing potential host-oriented therapeutics for SFTS and other lethal acute viral infections known to be inhibited by CCBs in vitro. | Hao Li Lei-Ke Zhang Shu-Fen Li Shao-Fei Zhang Wei-Wei Wan Yu-Lan Zhang Qi-Lin Xin Ke Dai Yuan-Yuan Hu Zhi-Bo Wang Xiang-Tao Zhu Yu-Jie Fang Ning Cui Pan-He Zhang Chun Yuan Qing-Bin Lu Jie-Ying Bai Fei Deng Geng-Fu Xiao Wei Liu Ke Peng | 2019 | Cell Research2019，29，9： | 15 |
| 10 | Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibitingβ-catenin-mediated epithelial–mesenchymal transition显示文摘Non-small cell lung cancer(NSCLC)is characterized by a high incidence of metastasis and poor survival.As epithelial–mesenchymal transition(EMT)is well recognized as a major factor initiating tumor metastasis,developing EMT inhibitor could be a feasible treatment for metastatic NSCLC.Recent studies show that triptolide isolated from Tripterygium wilfordii Hook F attenuated the migration and invasion of breast cancer,colon carcinoma,and ovarian cancer cells,and EMT played important roles in this process.In the present study we investigated the effect of triptolide on the migration and invasion of NSCLC cell lines.We showed that triptolide(0.5,1.0,2.0 nM)concentration-dependently inhibited the migration and invasion of NCI-H1299 cells.Triptolide treatment concentration-dependently suppressed EMT in NCI-H1299 cells,evidenced by significantly elevated E-cadherin expression and reduced expression of ZEB1,vimentin,and slug.Furthermore,triptolide treatment suppressedβ-catenin expression in NCI-H1299 and NCI-H460 cells,overexpression ofβ-catenin antagonized triptolide-caused inhibition on EMT,whereas knockout ofβ-catenin enhanced the inhibitory effect of triptolide on EMT.Administration of triptolide(0.75,1.5 mg/kg per day,ip,every 2 days)for 18 days in NCI-H1299 xenograft mice dose-dependently suppressed the tumor growth,restrained EMT,and decreased lung metastasis,as evidence by significantly decreased expression of mesenchymal markers,increased expression of epithelial markers as well as reduced number of pulmonary lung metastatic foci.These results demonstrate that triptolide suppresses NSCLC metastasis by targeting EMT via reducingβ-catenin expression.Our study implies that triptolide may be developed as a potential agent for the therapy of NSCLC metastasis. | Qiu-di Deng Xue-ping Lei Yi-hang Zhong Min-shan Chen Yuan-yu Ke Zhan Li Jing Chen Li-juan Huang Yu Zhang Lu Liang Zhong-xiao Lin Qing Liu Song-pei Li Xi-yong Yu | 2021 | Acta Pharmacologica Sinica2021，42，9： | 12 |
| 11 | Collagen scaffold combined with human umbilical cord-mesenchymal stem cells transplantation for acute complete spinal cord injury显示文摘Currently, there is no effective strategy to promote functional recovery after a spinal cord injury. Collagen scaffolds can not only provide support and guidance for axonal regeneration, but can also serve as a bridge for nerve regeneration at the injury site. They can additionally be used as carriers to retain mesenchymal stem cells at the injury site to enhance their effectiveness. Hence, we hypothesized that transplanting human umbilical cord-mesenchymal stem cells on collagen scaffolds would enhance healing following acute complete spinal cord injury. Here, we test this hypothesis through animal studies and a phase I clinical trial.(1) Animal experiments: Models of completely transected spinal cord injury were established in rats and canines by microsurgery. Mesenchymal stem cells derived from neonatal umbilical cord tissue were adsorbed onto collagen scaffolds and surgically implanted at the injury site in rats and canines;the animals were observed after 1 week–6 months. The transplantation resulted in increased motor scores, enhanced amplitude and shortened latency of the motor evoked potential, and reduced injury area as measured by magnetic resonance imaging.(2) Phase I clinical trial: Forty patients with acute complete cervical injuries were enrolled at the Characteristic Medical Center of Chinese People's Armed Police Force and divided into two groups. The treatment group(n = 20) received collagen scaffolds loaded with mesenchymal stem cells derived from neonatal umbilical cordtissues;the control group(n = 20) did not receive the stem-cell loaded collagen implant. All patients were followed for 12 months. In the treatment group, the American Spinal Injury Association scores and activities of daily life scores were increased, bowel and urinary functions were recovered, and residual urine volume was reduced compared with the pre-treatment baseline. Furthermore, magnetic resonance imaging showed that new nerve fiber connections were formed, and diffusion tensor imaging showed that electrophysiological activity was recovered after the treatment. No serious complication was observed during follow-up. In contrast, the neurological functions of the patients in the control group were not improved over the follow-up period. The above data preliminarily demonstrate that the transplantation of human umbilical cord-mesenchymal stem cells on a collagen scaffold can promote the recovery of neurological function after acute spinal cord injury. In the future, these results need to be confirmed in a multicenter, randomized controlled clinical trial with a larger sample size. The clinical trial was approved by the Ethics Committee of the Characteristic Medical Center of Chinese People's Armed Police Force on February 3, 2016(approval No. PJHEC-2016-A8). All animal experiments were approved by the Ethics Committee of the Characteristic Medical Center of Chinese People's Armed Police Force on May 20, 2015(approval No. PJHEC-2015-D5). | Wu-Sheng Deng Ke Ma Bing Liang Xiao-Yin Liu Hui-You Xu Jian Zhang Heng-Yuan Shi Hong-Tao Sun Xu-Yi Chen Sai Zhang | 2020 | Neural Regeneration Research2020，15，9： | 11 |
| 12 | A Novel Approach to Automatic Security Protocol Analysis Based on Authentication Event Logic显示文摘Since security protocols form the cornerstones of modern secure networked systems, it is important to develop informative, accurate, and deployable approach for finding errors and proving that protocols meet their security requirements. We propose a novel approach to check security properties of cryptographic protocols using authentication event logic. Compared with logic of algorithm knowledge, authentication event logic guarantees that any well-typed protocol is robustly safe under attack while reasoning only about the actions of honest principals in the protocol. It puts no bound on the size of the principal and requires no state space enumeration and it is decidable. The types for protocol data provide some intuitive explanation of how the protocol works. Our approach has led us to the independent rediscovery of flaws in existing protocols and to the design of improved protocols. | XIAO Meihua MA Chenglin DENG Chunyan ZHU Ke | 2015 | Chinese Journal of Electronics2015，24，1： | 10 |
| 13 | Detection of Pseudorabies Virus Antibodies in Human Encephalitis Cases显示文摘Pseudorabies virus(PRV),a veterinary pathogen that infects domestic animals as well as wild animals such as wild boar and feral swine,was recently reported to infect human and led to endophthalmitis and encephalitis.A retrospective seroepidemiologic survey was conducted using 1,335 serum samples collected from patients with encephalitis and ELISA positive rates were 12.16%,14.25%,and 6.52%in 2012,2013,and 2017,respectively. | LI Xiang Dong FU Shi Hong CHEN Ling Yan LI Fan DENG Jun Hua LU Xuan Cheng WANG Huan Yu TIAN Ke Gong | 2020 | Biomedical and Environmental Sciences2020，33，6： | 9 |
| 14 | Alkaloids from Isatis indigotica显示文摘Isaindigotone 1 and 3-(2’-hydroxyphenyl)-4(3H)-quinazolinone 2 were isolated from the roots of Isatis indigotica. Compound 1 was elucidated as a new alkaloid.Compound 2 was discovered for the first time from a natural | Ke Min DENG Xiao Yun WU Gen Jin YANG and Guo Wei QIN (Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai 200031) (School of Pharmacy, Second Military Medical University, Shanghai 200433) ( Visiting scholar from Dept. of Chemistr | 1997 | Chinese Chemical Letters1997，8，3： | 9 |
| 15 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 16 | Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease显示文摘背景长期的妨碍的肺的疾病(COPD ) 与在航线的粘液生产过剩通常是复杂的。最近人的激活钙的氯化物隧道的增加的表示(CaCC1 ) 1 被发现在气喘的航线在粘液生产过剩起一个重要作用。在支气管的纸巾与 COPD, CaCC1 的表情, MUC5AC 和粘液在中国病人的航线调查 CaCC1 和粘液生产过剩的关系是 examined.Methods 支气管的纸巾在 2004 从 4 月在韦斯特中国医院里从 fiberoptic bronchoscopy 和支气管的活体检视被获得到 7 月。25 个病人与 COPD 生产过剩作为病人被诊断,并且另外的 20 是控制题目。在支气管的纸巾的 CaCC1 , MUC5AC 和粘蛋白的表情被反向的transcriptase聚合酶链反应( RT-PCR )检测,在有 digoxigenin 的 situ 杂交(挖) -Iabeled RNA 探查, immunohistochemical 和 alcian 染色的蓝色周期的酸 Schiff (AB舞步), respectively.Results 与控制组相比, CaCC1 的更强壮的表情进一步与 COPD ( P0.01 )从病人在整个支气管的纸巾被检测。而且, CaCC1 mRNA 的更强壮的表情与气流阻塞的严厉有关。从 COPD 的样品显示出在控制题目(P0.01 ) 的比那些的为 MUC5AC 的更强壮的染色,染色的 AB 舞步在 COPD 病人在控制题目(P0.01 ) 与那作比较的 submucosal 腺揭示了更多的粘蛋白。 CaCC1 mRNA 的表达式层次否定地分别地与病人一起被相关在/强迫了的一秒( FEV1 )强迫了吐气的体积重要能力( FVC )数据,FEV1%预言了数据,V50%预言了数据,V25%预言了数据( r=0.43 , r=0.43 , r=0.35 , r=0.36 , P0.01 , P0.01 , P0.05 , P0.05 )。当 CaCC1 mRNA 的表示层次很好与 MUC5AC 的表示层次被相关时,航线上皮和 PAS-AB 的 mRNA 染色了 submucosal 腺的区域(r=0.39, r=0.46, P0.05, P0.01 ) 。MUC5AC mRNA 的表示层次否定地与病人的 FEV1/FVC 数据(P=0.01 ) 被相关, FEV1%pred 数据(P=0.01 ) , V50% 预言了数据, V25% 预言了数据(r=0.53, r=0.53, r=0.48, r=0.43, P0.01, P0.01, P0.01, P0.01 ) 。当 MUC5AC mRNA 的表示层次很好被相关与时断然, PAS-AB 染色了 submucosal 腺(P0.05 ) 的区域,并且关联系数是这些结果建议的 0.43 .Conclusion CaCC1 的更强壮的基因表示存在,与在有 COPD 的中国病人的航线的粘液生产过剩复杂。 | WANG Ke FENG Yu-ling WEN Fu-qiang CHEN Xue-rong OU Xue-mei XU Dan YANG Jie DENG Zhi-pin | 2007 | Chinese Medical Journal2007，，12： | 8 |
| 17 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 18 | A novel alkenoic acid ester and a new benzophenone from Ranunculus ternatus显示文摘新奇 alkenoic 酸酉旨,(E)-4-hydroxy-dodec-2-enedioic acid-12-O-methyl 酉旨和新 benzophenone,和已知的混合物的乙醇(S)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate, ,(E)-4-hydroxy-dodec-2-enedioic 酸从毛莨属 ternatus 的根被孤立。他们的结构被分光镜的方法阐明。 | Ying Xiong Ke Zhong Deng Wen Yuan Gao Yuan Qiang Guo Tie Jun Zhang | 2007 | Chinese Chemical Letters2007，18，11： | 8 |
| 19 | Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma显示文摘The p53 signaling pathway works as a potent barrier to tumor progression.Two single nucleotide polymor-phisms(SNPs)in the gene loci of p53 pathway,p53 codon 72 Arg72Pro and MDM2 SNP309(T>G),have been shown to cause perturbation of p53 function,but the effect of the two SNPs on the risk of hepatocellular carcinoma(HCC)remains inconsistent.This study in-vestigated the influence of combined p53 Arg72Pro and MDM2 SNP309 on the risk of developing HCC in pa-tients with chronic hepatitis B virus infection,and evaluated the significance of the two combined SNPs on patient prognosis.In total,350 HCC patients,230 non-HCC patients,and 96 healthy controls were geno-typed for the p53 Arg72Pro and MDM2 SNP309.The combined p53 Pro/Pro and MDM2 G/G genotype was significantly associated with HCC risk(P=0.047).Mul-tivariate analysis indicated that combined p53 Pro/Pro and MDM2 G/G genotype was an independent factor affecting recurrence and survival(P<0.05).Patients with combined p53 Pro/Pro and MDM2 G/G genotypes had a poorer prognosis than other genotypes,P<0.01 for both disease-free survival(DFS)and overall survival(OS).DFS and OS rates also differed significantly be-tween Barcelona Clinic Liver Cancer(BCLC)stage A patients with combined p53 Pro/Pro and MDM2 G/G and other genotypes(P<0.05).Thus,the combined p53 Pro/Pro and MDM2 G/G genotype is associated with increased risk of developing HCC and is an independ-ent adverse prognostic indicator in early stage HCC. | Yun Yang Tian Xia Ning Li Jin Zhang Yuan Yang Wenming Cong Qiang Deng Ke Lan Weiping Zhou | 2013 | Protein & Cell2013，4，1： | 8 |
| 20 | Seasonal variability in free-living marine nematode community structure in a sandy beach of the Taiping Bay of Qingdao,China显示文摘Nematode assemblage composition, trophic structure and biodiversity were followed over an annual cycle in a sandy beach of the Taiping Bay of Qingdao, China. Nematode assemblage in the sandy beach maintained a high genus diversity (75 genera). Microlaimus and Bathylaimus were the dominant genus of the nematode assemblage, accounting for 66% of the total nematode abundance. The nematodes' dominant trophic structure changed seasonally as a response to the seasonal changes in food quality. Epigrowth-feeder nematodes (2A) were the dominant trophic groups in the trophic structure with the highest abundance in spring because of phytoplankton bloom, while the feeding type (1B) showed higher abundance in summer that was due to the increasing of sediment detritus after spring bloom. Furthermore, species diversity and evenness calculated on nematodes identified to the genus level displayed significant temporal changes, which was also reflected by the index of trophic diversity. According to the cluster analysis, the nematode community structure of the whole year was clearly separated into two periods (A and B). Biota-Environment matching (BIOENV) results showed that seawater temperature,sediment Chl a and grain size were responsible for the nematode community structure variation in spring and summer period (Period A). However, seawater/interstitial water temperature, interstitial water dissolved oxygen concentration,interstitial water salinity, and sediment Ph a a were more important in constructing the autumn and winter period (Period B) nematode community structure. | LIU Haibin ZHANG Zhinan FAN Shiliang HUA Er DENG Ke | 2008 | Acta Oceanologica Sinica2008，27，2： | 7 |
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