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| 1 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 2 | Mineralogical Characteristics of Unusual Black Talc Ores in Guangfeng County, Jiangxi Province, China显示文摘Talc is a hydroxyled, magnesium-rich, layered silicate that has the ideal chemical formula Mg3Si4O10(OH)2. Due to its unique properties, such as softness, chemical inertness, high thermal stability, low electrical conductivity, lamellar habit, adsorption properties, and occurrence of a wide range of particle sizes that can be easily reduced by milling and high specific surface area, talc is widely used in many industries. A stratified deposit of unusual black talc, an occurrence of talc estimated to be more than half a billion tons, was found exposed in the late Neoproterozoic Dengying Formation, located in Guangfeng County, Jiangxi Province, southeastern China. The ores occur primarily as oolitic structures (Fig. 1). The mineralogical and geochemical characteristics of the ores were investigated by using multiple techniques. The ores were found to mainly consist of talc (30%–70%), dolomite, quartz, and magnesite. Most of talc crystals are ultrafine (with an average crystallite size of smaller than 5 μm) and appear as irregular broken or distorted lamellar flakes. The total organic carbon (TOC) content of the black talc ore samples is generally lower than 1.0%. Electron-microprobe analysis (EPMA) revealed low contents of Na, K, Ca and Mn, Fe, Ni, Al in the talc oolitic particles. The talc ores have low contents of toxic elements and relatively high contents of Li and Zn. The infrared spectrum of the black talc is similar to that of white talc from Trimouns (Pyrenees, France), and their Brunauer–Emmett-Teller (BET) specific surface areas, ranging from 15.7 to 23.2 m2/g, is much higher than those of white talc (normally lower than 5.0 m2/g), which may be due to the small size of the talc crystals. | WANG Rucheng LI Chengxiang LU Xiancai ZHANG Ming | 2013 | 矿物学报2013，33，S1： | 6 |
| 3 | A novel true triaxial test system for microwave-induced fracturing of hard rocks显示文摘This study introduces a test system for microwave-induced fracturing of hard rocks under true triaxial stress.The test system comprises a true triaxial stress loading system,an open-ended microwaveinduced fracturing system,a data acquisition system,an acoustic emission(AE)monitoring system,and an auxiliary specimen loading system.Microwave-induced surface and borehole fracturing tests under true triaxial stress were fulfilled for the first time,which overcomes the problem of microwave leakage in the coupling loading of true triaxial stress and microwave.By developing the dynamic monitoring system,the thermal response and fracture evolution were obtained during microwave irradiation.The monitoring system includes the infrared thermometry technique for monitoring rock surface temperature,the distributed optic fiber sensing technique for monitoring temperature in borehole in rock,the AE technique and two-dimensional digital speckle correlation technique for monitoring the evolution of thermal damage and the rock fracturing process.To validate the advantages of the test system and investigate the characteristics of microwave-induced fracturing of hard rocks,the study demonstrates the experimental methods and results for microwave-induced surface and borehole fracturing under true triaxial stress.The results show that thermal cracking presented intermittent characteristics(calm eactiveecalm)during microwave-induced surface and borehole fracturing of basalt.In addition,true triaxial stress can inhibit the development and distribution of thermal cracks during microwave-induced surface fracturing.When microwave-induced borehole fracturing occurs,it promotes the distribution of thermal cracks in rock,but inhibits the width of cracks.The results also prove the reliability of the test system. | Xia-Ting Feng Jiuyu Zhang Chengxiang Yang Jun Tian Feng Lin Shiping Li Xiangxin Su | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，5： | 5 |
| 4 | The Strigolactone-Related Mutants have Enhanced Lamina Joint Inclination Phenotype at the Seedling Stage显示文摘Strigolactones(SLs)are a class of newly discovered plant hormones and play diverse roles in plant growth and development.Recently,it has been demonstrated that SLs negatively regulate shoot branching by inhibiting bud outgrowth in plants(Umehara et al.,2008).Several genes involved in SL biosynthesis or signaling had been identified in both monocots and dicots.Loss-of-function mutants corresponding to these genes exhibit enhanced shoot branching phenotype(Beveridge and Kyozuka,2010).In rice,the SL biosynthetic mutants,d17/htd1 and d10,are caused by mutation of carotenoid cleavage dioxygenase 7(CCD7)and carotenoid cleavage dioxygenase 8(CCD8),respectively(Zou et al.,2006;Arite et al,2007).The SL biosynthetic mutant,d27,is caused by a mutation of | Xiaoming Li Shiyong Sun Chengxiang Li Shenglong Qiao Tao Wang Linna Leng Hongyun Shen Xuelu Wang | 2014 | Journal of Genetics and Genomics2014，41，11： | 3 |
| 5 | Guest editorial: special issue on high mobility wireless communications显示文摘The high-speed railway and high-way networks are now expanding at a phenomenal speed in China and in many other parts of the world. The related broadband wireless communication over high-speed trains and highway vehicles is a very challenging task due to hostile transmission channel conditions. The demand for such services is growing rapidly, following the proliferation of laptop/tablet computers and | Pingzhi FAN Erdal PANAYIRCI Ping LI Chengxiang WANG Vahid TAROKH | 2012 | Journal of Modern Transportation2012，20，4： | 2 |
| 6 | Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels显示文摘Physiological repair of large-sized bone defects is great challenging in clinic due to a lack of ideal grafts suitable for bone regeneration.Decalcified bone matrix(DBM)is considered as an ideal bone regeneration scaffold,but low cell seeding efficiency and a poor osteoinductive microenvironment greatly restrict its application in large-sized bone regeneration.To address these problems,we proposed a novel strategy of bone regeneration units(BRUs)based on microgels produced by photo-crosslinkable and microfluidic techniques,containing both the osteogenic ingredient DBM and vascular endothelial growth factor(VEGF)for accurate biomimic of an osteoinductive microenvironment.The physicochemical properties of microgels could be precisely controlled and the microgels effectively promoted adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.BRUs were successfully constructed by seeding BMSCs onto microgels,which achieved reliable bone regeneration in vivo.Finally,by integrating the advantages of BRUs in bone regeneration and the advantages of DBM scaffolds in 3D morphology and mechanical strength,a BRU-loaded DBM framework successfully regenerated bone tissue with the desired 3D morphology and effectively repaired a large-sized bone defect of rabbit tibia.The current study developed an ideal bone biomimetic microcarrier and provided a novel strategy for bone regeneration and large-sized bone defect repair. | Junxiang Hao Baoshuai Bai Zheng Ci Jincheng Tang Guanhuai Hu Chengxiang Dai Mengyuan Yu Meng Li Wei Zhang Yixin Zhang Wenjie Ren Yujie Hua Guangdong Zhou | 2022 | Bioactive Materials2022，7，8： | 2 |
| 7 | The syntactical pattern recognition for the leakage current of transmission-line insulators显示文摘 | YAO Chenguo WANG Jian LI Chengxiang | 2011 | IEEE Transactions on Pow- er Delivery2011，26，4： | 1 |
| 8 | Matrix-assisted pulsed laser evaporation of polyimide thin films and the XPS study显示文摘Compared with the traditional thin film techniques, the matrix-assisted pulsed laser evaporation (MAPLE) technique has many advantages in the deposition of polymer and organic thin films. It has a wide range of applications in many fields, such as non-linear optics, luminescent devices, electronics, various sensors. We have successfully deposited polyimide thin films by using the MAPLE technique. These films were characterized with XPS. The XPS spectra showed that the single-photon effect is ob-vious at low laser fluence and the chemical bonds will be broken, resulting in decomposition of the films. Contrarily, the single-photon effect will decrease and the multi-photon effect and the photothermal effect will increase at high laser fluence, resulting in the protection of the structure of the polyimide thin films and the obvious decrease in decomposition. High laser fluence is more suitable for the deposition of polymer and organic thin films than low laser fluence. | WANG Wei LI ChengXiang ZHANG GuoBin SHENG LiuSi | 2008 | Science China Chemistry2008，51，10： | 1 |
| 9 | Morphology tailoring of hydroxyapatite nanoparticles by hydrothermal processing with amino acids 显示文摘 | GAO Wcimin LI Qunyan RUAN Chengxiang | 2005 | Key Eng Mater2005，280，2： | 1 |
| 10 | Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is one type of the most aggressive breast can cers with poor prog no sis.It is of great urgency to develop new therapeutics for treati ng TNBC.Based on curre nt treatment guideline and genetic informatio n of TNBC,a combi nation al therapy platform in tegrati ng chemotherapy drugs and mRNA encoding tumor suppressor proteins may become an efficacious strategy.In this study,we developed paclitaxel amino lipid(PAL)derived nanoparticles(NPs)to incorporate both chemotherapy drugs and P53 mRNA.The PAL P53 mRNA NPs showed superior properties compared to Abraxane? and Lipusu? used in the clinic including high paclitaxel loading capacity(24 wt.%,calculated by paclitaxel in PAL),PAL encapsulation efficiency(94.7%±6.8%)and mRNA encapsulation efficiency(88.7%±0.7%).Meanwhile,these NPs displayed synergetic cytotoxicity of paclitaxel and P53 mRNA in cultured TNBC cells.More importantly,we demonstrated in vivo anti-tumor efficacy of PAL P53 mRNA NPs in an orthotopic TNBC mouse model.Overall,these chemotherapy drugs derived mRNA NPs provide a new platform to integrate chemotherapy and personalized medicine using tumor genetic information,and therefore represent a promising approach for TNBC treatment. | Chengxiang Zhang Xinfu Zhang Weiyu Zhao Chunxi Zeng Wenqing Li Bin Li Xiao Luo Junan Li Justin Jiang Binbin Deng David W. McComb Yizhou Dong | 2019 | Nano Research2019，12，4： | 1 |
| 11 | Photocatalytic degradation of gaseous toluene on Fe-TiO 2 under visible light irradiation: A study on the structure, activity and deactivation mechanism显示文摘 | Song Sun Jianjun Ding Jun Bao Chen Gao Zeming Qi Xiaoyan Yang Bo He Chengxiang Li | 2012 | Applied Surface Science2012，，12： | 1 |
| 12 | A new type of dielectric composite with X7R characteristic and high dielectric constant 显示文摘 | Longtu Li Chengxiang Ji | 2001 | Mater Lett2001，48，： | 1 |
| 13 | Grafting Propagation Techniques of Red Sandalwood(Pterocarpus santalinus),a Precious Hongmu Tree Species显示文摘[Objectives] This article aimed to study the grafting propagation techniques of red sandalwood ( Pterocarpus santalinus ), so as to provide technical support for the effective propagation of seedlings of this precious Hongmu species.[Methods] Based on the analysis and comparison of the growth performance of the Hongmu tree species introduced to China, taking 1 to 2-year-old Pterocarpus indicus seedlings as rootstocks and single-bud stems of P. santalinus as scions, grafting was carried out from January to April using three grafting propagation methods, cut grafting propagation, skin grafting propagation and oblique grafting propagation.[Results] The results of several years of experiments show that in early spring, P. santalinus could be propagated well using the grafting propagation methods of skin grafting propagation and oblique grafting propagation, with survival rate over 80%. For rootstocks with young age or thin stems, the joint unions of the oblique grafting propagation healed well, without apparent protrusions, unlike those of skin grafting propagation. The survival rate of oblique grafting propagation that is fast and reliable was higher than that of cut grafting propagation.[Conclusions] It is feasible to use the grafting propagation methods to propagate P. santalinus seedlings. This is a traditional and innovative technology path in the propagation of high-quality seedlings of precious Hongmu trees, and can be promoted and applied in industrial practice. | Xiaonan HUANG Yanming LI Yiqing LI Tingting LIU Siting CHEN Chengxiang XU Yingshan QIU Yesheng LIANG | 2019 | Asian Agricultural Research2019，11，7： | 1 |
| 14 | Co-Production of High-Grade Dissolving Pulp,Furfural,and Lignin from Eucalyptus via Extremely Low Acid Pretreatment and Pulping Technologies and Catalysis显示文摘Hemicellulose and lignin are not reasonably utilized during the dissolved pulp preparation process.This work aimed to propose a process for the co-production of dissolving pulp,furfural,and lignin from eucalyptus.High-grade dissolving pulp was prepared from eucalyptus using a combination of extremely low acid(ELA)pretreatment,Kraft cooking,and elementary chlorine-free(ECF)bleaching.The obtained pre-hydrolysate was catalytic conversion into furfural in a biphasic system,and lignin during Kraft cooking and ECF was recovered.The process condition was discussed as well as the mass flow direction.The results showed that ELA pretreatment could effectively remove 80.1%hemicellulose.Compared with traditional hydrothermal pretreatment,the ELA pretreatment significantly increased the xylose yield from 5.05 to 14.18 g/L at 170℃ for 2 h,which had practical significance for furfural production.The 82.7%furfural yield and 82.9%furfural selectivity were obtained from xylose-rich pre-hydrolysate using NaCl as a phase modifier in a biphasic system with 4-methyl-2-pentanone(MIBK)as an organic phase by ion exchange resin catalysts at 190℃ for 2 h.Subsequently,the pretreated eucalyptus was subjected to Kraft cooking,and the optimal alkali amount was 14%.Then,the Kraft pulp was bleached using the O-D1-EP-D_(2) sequence,and dissolving pulp was obtained with an ISO brightness of 86.0%,viscosity of 463 mL/g,andα-cellulose content of 95.4%.The Kraft lignin which has a potential application was investigated by 2D-HSQC NMR and 31P NMR.The results showed that the S/G ratio of Kraft lignin was 1.93,and the content of phenolic hydroxyl groups was 2.53 mmol/g.Moreover,based on the above proposed process,30.5 g dissolving pulp,5.5 g furfural,and 21.2 g lignin per 100 g eucalyptus chips(oven dry)were produced.This research will provide new catalysis and pulping technical routes for dissolving pulp,furfural,and Kraft lignin products,which are in great demand in the chemical industry. | Chengxiang Li Yue Wu Chunhui Zhang Yao Liu Qixuan Lin Junli Ren | 2023 | Journal of Renewable Materials2023，11，6： | 1 |
| 15 | Gene Transfer and Drug Delivery with Electric Pulse Generators显示文摘 | Chenguo Yao Fei Guo Chengxiang Li Caixin Sun | 2013 | Current Drug Metabolism2013，，3： | 1 |
| 16 | Particle clustering(mesoscale structure)of high-flux gas-solid circulating fluidized bed显示文摘Particle clustering is an important dynamic phenomenon in circulating-fluidized-bed(CFBs)systems,and has been suggested as a key contributing factor to the non-uniform hydrodynamics of CFBs.Studies show that particle clusters can be affected by solids flux,in terms of frequency,duration,and solids holdup.To understand the characteristics of particle clusters under high-solids-flux conditions,experimental and modeling studies in high-solids-flux gas-solids CFBs were reviewed and summarized.Optical and electrical measurements and imaging methods were used to monitor the particle-clustering phenomenon in CFBs.Particles were found to cluster in high-flux CFBs,and were characterized by a denser cluster-solids holdup and a shorter time fraction,which was different from the behavior in low-flux CFBs.Particle properties affected particle clustering in high-flux CFBs significantly.In modeling work,Eulerian-Eulerian and Eulerian-Lagrangian methods were used to study the particle-cluster characteristics.Good results can be obtained by using the Eulerian-Eulerian method to simulate the CFB system,especially the high-flux CFBs,and by considering the effects of particle clusters.The Eulerian-Lagrangian method is used to obtain detailed cluster characteristics.Because of limits in computing power,no obvious results exist to model particle clusters under high-solids-flux conditions.Because high-solids-flux conditions are used extensively in industrial applications,further experimental and numerical investigations on the clustering behavior in HF/DCFBs are required. | Chengxiu Wang Chengxiang Li Xingying Lan Yingya Wu Jinsen Gao | 2020 | Particuology2020，18，1： | 1 |
| 17 | Cardiac-derived adiponectin induced by long-term insulin treatment ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic mice via AMPK signaling显示文摘 | Haifeng Pei Yan Qu Xiaoyan Lu Qiujun Yu Kun Lian Peilin Liu Wenjun Yan Jingyi Liu Yanzhuo Ma Yi Liu Chengxiang Li Weijie Li Wayne Bond Lau Haifeng Zhang Ling Tao | 2013 | Basic Research in Cardiology2013，，1： | 1 |
| 18 | Detection of homozygosity in near isogenic Lines of non-susceptible to Zhenjiang Strain of densonucleosis virus in silkworm显示文摘 | Li Muwang Hou Chengxiang Zhao Yunpo | 2007 | African Journal of Biotechnology2007，6，14： | 1 |
| 19 | Linkage and mapping analyses of the densonucleosis non-susceptible gene nsd-Z in the silkworm Bombyx mori using SSR markers显示文摘 | Li Muwang Guo Qiuhoag Hou Chengxiang | 2006 | Genome2006，，49： | 1 |
| 20 | Bioleaching of chalcopyrite by Acidithiobacillus ferrooxidans显示文摘 | XingQing Zhao RuCheng Wang XianCai Lu JianJun Lu ChengXiang Li Juan Li | 2013 | Minerals Engineering2013，，： | 1 |
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