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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 3 | Comparisons of Two Ensemble Mean Methods in Measuring the Average Error Growth and the Predictability显示文摘In this paper, taking the Lorenz system as an example, we compare the influences of the arithmetic mean and the geometric mean on measuring the global and local average error growth. The results show that the geometric mean error (GME) has a smoother growth than the arithmetic mean error (AME) for the global average error growth, and the GME is directly related to the maximal Lyapunov exponent, but the AME is not, as already noted by Krishnamurthy in 1993. Besides these, the GME is shown to be more appropriate than the AME in measuring the mean error growth in terms of the probability distribution of errors. The physical meanings of the saturation levels of the AME and the GME are also shown to be different. However, there is no obvious difference between the local average error growth with the arithmetic mean and the geometric mean, indicating that the choices of the AME or the GME have no influence on the measure of local average predictability. | DING Ruiqiang LI Jianping | 2011 | Acta meteorologica Sinica2011，25，4： | 7 |
| 4 | Historical trends of PCBs and PBDEs as reconstructed in a lake sediment from southern Tibetan Plateau显示文摘High-altitude lake sediment can be used as a natural archive to reconstruct the history of pollutants. In this work, the temporal distribution of polychlorinated biphenyls(PCBs) and polybrominated diphenyl ethers(PBDEs) were determined using a high-resolution gas chromatography coupled with high-resolution mass spectrometer(HRGC/HRMS) in an alpine lake sediment core collected from the southern Tibetan Plateau(TP) to examine whether the expected decreasing trends due to the implementation of the international Conventions could be observed. The concentrations of PCBs and PBDEs in the sediment core were in the range of 11.8–142 pg/g dw and ND-457 pg/g dw, and their fluxes were in the range of 2.51–31.7 ng/(m^2 ·yr) and ND-43.2 ng/(m^2 ·yr), respectively. The prevalence of low-chlorinated(tri-CB) PCBs and low-brominated(tri-to tetra-) PBDEs in most sections of the sediment profiles was observed, suggesting that the light molecular weight PCBs and PBDEs have most likely reached lake sediments by long-range atmospheric transport from distant sources. Despite the restrictions on their applications, the sediment records for the concentrations and fluxes showed no corresponding decreasing trend with restrictions for PCBs, which suggested that these POPs(e.g., PCBs) were still emitted to the environment owing to the influence of primary or secondary emissions. To our knowledge, this is the first report on input history of atmospheric PCBs and PBDEs recorded in TP Lake sediment. | Ruiqiang Yang Ting Xie Pu Wang Yingming Li Qinghua Zhang Guibin Jiang | 2020 | Journal of Environmental Sciences2020，32，12： | 7 |
| 5 | Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells显示文摘 | Chong Li Song Wu Zhao Yang Xiaolong Zhang Qi Zheng Ling Lin Zexiong Niu Ruiqiang Li Zhiming Cai Lei Li | 2017 | Cell Research2017，27，4： | 7 |
| 6 | Determining the Spectrum of the Nonlinear Local Lyapunov Exponents in a Multidimensional Chaotic System显示文摘For an n-dimensional chaotic system, we extend the definition of the nonlinear local Lyapunov exponent(NLLE) from one-to n-dimensional spectra, and present a method for computing the NLLE spectrum. The method is tested on three chaotic systems with different complexity. The results indicate that the NLLE spectrum realistically characterizes the growth rates of initial error vectors along different directions from the linear to nonlinear phases of error growth. This represents an improvement over the traditional Lyapunov exponent spectrum, which only characterizes the error growth rates during the linear phase of error growth. In addition, because the NLLE spectrum can effectively separate the slowly and rapidly growing perturbations, it is shown to be more suitable for estimating the predictability of chaotic systems, as compared to the traditional Lyapunov exponent spectrum. | Ruiqiang DING Jianping LI Baosheng LI | 2017 | Advances in Atmospheric Sciences2017，34，9： | 6 |
| 7 | The genetics of tiger pelage color variations显示文摘 | Xiao XU Gui-Xin Dong Anne Schmidt-Kuntzel Xue-Li Zhang Yan Zhuang Run Fang Xin Sun Xue-Song Hu Tian-You Zhang Han-Dong Yang De-Lu Zhang Laurie Marker Zheng-Fan Jiang Ruiqiang Li Shu-Jin Luo | 2017 | Cell Research2017，27，7： | 5 |
| 8 | Influence of the NAO on Wintertime Surface Air Temperature over East Asia:Multidecadal Variability and Decadal Prediction显示文摘In this paper,we investigate the influence of the winter NAO on the multidecadal variability of winter East Asian surface air temperature(EASAT)and EASAT decadal prediction.The observational analysis shows that the winter EASAT and East Asian minimum SAT(EAmSAT)display strong in-phase fluctuations and a significant 60-80-year multidecadal variability,apart from a long-term warming trend.The winter EASAT experienced a decreasing trend in the last two decades,which is consistent with the occurrence of extremely cold events in East Asia winters in recent years.The winter NAO leads the detrended winter EASAT by 12-18 years with the greatest significant positive correlation at the lead time of 15 years.Further analysis shows that ENSO may affect winter EASAT interannual variability,but does not affect the robust lead relationship between the winter NAO and EASAT.We present the coupled oceanic-atmospheric bridge(COAB)mechanism of the NAO influences on winter EASAT multidecadal variability through its accumulated delayed effect of~15 years on the Atlantic Multidecadal Oscillation(AMO)and Africa-Asia multidecadal teleconnection(AAMT)pattern.An NAO-based linear model for predicting winter decadal EASAT is constructed on the principle of the COAB mechanism,with good hindcast performance.The winter EASAT for 2020-34 is predicted to keep on fluctuating downward until~2025,implying a high probability of occurrence of extremely cold events in coming winters in East Asia,followed by a sudden turn towards sharp warming.The predicted 2020/21 winter EASAT is almost the same as the 2019/20 winter. | Jianping LI Tiejun XIE Xinxin TANG Hao WANG Cheng SUN Juan FENG Fei ZHENG Ruiqiang DING | 2022 | Advances in Atmospheric Sciences2022，39，4： | 4 |
| 9 | Influence of the Preceding Austral Summer Southern Hemisphere Annular Mode on the Amplitude of ENSO Decay显示文摘There is increasing evidence of the possible role of extratropical forcing in the evolution of ENSO.The Southern Hemisphere Annular Mode(SAM) is the dominant mode of atmospheric circulation in the Southern Hemisphere extratropics.This study shows that the austral summer(December–January–February; DJF) SAM may also influence the amplitude of ENSO decay during austral autumn(March–April–May;MAM).The mechanisms associated with this SAM–ENSO relationship can be briefly summarized as follows:The SAM is positively(negatively) correlated with SST in the Southern Hemisphere middle(high) latitudes.This dipole-like SST anomaly pattern is referred to as the Southern Ocean Dipole(SOD).The DJF SOD,caused by the DJF SAM,could persist until MAM and then influence atmospheric circulation,including trade winds,over the Nio3.4 area.Anomalous trade winds and SST anomalies over the Nio3.4 area related to the DJF SAM are further developed through the Bjerkness feedback,which eventually results in a cooling(warming) over the Nio3.4 area followed by the positive(negative) DJF SAM. | Fei ZHENG Jianping LI Ruiqiang DING | 2017 | Advances in Atmospheric Sciences2017，34，11： | 3 |
| 10 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 11 | Comparison of Nonlinear Local Lyapunov Vectors with Bred Vectors, Random Perturbations and Ensemble Transform Kalman Filter Strategies in a Barotropic Model显示文摘The breeding method has been widely used to generate ensemble perturbations in ensemble forecasting due to its simple concept and low computational cost. This method produces the fastest growing perturbation modes to catch the growing components in analysis errors. However, the bred vectors(BVs) are evolved on the same dynamical flow, which may increase the dependence of perturbations. In contrast, the nonlinear local Lyapunov vector(NLLV) scheme generates flow-dependent perturbations as in the breeding method, but regularly conducts the Gram–Schmidt reorthonormalization processes on the perturbations. The resulting NLLVs span the fast-growing perturbation subspace efficiently, and thus may grasp more components in analysis errors than the BVs.In this paper, the NLLVs are employed to generate initial ensemble perturbations in a barotropic quasi-geostrophic model.The performances of the ensemble forecasts of the NLLV method are systematically compared to those of the random perturbation(RP) technique, and the BV method, as well as its improved version—the ensemble transform Kalman filter(ETKF)method. The results demonstrate that the RP technique has the worst performance in ensemble forecasts, which indicates the importance of a flow-dependent initialization scheme. The ensemble perturbation subspaces of the NLLV and ETKF methods are preliminarily shown to catch similar components of analysis errors, which exceed that of the BVs. However, the NLLV scheme demonstrates slightly higher ensemble forecast skill than the ETKF scheme. In addition, the NLLV scheme involves a significantly simpler algorithm and less computation time than the ETKF method, and both demonstrate better ensemble forecast skill than the BV scheme. | Jie FENG Ruiqiang DING Jianping LI Deqiang LIU | 2016 | Advances in Atmospheric Sciences2016，33，9： | 3 |
| 12 | Determination of the Backward Predictability Limit and Its Relationship with the Forward Predictability Limit显示文摘In this work, two types of predictability are proposed—forward and backward predictability—and then applied in the nonlinear local Lyapunov exponent approach to the Lorenz63 and Lorenz96 models to quantitatively estimate the local forward and backward predictability limits of states in phase space. The forward predictability mainly focuses on the forward evolution of initial errors superposed on the initial state over time, while the backward predictability is mainly concerned with when the given state can be predicted before this state happens. From the results, there is a negative correlation between the local forward and backward predictability limits. That is, the forward predictability limits are higher when the backward predictability limits are lower, and vice versa. We also find that the sum of forward and backward predictability limits of each state tends to fluctuate around the average value of sums of the forward and backward predictability limits of sufficient states.Furthermore, the average value is constant when the states are sufficient. For different chaotic systems, the average value is dependent on the chaotic systems and more complex chaotic systems get a lower average value. For a single chaotic system,the average value depends on the magnitude of initial perturbations. The average values decrease as the magnitudes of initial perturbations increase. | Xuan LI Ruiqiang DING Jianping LI | 2019 | Advances in Atmospheric Sciences2019，36，6： | 1 |
| 13 | Interdec- adal shift in the relationship between the East Asian summer monsoon and the tropical Indian Ocean 显示文摘 | DING Ruiqiang HA Kyung-ja LI Jianping | 2010 | Climate Dynamics2010，34，7： | 1 |
| 14 | A human gut microbial gene catalogue established by metagenomic sequencing显示文摘 | Junjie Qin Ruiqiang Li Jeroen Raes | 2010 | Nature2010，464，7285： | 1 |
| 15 | Relationships between the Extratropical ENSO Precursor and Leading Modes of Atmospheric Variability in the Southern Hemisphere显示文摘Previous studies suggest that the atmospheric precursor of El Ni ?no–Southern Oscillation(ENSO) in the extratropical Southern Hemisphere(SH) might trigger a quadrapole sea surface temperature anomaly(SSTA) in the South Pacific and subsequently influence the following ENSO. Such a quadrapole SSTA is referred to as the South Pacific quadrapole(SPQ).The present study investigated the relationships between the atmospheric precursor signal of ENSO and leading modes of atmospheric variability in the extratropical SH [including the SH annular mode(SAM), the first Pacific–South America(PSA1) mode, and the second Pacific–South America(PSA2) mode]. The results showed that the atmospheric precursor signal in the extratropical SH basically exhibits a barotropic wavenumber-3 structure over the South Pacific and is significantly correlated with the SAM and the PSA2 mode during austral summer. Nevertheless, only the PSA2 mode was found to be a precursor for the following ENSO. It leads the SPQ-like SSTA by around one month, while the SAM and the PSA1 mode do not show any obvious linkage with either ENSO or the SPQ. This suggests that the PSA2 mode may provide a bridge between the preceding circulation anomalies over the extratropical SH and the following ENSO through the SPQ-like SSTA. | Jianhuang QIN Ruiqiang DING Zhiwei WU Jianping LI Sen ZHAO | 2017 | Advances in Atmospheric Sciences2017，34，3： | 1 |
| 16 | Enhanced ferroelectric polarization with less wake-up effect and improved endurance of Hf_(0.5)Zr_(0.5)O_(2)thin films by implementing W electrode显示文摘This paper reports the improvement of electrical,ferroelectric and endurance of Hf_(0.5)Zr_(0.5)O_(2)(HZO)thinfilm capacitors by implementing W electrode.The W/HZO/W capacitor shows excellent pristine 2 P_(r)values of 45.1 gC/cm^(2)at±6 V,which are much higher than those of TiN/HZO/W(34.4μC/cm^(2))and W/HZO/TiN(26.9μC/cm^(2))capacitors.Notably,the maximum initial 2 P_(r)value of W/HZO/W capacitor can reach as high as 57.9μC/cm^(2)at±7.5 V.These strong ferroelectric polarization effects are ascribed to the W electrode with a fairly low thermal expansion coefficient which provides a larger in-plane tensile strain compared with TiN electrode,allowing for enhancement of o-phase formation.Moreover,the W/HZO/W capacitor also exhibits higher endurance,smaller wake-up effect(10.1%)and superior fatigue properties up to 1.5×10^(10)cycles compared to the TiN/HZO/W and W/HZO/TiN capacitors.Such improvements of W/HZO/W capacitor are mainly due to the decreased leakage current by more than an order of magnitude compared to the W/HZO/TiN capacitor.These results demonstrate that capping electrode material plays an important role in the enhancement of o-phase formation,reduces oxygen vacancies,mitigates wake-up effect and improves reliability. | Dao Wang Yan Zhang Jiali Wang Chunlai Luo Ming Li Wentao Shuai Ruiqiang Tao Zhen Fan Deyang Chen Min Zeng Jiyan Y.Dai Xubing B.Lu J-M.Liu | 2022 | Journal of Materials Science & Technology2022，，9： | 1 |
| 17 | Interfacial-Strain-Induced Structural and Polarization Evolutions in Epitaxial Multiferroic BiFeO_3(001) Thin Films显示文摘Varying the film thickness is a precise route to tune the interfacial strain to manipulate the properties of the multiferroic materials.Here,to explore the effects of the interfacial strain on the properties of the multiferroic BiFeO_3films,we investigated thickness-dependent structural and polarization evolutions of the BiFeO_3 films.The epitaxial growth with an atomic stacking sequence of BiO/TiO_2 at the interface was confirmed by scanning transmission electron microscopy.Combining X-ray diffraction experiments and first-principles calculations,a thickness-dependent structural evolution was observed from a fully strained tetragonality to a partially relaxed one without any structural phase transition or rotated twins.The tetragonality(c/a) of the BiFeO_3 films increases as the film thickness decreases,while the polarization is in contrast with this trend,and the size effect including the depolarization field plays a crucial role in this contradiction in thinner films.These findings offer an alternative strategy to manipulate structural and polarization properties by tuning the interfacial strain in epitaxial multiferroic thin films. | 郭海中 Ruiqiang Zhao Kui-juan Jin Lin Gu Dongdong Xiao Zhenzhong Yang Xiaolong Li Le Wang Xu He Junxing Gu Qian Wan Can Wang Huibin Lu Chen Ge Meng He Guozhen Yang | 2015 | 功能材料信息2015，12，3： | 1 |
| 18 | SOAP: Short Oligonucleotide Alignment Program显示文摘 | Li Ruiqiang | 2008 | Bioinformatics2008，24，5： | 1 |
| 19 | SOAP2:an improved ultrafast tool for short read alignment显示文摘 | Ruiqiang Li Chang Yu Jun Wang | 2009 | Bioinformatics2009，25，15： | 1 |
| 20 | A human gut microbial genecatalogue established by metagenomic sequencing显示文摘 | QIN Junjie LI Ruiqiang RAES J | 2010 | Nature2010，464，： | 1 |
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