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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 3 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 4 | Compound Zhebei granules combined with chemotherapy for the treatment of refractory acute leukemia: a randomized clinical trial显示文摘OBJECTIVE: To observe the effect of compound Zhebei granules(CZBG) with chemotherapy in the treatment of refractory acute leukemia.METHODS: In this multicenter, double-blind, placebo-controlled clinical trial, we used a central(online) randomization system to assign 235 patients to two treatment groups. A total of 118 patients received chemotherapy combined with CZBG(4 g,twice daily) and 117 patients received chemotherapy plus placebo. The clinical efficacy was evaluated at the end of one chemotherapeutic cycle.RESULTS: In the full analysis set, in which deaths due to disease progression were regarded as inefficacy, the rates of complete remission(CR) and partial remission(CR + PR) were 32.35% and 50.00%,respectively, for the chemotherapy combined with CZBG group, and 23.08% and 35.58%, respectively,for the chemotherapy plus placebo group. There was a statistically significant difference between the two groups according to a ysis set(PPχ2test(P < 0.05). In the per protocol analS), the CR(33.67%),CR+PR(52.04%) response rates for the chemotherapy plus CZBG group were significantly different from the response rates of the control group(CR:24.24% and CR+PR: 37.37%), respectively(P < 0.05).CONCLUSION: CZBG plus chemotherapy can improve the clinical remission rate of refractory acute leukemia after one just one therapeutic cycle. | Hou Li Yang Shulian Yang Wenhua Zhou Yuhong Liu Feng Yang Hongyong Sun Weizheng Li Dongyun Xu Yamei Chen Xinyi | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 13 |
| 5 | Transcriptome sequencing and characterization of ungerminated and germinated spores of Nosema bombycis显示文摘Nosema bombycis 是一 obligate 利用特殊机制感染 Bombyx mori 的细胞内部的寄生真菌。萌芽,通过哪个 microsporidia 感染主人房间的一个 indispensible 过程,从休眠状态为 microsporidia 被认为是一个关键发展拐弯处点到繁殖状态。因此,阐明在萌芽为寄生虫控制是关键的前后, transcriptome 变化。然而, microsporidia 的萌芽的分子的基础仍然保持未知。调查这个萌芽过程, N 的 transcriptome。bombycis ungerminated 孢子和发芽孢子被定序并且分析。超过 6000 万个高质量的抄本读用 RNA-Seq 技术从这二个组被产生。在汇编以后,分别地, 2756 和 2690 unigenes 被识别并且随后基于已知的蛋白质注解了。在差别的分析表示了基因以后, 66 基因被识别是在这二个组之间的表示的差别(P 0.05 ) 。蛋白质联系磷酸酶的基因是由 RNA-Seq 和 immunoblot 分析决定了首先被识别显著地起来调整,显示那 dephosphorylation 可能潜在地贡献 microsporidia 萌芽。编码涉及 glycometabolism,孢子墙蛋白质和 N 的篦麻毒素 B lectin 的蛋白质的 DEG。bombycis 也被分析。基因和染色体分析的基因本体论和京都百科全书揭示了为一些特定的生物函数和进程负责的基因。在这研究产生的数据集在 N 提供 transcriptome 变化的基本描述。bombycis 在萌芽期间。transcriptome 数据的分析和是与萌芽有关的柔韧的候选人基因的某些功能的基因的鉴定将帮助提供孢子萌芽和侵略的深理解。 | Han Liu Mingqian Li Xinyi He Shunfeng Cai Xiangkang He Xingmeng Lu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 10 |
| 6 | Influence of physical properties of carrier on the performance of dry powder inhalers显示文摘Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance.The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs. | Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 8 |
| 7 | Cooperative Jamming for Physical Layer Security in Hybrid Satellite Terrestrial Relay Networks显示文摘To integrate the satellite communications with the LTE/5G services, the concept of Hybrid Satellite Terrestrial Relay Networks(HSTRNs) has been proposed. In this paper, we investigate the secure transmission in a HSTRN where the eavesdropper can wiretap the transmitted messages from both the satellite and the intermediate relays. To effectively protect the message from wiretapping in these two phases, we consider cooperative jamming by the relays, where the jamming signals are optimized to maximize the secrecy rate under the total power constraint of relays. In the first phase, the Maximal Ratio Transmission(MRT) scheme is used to maximize the secrecy rate, while in the second phase, by interpolating between the sub-optimal MRT scheme and the null-space projection scheme, the optimal scheme can be obtained via an efficient one-dimensional searching method. Simulation results show that when the number of cooperative relays is small, the performance of the optimal scheme significantly outperforms that of MRT and null-space projection scheme. When the number of relays increases, the performance of the null-space projection approaches that of the optimal one. | Su Yan Xinyi Wang Zongling Li Bin Li Zesong Fei | 2019 | China Communications2019，16，12： | 7 |
| 8 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 9 | Variations in organic carbon loading of surface sediments from the shelf to the slope of the Chukchi Sea,Arctic Ocean显示文摘The content of organic carbon(OC) normalized to the specific surface area(SSA) of sediment is widely used to trace variations in OC loading(OC/SSA).This study presents observations of OC/SSA of surface sediments collected in the Chukchi Sea,a typical Arctic marginal sea.Shelf sediments exhibit much higher OC/SSA values than slope sediments in the study area.Compared with OC/SSA values reported from the East Siberian Shelf and Mackenzie River,the slope sediments possess lower OC loading.This abrupt decrease in OC/SSA is mostly related to the lower primary production on slope as well as possible oxidization processes.The results of linear regression analysis between OC and SSA indicate a sedimentary source rock for the OC in the Chukchi Sea sediments.Moreover,shelf sediments with low SSA possess a larger rock OC fraction than slope sediments do.The dataset of the present study enables a more thorough understanding of regional OC cycling in the Chukchi Sea. | LI Zhongqiao WANG Xinyi JIN Haiyan JI Zhongqiang BAI Youcheng CHEN Jianfang | 2017 | Acta Oceanologica Sinica2017，36，8： | 6 |
| 10 | Regulation of non-classical immune parameters in immune thrombocytopenic purpura mice by a spleen-invigorating,qi-replenishing and blood-containing formula显示文摘Objective:This study investigated the regulatory effect of non-classical immune parameters on immune thrombocytopenic purpura(ITP)mice by a spleen-invigorating,qi-replenishing and blood-containing formula(SQBF).Method:A total of 80 BALB/c mice were randomly divided into four equal groups(20 mice each):control group,model group,prednisone group and spleen-invigorating,qi-replenishing and blood-containing(SQBF)group.Mice in the model group,prednisone group,and SQBF group were administered anti-platelet serum to induce ITP.The dynamic variations of platelet counts in ITP mice were measured with an automatic blood analyzer before modeling and 48 h,and 8,12 and 15 days following APS injection.Levels of b-endorphin(b-EP),vasoactive intestinal peptide(VIP)and salivary IgA(SIgA)were detected by enzyme-linked immunosorbent assay(ELISA)on 15th day of experiment.Results:SQBF enhanced peripheral blood platelet counts in ITP mice similar to that of prednisone,and both groups showed a statistically significant response compared with the model group(P<.01).The SQBF significantly decreased b-EP levels compared with the model and prednisone intervention groups(P<.05),significantly increased the levels of VIP and SIgA in ITP mice compared with the model group(P<.05)and had significant protective effects on the thymus of ITP mice compared with the model group(P<.01).Conclusions:The SQBF had a similar effect to prednisone with regards to enhancing peripheral blood platelet counts in ITP mice.Furthermore,it decreased b-EP levels and increased VIP and SIgA,and protected the thymus.This shows that,on base of the brain-gut axis functions,some non-classical immune vascular active factors or neurotransmitters are also involved in immune responses,and also have relationship with the onset of ITP and bleeding and/or hemostasis.It needs further study to determine whether a change in these active factors is related to immediate hemostasis. | Tiantian Li Hao He Li Hou Yue Xu Xiaoyong Wu Yanping Sun Lei Zheng Zhixiong Chen Xinyi Chen Bei Qin | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，2： | 6 |
| 11 | In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus显示文摘As D-amino acids play important roles in the physiological metabolism of bacteria,combination of D-amino acids with antibiotics may provide synergistic antibacterial activity. The aim of the study was to evaluate in vitro and in vivo activity of D-serine alone and in combination withβ-lactams against methicillin-resistant Staphylococcus aureus(MRSA) strains, and to explore the possible sensitization mechanisms. The activity of D-serine, β-lactams alone and in combinations was evaluated both in vitro by standard MICs, time–kill curves and checkerboard assays, and in vivo by murine systemic infection model as well as neutropenic thigh infection model. An in vitro synergistic effect was demonstrated with the combination of D-serine and β-lactams against MRSA standard and clinical strains.Importantly, the combinations enhanced the therapeutic efficacy in the animal models as compared toβ-lactam alone groups. Initial mechanism study suggested possible revision of D-alanine-D-alanine residue to D-alanine-D-serine in peptidoglycan by adding of D-alanine in the medium, which may cause decreased affinity to PBPs during transpeptidation. In conclusion, D-serine had synergistic activity in combination with β-lactams against MRSA strains both in vitro and in vivo. Considering the relatively good safety of D-serine alone or in combination with β-lactams, D-serine is worth following up as new anti-MRSA infection strategies. | Qing Wang Yuemeng Lv Jing Pang Xue Li Xi Lu Xiukun Wang Xinxin Hu Tongying Nie Xinyi Yang Yan Q.Xiong Jiandong Jiang Congran Li Xuefu You | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 6 |
| 12 | Ricin-B-lectin enhances microsporidia Nosema bombycis infection in BmN cells from silkworm Bombyx mori显示文摘 | Han Liu Mingqian Li Shunfeng Cai Xinyi He Yongqi Shao Xingmeng Lu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 6 |
| 13 | New dammarane-type saponins from the leaves of Panax notoginseng显示文摘Two new triterpenoid saponins named notoginsenoside-Ng3(1) and notoginsenoside-Ng4(2) along with three known saponins (3-5), were isolated from a water extract of the leaves of Panax notoginseng. Their structures were elucidated by HRESIMS, NMR, X-ray techniques and acid hydrolysis. Moreover,compound 2 was characterized with the conjugated double bonds side-chain, which was rarely found in this plant. The absolute configuration of notoginsenoside Fa (3) with five sugars was confirmed by the single-crystal X-ray diffraction for the first time. Acetylcholinesterase inhibitory activity experiments were also conducted, all the isolated saponins showed weak inhibitory activities in the final concentration of 0.16 mmol/L. | Jiwu Huang Chuangjun Li Junzi Cao Jie Ma Yiqian Du Xinyi Liu Jingzhi Yang Dongming Zhang | 2019 | Chinese Chemical Letters2019，30，2： | 6 |
| 14 | Physical sensors for skin-inspired electronics显示文摘Skin,the largest organ in the human body,is sensitive to external stimuli.In recent years,an increasing number of skin-inspired electronics,including wearable electronics,implantable electronics,and electronic skin,have been developed because of their broad applications in healthcare and robotics.Physical sensors are one of the key building blocks of skin-inspired electronics.Typical physical sensors include mechanical sensors,temperature sensors,humidity sensors,electrophysiological sensors,and so on.In this review,we systematically review the latest advances of skin-inspired mechanical sensors,temperature sensors,and humidity sensors.The working mechanisms,key materials,device structures,and performance of various physical sensors are summarized and discussed in detail.Their applications in health monitoring,human disease diagnosis and treatment,and intelligent robots are reviewed.In addition,several novel properties of skin-inspired physical sensors such as versatility,self-healability,and implantability are introduced.Finally,the existing challenges and future perspectives of physical sensors for practical applications are discussed and proposed. | Shuo Li Yong Zhang Yiliang Wang Kailun Xia Zhe Yin Huimin Wang Mingchao Zhang Xiaoping Liang Haojie Lu Mengjia Zhu Haomin Wang Xinyi Shen Yingying Zhang | 2020 | InfoMat2020，2，1： | 5 |
| 15 | Network selection policy based on efective capacity in heterogeneous wireless communication systems显示文摘A great deal of previous research was based on the concept of Shannon theory without considering the delay characteristic.However,in reality,diferent services have diferent delay constraints.In this paper,two new network selection policies are proposed for heterogeneous wireless communication systems using efective capacity,which incorporate delay in the transmission rate.Users can access the proper network after considering the delay demands of diferent services.Our proposed policies aim to maximize the entire throughput with diferent delay constraints.Both the mathematical analysis and simulations show that the proposed network selection policies can improve network throughput while providing quality-of-service guarantees. | JIANG Jian LI JianDong HOU RongHui LIU XinYi | 2014 | Science China(Information Sciences)2014，57，2： | 5 |
| 16 | Proteomic analysis of BmN cells (Bombyx morl) in response to infection with Nosema bombycis显示文摘Nosema bombycis (N。bombycis, Nb ) 一 obligate 细胞内部的寄生虫,它能在蚕引起蚕胞子虫病疾病。调查 N 的效果。主人房间上的 bombycis 感染,从没感染 N 的 BmN 房间的 proteomes。在不同感染阶段的 bombycis 与二维的胶化电气泳动和 MALDI-TOF/TOF 集体 spectrometry 被描绘,它鉴别 24 差别与重要紧张差别表示了主人蛋白质(P < 0.05 ) 同时至少指在嘲笑 -- 并且 N。bombycis 感染了房间。尤其是,基因本体论分析证明这些蛋白质涉及许多重要生物反应。在感染阶段期间,涉及精力新陈代谢和氧化应力的蛋白质有起来调整的表示。二蛋白质参予了 ubiquitin 依赖的蛋白质分解代谢的过程有的下面调整的表示。量的即时聚合酶链反应被用来分析这些识别蛋白质的 transcriptional 侧面。一起拿,在为识别蛋白质的生物反应的丰富变化,通常认为的功能,和参予在 N 生产一个主人应答的蛋白质模型。感染 bombycis 的 BmN 房间。这些调查结果在宿主细胞上关于精力缺点寄生虫的效果推进我们的知识。 | Xinyi He Xiangkang He Han Liu Mingqian Li Shunfeng Cai Zhangwuke Fu Xingmeng Lu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 5 |
| 17 | Nosema bombycis (Microsporidia) suppresses apoptosis in BmN cells (Bombyx mori)显示文摘Nosema bombycis (N。bombycis, Nb ) 一真菌相关并且要求在蚕引起长期的蚕胞子虫病疾病的细胞内部的寄生虫。在感染主人以后,孢子从主人房间获得精力并且幸存几天。在病原体和宿主细胞之间的这共生建议那 N。bombycis 阻止 apoptosis 和宿主细胞的反应的氧种(ROS ) 生产为它的生长和发展创造最佳的环境条件。在这研究,不同方法被用来证明那 N。bombycis 在 BmN 房间压制了 apoptosis。流动 cytometry 分析结果证明孢子在感染以后在 2 和 5 天压制了 BmN 房间的 apoptosis (P < 0.05 ) 。与放线菌素 D (ActD ) 处理相比, BmN 房间的 apoptosis 显然在孢子感染以后被减少(P < 0.01 ) 。在感染以后的 48 个小时, BmN 房间的 ROS 生产在为 6 h 的 ActD 处理以后与那相比是下面调整的。而且, N。bombycis 阻止了 apoptosomes 的形成由下面调整 apaf-1 和细胞色素 C 的表示。另外, N。bombycis 也起来调整 buffy 的表示。西方的污点分析证明孢子减少了在 48 和 98 h 柱子感染的主人细胞色素 C 的水平。因此,我们的结果建议了那 N。bombycis 禁止了主人房间的 mitochondrial apoptotic 小径为它的自己的幸存创造最佳的环境。 | Xinyi He Zhangwuke Fu Mingqian Li Han Liu Shunfeng Cai Nana Man Xingmeng Lu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 18 | ROS-responsive cyclodextrin nanoplatform for combined photodynamic therapy and chemotherapy of cancer显示文摘Cyclodextrin(CD) has special spatial structure and well biological safety,so it has been widely used for constructing CD-based na noplatforms.Through functionalization,cyclodextrin can form various stimulusresponse nanoplatforms,such as pH,temperature,redox,light and magnetic fields.In this study,we designed a highly sensitive reactive oxygen species(ROS)-responsive polymer PCP which encapsulated doxorubicin(DOX) and purpurin 18(P18) to achieve the syne rgy of photodynamic and chemotherapy.The high content of reactive oxygen species(ROS) in the tumor microenvironment(TME) triggers the cleavage of the borate bond of MPEG-CD-PHB(PCP),thereby promoting the re lease of drugs.When irradiated with nea rinfrared laser,the photosensitizer P18 released by polymer micelles can produce reactive oxygen species to promote cell apoptosis.Compared with monotherapy,a series of experiments confirmed that our micelles had enhanced anti-cancer activity.This work was beneficial to the design of ROS-responsive materials and provides an effective strategy for the application of collaborative anti-tumor therapy. | Die Jia Xianbin Ma Yi Lu Xinyi Li Shengxin Hou Yuan Gao Peng Xue Yuejun Kang Zhigang Xu | 2021 | Chinese Chemical Letters2021，32，1： | 4 |
| 19 | A novel intronic circular RNA,circGNG7,inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82显示文摘Background:There is increasing evidence that circular RNAs(circRNAs)play a significant role in pathological processes including tumorigenesis.In contrast to exonic circRNAs,which are the most frequently reported circRNAs in cancer so far,the studies of intronic circRNAs have been greatly lagged behind.Here,we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma(HNSCC).Methods:We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC patients.Then,we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC patients.We also identified interactions between circGNG7 and functional proteins,which alter downstream signaling that regulate HNSCC progression.Results:In this study,we identified a new intronic circRNA,circGNG7,and validated its functional roles in HNSCC progression.CircGNG7 was predominately localized to the cytoplasm,and its expression was downregulated in both HNSCC tissues andCAL27,CAL33,SCC4,SCC9,HN6,and HN30 cells.Low expression of circGNG7 was significantly correlated with poor prognosis in HNSCC patients.Consistent with this finding,overexpression of circGNG7 strongly inhibited tumor cell proliferation,colony formation,in vitro migration,and in vivo tumor growth.Mechanistically,the expression of circGNG7 in HNSCC cells was regulated by the transcription factor SMAD family member 4(SMAD4).Importantly,we discovered that circGNG7 could bind to serine residues 78 and 82 of the functional heat shock protein 27(HSP27),occupying its phosphorylation sites and hindering its phosphorylation,which reduced HSP27-JNK/P38 mitogen-activated protein kinase(MAPK)oncogenic signaling.Downregulation of circGNG7 expression in HNSCC increased HSP27-JNK/P38 MAPK signaling and promoted tumor progression.Conclusions:Our results revealed that a new intronic circRNA,circGNG7,functions as a strong tumor suppressor and that circGNG7/HSP27-JNK/P38 MAPK signaling is a novel mechanism by which HNSCC progression can be controlled. | Houyu Ju Zhenrong Hu Dongliang Wei Jinyun Huang Xinyi Zhang Mengyu Rui Zhi Li Xiaomeng Zhang Jingzhou Hu Wei Guo Guoxin Ren | 2021 | Cancer Communications2021，41，11： | 4 |
| 20 | Electron-withdrawing functional ligand promotes CO2 reduction catalysis in single atom catalyst显示文摘Electrochemical carbon dioxide reduction reaction (CO2RR) powered by renewable electricity offers an attractive approach to reduce carbon emission and at the same time produce valuable chemicals/fuels.To design efficient CO2 reduction electrocatalyst,it is important to understand the structure-activity relationship.Herein,we design a series of single Co atoms electrocatalysts with well-defined active sites electronic structures,which exhibit outstanding CO2RR activity with controllable selectivity to CO.Experimental and density functional theory (DFT) calculation studies show that introducing nitro (amino) ligand next to single Co atom catalytic center with electron-withdrawing (electron-donating) capability favors (hinders) CO2 reduction catalysis.This work provides an in-depth understanding of how functional ligand affects the splitting of transition metal 3d electron orbital,thereby changing the electron transfer from transition metal active site to CO2,which is closely related to the Gibbs free energy of the rate-determining step (CO2+e^-+*→*CO2^-). | Xinyi Ren Song Liu Huicong Li Jie Ding Linghui Liu Zhichong Kuang Ling Li Hongbin Yang Fuquan Bai Yanqiang Huang Tao Zhang Bin Liu | 2020 | Science China Chemistry2020，63，12： | 3 |
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