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| 1 | Continuous Low-Level Vagus Nerve Stimulation Reduces Stellate Ganglion Nerve Activity and Paroxysmal Atrial Tachyarrhythmias in Ambulatory Canines显示文摘 | Mark J. Shen Tetsuji Shinohara Hyung-Wook Park Kyle Frick Daniel S. Ice Eue-Keun Choi Seongwook Han Mitsunori Maruyama Rahul Sharma Changyu Shen Michael C. Fishbein Lan S. Chen John C. Lopshire Douglas P. Zipes Shien-Fong Lin Peng-Sheng Chen | 2011 | Circulation2011，，20： | 2 |
| 2 | Direct displacement-based design for seismic retrofit of existing buildings using nonlinear viscous dampers 显示文摘 | LIN Yuyuan CHANG Kuochun CHEN Changyu | | Bull Earthquake Engineering0，6，： | 1 |
| 3 | Nonbinary LDPC-coded mode-multiplexed coherent optical OFDM 1,28-Tbit/s 16-QAM signal transmission over 2000 km of few-mode fibers with mode-dependent loss显示文摘 | Lin Changyu Djordjevic I B Zou Ding | | 0，，05： | 1 |
| 4 | Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1显示文摘Renal interstitial fibrosis(RIF)is the crucial pathway in chronic kidney disease(CKD)leading to the end-stage renal failure.However,the underlying mechanism of Shen Qi Wan(SQW)on RIF is not fully understood.In the current study,we investigated the role of Aquaporin 1(AQP1)in SQW on tubular epithelial-to-mesenchymal transition(EMT).A RIF mouse model induced by adenine and a TGF-β1-stimulated HK-2 cell model were etablished to explore the involvement of AQP 1 in the protective effect of SQW on EMT in vitro and in vivo.Subsequently,the molecular mechanism of SQW on EMT was explored in HK-2 cells with AQP1 knockdown.The results indicated that SQW alleviated kidney injury and renal collagen deposition in the kidneys of mice induced by adenine,increased the protein expression of E-cadherin and AQP1 expression,and decreased the expression of vimentin andα-smooth muscle actin(α-SMA).Similarly,treatmement with SQW-containing serum significantly halted EMT process in TGF-β1 stimulated HK-2 cells.The expression of snail and slug was significantly upregulated in HK-2 cells after knockdown of AQP1.AQP1 knockdown also increased the mRNA expression of vimentin andα-SMA,and decreased the expression of E-cadherin.The protein expression of vimentin increased,while the expression of E-cadherin and CK-18 significantly decreased after AQP1 knockdown in HK-2 cells.These results revealed that AQP1 knockdown promoted EMT.Furthermore,AQP1 knockdown abolished the protective effect of SQW-containing serum on EMT in HK-2 cells.In sum,SQW attentuates EMT process in RIF through upregulation of the expression of AQP1. | LIN Yiyou WEI Jiale ZHANG Yehui HUANG Junhao WANG Sichen LUO Qihan YU Hongxia JI Liting ZHOU Xiaojie LI Changyu | 2023 | Chinese Journal of Natural Medicines2023，21，5： | 1 |
| 5 | Integrating wireless and speech technologies for synchronous on-site data collection显示文摘 | Ming Kuan Tsai Jyh Bin Yang ChangYu Lin | 2007 | Automation in Construction2007，，16： | 1 |
| 6 | Thermome- chanical and Optical Properties of Biodegradable Poly(L- Lactide)/Silica Nanocomposites by Melt Compounding显示文摘 | Wen Xin Lin Ying Han Changyu | 2009 | Journal of Applied Polymer Science2009，114，6： | 1 |
| 7 | Shen-Qi-Wan Protects the Renal Peritubular Capillary Injury from Adenine-mediated Damage by Upregulating Aquaporin 1显示文摘Background:Shen-Qi-Wan(SQW),a commonly used prescription against chronic kidney disease(CKD)in Tradi-tional Chinese Medicine(TCM),has a nephroprotective action in adenine-induced kidney injury.However,the mechanism of SQW in renal injury remains unclear.Objective:This study was undertaken to measure the effect of SQW on peritubular capillary injury both in vivo and in vitro assays.Methods:The effect of SQW on the peritubular capillary injury was evaluated according to measuring hypothalamic-pituitary-adrenal(HPA)function,inflammatory cytokines,VEGF(vascular endothelial growth fac-tor),CD34(Cluster of differentiation 34),and AQP1(Aquaporin 1)levels in the kidney,cell migration,and lumen forming capacity.Results:SQW supplementation could ameliorate dysfunction of the HPA and renal function loss induced by adenine.SQW also significantly inhibited the inflammatory cytokines including MCP-1(monocyte chemotactic protein-1)and VCAM-1(vascular cell adhesion molecule-1)level.Alternatively,SQW administration showed an ameliorating effect from the toxicity and alleviated the injury of capillaries around renal tubules instigated by adenine through increasing AQP1 mRNA and protein level.SQW medicated the serum enhanced the migration and lumen formation ability of HMEC-1 cells,and significantly increased AQP1 protein level.Moreover,AQP1 knockdown efficiently inhibited the migration and lumen formation ability in HMEC-1 cells,and weakened the effect of SQW medicated serum.Conclusion:These results suggested that SQW attenuated peritubular capillary injury in adenine-induced CKD model rats through boosting angiogenesis in endothelial cell,and AQP1 may be a potential target of SQW for treating the renal injury. | Yuting Bao Yehui Zhang Yuanxiao Yang Xueming Chen Luning Lin Yunbo Fu Liting Ji Changyu Li | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，1： | 1 |
| 8 | Performance of diaphragm wall constructed using top-down method 显示文摘 | Ou Changyu Liao Juitang Lin Hornda | 1998 | Journal of Geotechnical and Geoenviromental Engineering1998，124，9： | 1 |
| 9 | Improved phase retrieval in holographic data storage based on a designed iterative embedded data显示文摘Embedded data are used to retrieve phases quicker with high accuracy in phase-modulated holographic data storage(HDS).We propose a method to design an embedded data distribution using iterations to enhance the intensity of the high-frequency signal in the Fourier spectrum.The proposed method increases the antinoise performance and signal-to-noise ratio(SNR)of the Fourier spectrum distribution,realizing a more efficient phase retrieval.Experiments indicate that the bit error rate(BER)of this method can be reduced by a factor of one after 10 iterations. | Changyu YU Suping WANG Ruixian CHEN Jianying HAO Qijing ZHENG Jinyu WANG Xianying QIU Kun WANG Dakui LIN Yi YANG Hui LI Xiao LIN Xiaodi TAN | 2021 | Frontiers of Optoelectronics2021，14，4： | 0 |
| 10 | VvWRKY5 enhances white rot resistance in grape by promoting the jasmonic acid pathway显示文摘Grape white rot is a disease caused by Coniella diplodiella(Speg.)Sacc.(Cd)can drastically reduce the production and quality of grape(Vitis vinifera).WRKY transcription factors play a vital role in the regulation of plant resistance to pathogens,but their functions in grape white rot need to be further explored.Here,we found that the expression of the WRKY IIe subfamily member VvWRKY5 was highly induced by Cd infection and jasmonic acid(JA)treatment.Transient injection and stable overexpression(in grape calli and Arabidopsis)demonstrated that VvWRKY5 positively regulated grape resistance to white rot.We also determined that VvWRKY5 regulated the JA response by directly binding to the promoters of VvJAZ2(a JA signaling suppressor)and VvMYC2(a JA signaling activator),thereby inhibiting and activating the transcription of VvJAZ2 and VvMYC2,respectively.Furthermore,the interaction between VvJAZ2 and VvWRKY5 enhanced the suppression and promotion of VvJAZ2 and VvMYC2 activities by VvWRKY5,respectively.When VvWRKY5 was overexpressed in grape,JA content was also increased.Overall,our results suggested that VvWRKY5 played a key role in regulating JA biosynthesis and signal transduction as well as enhancing white rot resistance in grape.Our results also provide theoretical guidance for the development of elite grape cultivars with enhanced pathogen resistance. | Zhen Zhang Changyue Jiang Cui Chen Kai Su Hong Lin Yuhui Zhao Yinshan Guo | 2023 | Horticulture Research2023，10，10： | 0 |
| 11 | Berry texture QTL and candidate gene analysis in grape(Vitis vinifera L.)显示文摘Berry texture is a noteworthy economic trait for grape;however,the genetic bases and the complex gene expression and regulatory mechanism for the diverse changes in berry texture are still poorly understood.In this study,the results suggest that it is difficult to obtain high-mesocarp firmness(MesF)and high-pericarp puncture hardness(PPH)grape cultivars with high pericarp brittleness(PerB).The high-density linkage map was constructed using whole-genome resequencing based on 151 F1 individuals originating from intraspecific hybridization between the firm-flesh cultivar‘Red Globe’and soft-flesh cultivar‘Muscat Hamburg’.The total length of the consensus map was 1613.17 cM,with a mean genetic distance between adjacent bin markers of 0.59 cM.Twenty-seven quantitative trait loci(QTLs)for berry MesF,PPH,and PerB were identified in linkage groups(LGs)1,3,4,6,8,9,10,11,14,16,and 17,including twelve QTLs that were firstly detected in LGs 6,11,and 14.Fourteen promising candidate genes were identified from the stable QTL regions in LGs 10,11,14,and 17.In particular,VvWARK2 and VvWARK8 refer to chromosome 17 and are two promising candidate genes for MesF and PPH,as the VvWARK8 gene may increase pectin residue binding with WARK for high berry firmness maintenance and the allele for VvWARK2 carrying the‘CC’and‘GA’genotypes at Chr17:1836764 and Chr17:1836770 may be associated with non-hard texture grape cultivars.In addition,real-time quantitative polymerase chain reaction(RT-qPCR)verification revealed that the promising candidate transcription factor genes VvMYB4-like,VvERF113,VvWRKY31,VvWRKY1,and VvNAC83 may regulate cell wall metabolism candidate gene expression for grape berry texture changes. | Hong Lin Li Ma Qiuyu Guo Cheng Liu Yangming Hou Zhendong Liu Yuhui Zhao Changyue Jiang Xiuwu Guo Yinshan Guo | 2023 | Horticulture Research2023，10，12： | 0 |
| 12 | 高产酒精肺炎克雷伯菌引起的非酒精性脂肪肝病显示文摘文章简介非酒精性脂肪肝(NAFLD)具有进展为肝硬化和肝细胞癌的风险,其潜在病因多种多样,目前认为NAFLD与肠道微生物群的变化有关,然而,它们之间的因果关系尚不清楚。研究团队发现肠道菌群中高产酒精的肺炎克雷伯菌(HiAlc Kpn)可能是NAFLD的一个病因。在NAFLD患者人群中,高达60%的患者肠道菌群中含有HiAlc Kpn。 | 袁静 Chen Chen Jinghua Cui Jing Lu Chao Yan Xiao Wei Xiangna Zhao NanNan Li Shaoli Li Guanhua Xue Weiwei Cheng Boxing Li Huan Li Weishi Lin Changyu Tian Jiangtao Zhao Juqiang Han Daizhi An Qiong Zhang Hong Wei Minghua Zheng Xuejun Ma Wei Li Xiao Chen Zheng Zhang Hui Zeng Sun Ying JianXin Wu Ruifu Yang 刘翟 | 2020 | 科学新闻2020，，2： | 0 |
| 13 | Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer:a randomized,non-inferiority,multicenter trial显示文摘We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757;P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. | Danhui Weng Huihua Xiong Changkun Zhu Xiaoyun Wan Yaxia Chen Xinyu Wang Youzhong Zhang Jie Jiang Xi Zhang Qinglei Gao Gang Chen Hui Xing Changyu Wang Kezhen Li Yaheng Chen Yuyan Mao Dongxiao Hu Zimin Pan Qingqin Chen Baoxia Cui Kun Song Cunjian Yi Guangcai Peng Xiaobing Han Ruifang An Liangsheng Fan Wei Wang Tingchuan Xiong Yile Chen Zhenzi Tang Lin Li Xingsheng Yang Xiaodong Cheng Weiguo Lu Hui Wang Beihua Kong Xing Xie Ding Ma | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 14 | Nonbinary LDPC BICM for Next-Generation High-Speed Optical Transmission Systems显示文摘We propose a nonbinary byte-interleaved coded-modulation scheme with inner and outer turbo-like iterative decoder.The net coding gain is 0.6 d B higher than the state-of-the-art binary single parity check(SPC)low-density parity-check(LDPC)based turbo-product counterpart,with adjustable iterations and lower error-floor.We provide the details of Bahl-CockeJelinek-Raviv(BCJR)based inner code decoder and optimum signal constellation design(OSCD)method in this paper.The single-mode fiber(SMF)channel simulation is also discussed. | LIN Changyu Ivan B. Djordjevic WANG Weiming CAI Yi | 2017 | ZTE Communications2017，15，1： | 0 |
| 15 | Normalized transfer function for characterizing conversion efficiency and harmonic distortion of all-optical sampling显示文摘A novel method for characterizing the nonlinearity of all-optical sampling is proposed based on the normalized transfer function.Simulation results demonstrate the effectiveness of our method.Furthermore,an all-optical sampling experiment is performed to verify our method.Both simulation and experiment show consistency between our method and the measurements.The method only requires normalization and polynomial fitting of the transfer curve,and enables direct expression of the nonlinearity with the coefficients of the normalized transfer function. | ZHANG ShangJian LIN ChangYu LI Xuan ZOU ZhiTai LIU Yong LIU YongZhi | 2011 | Chinese Science Bulletin2011，56，15： | 0 |
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