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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 3 | Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis显示文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs. | Zhang Dan Wang Kaihuan Zheng Jiewen Wu Jiarui Duan Xiaojiao Ni Mengwei Liu Shuyu Zhang Bing Zhao Yi | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 4 | An update: Epstein-Barr virus and immune evasion via microRNA regulation显示文摘Epstein-Barr virus(EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans. To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that micro RNAs(mi RNAs) are powerful regulators of the maintenance of cellular homeostasis. In this review, we summarize current progress on how EBV utilizes mi RNAs for immune evasion. EBV encodes mi RNAs targeting both viral and host genes involved in the immune response. The mi RNAs are found in two gene clusters, and recent studies have demonstrated that lack of these clusters increases the CD4^+ and CD8^+ T cell response of infected cells. These reports strongly indicate that EBV mi RNAs are critical for immune evasion. In addition, EBV is able to dysregulate the expression of a variety of host mi RNAs, which influence multiple immune-related molecules and signaling pathways. The transport via exosomes of EBV-regulated mi RNAs and viral proteins contributes to the construction and modification of the inflammatory tumor microenvironment.During EBV immune evasion, viral proteins, immune cells, chemokines, pro-inflammatory cytokines, and pro-apoptosis molecules are involved. Our increasing knowledge of the role of mi RNAs in immune evasion will improve the understanding of EBV persistence and help to develop new treatments for EBV-associated cancers and other diseases. | Lielian Zuo Wenxin Yue Shujuan Du Shuyu Xin Jing Zhang Lingzhi Liu Guiyuan Li Jianhong Lu | 2017 | Virologica Sinica2017，32，3： | 9 |
| 5 | Middle-Miocene transformation of tectonic regime in the Himalayan orogen显示文摘Understanding the multiple tectonic transformations during the Himalayan orogeny is significant in evaluating the evolution of Himalayan orogen.In the Gyirong area in south Tibet,deformed leucogranitic veins in the biotite-plagioclase gneisses of Greater Himalayan crystalline complex(GHC) constitute south-vergent asymmetric folds.The reconstruction of the veins shows that they experienced two generations of deformation under different tectonic regimes:an earlier top-to-north extension and a later top-to-south thrusting,implying a tectonic transformation from N-S extension to N-S shortening.Zircons LA-ICP-MS U-Pb dating of the leucogranite shows that it was emplaced during 21.03-18.7 Ma.The data suggest that the tectonic transformation occurred after 18.7 Ma.The chronological data of South Tibet detachment system(STDS) and North-South trending rift(NSTR) from Gyirong and other areas indicate that the Himalayan orogeny was in a period of tectonic transformation from N-S extension to N-S shortening during 19-13 Ma.The transformation of tectonic regime was probably controlled by the India-Asia convergence rate.An increase in the convergence rate resulted in N-S shortening of the orogen,thrusting and folding,with coeval formation of the NSTR in Tibet.A decrease in the convergence rate led to N-S extension and reactivation of the STDS. | WANG XiaoXian ZHANG JinJiang LIU Jiang YAN ShuYu WANG JiaMin | 2013 | Chinese Science Bulletin2013，58，1： | 8 |
| 6 | The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses显示文摘在真核细胞的房间的送信人 RNA (mRNA ) 周转以弄短开始 poly 在 3 鈥 ? 结束的(A) 尾巴,一个过程叫了 deadenylation。在酵母, deadenylation 反应被 CCR4 和联系 CCR4 的因素主要调停 1 (CAF1 ) ,描述得好的蛋白质建筑群的二个部件 CCR4 不说出。我们这里报导那 AtCAF1a 和 AtCAF1b,酵母 CAF1 基因的通常认为的 Arabidopsis 相当或相同的事物,部分面对咖啡因或在高温度补充酵母 caf1 异种的生长缺点。AtCAF1a 和 AtCAF1b 的表示被多重压力相关的荷尔蒙和刺激导致。在 vitro 的 AtCAF1a 和在预言的活跃地点的点变化破坏这项活动。破坏 AtCAF1a 或 AtCAF1b 的表示的 T-DNA 插入异种在压力相关的 mRNAs 的 deadenylation 是有缺点的,显示二 AtCAF1 蛋白质涉及在 vivo 的调整 mRNA deadenylation。有趣地, AtCAF1a 和 AtCAF1b 表演的单个、双的异种减少了表示致病相关( PR )基因 PR1 和 PR2 并且更产生 Pseudomonas syringae pv 西红柿 DC3000 ( Pst DC3000 )感染,而转基因的植物过去表示的 AtCAF1a 表演提高了 PR1 和 PR2 的表示并且增加了抵抗到一样的病原体。我们的结果在到病原体感染的调整 mRNA deadenylation 和防卫回答建议 AtCAF1 蛋白质的角色。 | Wenxing Liang Changbao Li Fang Liu Hongling Jiang Shuyu Li Jiaqiang Sun Xiaoyan Wu Chuanyou Li | 2009 | Cell Research2009，19，3： | 8 |
| 7 | Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage显示文摘Chemotherapeutic agents are extensively used to treat malignancies.However,chemotherapy-induced ovarian damage and reduced fertility are severe side effects.Recently,stem cell transplantation has been reported to be an effective strategy for premature ovarian insufficiency(POI)treatment,but safety can still be an issue in stem cell-based therapy.Here,we show the protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium(hUCMSC-CM)on a cisplatin(Cs)-induced ovarian injury model.hUCMSC-CM can relieve Cs-induced depletion of follicles and preserve fertility.In addition,hUCMSC-CM can decrease apoptosis of oocytes and granulosa cells induced by Cs.RNA sequencing analysis reveals the differentially expressed genes of ovaries after Cs and hUCMSC-CM treatments,including genes involved in cell apoptosis.Furthermore,we show that the granulocyte colony-stimulating factor(G-CSF)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)pathway plays an important role in protecting granulosa cells from Cs-induced apoptosis.Together,we confirm the protective effects of hUCMSC-CM on ovarian reserve and fertility in mice treated with Cs,highlighting the remarkable therapeutic effects of hUCMSC-CM. | Liming Hong Long Yan Zhimin Xin Jie Hao Wenjing Liu Shuyu Wang Shujie Liao Hongmei Wang Xiaokui Yang | 2020 | Journal of Molecular Cell Biology2020，12，5： | 7 |
| 8 | The effects of vegetation restoration strategies and seasons on soil enzyme activities in the Karst landscapes of Yunnan, southwest China显示文摘Soil enzymes play a vital role in biogeochemical cycling and ecosystem functions.In this study,we examined the response of six soil enzymes to changes in physicochemical properties resulting from changes in season and vegetation and geological conditions.Catalase,urease,acid phosphatase,invertase,amylase,and cellulase not only promote carbon,nitrogen,and phosphorus cycling,but also participate in the decomposition of harmful substances.Thirty-six soil samples were collected from karst and non-karst areas in two different seasons and from three different types of vegetation in Yunnan province,southwest China.Both vegetation types and season had significant effects on soil physicochemical properties and enzyme activities.In the same plot,soil water content,electrical conductivity,organic carbon,total nitrogen,and total phosphorus increased in the rainy season,indicating enhanced microbial metabolic activity.With the exception of urease activity,the remaining five enzymes showed higher activity in the rainy season.Changes in activities between the two seasons were significant in all samples.In the same season,activity levels of soil enzymes were higher in karst areas than in non-karst areas,and higher in natural forest than in artificial forests.The transformative abilities of soil elements are higher in karst areas than in non-karst areas,and higher in natural forests than in artificial forests.Correlation analysis showed that the activities of the six enzymes correlated significantly;however,soil physical and chemical indices,such as organic matter,pH,and moisture,which are essential for enzyme activity,differed by season.Redundancy analysis also revealed that the main factors influencing enzyme activity differed between the two seasons.The results from this study provide a theoretical basis for further research on the restoration of natural ecological systems in karst landscapes. | Zhouzhou Fan Shuyu Lu Shuang Liu Zhaorong Li Jiaxin Hong Jinxing Zhou Xiawei Peng | 2020 | Journal of Forestry Research2020，31，5： | 5 |
| 9 | Responses of plant community to the linkages in plant-soil C:N:P stoichiometry during secondary succession of abandoned farmlands,China显示文摘Succession is one of the central themes of ecology;however,the relationship between aboveground plant communities and underground soils during secondary succession remains unclear.In this study,we investigated the composition of plant community,plant-soil C:N:P stoichiometry and their relationships during secondary succession after the abandonment of farmlands for 0,10,20,30,40 and 50 a in China,2016.Results showed that the composition of plant communities was most diverse in the farmlands after secondary succession for 20 and 50 a.Soil organic carbon and total nitrogen contents slightly decreased after secondary succession for 30 a,but both were significantly higher than those of control farmland(31.21%-139.10%and 24.24%-121.21%,respectively).Moreover,C:N ratios of soil and microbe greatly contributed to the changes in plant community composition during secondary succession of abandoned farmlands,explaining 35.70%of the total variation.Particularly,soil C:N ratio was significantly and positively related with the Shannon-Wiener index.This study provides the evidence of synchronous evolution between plant community and soil during secondary succession and C:N ratio is an important linkage between them. | LIU Weichao FU Shuyue YAN Shengji REN Chengjie WU Shaojun DENG Jian LI Boyong HAN Xinhui YANG Gaihe | 2020 | Journal of Arid Land2020，12，2： | 5 |
| 10 | Effects of regulated deficit irrigation on soil salinity,physiological processes and fruit quality of gray jujube under desert conditions显示文摘Regulated deficit irrigation(RDI)was applied to gray jujube trees in an oasis region,to determine the effects of this irrigation system on soil salinity,gray jujube physiological processes,fruit yield,and fruit quality.Treatments consisted of severe,moderate and low deficit irrigation(irrigated with 85%,70%and 55%of CK,respectively)at the flowering stage to fruit set stage.During the other growth stages,all treatments were irrigated with 80%of pan evaporation,which was the same as that in control.The results indicated that soil salinity was enhanced during the periods of water stress,but the high value of soil salinity declined by 3.48%-37.27%,at each depth,after irrigation was resumed.RDI caused a decline in the photosynthetic rate,transpiration rate,and stomatal conductance,but enhanced the water use efficiency of the leaves.However,the leaf photosynthetic rate was effectively enhanced after the recovery of irrigation,especially in the moderate deficit irrigation treatment,which exceeded the control.This led to an improved fruit yield,which was 9.57%higher than that of the control.The deficit treatments caused a significant increase in the soluble solid content,soluble sugar content,single fruit weight and sugar/acid ratio.Enhanced vitamin C content,resulting from deficit treatments,has also been observed in the gray jujube.Therefore,this research shows that RDI provides some benefits in the production of gray jujube trees in desert conditions. | Zhipeng Liu Chengli Zhu Shuyu Wu Weihua Guo Yitikaer Abudushalamu Xiyun Jiao Shipei Gao Jie Wang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，3： | 3 |
| 11 | Recent developments and progress of inorganic photo-stimulated phosphors显示文摘Photo-stimulated luminescence(PSL) is the process in which trapped charges are released by photons and produce luminescence through recombination. The variegated optical characteristics of photostimulated phosphors(PSPs) have drawn increasing attention and a large body of work encompassing mechanism and application of PSPs has been addressed. The optical data storage capacity resulting from abundant defect states enables PSPs to be applied to information storage. Moreover, PSPs provide potential application for anti-counterfeiting, as color changes due to the tunneling process. Recently, near infrared(NIR) light PSPs have been developed, exhibiting enormous potential for in vivo bio-imaging, as the stable and high noise-signal ratio characteristic of PSL. In this review, we devote to introducing the development and process of PSPs, and the challenge and future advance have also been demonstrated. | Xiaotong Fan Zhichao Liu Xiuxia Yang Wenbo Chen Wei Zeng Shuyu Tian Xue Yu Jianbei Qiu Xuhui Xu | 2019 | Journal of Rare Earths2019，37，7： | 2 |
| 12 | Ultra-robust triboelectric nanogenerator for harvesting rotary mechanical energy显示文摘 | Xinyu Du Nianwu Li Yuebo Liu Jiaona Wang Zuqing Yuan Yingying Yin Ran Cao Shuyu Zhao Bin Wang Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，5： | 2 |
| 13 | Three-dimensional structure of the hepatitis B core antigen particle truncated at residue 154显示文摘The three-dimensional structure of recombinant hepatitis B core antigen(HBcAg) particles truncated at residue 154(HBcAg-154) was determined to 7.8 ? resolution by cryo-electron microscopy(cryoEM) and computer reconstruction.The capsid of HBcAg-154 is mainly constituted by α-helical folds,highly similar to that of HBcAg-149.The C-terminal region between residues 155 and 183 of the core protein is more crucial to the encapsidation of RNA,and the short C-terminal tail of HBcAg-154 results in a nearly empty capsid. | LIU ShuYu HE Jian LI KunPeng DAI AGuang CAI ChangJie ZHANG JingQiang | 2011 | Science China(Life Sciences)2011，54，2： | 2 |
| 14 | Assessment of Co-Cr-Ni ternary system by CALPHAD technique显示文摘The Co-Cr-Ni ternary system was critically assessed using the CALPHAD technique.The solution phases including the liquid,γ(Co,Ni),εCo and αCr phases were described by a substitutional solution model.The·phase was characterized by a three-sublattice model of (Co,Ni)8Cr4(Co,Cr,Ni)18 in order to reproduce its homogeneity range determined by experiments.A self-consistent set of thermodynamic parameters for each phase was derived. | Yang, Shuyu Jiang, Min Li, Hongxiao Liu, Yang Wang, Lei | 2012 | Rare Metals2012，31，1： | 2 |
| 15 | RhizoVision Crown:An Integrated Hardware and Software Platform for Root Crown Phenotyping显示文摘Root crown phenotyping measures the top portion of crop root systems and can be used for marker-assisted breeding,genetic mapping,and understanding how roots influence soil resource acquisition.Several imaging protocols and image analysis programs exist,but they are not optimized for high-throughput,repeatable,and robust root crown phenotyping.The RhizoVision Crown platform integrates an imaging unit,image capture software,and image analysis software that are optimized for reliable extraction of measurements from large numbers of root crowns.The hardware platform utilizes a backlight and a monochrome machine vision camera to capture root crown silhouettes.The RhizoVision Imager and RhizoVision Analyzer are free,open-source software that streamline image capture and image analysis with intuitive graphical user interfaces.The RhizoVision Analyzer was physically validated using copper wire,and features were extensively validated using 10,464 groundtruth simulated images of dicot and monocot root systems.This platform was then used to phenotype soybean and wheat root crowns.A total of 2,799 soybean(Glycine max)root crowns of 187 lines and 1,753 wheat(Triticum aestivum)root crowns of 186 lines were phenotyped.Principal component analysis indicated similar correlations among features in both species.The maximum heritability was 0.74 in soybean and 0.22 in wheat,indicating that differences in species and populations need to be considered.The integrated RhizoVision Crown platform facilitates high-throughput phenotyping of crop root crowns and sets a standard by which open plant phenotyping platforms can be benchmarked. | Anand Seethepalli Haichao Guo Xiuwei Liu Marcus Griffiths Hussien Almtarfi Zenglu Li Shuyu Liu Alina Zare Felix B.Fritschi Elison B.Blancaflor Xue-Feng Ma Larry M.York | 2020 | Plant Phenomics2020，2，1： | 2 |
| 16 | Detection of organophosphorus compounds using a molecularly imprinted photonic crystal显示文摘 | Feng Liu Shuyue Huang Fei Xue Yifei Wang Zihui Meng Min Xue | 2011 | Biosensors and Bioelectronics2011，，1： | 2 |
| 17 | Copper-Catalyzed Asymmetric Hydroamination:A Unified Strategy for the Synthesis of Chiralβ-Amino Acid and Its Derivatives显示文摘Catalytic asymmetric aza-Michael represents one of the most convenient and atom-economical approaches for the rapid construction of biologically active chiralβ-amino acid frameworks.However,the direct enantioselective addition of nitrogen-based nucleophiles to intrinsically low reactivity ofα,β-unsaturated carboxylic acid,ester,and amide,as well as simpleα,β-unsaturated nitrile,remains a long-standing challenge. | Ge Zhang Yujie Liang Tao Qin Tao Xiong Shuyu Liu Wei Guan Qian Zhang | 2021 | CCS Chemistry2021，3，7： | 1 |
| 18 | The analysis of the electro-mechanical model of the cylindrical radial composite iezoelectric ceramic transducer显示文摘 | Liu Shiqing Lin Shuyu | 2009 | Sensors and Actuators A2009，155，1： | 1 |
| 19 | Research on the threshold effect of population aging on the industrial structure upgrading in China显示文摘This paper constructs coefficients of the integral and the internal structure upgrading in the secondary and tertiary industries, selects per capita real gross domestic product as a threshold variable and build panel threshold model according to inter-provincial panel data of China from 1998 to 2016. Results indicated that population aging has a double threshold effect on the integral industrial structure upgrading, whose influence increases first and then decreases, significantly promoting the upgrading process. As for internal structure, population aging has no significant threshold effect on the upgrading in the secondary industry, but exerts a single negative threshold effect in the tertiary industry. When economic development is under the threshold, its negative impact is greater. Further analysis also suggests that regional differences exist significantly in the threshold effect of population aging on the industrial structure upgrading. | Chengkun Liu Shuyu Li Xindong Zhao | 2019 | Chinese Journal of Population,Resources and Environment2019，17，1： | 1 |
| 20 | Exosomes in cancer immunoediting and immunotherapy显示文摘As an important means of communication among cells,exosomes are being studied more and more widely,especially in the context of cancer immunotherapy.In the phase of tumor immunoediting,exosomes derived from tumor cells and different immune cells have complex and changeable physiological functions,because they carry different proteins and nucleic acid from the source cells.Based on the role of exosomes in the communication between different cells,cancer treatment methods are also under continuous research.This review briefly introduces the molecular composition of exosomes,which is closely related to their secretion mechanism.Subsequently,the role of exosomes encapsulating different information molecules is summarized.The role of exosomes in the three phases of tumor immunoediting is introduced in detail,and the relevant literature of exosomes in the tumor immunemicroenvironment is summarized by using a novel framework for extracting relevant documents.Finally,it summarizes the various exosome-based immunotherapies currently proposed,as well as the challenges and future prospects of exosomes in tumor immunotherapy. | Yarong Zhao Luotong Liu Rongze Sun Guilin Cui Shuyu Guo Songren Han Ziwei Li Tian Bai Lesheng Teng | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 1 |
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