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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | The Arabidopsis P450 protein CYP82C2 modulates jasmonateinduced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis显示文摘Jasmonic 酸(JA ) 是对草食动物和一些微生物引起的病原体调整大量植物防卫回答的一个丰满的导出酸的发信号分子。分子的基因研究证实了 JA 也在植物开发的几个方面执行一个关键角色。这里,我们描述 Arabidopsis 变异的 jasmonic acid-hypersensitive1-1 (jah1-1 ) 的描述,它在 JA 回答的几个方面是有缺点的。尽管异种在根生长抑制展出增加的敏感到 JA,它显示出 JA 可诱导的防卫基因和减少的抵抗的减少的表示到 necrotrophic 真菌 Botrytis cinerea。基因克隆研究显示这些缺点被一个变化在细胞色素 P450 蛋白质 CYP82C2 引起。我们提供证明的证据到 B 的 jah1-1 异种的损害抵抗。cinerea 被导致 JA 的防卫基因的减少的表示伴随并且减少了导致 JA 的吲哚 glucosinolates (IG ) 的累积。相反地,提高的抵抗到 B。在 CYP82C2-overexpressing 植物的 cinerea 被导致 JA 的防卫基因的增加的表示伴随并且提高了导致 JA 的 IG 的层次。我们证明 CYP82C2 影响 IG biosynthetic 先锋的导致 JA 的累积色氨酸(Trp ) ,然而并非导致 JA 的 IAA 或导致病原体的 camalexin。一起,我们 CYP82C2 可以在导出 Trp 的第二等的代谢物的新陈代谢扮演在下面的一个假设在 JA 在哪个铺平调节的结果支持被提高。jah1-1 异种应该因此在向理解位于调停 JA 的微分回答的复杂性下面的机制的未来研究是重要的,它是重要的让植物使他们的生长适应千变万化环境。 | Fang Liu Hongling Jiang Songqing Ye Wen-Ping Chen Wenxing Liang Yingxiu Xu Bo Sun Jiaqiang Sun Qiaomei Wang Jerry D Cohen Chuanyou Li | 2010 | Cell Research2010，20，5： | 10 |
| 3 | NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human coloreetal cancer显示文摘Colorectal 癌症(CRC ) 是与病态和死亡的增加的发生被联系的一个普通恶意的肿瘤。鼻咽的联系癌的基因(NGX6 ) 6 是肿瘤转移的新奇候选人 suppressor 基因,它在 CRC 是下面调整的。在现在的学习,我们构造了 colorectal 织物 microarray 在 CRC 纸巾检验 NGX6, phospho-c-Jun N 终端 kinase (p-JNK ) ,和 phospho 细胞外的调整信号的 kinase (津贴) 的表示侧面。而 p-JNK 和津贴的表情在 CRC 纸巾是更高的,我们发现 NGX6 表示在 CRC 纸巾和变形淋巴节点是更低的,比在正常肠的 mucosa。NGX6, p-JNK,和津贴的表情与 colorectal 纸巾的临床的病理学的特征被联系。NGX6 overexpression 禁止了激活和 JNK1 的原子 translocation,它在细胞质导致了 p-JNK 的累积,但是没禁止激活和 ERK1/2 的原子 translocation。NGX6 也禁止了抄写因素 AP-1 (c-jun 和 c-fos ) 和 Ets-1 的表示。另外, NGX6 overexpression 减少了 cyclin D1 并且戏剧性地的表示压制了 cyclin D1 倡导者的 transcriptional 效率。我们建议那 NGX6 表情沉醉于人的 colorectal carcinogenesis 的多步过程。它的 overexpression 能禁止抄写因素的表示 AP-1 和 Ets-1,和下面调整在人的 CRC 的 cyclin D1 倡导者的 transcriptional 活动。 | Ya Peng Hongtao Li Minghua Wu Xiaoyan Wang Songqing Fan Fen Liu Bo Xiang Qin Guo Xueyuan Tang Shourong Shen | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 8 |
| 4 | Oil Shale Resources and Its Distribution in China显示文摘油页岩是有高灰内容,油收益比 3.5% 高的一种稳固的易燃的器官的矿物质,热产量比 4187J/g 等于或高。它也在有机物的高内容展示,主要象 sapropel 腐殖一样 sapropel 和腐殖的物质创作了。页岩油能在低温度通过干燥蒸馏被获得。作为一种重要精力和非常规的油和煤气的资源,油页岩尽最大努力起一个重要作用燃料和热电。 | Liu Zhaojun Dong Qingshui Zhu Jianwei Guo Wei Ye Songqing Liu Rong Zhang Hailong | 2007 | China Oil & Gas2007，14，3： | 2 |
| 5 | A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5显示文摘Studies of herpes simplex virus type 1(HSV-1)infection have shown that many known and unknown cellular molecules involved in viral proliferation are up-regulated following HSV-1 infection.In this study,using two-dimensional polyacrylamide gel electrophoresis,we found that the expression of the HSV-1 infection response repressive protein(HIRRP,GI 16552881)was up-regulated in human L02 cells infected with HSV-1.HIRRP,an unknown protein,was initially localized in the cytoplasm and then translocated into the nucleus of HSV-1-infected cells.Further analysis showed that HIRRP represses HSV-1proliferation by inhibiting transcription of the viral genome by interacting with the cellular transcription factor,ATF5,via its N-terminal domain.ATF5 represses the transcription of many host genes but can also act as an activator of genes containing a specific motif.We found that ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection;HIRRP then induces feedback repression of this transcription by interacting with ATF5. | WU LianQiu ZHANG XueMei CHE YanChun ZHANG Ying TANG SongQing LIAO Yun NA RuiXiong XIONG XiangLin LIU LongDing LI QiHan | 2013 | Science China(Life Sciences)2013，56，12： | 2 |
| 6 | Stability analysis of complex -valued neural networks with probabilistic time - varying delays 显示文摘 | SONGQ K ZHAO Z J LIU Y R | 2015 | NEUROCOMPUTING2015，159，： | 1 |
| 7 | The value of muhidetectorrow CT in the preoperative detection of pancreatic insulinomas 显示文摘 | Liu Y SongQ Jin HT | 2009 | Radio Med2009，114，8： | 1 |
| 8 | Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl- d -aspartate receptor 2B subunit显示文摘 | YaGuo Zheng SongQing Cui Yue Liu Juan Zhang Wei Zhang Jing Zhang XiaoPing Gu ZhengLiang Ma | 2012 | Brain Research Bulletin (-)2012，，4： | 1 |
| 9 | Composite Metallogenic Systems in the Weihai Area of Shandong and Evolution of Continental Dynamic Regimes显示文摘摘要:把地区性的地质的调查基于9张l:50,000规模并且由 metallogenic 系统的理论和综合分析指导了结构并且 metallogenic 特征,这份报纸在此提出 Weihai 区域的合成 metallogenic 系统,山东省,瞄准在区域在起源和众多的存款的控制矿石的结构上解决这些问题。它的科学意义在下列三个方面被反映:(1 ) 合成 metallogenic 系统的基本特征能被认出,它由二种类型组成:原生地变形热水的 metallogenic 系统和中生代 magmatic 热水的 metallogenic 系统(即 Indosinian 早 Yanshanian 接触交代矿床 metallogenic 系列和中间迟了的 Yanshanian magmatic 热水的 metallogenic 系列) 。二个系列分别地显示弓形、 NW 正确的侧面的安排和 N-S 平行带的分布,与相应矿物质集合是 Au+Ag+Pb+Zn,等等;并且 Cu+Mo+Fe, Au+Ag+Cu+Pb-Zn+Mo+Co-Ni+suIfides+silicides+K-feldspar,等等(2 ) 合成 metallogenic 系统可以被用来解释沉积物的复杂基因关系。通过在三主要 metallogenic 之间的关系的分析,间隔和他们的相应来源摇系列(Jingshan 和 Rongcheng 组;超级单位的 Wendong 和早中间的 Yanshanian Weideshan 超级单位;并且中间迟了的 Yanshanian Weideshan 和 Laoshan 超级单位) 象 Fanjiabu 金沉积物的案例研究一样,我们区分了在接触交代矿床(skarn类型)之间的同宗象 noncognate 重叠在之间一样的 metallogenic 系列和magmatic热水的 metallogenic 系列二并且变形热水的 metallogenic 系统。(3 ) 合成 metallogenic 系统是容易与大陆人的进化有关动态政体。变形热水的 metallogenic 系统的形成从扩展经历了 tectono 动态的政体的三种不同类型的转变 ? 压缩 ? 砍接触交代矿床(skarn 类型) 的从压缩的 metallogenic 系统 ? 扩展 ? 压缩;并且从扩展的 magmatic 热水的 metallogenic 系统的 ? 和平的板的 subductive 压缩。三种类型的进化都被归因于洞关上或 paleocontinent 的分叉集中,和所有他们的矿化作用从集中的结束对应于转变的间隔到 Weihai paleocontinent 的早集成。都,这些将有益于我们大陆人 metallogenic 过程的动力学的更深的学习。 | SUN Zhongshi WANG Peifu DENG Jun WANG Qingfei WANG Jianping MU Taisheng SUN Li FAN Siqi YE Songqing LIU Zhenghong CUI Shuxue | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 1 |
| 10 | Component Evaporation of Ti-15-3 Melt during ISM Processing显示文摘How to control melt composition is the key for getting high quality alloy melt. The paper made the following efforts: (1) The activity coefficients in Ti-15-3 melt have been calculated. (2) Taking advantage of the activity coefficients, the evaporation losses of components in Ti-15-3 melt during ISM process have been studied. The calculated results show that there is a critical vacuum degree (about 1.33 Pa) during melting process. | Yanqing SU Jingjie GUO HongSheng DING Songqing LIU Yuan LIU GuiZhong LIU and Jun JIA National Key Laboratory of Precision Hot Processing of Metals, Harbin institute of Technology, Harbin 150001, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 1 |
| 11 | Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl- d -aspartate receptor 2B subunit显示文摘 | YaGuo Zheng SongQing Cui Yue Liu Juan Zhang Wei Zhang Jing Zhang XiaoPing Gu ZhengLiang Ma | 2012 | 2012 (4-5)2012，，4： | 1 |
| 12 | Renewable phenol biosensor based on a tyrosinase - colloidal gold modified carbon paste electrode显示文摘 | LIU Songqing YU Jiuhong JU Huangxian | 2003 | J Electroanal Chem2003，540，： | 1 |
| 13 | Experiments on the influences of well pattern on water flooding characteristics of dissolution vug-cave reservoir显示文摘Based on the similarity criterion, volcanic rock samples were taken from outcrops to make experimental models. Water flooding experiments of five-spot well pattern, nine-spot well pattern, five-spot to nine-spot well pattern, the relationship between relative well and fracture positions, and injection rate in dissolution vug-cave reservoirs with/without fractures were carried out to analyze variation regularities of development indexes, find out development characteristics of water flooding with different well patterns and sort out the optimal water flooding development mode. For dissolution vug-cave reservoirs without fractures, five-spot well pattern waterflooding has very small sweeping area, serious water channeling and low oil recovery. When the well pattern was adjusted from five-spot to nine-spot well pattern, oil recovery could be largely improved, but the corner well far from the injector is little affected. In dissolution vug-cave reservoirs with fractures, when the injector and producer are not connected by fractures, the fractures could effectively connect the poorly linked vugs to improve the development effect of water flooding. Whether there are fractures or not in dissolution vug-cave reservoirs, the development effect of nine-spot well-pattern is much better than that of five-spot well pattern and five-spot to nine-spot well pattern, this is more evident when there are fractures, and the edge well has better development indexes than corner well. At the high-water cut stage of water flooding with nine-spot well pattern, the oil recovery can be further improved with staggered line-drive pattern by converting the corner well into injection well. It is helpful to increase the oil production of corner well of nine-spot well pattern by increasing the injection rate, and improve ultimate oil recovery, but the water-free production period would be greatly shortened and water-free recovery would decrease. | WANG Jing LIU Huiqing ZHANG Jing ZHAO Wei HUANG Yitao KANG Zhijiang ZHENG Songqing | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 14 | Modeling and analysis of actively Q-switched Fe:ZnSe laser pumped by a 2.8μm fiber laser显示文摘A theoretical model concerning active Q-switching of an Fe:ZnSe laser pumped by a continuous-wave(CW)2.8μm fiber laser is developed.Calculations are compared with the recently reported experiment results,and good agreement is achieved.Effects of principal parameters,including pump power,output reflectivity,ion concentration and temperature of crystal,on the laser output performance are investigated and analyzed.Numerical results demonstrate that similar to highly efficient CWFe:ZnSe laser,low temperature of the crystal is significant to obtain high peak power Q-switched pulses.The numerical simulation results are useful for optimizing the design of actively Q-switched Fe:ZnSe laser. | LIANG Xiaolin ZHOU Songqing LIU Zhizhuang BAO Bengang | 2023 | Optoelectronics Letters2023，19，9： | 0 |
| 15 | BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway显示文摘Increasing evidence has shown a strong association between tumor-suppressor genes and inflammation.However,the role of BRD7 as a novel tumor suppressor in inflammation remains unknown.In this study,by observing BRD7 knockout mice for 6–12 months,we discovered that compared with BRD7+/+mice,BRD7^(−/−)mice were more prone to inflammation,such as external inflammation and abdominal abscess.By using mouse embryo fibroblast(MEF)cells from the BRD7 knockout mouse,an in vitro lipopolysaccharide(LPS)-stimulated MEF cell line was established.The mRNA levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),chemokine(C-X-C motif)ligand 1(CXCL-1)and inducible nitric oxide synthase(iNOS)were significantly increased in BRD7^(−/−)MEF cells compared with BRD7+/+MEF cells after LPS stimulation for 1 or 6 h.In addition,the cytoplasm-to-nucleus translocation of nuclear factor kappa-B(NF-κB;p65)and an increased NF-κB reporter activity were observed in BRD7^(−/−)MEF cells at the 1 h time point but not at the 6 h time point.Furthermore,an in vivo dextran sodium sulfate(DSS)-induced acute colitis model was created.As expected,the disease activity index(DAI)value was significantly increased in the BRD7^(−/−)mice after DSS treatment for 1–5 days,which was demonstrated by the presence of a significantly shorter colon,splenomegaly and tissue damage.Moreover,higher expression levels of IL-6,TNF-α,p65,CXCL-1 and iNOS,and an increased level of NF-κB(p65)nuclear translocation were also found in the DSS-treated BRD7^(−/−)mice.These findings suggest that BRD7 has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway,which provides evidence to aid in understanding the therapeutic effects of BRD7 on inflammatory diseases. | Ran Zhao Yukun Liu Heran Wang Jing Yang Weihong Niu Songqing Fan Wei Xiong Jian Ma Xiaoling Li Joshua B Phillips Ming Tan Yuanzheng Qiu Guiyuan Li Ming Zhou | 2017 | Cellular & Molecular Immunology2017，14，10： | 0 |
| 16 | Controlling factors of remaining oil distribution after water flooding and enhanced oil recovery methods for fracturecavity carbonate reservoirs in Tahe Oilfield显示文摘Based on comprehensive analysis of core, well logging, seismic and production data, the multi-scale reservoir space, reservoir types, spatial shape and distribution of fractures and caves, and the configuration relationship with production wells in fracture-cavity carbonate reservoirs were studied systematically, the influence of them on the distribution of residual oil was analyzed, and the main controlling factors mode of residual oil distribution after water flooding was established. Enhanced oil recovery methods were studied considering the development practice of Tahe oilfield. Research shows that the main controlling factors of residual oil distribution after water flooding in fracture-cavity carbonate reservoirs can be classified into four categories: local high point, insufficient well control, flow channel shielding and weak hydrodynamic. It is a systematic project to improve oil recovery in fracture-cavity carbonate reservoirs. In the stage of natural depletion, production should be well regulated to prevent bottom water channeling. In the early stage of waterflooding, injection-production relationship should be constructed according to reservoir type, connectivity and spatial location to enhance control and producing degree of waterflooding and minimize remaining oil. In the middle and late stage, according to the main controlling factors and distribution characteristics of remaining oil after water flooding, remaining oil should be tapped precisely by making use of gravity differentiation and capillary force imbibition, enhancing well control, disturbing the flow field and so on. Meanwhile, backup technologies of reservoir stimulation, new injection media, intelligent optimization etc. should be developed, smooth shift from water injection to gas injection should be ensured to maximize oil recovery. | ZHENG Songqing YANG Min KANG Zhijiang LIU Zhongchun LONG Xibin LIU Kunyan LI Xiaobo ZHANG Shiliang | 2019 | Petroleum Exploration and Development2019，46，4： | 0 |
| 17 | Targeted Poverty Alleviation and Justice显示文摘Poverty generally means a lack of material wealth,but this lack is often regarded as an evil,a symptom to be treated;thus,in the actual context,poverty reduction at all costs becomes a recognized good.Nevertheless,poverty may cause“evil”,but poverty itself does not mean evil.If multiple moral evaluations of poverty are eliminated,the impoverished individuals,especially those preferring to a lifestyle of rejection of material comforts can be looked at from a position of value-neutrality.In this way,poverty neither means evil nor deprivation of capabilities.Consequently,the ethical basis of the strategy,“Targeted Poverty Alleviation”should not be based on the moral judgment that“poverty is evil”or the ethical narrative that“poverty may lead to evil”,but rather“social justice”in this sense.Here I present an account that,“poverty”may take many forms in reality and“Targeted Poverty Alleviation”should have its restraint or limitations;meanwhile,defending the freedom and dignity of those who lack wealth is a more fundamental form of justice than reducing poverty. | LIU Songqing CHEN Shuiying | 2022 | Cultural and Religious Studies2022，10，5： | 0 |
| 18 | Bi_(2)O_(2)Se nanoplates for broadband photodetector and full-color imaging applications显示文摘Broadband light detection and sensing are widely applied in modern technology.As a promising candidate for next-generation two-dimensional(2D)optoelectronic material,bismuth oxyselenide(Bi_(2)O_(2)Se)nanoplates exhibit many prospects in the application of visible light detection due to their peculiar properties.In this work,we report the photodetection performance of single-crystal 2D Bi_(2)O_(2)Se nanoplates grown on SiO_(2)based on a ternary-alloy growth model by utilizing chemical vapor deposition(CVD).The Bi_(2)O_(2)Se nanoplates were found to have an even and uniform square shape with side lengths up to 15μm and an approximate thickness of 15 nm.A visible-light photodetector was fabricated based on a CVD-grown Bi_(2)O_(2)Se nanoplate,and characterized by a set of illumination experiments using a 400 nm laser at temperatures ranging from 77 to 370 K.The device exhibited superior performance at the temperature of 77 K,with a responsivity of 523 A/W,a specific detectivity of 1.37×10^(11)Jones,a response time of 0.2175 ms,an external quantum efficiency of 162,119.44%,resulting in high-quality and fullcolor imaging in the visible spectrum.These results indicate that the single-crystalline Bi_(2)O_(2)Se nanoplates have excellent potential in broadband photodetection and non-cryogenic imaging. | Han Wang Songqing Zhang Xingxuan Wu Huijia Luo Junliang Liu Zesheng Mu Ruirui Liu Guang Yuan Yujun Liang Jin Tan Yongling Ren Wen Lei | 2023 | Nano Research2023，16，5： | 0 |
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