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| 1 | ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression显示文摘Mutations in LR RK2(Leucine rich repeat kinase 2)are a major cause of Parkinson’s disease(PD).We and others reported recently that expression of the pathogenic gain-of-function mutant form of LRRK2,LRRK2 G2019S,induc-es mitochondrial fi ssion in neurons through DLP1.Here we provide evidence that expression of LRRK2 G2019S stimulates mitochondria loss or mitophagy.We have char-acterized several LRRK2 interacting proteins and found that LRRK2 interacts with ULK1 which plays an essential role in autophagy.Knockdown of either ULK1 or DLP1 expression with shRNAs suppresses LRRK2 G2019S expression-induced mitochondrial clearance,suggesting that LRRK2 G2019S expression induces mitochondrial fi ssion through DLP1 followed by mitophagy via an ULK1 dependent pathway.In addition to ULK1,we found that LRRK2 interacts with the endogenous MKK4/7,JIP3 and coordinates with them in the activation of JNK signaling.Interestingly,LRRK2 G2019S-induced loss of mitochon-dria can also be suppressed by 3 different JNK inhibitors,implying the involvement of the JNK pathway in the path-ogenic mechanism of mutated LRRK2.Thus our fi ndings may provide an insight into the complicated pathogenesis of PD as well as some clues to the development of novel therapeutic strategies. | Yuangang Zhu Chunyan Wang Mei Yu Jie Cui Liang Liu Zhiheng Xu | 2013 | Protein & Cell2013，4，9： | 6 |
| 2 | Towards a universal organogelator:A general mixing approach to fabricate various organic compounds into organogels显示文摘Low-molecular-weight organogels(LMOG) have been attracting a surge interest in fabricating soft materials.Although the finding of the gelator molecules has been developed from serendipity to objective design,the achievement of the gelator molecules still needs good design and tedious organic synthesis.In this paper,we proposed a simple and general mixing approach to get the organogel for nearly all the organic compounds and even soluble nanoparticles without any modification.We have designed a universal gelator molecule,which forms organogels with more than 40 kinds of organic solvents from aploar to polar solvents.More interestingly,when other organic compounds or even nanomaterials,which are soluble in certain organic solvents,are mixed with this gelator molecule,they can form organogels no matter whether the individual compounds could form organogel or not.This method is applicable to nearly all kinds of soluble organic compounds and opens an efficient and universal way to fabricate gel materials. | DUAN PengFei LI YuanGang JIANG Jian WANG TianYu LIU MingHua | 2011 | Science China Chemistry2011，54，7： | 5 |
| 3 | Developing conservation strategies for Pinus koraiensis and Eleutherococcus senticosus by using model-based geographic distributions显示文摘We described potential changes in the geographic distribution and occurrence probability of Pinus koraiensis Sieb. et Zucc. and Eleutherococcus senticosus(Rupr. et Maxim.) Maxim. in the counties of northeast China. This information was used to identify priority areas for protection and provide protection and management recommendations within each studied county. The two species were mapped in 2884 study plots throughout this region over a 4-year period(38 400N–53 300 N, 115 050E–135 020E). We used the species distribution models(Maxent), systematic conservation planning models(Marxan), and Geographic Information Systems(Arc GIS10.0). The distributions of two species were correlated in the study area, enabling unique and economically viable joint conservation measures to be implemented. Three models were combined to identify feasible priority conservation sites. We used local spatial statistics to assess all identified conservation areas in relation to potential climate change based shifts in the geographic distribution of the two species. Model-based conservation strategies were used to identify effective measures to protect and utilize these two tree species in the study region. This study presents a novel technique for assessing wild plant distributions, in addition to serving as a model for the conservation of other species within the framework of general forest management, ecological construction, and geographical surveying. | Jizhong Wan Chunjing Wang Jinghua Yu Siming Nie Shijie Han Juzhao Liu Yuangang Zu Qinggui Wang | 2016 | Journal of Forestry Research2016，27，2： | 4 |
| 4 | Breaking the spores of the fungus Ganoderma lucidum by supercritical CO2 显示文摘 | FU Yujie LIU Wei ZU Yuangang | 2009 | Food Chem2009，112，1： | 1 |
| 5 | Gelatinginduced supramolecular chirality of achiral porphyrins: chiroptical switch between achiral molecules and chiral assemblies 显示文摘 | Li Yuangang Wang Tianyu Liu Minghua | 2007 | Soft Matter2007，3，： | 1 |
| 6 | A Combined Approach to Cartographic Displacement for Buildings Based on Skeleton and Improved Elastic Beam Algorithm显示文摘 | LIU Yuangang GUO Qingsheng SUN Yageng | 2014 | PLoS One2014，9，11： | 1 |
| 7 | Enzyme digestion to isolate and culture human scalp dermal papilla cells: a more efficient method显示文摘 | Jinjin J. Wu Rongqing Q. Liu Yuangang G. Lu Tangyou Y. Zhu Bo Cheng Xue Men | 2005 | Archives of Dermatological Research2005，，2： | 1 |
| 8 | Oxidative stability of fish oil supplemented with carnosic acid compared with synthetic antioxidants during long-term storage显示文摘 | Hua Wang Fang Liu Lei Yang Yuangang Zu Han Wang Shengzhuo Qu Ying Zhang | 2011 | Food Chemistry2011，，1： | 1 |
| 9 | Building Displacement Based on the Topological Structure 显示文摘 | Sun Yageng Guo Qingsheng Liu Yuangang | 2014 | The Cartographic Journal2014，，： | 1 |
| 10 | Oxidative stability of sunflower oil supplemented with carnosic acid compared with synthetic antioxidants during accelerated storage显示文摘 | Ying Zhang Lei Yang Yuangang Zu Xiaoqiang Chen Fuji Wang Fang Liu | 2009 | Food Chemistry2009，，3： | 1 |
| 11 | Breaking the spores of the fungus Ganoderma lucidum by supercritical CO2 显示文摘 | FU Yujie LIU Wei ZU Yuangang | 2009 | Food Chemistry2009，112，1： | 1 |
| 12 | Rapid microwave-assisted transesterification for the preparation of fatty acid methyl esters from the oil of yellow horn (Xanthoceras sorbifolia Bunge.)显示文摘 | Yuangang Zu Su Zhang Yujie Fu Wei Liu Zhiguo Liu Meng Luo Thomas Efferth | 2009 | European Food Research and Technology2009，，1： | 1 |
| 13 | Oxidative stability of fish oil supplemented with carnosic acid compared with synthetic antioxidants during long-term storage显示文摘 | Hua Wang Fang Liu Lei Yang Yuangang Zu Han Wang Shengzhuo Qu Ying Zhang | 2011 | Food Chemistry2011，，1： | 1 |
| 14 | Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins显示文摘 | Fu Yujie Zu Yuangang Liu Wei | 2007 | Journal of Chromatography A2007，1139，2： | 1 |
| 15 | Sericin for Resistance Switching Device with Multilevel Nonvolatile Memory显示文摘 | Hong Wang Fanben Meng Yurong Cai Liyan Zheng Yuangang Li Yuanjun Liu Yueyue Jiang Xiaotian Wang Xiaodong Chen | 2013 | Adv Mater2013，，38： | 1 |
| 16 | Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins 显示文摘 | FU Yujie ZU Yuangang LIU Wei | 2007 | Journal of Chromatography A2007，1139，2： | 1 |
| 17 | Development of an ionic liquid-based microwave-assisted method for simultaneous extraction and distillation for determina-tion of proanthocy-anidins and essential oil in Cortex cinnamomi 显示文摘 | Ye Liu Lei Yang Yuangang Zu | 2012 | Food Chemistry2012，135，： | 1 |
| 18 | Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins显示文摘 | Yujie Fu Yuangang Zu Wei Liu | 2007 | Chromatography A2007，，1139： | 1 |
| 19 | The in vitro and in vivo anti-tumor effects of MTX-Fe_3O_4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO_2显示文摘The in vitro and in vivo anti-tumor efficacy of methotrexate-loaded Fe3O4-poly-L-lactide-poly(ethylene glycol)-poly-L-lactide magnetic composite microspheres(MTX-Fe3O4-PLLA-PEG-PLLA MCMs,MMCMs),which were produced by co-precipitation(C)and microencapsulation(M)in a supercritical process,was evaluated at various levels:cellular,molecular,and integrated.The results at the cellular level indicate that MMCMs(M)show a better anti-proliferation activity than raw MTX and could induce morphological changes of cells undergoing apoptosis.At the molecular level,MMCMs(M)lead to a significantly higher relative mRNA expression of bax/bcl-2 and caspase-3 than MMCMs(C)at 10μg mL-1(P<0.01);and the pro-caspase-3protein expression measured by Western blot analysis also demonstrates that MMCMs(M)can effectively activate pro-caspase-3.At the integrated level,mice bearing a sarcoma-180 tumor are used;in vivo anti-tumor activity tests reveal that MMCMs(M)with magnetic induction display a much higher tumor suppression rate and lower toxicity than raw MTX.Pharmacokinetic studies show that MMCMs(M)with magnetic induction significantly increase the accumulation of MTX in the tumor tissue compared with the other treatments.These results suggest that the MMCMs(M)prepared by the SpEDS process have great potential to play a positive role in the magnetic targeted therapy field. | CHEN AiZheng DANG TingTing WANG ShiBin TANG Na LIU YuanGang WU WenGuo | 2014 | Science China(Life Sciences)2014，57，7： | 1 |
| 20 | Preparative separation ovitexin and isovitexin from pigeonpea extracts with macroporous resin 显示文摘 | Fu Yujie Zu Yuangang Liu Wei | 2007 | Journal of Chromatography A2007，，： | 1 |
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