|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of urbanization on changes in temperature extremes in Beijing during 1978–2008显示文摘To quantify the impact of urbanization on changes in observed surface air temperature and extremes,a homogenized dataset of daily mean,maximum and minimum temperature(Tm,Tmax and Tmin)observations at 20 stations in Greater Beijing(GBJ)from1978 to 2008 is analyzed.In contrast with previous studies,a cluster analysis is done to objectively classify observing stations into four categories(urbanized,suburban,rural and mountain),which is checked with remote-sensing night-light images since the1990s.At urbanized sites,there is an added warming trend in annual mean Tm representing an average of 10.9%(up to 18.4%or0.12°C/decade at the most strongly influenced site)of overall warming.Corresponding contributions for Tmin are 12.7%(up to20.8%or 0.19°C/decade)and 24%for diurnal temperature range DTR(up to 37.4%or 0.149°C/decade)over the last three decades.Although it has not had a significant impact on daytime records(Tmax),urbanization has enhanced the increasing(decreasing)trend of extremely warm(cold)nights by an average of 12.7%or 2.07 d/decade(29.0%or 5.06 d/decade)at the urbanized sites since the 1970s. | WANG Jun YAN ZhongWei LI Zhen LIU WeiDong WANG YingChun | 2013 | Chinese Science Bulletin2013，58，36： | 18 |
| 2 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 3 | Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway显示文摘Matrine 被使用了在反煽动性并且反癌症治疗很长时间。然而,在 colorectal 癌症(CRC ) 的反变形的效果和相关机制仍然是不清楚的。在这研究,我们调查了 matrine 的管理是否能经由调整表明小径的 p38 禁止人的 CRC 房间的增长,活动性,和侵略。结果证明 matrine 在 vitro 并且在 vivo 禁止了 CRC 房间的移植和侵略。在为 24 h 与 matrine 被对待以后,另外,表示在 CRC 房间矩阵 metalloproteinase-2 (MMP-2 ) 和 MMP-9 以及朊酶活动铺平以一种剂量依赖者方式被减少。而且, matrine 显然减少了 p38 的 phosphorylation 水平。有 p38 禁止者(SB203580 ) 和 matrine 的联合治疗在 CRC 房间导致了侵略以及 MMP-2/-9 表示的 synergistic 减小。matrine 在 vivo 禁止了 CRC 肿瘤的增长和转移,这也被发现。在结论, p38 发信号小径可以由减少 MMP-2/-9 的表示在 CRC 房间的移植和侵略上在 matrine 的禁止的效果包含,建议 matrine 可以是为 CRC 的一个潜在的治疗学的代理人。 | Hongtao Ren Shuqun Zhang Hongbing Ma Yali Wang Di Liu Xijing Wang Zhongwei Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 16 |
| 4 | Biomass-derived nitrogen-doped hierarchical porous carbon as efficient sulfur host for lithium–sulfur batteries显示文摘Lithium-sulfur(Li-S) battery is a potential energy storage technology with high energy density and low cost. However, the gap between theoretical expectation and practical performance limits its wide implementation. Herein, we report a nitrogen-doped porous carbon derived from biomass pomelo peel as sulfur host material for Li-S batteries. The hierarchical porous architecture and the polar surface introduced by N-doping render a favorable combination of physical and chemical sulfur confinements as well as an expedite electron/ion transfer, thus contributing to a facilitated and stabilized sulfur electrochemistry. As a result, the corresponding sulfur composite electrodes exhibit an ultrahigh initial capacity of 1534.6 mAh g^-1, high coulombic efficiency over 98% upon 300 cycles, and decent rate capability up to 2 C. This work provides an economical and effective strategy for the fabrication of advanced carbonaceous sulfur host material as well as the significant improvement of Li-S battery performance. | Qinghuiqiang Xiao Gaoran Li Minjie Li Ruiping Liu Haibo Li Pengfei Ren Yue Dong Ming Feng Zhongwei Chen | 2020 | Journal of Energy Chemistry2020，29，5： | 15 |
| 5 | The electromagnetic wave experiment for CSES mission: Search coil magnetometer显示文摘The seismic activities on the Earth can produce a disturbance of the electromagnetic field and particles in the ionosphere. The search coil magnetometer(SCM) mounted on China Seismo-Electromagnetic satellite(CSES) is designed to measure the magnetic field fluctuation of low frequency electromagnetic waves in the frequency range of 10 Hz–20 k Hz. The SCM comprises a three-axis search coil sensor mounted on a 4.5 m boom and an electronic box inside satellite module. The sampling rate of the SCM is 51.2 k Hz and the time resolution of the power spectrum density(PSD) is 2 s. The frequency resolution is 12.5 Hz.There are three operation modes: survey, detailed survey and calibration. In the survey mode, the SCM can provide a PSD in the whole frequency range of 10 Hz–20 k Hz and wave forms in the low frequency range below 2 k Hz while in the detailed survey mode the SCM can provide both PSD and wave forms in the whole frequency range of 10 Hz–20 k Hz. The sensitivity of the SCM instrument is 5.0×10^(-4) n T Hz^(-1/2) at 10 Hz, 5.0×10^(–5) n T Hz^(-1/2) at 200 Hz, 3.4×10^(-5) n T Hz^(-1/2) at 2 k Hz and 1.1×10^(-4) n T Hz^(-1/2) at 20 k Hz. The telemetry rate is ~0.85 Mbps in the survey mode and ~3.0 Mbps in the detailed survey mode. The phase difference between three axes can be made generally with a precision of less than 1.0°. The dynamic range of the SCM instrument is over 100 d B. The orthogonality of three mechanical axes of search coil senor is better than 0.13°. The performance of SCM can satisfy the requirement of scientific objectives of CSES mission. | CAO JinBin ZENG Li ZHAN Feng WANG ZuoGui WANG Yan CHEN Yu MENG QingChun JI ZhanQiang WANG PengFei LIU ZhongWei MA LingYu | 2018 | Science China(Technological Sciences)2018，61，5： | 13 |
| 6 | High-performance planar heterojunction perovskite solar cells: Preserving long charge carrier diffusion lengths and interracial engineering显示文摘 | Sai Bai Zhongwei Wu Xiaojing Wu Yizheng Jin Ni Zhao Zhihui Chen Qingqing Mei Xin Wang Zhizhen Ye Tao Song Ruiyuan Liu Shuit-tong Lee Baoquan Sun | 2014 | Nano Research2014，7，12： | 13 |
| 7 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
| 8 | PERFORMANCE IMPROVEMENT OF CENTRIFUGAL FAN BY MEANS OF NUMERICAL SIMULATION显示文摘数字模拟被用来在一台模型离心通风机调查流动地让蒸气发电站以便改进表演。在测试模型扇子期间,效率仅仅与入口盒子是 62.5% ,这被发现,没有它效率是 83% 。另外,测试钻塔的强壮的颤动与入口盒子被观察。如果扇子的气体动力学能被学习,它将是高度合乎需要的。因此,数字模拟被执行与入口盒子调查一把模型扇子的内部流动特征。从入口的整个区域关的 CFD 分析表演的结果被作为转子的方向相反地旋转的一个螺线旋涡占据,它显著地在扇子内影响大多数流动区域。为这个原因,一个哑巴盘子在入口盒子中被安排阻碍螺线旋涡的产生,从在改革以后的 CFD 的结果证明修正是安静的有效,以前的大螺线顶点有效地被破坏了,大的被代替赞成二个小旋涡。然而,二个小旋涡在转子和下列部分的内部流动上有小效果。最后,模型扇子的效率被测试改进,测试钻塔的强壮的颤动消失。这类修正尽最大努力被使用了车站,扇子效率成功地涨到 84% 。 | ZHANG Bo HUANG Shujuan SUN Zhongwei HUI Shien LIU Jiayu QI Chunsong | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 8 |
| 9 | Polypeptide dendrimers: Self-assembly and drug delivery显示文摘Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe.The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell.The biocompatibility of the micelles was studied.The release of the anticancer drug doxorubicin from the micelles was investigated in vitro.The results showed that the sustaining release of the drug could last for 60 h.The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells,75% cancer cells were killed under appropriate in vitro incubation. | XU XiangHui LI CaiXia LI HaiPing LIU Rong JIANG Chao WU Yao HE Bin GU ZhongWei | 2011 | Science China Chemistry2011，54，2： | 6 |
| 10 | Distribution and partitioning of heavy metals in large anthropogenically impacted river, the Pearl River, China显示文摘In order to evaluate the distribution and partitioning characteristics of heavy metals in the large anthropogenically impacted Pearl River Basin, the contents of ‘‘anthropophile'' elements(Cr, Ni, Cu, Zn, Cd and Pb,which are clearly influenced by human activities) were determined, and their partitioning coefficients(Kd) between water and sediments and enrichment factors(EF) were calculated for samples collected at different locations along the Pearl River main stream. The modified BCR sequential extraction procedure(proposed by the European Community Bureau of Reference in 1993), which involves the successive extraction of metals in a decreasing order of reactivity, was applied. Sediment samples from the upper,middle, and lower reaches were included in this study. The results showed that the content of most metals in water and sediment samples gradually increases from upstream to downstream, suggesting a possible input from human activities as shown by their increasing high EF, ranged from 1.4 to 3.9 for Cu, from 1.4 to 6.7 for Zn, from 2.5 to59.1 for Cd, and from 1.7 to 8.9 for Pb, respectively. Thehigher partition coefficients(Kd) for Cr, Zn, and Pb(10~5–10~6) indicated that they were mainly transported in solid phase, while parts of Ni, Cu, and Cd were transported in dissolved phase as they display relatively lower Kdin the range of 10~4–10~5. According to the results of the BCR leaching, the percentage of non-residual fraction of heavy metals in the sediments showed a decreasing order of Cd [ Pb [ Zn [ Cu [ Ni [ Cr, implying that Cd and Pb were more active and bioavailable compared to the other four metals, and thus would be potentially more harmful to the watershed ecosystem. | Silan Liu Zhongwei Wang Yuanyuan Zhang Yulong Liu Wei Yuan Ting Zhang Yujie Liu Ping Li Li He Jiubin Chen | 2019 | Acta Geochimica2019，38，2： | 5 |
| 11 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 12 | Impact of Urbanization on Low-Temperature Precipitation in Beijing during 1960–2008显示文摘Daily precipitation and temperature records at 13 stations for the period 1960–2008 were analyzed to identify climatic change and possible effects of urbanization on low-temperature precipitation [LTP, precipitation of 0.1 mm d 1occurring under a daily minimum temperature(Tmin) of 0 C] in the greater Beijing region(BJR), where a rapid process of urbanization has taken place over the last few decades. The paper provides a climatological overview of LTP in BJR. LTP contributes 61.7% to the total amount of precipitation in BJR in the cold season(November–March). There is a slight increasing trend [1.22 mm(10 yr) 1] in the amount of total precipitation for the cold season during 1960–2008. In contrast, the amount of LTP decreases by 0.6 mm(10 yr) 1. The warming rate of Tmin in BJR is 0.66 C(10 yr) 1. Correspondingly, the frequency of LTP decreases with increasing Tmin by 0.67 times per C. The seasonal frequency and amount of LTP in southeast BJR(mostly urban sites) are 17%–20% less than those in the northwestern(rural and montane sites). The intensity of LTP for the urban sites and northeastern BJR exhibited significant enhancing trends [0.18 and 0.15 mm d 1(10 yr) 1, respectively]. The frequency of slight LTP(<0.2 mm d 1) significantly decreased throughout BJR [by about 15.74%(10 yr) 1in the urban area and northeast BJR], while the contribution of the two heaviest LTP events to total LTP amount significantly increased by 3.2%(10 yr) 1. | HAN Zuoqiang YAN Zhongwei LI Zhen LIU Weidong WANG Yingchun | 2014 | Advances in Atmospheric Sciences2014，31，1： | 5 |
| 13 | Production of aneuhaploid and euhaploid sporocytes by meiotic restitution in fertile hybrids between durum wheat Langdon chromosome substitution lines and Aegilops tauschii显示文摘Fertile F1 hybrids were obtained between durum wheat (Triticum durum Desf.) Langdon (LDN) and its 10 disomic substitution (LDN DS) lines with Aegilops tauschii accession AS60 without embryo rescue. Selfed seedset rates for hybrids of LDN with AS60 were 36.87% and 49.45% in 2005 and 2006, respectively. Similar or higher selfed seedset rates were observed in the hybrids of 1D (1A), 1D (1B), 3D (3A), 4D (4B), 7D (7A), and 2D (2B) with AS60, while lower in hybrids of 3D (3B) + 3BL, 5D (5A) + 5AL, 5D (5B) + 5B and 6D (6B) + 6BS with AS60 compared with the hybrids of LDN with AS60. Observation of male gametogenesis showed that meiotic restitution, both first-division restitution (FDR) and single-division meiosis (SDM) resulted in the formation of functional unreduced gametes, which in turn produced seeds. Both euhaploid and aneuhaploid gametes were produced in F1 hybrids. This suggested a strategy to simultane-ously transfer and locate major genes from the ancestral species T. turgidum or Ae. tauschii. Moreover, there was no significant difference in the aneuhaploid rates between the F1 hybrids of LDN and LDN DS lines with AS60, suggesting that meiotic pairing between the two D chromosomes in the hybrids of LDN DS lines with AS60 did not promote the formation of aneuhaploid gametes. | Lianquan Zhang Qijiao Chen Zhongwei Yuan Zhiguo Xiang Youliang Zheng Dengcai Liu | 2008 | Journal of Genetics and Genomics2008，35，10： | 5 |
| 14 | Wheat breeding in the hometown of Chinese Spring显示文摘The common wheat landrace Chinese Spring(CS) was made famous by the work of Ernie Sears, a great cytogenetist, who developed a number of CS-based aneuploid series that were used to identify individual wheat chromosomes. Based on this, a standard karyotype and nomenclature system was developed for wheat chromosomes that allowed wheat researchers to analyze and manipulate the wheat genome with unprecedented precision and efficiency. Nevertheless, not much is known about the utilization of CS at its hometown, Chengdu in Sichuan province, during early wheat breeding activity. In this review, we follow the speculation that CS is a selection from the Cheng-du-guang-tou(CDGT) landrace. We provide a description of how CDGT became a founder landrace for wheat breeding activities in early times. We show that CDGT-derived varieties were reinforced genetically by crosses to six more exotic parents. These varieties remained the major elite cultivar for several decades. Later, synthetic hexaploid wheats were introduced into the breeding program, firstly using those from CIMMYT and later using materials produced with local tetraploid wheat and goat grass. Finally, we discuss the strategies and future directions to improve wheat yield and resistance through an expanded genetic basis,especially by recapturing lost genetic variations from landraces and related wild species, a process that may set an example for wheat breeders in China and elsewhere. | Dengcai Liu Lianquan Zhang Ming Hao Shunzong Ning Zhongwei Yuan Shoufen Dai Lin Huang Bihua Wu Zehong Yan Xiujin Lan Youliang Zheng | 2018 | The Crop Journal2018，6，1： | 4 |
| 15 | microRNAs in heart failure显示文摘Heart failure is the leading cause of mortality in the world and represents the fastest growing subclass of cardiovascular diseases.An increasing body of evidence indicates an important role for microRNAs (miRNAs)in the pathogenesis and progression of heart failure.miRNAs are a class of small non-coding RNAs about 20 to 24 nucleotides (nt) (a few less than 20 nt) to regulate target gene expression at the post-transcriptional level.Mature miRNAs are formed after shearing a period of hairpin loop structure,the length of 70-80 nt and single stranded RNA precursors (pre-miRNA) with Dicer or nuclease as similar as Dicer.They primarily function posttranscriptionally by base pairing to sequence motifs in the 3' untranslated region (3'UTR) of target mRNAs in a sequence-specific,tissue-specific and developmental stagespecific matter.1-3 miRNAs have the role of regulation of cell proliferation and death,neuronal differentiation,ontogeny and other biological function.In 2006,scientists noticed that miRNAs play an extremely important role in the occurrence and development process of heart disease.To date,many miRNAs that play a role in diverse aspects of cardiac remodeling and heart failure development have been identified. | Xing Yujie Gao Dengfeng Liu Zhongwei Niu Xiaolin | 2014 | Chinese Medical Journal2014，，18： | 4 |
| 16 | Reinforced polysulfide barrier by g-C_(3)N_(4)/CNT composite towards superior lithium-sulfur batteries显示文摘The notorious shuttle effect has long been obstructing lithium-sulfur(Li-S) batteries from yielding the expected high energy density and long lifespan.Herein,we develop a multifunctional polysulfide barrier reinforced by the graphitic carbon nitride/carbon nanotube(g-C_3 N_4/CNT) composite toward inhibited shuttling behavior and improved battery performance.The obtained g-C_3 N_4 delivers a unique spongelike architecture with massive ion transfer pathways and fully exposed active interfaces,while the abundant C-N heteroatomic structures impose strong chemical immobilization toward lithium polysulfides.Combined with the highly conductive agent,the g-C_3 N_4/CNT reinforced separator is endowed with great capability of confining and reutilizing the active sulfur within the cathode,thus contributing to an efficient and stable sulfur electrochemistry.Benefiting from these synergistic attributes,Li-S cells based on g-C_3 N_4/CNT separator exhibit an excellent cyclability with a minimum decay rate of 0.03% per cycle over 500 cycles and decent rate capability up to 2 C.Moreover,a high areal capacity of 7.69 mAh cm^(-2)can be achieved under a raised sulfur loading up to 10.1 mg cm^(-2).demonstrating a facile and efficient pathway toward superior Li-S batteries. | Xiangliang Wang Gaoran Li Minjie Li Ruiping Liu Haibo Li Tengyu Li Mingzhu Sun Yirui Deng Ming Feng Zhongwei Chen | 2021 | Journal of Energy Chemistry2021，30，2： | 4 |
| 17 | Dark solitons in WS_2 erbium-doped fiber lasers显示文摘Tungsten disulfide(WS_2) is a type of anisotropic-layered compound and has broadband saturable absorption features as saturable absorbers(SAs). With WS_2-based SAs, dark solitons in erbium-doped fiber(EDF) lasers are first obtained. For the generated dark solitons, the center wavelength is measured to be 1530 nm, and the repetition rate is about 116.5 MHz. A series of optical spectra is exhibited. The electrical signal-to-noise ratio is better than 94 d B.Results in this paper demonstrate that WS_2-based SAs are the promising SAs for generating dark solitons in EDF lasers. | Wenjun Liu Lihui Pang Hainian Han Zhongwei Shen Ming Lei Hao Teng Zhiyi Wei | 2016 | Photonics Research2016，4，3： | 4 |
| 18 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 19 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 20 | Human Vγ9Vδ2-T cells efficiently kill influenzavirus-infected lung alveolar epithelial cells显示文摘 | Hong Li Zheng Xiang Ting Feng Jinrong Li Yinping Liu Yingying Fan Qiao Lu Zhongwei Yin Meixing Yu Chongyang Shen Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员