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| 1 | 五个月短程化疗及六个月全程间歇方案治疗菌阳肺结核的临床对照研究显示文摘目的考核利福喷丁(L)的疗效;缩短疗程或全程间歇以减少用药次数;观察全程应用吡嗪酰胺(Z)对疗效及毒副反应的影响。方法以利福平(R)为对照,采用5个月疗程方案(Ⅰ组2SHRZ/3R2H2Z2,Ⅱ组2SHRZ/3L1H2Z2)、6个月全间歇方案(Ⅲ组2S3H3R3Z3/4L1H2Z2,Ⅳ组2S3H3R3Z3/4L1H2E2),观察Z的全程应用结果,巩固期以乙胺丁醇(E)为对照。366例初治菌阳肺结核随机分入以上4组。结果(1)339例完成疗程者中329例治疗成功,满疗程时痰菌阴转率Ⅰ~Ⅳ组分别为970%、941%、1000%、972%。X线病灶有效率依序为960%、976%、1000%和944%。5个月组与6个月组空洞关闭率分别为77%及76%。各组相互比较均无显著性差异(P>0.05),未见严重副作用。(2)305例完成3年随访,Ⅰ、Ⅱ、Ⅲ、Ⅳ组细菌学加X线复发分别为2、3、6和3例。结论本研究结果进一步证明L是长效、高效、安全、便于督导的新药;巩固期用Z无必要;现有基本药物合理联用有可能缩短疗程为5个月,值得进一步研究。 | National Cooperative Group On Clinical Study of Pulmonary Tuberculosis (Report prepared by Chu Naihui , Yan Biya, Zhu Lizhen). Beijing Tuberculosis and Thoracic Tumor Institute, Beijing 101149 | 1998 | 中华结核和呼吸杂志1998，21，7： | 26 |
| 2 | Effect of Zn addition on microstructure and mechanical properties of an Al–Mg–Si alloy显示文摘In the present work, an Al–0.66Mg–0.85Si–0.2Cu alloy with Zn addition was investigated by electron back scattering diffraction(EBSD), high resolution electron microscopy(HREM), tensile and Erichsen tests. The mechanical properties of the alloy after pre-aging met the standards of sheet forming. After paint baking, the yield strength of the alloy was improved apparently. GP(Ⅱ) zones and η'phases were formed during aging process due to Zn addition. With the precipitation of GP zones, β″ phases, GP(Ⅱ) zones and η'phases, the alloys displayed excellent mechanical properties. | Lizhen Yan Yongan Zhang Xiwu Li Zhihui Li Feng Wang Hongwei Liu Baiqing Xiong | 2014 | Progress in Natural Science:Materials International2014，24，2： | 13 |
| 3 | Numerical analysis and geophysical monitoring for stability assessment of the Northwest tailings dam at Westwood Mine显示文摘The Westwood Mine aims to reuse the tailings storage facility #1(TSF #1) for solid waste storage, but,downstream of the Northwest dike is considered critical in terms of stability. This paper uses numerical modeling along with geophysical monitoring for assessing the Northwest dike stability during the restoration phase. The impact of waste rock deposition in the upstream TSF #1 is considered. The geophysical monitoring is based on electrical resistivity methods and was used to investigate the internal structure of the dike embankment in different deposition stages. The numerical simulations were performed with SLOPE/W code. The results show a factor of safety well above the minimum recommended value of 1.5. Geophysical monitoring revealed a vertical variation in the electrical resistivity across the dike, which indicates a multilayer structure of the embankment. Without any current in situ data, the geophysical monitoring helped estimating the nature of the materials used and the internal structure of the embankment. These interpretations were validated by geological observation of geotechnical log of the embankment. Based on this study, it is recommended that the water polishing pond be partly filled before waste rock is deposited in TSF #1. In addition, to ensure the stability of the dike, the piezometric head monitoring prior to and during waste rock deposition is recommended. | Coulibaly Yaya Belem Tikou Cheng LiZhen | 2017 | International Journal of Mining Science and Technology2017，27，4： | 11 |
| 4 | Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue显示文摘Excess lipid storage in adipose tissue results in the development of obesity and other metabolic disorders including diabetes,fatty liver and cardiovascular diseases.The lipid droplet(LD)is an important subcellular organelle responsible for lipid storage.We previously observed that Fsp27,a member of the CIDE family proteins,is localized to LD-contact sites and promotes atypical LD fusion and growth.Cidea,a close homolog of Fsp27,is expressed at high levels in brown adipose tissue.However,the exact role of Cidea in promoting LD fusion and lipid storage in adipose tissue remains unknown.Here,we expressed Cidea in Fsp27-knockdown adipocytes and observed that Cidea has similar activity to Fsp27 in promoting lipid storage and LD fusion and growth.Next,we generated Cidea and Fsp27 double-deficient mice and observed that these animals had drastically reduced adipose tissue mass and a strong lean phenotype.In addition,Cidea/Fsp27 double-deficient mice had improved insulin sensitivity and were intolerant to cold.Furthermore,we observed that the brown and white adipose tissues of Cidea/Fsp27double-deficient mice had significantly reduced lipid storage and contained smaller LDs compared to those of Cidea or Fsp27single deficient mice.Overall,these data reveal an important role of Cidea in controlling lipid droplet fusion,lipid storage in brown and white adipose tissue,and the development of obesity. | WU LiZhen ZHOU LinKang CHEN Cheng GONG JingYi XU Li YE Jing LI De LI Peng | 2014 | Science China(Life Sciences)2014，57，1： | 11 |
| 5 | Change of bacterialcommunity in the Malan Ice Core and its relation toclimate and environment显示文摘In order to understand the relationship be- tween the community structure of bacteria in ice core and the past climate and environment, we initiated the study on the microorganisms in the three selected ice samples from the Malan ice core drilled from the Tibetan Plateau. The 16S ribosomal DNA (rDNA) molecules were directly amplified from the melt water samples, and three 16S rDNA clone li- braries were established. Among 94 positive clones, eleven clones with unique restriction pattern were used for partial sequence and compared with eight reported sequences from the same ice core. The phylotypes were divided into 5 groups: alpha, beta, gamma proteobacteria; CFB, and other eubac- teria group. Among them, there were many “typical Malan glacial bacteria” pertaining to psychrophilies and new bacte- ria found in the ice core. At a longer time scale, the concen- tration distribution of “typical Malan glacial bacteria” with depth showed negative correlation with temperature varia- tions and was coincident with dirty layer. It implied the in- fluence of temperature on the microbial record through im- pact on the concentrations of the “typical Malan glacial bac- teria”. In addition, the nutrition contained in ice was another important factor controlling the distribution of microbial population in ice core section. Moreover, the result displayed an apparent layer distribution of bacterial community in the ice core section, which reflected the microbial response to the past climatic and environmental conditions at the time of deposition. | XIANGShurong YAOTandong ANLizhe LIZhen WUGuangjiad WANGYouqing XUBaiqing WANGJunxia | 2004 | Chinese Science Bulletin2004，49，17： | 10 |
| 6 | The effect of Scuteilaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats显示文摘Flavonoids 被显示了改进认知功能并且推迟痴呆前进。然而,内在的机制留下逃犯。在现在的学习,我们检验了从 S 提取的黄芩 baicalensis 茎叶总数 flavonoids (SSTF ) 的效果。在脉管的痴呆(VaD ) 的空间学习和记忆上的 baicalensis Georgi 老鼠模型并且探索了它的分子的机制。VaD 老鼠被普通颈动脉动脉的永久双边的吸藏开发。在恢复以后的七天, VaD 老鼠与 SSTF 的 50 或 100 mg/kg 被对待 60 天。空间学习和记忆在莫利斯舞水迷宫(MWM ) 被评估测试。字形物 hyperphosphorylation 和相关蛋白质 kinases 或磷酸酶的层次被西方的污点分析检验。在 VaD 老鼠,在 100 mg/kg 的 SSTF 处理显著地在在 MWM 测试训练试用减少了逃跑潜伏。在探针试用, SSTF 治疗在目标象限增加了寻找的时间和旅行距离。SSTF 处理在 VaD 老鼠在外皮和马头鱼尾的怪兽禁止了字形物 phosphorylation。同时, SSTF 减少了肝糖 synthase kinase 的活动 3 并且 cyclin 依赖的 kinase 5 在 VaD 老鼠。相反, SSTF 处理在 VaD 老鼠增加了蛋白质磷酸酶 2A 子单元 B 的水平。SSTF 处理显著地在 VaD 老鼠改进了空间认知。我们的结果建议 SSTF 可以通过在击以后协调 kinases 和磷酸酶的活动减轻 tau-hyperphosphorylation-induced neurotoxicity。SSTF 可以为 VaD 被开发进有希望的新奇治疗学。 | Yanjing Cao Lizhen Liang Jian Xu Jiali Wu Yongxing Yan Ping Lin Qiang Chen Fengming Zheng Qin Wang Qian Ren Zengmei Gou Yifeng Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 7 | Comparative study of the mechanical properties,micro-structure,and composition of the cranial and beak bones of the great spotted woodpecker and the lark bird显示文摘Woodpeckers are well able to resist head injury during repeated high speed impacts at 6-7 m s-1 with decelerations up to 1000 g.This study was designed to compare the mechanical properties,microstructures and compositions of cranial bone and beak bone of great spotted woodpecker(Dendrocopos major) and the Mongolian sky lark(Melanocorypha mongolica).Microstructures were observed using micro-computed tomography and scanning electron microscopy and their compositions were characterized by X-ray powder diffraction and Fourier-transform infrared spectroscopy.Under high stress,the cranial bone and the beak of the woodpecker exhibited distinctive mechanical features,which were associated with differences in micro-structure and composition,compared with those of the lark.Evolutionary optimization of bone micro-structure has enabled functional adaptation to the woodpecker's specific lifestyle.Its characteristic micro-structure efficiently avoids head impact injury and may provide potential clues to the prevention of brain injury using bio-inspired designs of shock-absorbing materials. | WANG LiZhen ZHANG HongQuan FAN YuBo | 2011 | Science China(Life Sciences)2011，54，11： | 9 |
| 8 | Paleoclimatic significance of mineral magnetic properties of loess sediments in northeastern Qinghai- Tibetan Plateau显示文摘Loess deposit in the northeastern Qinghai-Tibetan Plateau offers an excellent record of climate and environment changes in this region. We have conducted multiparameter mineral magnetic analyses of samples of loess deposits from the Dongchuan, Lalakou and Panzishan sections. The methods used include magnetic susceptibility, frequency-dependent susceptibility, temperature-dependent susceptibility, isothermal remanent magnetization acquisition, and magnetic hysteresis loops. The results reveal that magnetite is the dominant contributor to magnetic susceptibility. Maghemite and hematite is also present in the loess layers and paleosol horizons. The higher concentration of maghemite in paleosols suggests that the formation of maghemite occurred during in situ pedogenesis, which plays an important role in the enhancement of the magnetic susceptibility. Similar to that in the Chinese Loess Plateau lying to the east of the Liupan Mountains, magnetic granulometry in the studied loess and paleosols is predominantly pseudo-single-domain (PSD). However, the mean grain-size of the ferrimagnetic minerals in loess is evidently coarser (larger PSD and multidomain-like) than in paleosols (mainly PSD). The magnetic susceptibility of loess and paleosols is positively correlated with the content of ultrafine magnetite/maghemite grains, and hence with the intensity of in situ pedogenesis. Therefore, the enhanced magnetic susceptibility in the studied loess-paleosol sequences can be interpreted as being due to climatically induced in situ pedogenesis. | WANGXiaoyong LUHuayu LIZhen DENGChenglong TANHongbing | 2003 | Chinese Science Bulletin2003，48，19： | 9 |
| 9 | Non-covalently Functionalized Graphene Oxide-Based Coating to Enhance Thermal Stability and Flame Retardancy of PVA Film显示文摘The synergistic effect of conventional flame-retardant elements and graphene has received extensive attention in the development of a new class of flame retardants. Compared to covalent modification, the noncovalent strategy is simpler and expeditious and entirely preserves the original quality of graphene. Thus, non-covalently functionalized graphene oxide(FGO) with a phosphorus–nitrogen compound was successfully prepared via a one-pot process in this study. Polyethyleneimine and FGO were alternatively deposited on the surface of a poly(vinyl alcohol)(PVA) film via layer-by-layer assembly driven by electrostatic interaction, imparting excellent flame retardancy to the coated PVA film. The multilayer FGO-based coating formed a protective shield encapsulating the PVA matrix, effectively blocking the transfer of heat and mass during combustion. The coated PVA has a higher initial decomposition temperature of about 260 °C and a nearly 60% reduction in total heat release than neat PVA does. Our results may have a promising prospect for flame-retardant polymers. | Wenhua Chen Pengju Liu Lizhen Min Yiming Zhou Yuan Liu Qi Wang Wenfeng Duan | 2018 | Nano-Micro Letters2018，10，3： | 8 |
| 10 | Coactive design of explainable agent-based task planning and deep reinforcement learning for human-UAVs teamwork显示文摘Unmanned Aerial Vehicles(UAVs)are useful in dangerous and dynamic tasks such as search-and-rescue,forest surveillance,and anti-terrorist operations.These tasks can be solved better through the collaboration of multiple UAVs under human supervision.However,it is still difficult for human to monitor,understand,predict and control the behaviors of the UAVs due to the task complexity as well as the black-box machine learning and planning algorithms being used.In this paper,the coactive design method is adopted to analyze the cognitive capabilities required for the tasks and design the interdependencies among the heterogeneous teammates of UAVs or human for coherent collaboration.Then,an agent-based task planner is proposed to automatically decompose a complex task into a sequence of explainable subtasks under constrains of resources,execution time,social rules and costs.Besides,a deep reinforcement learning approach is designed for the UAVs to learn optimal policies of a flocking behavior and a path planner that are easy for the human operator to understand and control.Finally,a mixed-initiative action selection mechanism is used to evaluate the learned policies as well as the human’s decisions.Experimental results demonstrate the effectiveness of the proposed methods. | Chang WANG Lizhen WU Chao YAN Zhichao WANG Han LONG Chao YU | 2020 | Chinese Journal of Aeronautics2020，33，11： | 8 |
| 11 | Ni/Co-based metal-organic frameworks as electrode material for high performance supercapacitors显示文摘A novel bimetallic Ni/Co-based metal-organic framework(Ni/Co-MOF) was successfully synthesized via a simple solvothermal method, and used as electrode material for high performance supercapacitors. After doping of Co element, the Ni/Co-MOF materials retain the original crystalline topology structure of Ni_3(BTC)_2·12H_2O.The as-obtained Ni/Co-MOF demonstrates an excellent specific capacitance of 1067 and 780 F/g at current density of 1 and 10 A/g, respectively, and can also retain 68.4% of the original capacitance after 2500 cycles. These results suggest that bimetallic Ni/Co-based MOFs are promising materials for the next generation supercapacitance,owing to their excellent electrochemical performance. The synthetic procedure can be applied to synthesize other bimetallic MOFs and enhance their conductive property. | Shaofei Zhao Lizhen Zeng Gao Cheng Lin Yu Huaqiang Zeng | 2019 | Chinese Chemical Letters2019，30，3： | 7 |
| 12 | Combined application of a straw layer and flue gas desulphurization gypsum to reduce soil salinity and alkalinity显示文摘Burying a straw layer and applying flue gas desulphurization(FGD)gypsum are effective practices to ameliorate soil salinization or alkalization and to increase crop yield;however,little information exists on the effects of such integration in saline-alkali soils.A soil column experiment was conducted to investigate the effects of a straw layer plus FGD gypsum on soil salinity and alkalinity.We placed a straw layer(5 cm thick)at a depth of 30 cm and mixed FGD gypsum into the 0–20 cm soil layer at application rates of 7.5,15.0,22.5,and 30.0 t ha^-1,with no straw layer and FGD gypsum as a control(CK).The soil water content in the 0–30 cm soil layer was significantly higher(>7.8%)in the treated soil profiles after infiltration than in the CK,but decreased after evaporation.The electrical conductivity(EC)of the 10–30 cm soil layer was 230.2%and 104.9%higher in the treated soil profiles than in the CK after infiltration and evaporation,respectively,and increased with increasing rates of FGD gypsum application,with Ca^2+and SO4^2-being the main dissolved salts.Compared to those in the CK,the concentrations of Na^+,Cl^-,and HCO3-decreased in the treated soil profiles at depths above 55 cm,but the other soluble ions increased,after infiltration.A similar trend occurred after evaporation for all soluble ions except for HCO3-.The p H and exchangeable sodium percentage in the treated soil profiles were significantly lower than those in the CK over the entire profile,and decreased with increasing FGD gypsum application rates.Therefore,the incorporation of a straw layer plus FGD gypsum can reduce salinity and alkalinity,but the quantity of FGD gypsum should be controlled in saline-alkali soils. | Yonggan ZHAO Yan LI Shujuan WANG Jing WANG Lizhen XU | 2020 | Pedosphere2020，30，2： | 7 |
| 13 | Jiaweisinisan facilitates neurogenesis in the hippocampus after stress damage显示文摘The traditional Chinese medicine Jiaweisinisan has antidepressant effects, and can inhibit hypothalamus-pituitary-adrenal gland axis hyperactivity in stress-induced depression. In this study, rat hippocampal neural precursor cells were cultured in serum-free medium in vitro and a stress damage model was established with 120 μM corticosterone. Cells were treated with 10% (v/v) Jiaweisinisan drug-containing serum and the corticosterone antagonist RU38486. Results of the 3-(4,5-dimethylthiazol-2-yl)-3,5-di-phenytetrazoliumromide assay showed that both Jiaweisinisan drug-containing serum and RU38486 promoted the proliferation of neural precursor cells after corticosterone exposure. Immunofluorescence detection showed that after Jiaweisinisan drug-containing serum and RU38486 treatment, the 5-bromo-2-deoxyuridine/terminal deoxynucleotidyl transferase dUTP nick end labeling ratio in hippocampal neural precursor cells significantly increased, and the apoptotic rates of glial cells reduced, and neuron-like cell differentiation from neural precursor cells significantly increased. Our experimental findings indicate that Jiaweisinisan promotes hippocampal neurogenesis after stress damage. | Lili Wu Chuanlian Ran Shukao Liu Lizhen Liao Yanling Chen Hualei Guo Weikang Wu Can Yan | 2013 | Neural Regeneration Research2013，8，12： | 7 |
| 14 | Solubility and metastable zone width measurement of 3,4-bis (3-nitrofurazan-4-yl) furoxan (DNTF) in ethanol + water显示文摘The solubility and supersolubility of 3,4-bis(3-nitrofurazan-4-yl)furoxan(DNTF) in ethanol + water at different operation were determined by laser monitoring system under atmospheric pressure to study the metastable zone width(MSZW). The modified Apelblat equation was adopted to correlate the experimental solubility data, and the correlation result showed perfect consistent with the experimental data. The standard dissolution enthalpy, standard dissolution entropy and Gibbs energy were calculated according to the experimental solubility data. The effect of the cooling rate, stirring rate, temperature and the concentration of ethanol + water on the MSZW was studied. It was found that the MSZW of DNTF increased with the increasing cooling rate, decreasing temperature, decreasing stirring rate and decreasing ratio of water. And the apparent nucleation order of DNTF in ethanol + water was calculated by the relationship between the cooling rate and the MSZW. | Lizhen Chen Liang Song Guanchao Lan Jianlong Wang | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 7 |
| 15 | Human amniotic epithelial cell feeder layers maintain mouse embryonic stem cell pluripotency via epigenetic regulation of the c-Myc promoter显示文摘老鼠胚胎的干细胞(转换字符) 在老鼠的 feeder 层上典型地是有教养的胚胎的成纤维细胞(MEF ) ,与白血病,禁止的因素(LIF ) 增加了处于一个无差别的状态维持他们。我们以前证明了人的羊膜的上皮的房间(hAECs ) 能被用作 feeder 房间维持老鼠转换字符 pluripotency,但是为这的机制是未知的。在现在的学习,我们发现那 CpG 5 c-Myc 基因仍然是的岛在在 hAECs 上有教养的老鼠转换字符的 hypomethylated。另外,在 c-Myc 基因倡导者 histone H3 的 acetylation 和 histone H3K4 的 trimethylation 铺平比在在 MEF 上有教养的 ES 房间的那些在在 hAECs 上有教养的 ES 房间是更高的。这些数据建议 hAECs 能经由 c-Myc 的 epigenetic 修正改变鼠标转换字符基因表示,提供为处于一个无差别的状态的转换字符的导致 hAEC 的维护的可能的机制。 | Te Liu Weiwei Cheng Tianjin Liu Lihe Guo Qin Huang Lizhen Jiang Xiling Du Fuhui Xu Zhixue Liu Dongmei Lai | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 6 |
| 16 | Effects of Sm Substitution on Magnetic and Magneto—Optical Properties of TbCo/Cr Films显示文摘The effects of Sm substitution on magnetic and magneto-optical properties of TbCo/Cr films have been investigated. It was found that partial Tb substituted by Sm will directly affect the magnitude of saturation magnetization Ms and the Kerr rotation angle. These results are explained by the ferri-magnetical structure of the rare earth-transition metal alloy. When the magnetic layer composition was (Sm0.343Tb0.657)31 Co69, values of magnetization as high as 385emu/cm^3 and coercivity above 4.7kOe at room temperature were obtained. | LIZuo-Yi HUANGZhi-Xin LINGen-Qi JINFang LIZhen | 2003 | Chinese Physics Letters2003，20，6： | 6 |
| 17 | A Novel Feature-based Method for Sentiment Analysis of Chinese Product Reviews显示文摘Sentiment analysis of online reviews and other user generated content is an important research problem for its wide range of applications.In this paper,we propose a feature-based vector model and a novel weighting algorithm for sentiment analysis of Chinese product reviews.Specifically,an opinionated document is modeled by a set of feature-based vectors and corresponding weights.Different from previous work,our model considers modifying relationships between words and contains rich sentiment strength descriptions which are represented by adverbs of degree and punctuations.Dependency parsing is applied to construct the feature vectors.A novel feature weighting algorithm is proposed for supervised sentiment classification based on rich sentiment strength related information.The experimental results demonstrate the effectiveness of the proposed method compared with a state of the art method using term level weighting algorithms. | LIU Lizhen SONG Wei WANG Hanshi LI Chuchu LU Jingli | 2014 | China Communications2014，11，3： | 5 |
| 18 | High-conductivity free-standing Li_(6)PS_(5)Cl/poly(vinylidene difluoride)composite solid electrolyte membranes for lithium-ion batteries显示文摘Bulk-type all-solid-state batteries(ASSBs)using sulfide solid electrolyte are considered as a promising alternative to commercial lithium-ion batteries owing to their high energy density and safety.However,cell energy density is often comparatively low due to use of a thick solid electrolyte separator and a lithium alloy as anode.For achieving high-performance ASSBs,creating a thin free-standing electrolyte with high-conductivity and good cycling stability against lithium anode is essential.In this work,we present Li_(6)PS_(5)Cl/poly(vinylidene difluoride)(LPSCl/PVDF)composite electrolytes prepared by a slurry method.The influence of the PVDF content on the microstructure,morphology,ionic conductivity and activation energy of the LPSCl/PVDF electrolytes is systematically investigated.Free-standing LPSCl/PVDF membranes with a thickness of 100-120 mm and a high ionic conductivity of about 1·10^(-3) S cm^(-1) at 25℃ are obtained.After adding PVDF to the LPSCl electrolyte,the cycling stability of the LPSCl electrolyte against lithium metal improves significantly.Therefore,LPSCl/PVDF composite electrolytes are promising candidates to be used in ASSBs. | Shuo Wang Xue Zhang Sijie Liu Chengzhou Xin Chuanjiao Xue Felix Richter Liangliang Li Lizhen Fan Yuanhua Lin Yang Shen Jurgen Janek Ce-Wen Nan | 2020 | Journal of Materiomics2020，6，1： | 5 |
| 19 | Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy显示文摘Osteoarthritis is the most prevalent chronic and debilitating joint disease,resulting in huge medical and socioeconomic burdens.Intra-articular administration of agents is clinically used for pain management.However,the effectiveness is inapparent caused by the rapid clearance of agents.To overcome this issue,nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic agents.Given the therapeutic programs are inseparable from pathological progress of osteoarthritis,an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders.In this review,we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release.Then,we review the interactions of nanoparticles with cartilage microenvironment and the rational design.Furthermore,we highlight advances in the therapeutic schemes according to the pathology signals.Finally,armed with an updated understanding of the pathological mechanisms,we place an emphasis on the development of“smart”bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals.We anticipate that the exploration of nanoparticles by balancing the efficacy,safety,and complexity will lay down a solid foundation tangible for clinical translation. | Xu Li Bingyang Dai Jiaxin Guo Lizhen Zheng Quanyi Guo Jiang Peng Jiankun Xu Ling Qin | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 20 | Extraction and characterization of bound extracellular polymeric substances from cultured pure cyanobacterium(Microcystis wesenbergii)显示文摘Preliminary characterization of bound extracellular polymeric substances(bEPS) of cyanobacteria is crucial to obtain a better understanding of the formation mechanism of cyanobacterial bloom. However,the characterization of bEPS can be affected by extraction methods. Five sets(including the control) of bEPS from Microcystis extracted by different methods were characterized using three-dimensional excitation and emission matrix(3DEEM) fluorescence spectroscopy combined chemical spectrophotometry; and the characterization results of bEPS samples were further compared. The agents used for extraction were NaOH,pure water and phosphate buffered saline(PBS) containing cationic exchange resins,and hot water. Extraction methods affected the fluorescence signals and intensities in the bEPS. Five fluorescence peaks were observed in the excitation and emission matrix fluorescence spectra of bEPS samples. Two peaks(peaks T1 and T2) present in all extractions were identified as protein-like fluorophores,two(peaks A and C) as humic-like fluorophores,and one(peak E) as a fulvic-like substance.Among these substances,the humic-like and fulvic-like fluorescences were only seen in the bEPS extracted with hot water. Also,NaOH solution extraction could result in strong fluorescence intensities compared to the other extraction methods. It was suggested that NaOH at pH 10.0 was the most appropriate method to extract bEPS from Microcystis. In addition,dialysis could affect the yields and characteristics of extracted bEPS during the determination process. These results will help us to explore the issues of cyanobacterial blooms. | Lizhen Liu Boqiang Qin Yunlin Zhang Guangwei Zhu Guang Gao Qi Huang Xin Yao | 2014 | Journal of Environmental Sciences2014，26，8： | 5 |
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