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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese显示文摘Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6% vs.21.3%) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P<0.01) and to elevated blood glucose in the elderly group (HR=1.39,P<0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD. | ZHANG Ming Liang HOU Xu Hong ZHU Yun Xia LU Jun Xi PENG Liang Pu GU Hui Lin JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 7 |
| 4 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 5 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 6 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 7 | 23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9显示文摘23,24-Dihydrocucurbitacin B(designated as C95 in this article)is a cucurbitane triterpenoid that has been shown to possess a variety of pharmacological activities,such as anti-inflammatory and anti-HIV-1 activities etc.In this study,we investigated the effects of 23,24-dihydrocucurbitacin B on lipid regulation.We showed that 23,24-dihydrocucurbitacin B(1–5μM)dose-dependently promoted DiI-LDL uptake in HepG2 cells by upregulating low-density lipoprotein receptor(LDLR)protein.In HepG2 cells,23,24-dihydrocucurbitacin B(1–10μM)dose-dependently enhanced LDLR promoter activity by elevating the mature form of SREBP2(sterol regulatory element binding protein 2)protein levels on one hand,and inhibited PCSK9(proprotein convertase subtilisin/kexin type 9)promoter activity by attenuating HNF1α(hepatocyte nuclear factor-1α)protein levels in nuclei on the other hand.Consequently,the expression of LDLR protein markedly increased,whereas the PCSK9-mediated LDLR protein degradation decreased.In a high-cholesterol LVG golden Syrian Hamster model,administration of 23,24-dihydrocucurbitacin B(30 mg·kg?1?d?1,intragastric,for 3 weeks)significantly decreased the serum LDL-cholesterol(LDL-C)levels.PCSK9 protein levels in the serum and liver tissues were significantly decreased,whereas LDLR protein levels in liver tissues were significantly increased in the treated animals as compared with the control animals.In conclusion,our study demonstrates for the first time that 23,24-dihydrocucurbitacin B exhibits dual transcriptional regulation of LDLR and PCSK9 in HepG2 cells by increasing SREBP2 protein levels and decreasing HNF1αprotein levels in the nuclei.These results propose a new strategy to simultaneously manage LDLR and PCSK9 protein expression and provide a promising lead compound for drug development. | Hui-hui Li Jun Li Xian-jing Zhang Jiao-meng Li Cong Xi Wen-qiong Wang You-li Lu Li-jiang Xuan | 2020 | Acta Pharmacologica Sinica2020，41，3： | 5 |
| 8 | Associations between serum potassium and sodium levels and risk of hypertension: a community-based cohort study显示文摘ObjectiveSeveral 研究检验了在饮食的钾和钠和高血压之间的关系,但是很少评估了在事件高血压的浆液钾或钠和风险之间的协会。没有心血管的疾病,我们因此从中国多省的队学习在 839 个正常血压的个人的一个中国基于社区的 population.MethodsA 总数调查了在事件高血压的浆液钾和钠和风险之间的协会在 2012-2013 在 2007-2008 和后续调查参加了基线考试的人,在这研究被包括。机会比率(或) 并且为在与新发作的高血压的风险的关系的基线浆液钾和钠的 95% 信心间隔(95%CI ) 用 multivariate 被评估逻辑回归 models.ResultsDuring 五年后续, 218 (26.0%) 个人们进行了到高血压。逻辑回归为多重 confounders 调整证明在基线浆液钾水平的每 1 mEq/L 增长与高血压的 75% 增加的风险被联系(或:1.75;95%CI:1.01-3.04;P = 0.04 ) 。与有 4.20-4.79 mEq/L 的浆液钾水平的成年人相比,有水平 ≥ 的成年人;4.80 mEq/L 有高血压的 84% 增加的风险(或:1.84;95%CI:1.14-2.96;P = 0.01 ) 。在浆液钠和高血压的风险之间没有重要协会(或:0.96;95%CI:0.89-1.04;P = 0.33 ).ConclusionsBaseline 浆液钾水平,然而并非基线浆液钠水平,断然与在中国人口的事件高血压的风险有关。 | Lu XI Yong-Chen HAO Jing LIU Wei WANG Miao WANG Guo-Qi LI Yue QI Fan ZHAO Wu-Xiang XIE Yan LI Jia-Yi SUN Jun LIU Lan-Ping QIN Dong ZHAO | 2015 | Journal of Geriatric Cardiology2015，12，2： | 4 |
| 9 | Behaviours of REE and Other Trace Elements During Pedological Weathering-Evidence from Chemical Leaching of Loess and Palaeosol from the Luochuan Section in Central China显示文摘The chemical leaching method is used for a systematic analysis of distribution characteristics of acid-soluble and acid-insoluble REE and other trace elements from the Luochuan loess deposits. The study shows that the acid-insoluble phase in loess and palaeosol is a stable component of old aeolian dusts and is characteristic of the provenance; the acid-soluble phase is the unstable component in the weathering pedogenic process and reflects rock-forming features after accumulation of aeolian dusts. The acid-insoluble REE and acid-soluble Sr and Pb can be used as geochemical indicators respectively to trace the provenance characteristics and the weathering pedogenic process. | Chen Jun, Wan Hongtao, Department of Earth Sciences, Nanjing University, Nanjing, Jiangsuand Lu HuayuKey Lab. of Loess and Quaternary Geology, Chinese Academy of Sciences,Xi an, Shaanxi Liu Xinzhu | 1996 | Acta Geologica Sinica(English Edition)1996，70，3： | 4 |
| 10 | Rb Protein is Essential to the Senescence-Associated Heterochromatic Foci Formation Induced by HMGA2 in Primary WI38 Cells显示文摘细胞的老朽是提供一个障碍给肿瘤的转变的房间周期拘捕的一张不可逆的表格。Rb (Retinoblastoma ) 小径的正直为为衰老的状态的稳定性提供一个分子的基础的联系老朽的 heterochromatin foci (SAHF ) 的形成是必要的。令人惊讶地,尽管高活动性组 A2 蛋白质(HMGA2 ) 能支持 tumorigenesis 并且在肿瘤房间禁止 Rb 功能, HMGA2 的高级表示是足够的在主要房间导致 SAHF 形成。决定 Rb 蛋白质是否在导致 HMGA2 的 SAHF 形成是必要的因此变得重要。在这研究,我们由 HMGA2,典型衰老的标记在被看见的宫外的表示建立了细胞的老朽和 SAHF 汇编 WI38 房间模型,包括 p53, p21 和 p16 的著名 upregulation,并且提高了 SA -- 和 E2F 目标基因的 downregulation 染色的牛乳糖。我们然后证明 Rb 小径禁止者 E7 蛋白质能部分在 WI38 房间在 HMGA2 表示以后废除 SAHF 形成的能力,显示 Rb 是为导致 HMGA2 的 SAHF 形成的一个关键因素。然而, Rb 弄空完全没救 HMGA2 导致的房间生长拘捕,建议 Rb 不是为在 WI38 房间的导致 HMGA2 的老朽的一条独占的小径。 | Xi Shi Baoqing Tian Lingxia Liu Yanyan Gao Chi Ma Namusamba Mwichie Wenlong Ma Liping Han Baiqu Huang Jun Lu Yu Zhang | 2013 | Journal of Genetics and Genomics2013，40，8： | 4 |
| 11 | Malignant transformation of craniopharyngioma in an infradiaphragmatic case显示文摘Till now,13 cases of malignant craniopharyngioma (CP) have been reported around the world,including 11 cases of transformation from benign tumors and 2 cases of congenital ones.Irradiation seemed to contribute a lot to the cellular transformation.The controversies about the radical surgery or irradiation have not ceased for many decades.In this article,we report a case of infradiaphragmatic CP (Id-CP) in a child who experienced almost all current treatments.However,after multiple tumor recurrences,finally the malignant transformation occurred.The analysis of the tumor regrowth pattern and clinical characteristics provided some clues to standardize and individualize the treatment of Id-CP. | Lu Yuntao Qi Songtao Peng Junxiang Pan Jun Zhang Xi'an | 2014 | Chinese Medical Journal2014，，17： | 4 |
| 12 | Numerical Investigation of the Aerodynamic Performance Affected by Spiral Inlet and Outlet in a Positive Displacement Blower显示文摘The flow in the positive displacement blower is very complex.The existing two-dimensional numerical simulation cannot provide the detailed flow information,especially flow characteristics along the axial direction,which is unfavorable to improve the performance of positive displacement blower.To investigate the effects of spiral inlet and outlet on the aerodynamic performance of positive displacement blower,three-dimensional unsteady flow characteristics in a three-lobe positive displacement blower with and without the spiral inlet and outlet are simulated by solving Navier-Stokes equations coupled with RNG k-ε turbulent model.In the numerical simulation,the dynamic mesh technique and overset mesh updating method are used.The computational results are compared with the experimental measurements on the variation of flow rate with the outlet pressure to verify the validity of the numerical method presented.The results show that the mass flow rate with the change of pressure is slightly affected by the application of spiral inlet and outlet,but the internal flow state is largely affected.In the exhaust region,the fluctuations of pressure,velocity and temperature as well as the average values of velocity are significantly reduced.This illustrates that the spiral outlet can effectively suppress the fluctuations of pressure,thus reducing reflux shock and energy dissipation.In the intake area,the average value of pressure,velocity and temperature are slightly declined,but the fluctuations of them are significantly reduced,indicating that the spiral inlet plays the role in making the flow more stable.The numerical results obtained reveal the three-dimensional flow characteristics of the positive displacement blower with spiral inlet and outlet,and provide useful reference to improve performance and empirical correction in the noise-reduction design of the positive displacement blowers. | LIU Xiaomin LU Jun GAO Renheng XI Guang | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 4 |
| 13 | Cost-benefit analysis of China’s Action Plan for Air Pollution Prevention and Control显示文摘China’s rapid economic growth has caused severe air pollution and public health problems.Therefore,the Chinese government launched the Action Plan for Air Pollution Prevention and Control(hereinafter referred to as the“Air Plan”)in 2013-2017 to improve air quality and safeguard public health.In this study,an analytical framework for a cost-benefit analysis applicable to China was constructed,and the costs and benefits of the implementation of the“Air Plan”in 30 cities and provinces in China from 2013 to 2017 were evaluated.Results show that the total cost of implementation of the“Air Plan”is 1.6511 trillion RMB.The benefits of air quality improvement were determined to be 2.4691 trillion RMB through the willingness-to-pay method to calculate the economic loss of premature deaths.The net benefit related to the implementation of the“Air Plan”was 818 billion RMB.The public health benefit of air quality improvement was 1.5 times the cost of the nationwide implementation of the“Air Plan”.At the provincial level,net benefits that reach 279.3 billion RMB were the highest in Guangdong,whereas the benefit-cost ratio,where the benefit was 5.5 times the cost,was the highest in Fujian.Estimations in this study can serve as a reference for China in formulating similar environmental policies and implementing the “3-year Plan to Defend the Blue Sky”.In addition,these estimations have practical significance for advancing the long-term effective mechanisms of the cost-benefit analysis of China5s environmental policies. | Jing ZHANG Hongqiang JIANG Wei ZHANG Guoxia MA Yanchao WANG Yaling LU Xi HU Jia ZHOU Fei PENG Jun BI Jinnan WANG | 2019 | Frontiers of Engineering Management2019，6，4： | 4 |
| 14 | Efficacy of radiotherapy for the treatment of cystic echinococcosis in naturally infected sheep显示文摘Background:Radiotherapy is commonly used to treat cancers.To date,there has been no study focusing on the effects of radiotherapy on hydatid disease in large animals.In this study,we aim to investigate the efficiency and safety of radiotherapy for treating hydatid disease caused by Echinococcus granulosus in naturally infected sheep.Methods:Ultrasound was used to screen naturally infected sheep in an echinococcosis endemic area in Xinjiang,China.A computer tomography(CT)scan confirmed the presence of hydatid cysts.Twenty sheep naturally infected with E.granulosus in the liver and/or lungs were randomly assigned into four groups receiving no irradiation,or X-ray irradiation of low(30 Gy),medium(45 Gy),and high dose(60 Gy),respectively.After three months of radiotherapy,a CT scan was performed to measure the changes in the cysts.The hepatic parasite cysts and host tissues were collected for histology and gene expression analysis.Results:In the animals subject to irradiation,no significant differences were observed in their appetite,daily activities,and weight before and after radiotherapy.Severe calcification was noticed in the cysts subject to a high dose of radiation compared with the groups subject to low and medium doses.Hematoxylin and eosin staining showed that irradiation contributed to the damage of the cyst structure and nucleus in the germinal layers.Quantitative PCR demonstrated that expression of TPX and HSP70 significantly decreased in a dose-dependent manner(P<0.05).The expression of the EPC1 decreased in the medium-and high-dose groups compared with the low-dose group(P<0.05).Meanwhile,the expression of radiation-related apoptosis genes caspase-3 and Gadd45 decreased with an increase in the irradiation dose.Conclusions:Radiotherapy is an option with satisfactory efficiency and safety for treating cystic echinococcosis in sheep with partial response or stable disease at month 3.In future,inhibition of cystic activity using radiotherapy may serve as a new regimen for treating hydatid disease. | Rui Mao Wen-Bao Zhang Hong-Zhi Qi Tao Jiang Ge Wu Peng-Fei Lu Abudula Ainiwaer Ge Shang Lin Xu Jie Hao Xi Shou Hai-Tao Li Jun Li Song-An Zhang Yong-Xing Bao Hao Wen | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 15 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 16 | PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress显示文摘One of the physiological functions of cellular prion protein(PrP C )is believed to work as a cellular resistance to oxidative stress,in which the octarepeats region within PrP plays an important role.However,the detailed mechanism is less clear.In this study,the expressing plasmids of wild-type PrP (PrP-PG5)and various PrP mutants containing 0(PrP-PG0),9(PrP-PG9)and 12(PrP-PG12)octarepeats were generated and PrP proteins were expressed both in E.coli and in mammalian cells.Protein aggregation and formation of carbonyl groups were clearly seen in the recombinant PrPs expressed from E.coli after treatment of H2O2.MTT and trypan blue staining assays revealed that the cells expressing the mutated PrPs within octarepeats are less viable than the cells expressing wild-type PrP.Statistically significant high levels of intracellular free radicals and low levels of glutathione peroxidase were observed in the cells transfected with plasmids containing deleted or inserted octarepeats.Remarkably more productions of carbonyl groups were detected in the cells expressing PrPs with deleted and inserted octarepeats after exposing to H2O2.Furthermore,cells expressing wild-type PrP showed stronger resistant activity to the challenge of H2O2 at certain extent than the mutated PrPs and mock. These data provided the evidences that the octarepeats number within PrP is critical for maintaining its activity of antioxidation.Loss of its protective function against oxidative stress may be one of the possible pathways for the mutated PrPs to involve in the pathogenesis of familial Creutzfeldt-Jacob diseases. | AN Run1 ,2,DONG ChenFang 2,LEI YanJun 1,2,HAN Lu 2,LI Ping 2,CHEN JianMing 2,WANG GuiRong 2, SHI Qi 2 ,GAO Chen 2 ,JIANG HuiYing 2 ,ZHOU Wei 2 ,HAN Jun 2 ,CHU YongLie 1 ,DONG XiaoPing 2 1School of Medicine,Xi’an JiaoTong University,Xi’an 710061,China 2State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,YingXin Rd 100,Beijing 100052,China | 2008 | Science China(Life Sciences)2008，51，7： | 3 |
| 17 | EPR studies of Mn^(2+) in the Loess Plateau of central China: Implication for variation of the East Asia summer monsoon显示文摘Mn 2+ EPR intensity recorded in the Chinese loess_paleosol sequence shows close correlation with magnetic susceptibility and Sr content as well as the oscillation of paleoclimate. Thus Mn 2+ EPR signal can serve as an indicator sensitive to the East Asia summer monsoon intensity fluctuations. | CHEN Jun\+1, JI Junfeng\+1, SU Yuanxia\+2 and LU Huayu\+31. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Center of Material Analysis, Nanjing University, Nanjing 210093, China 3. Xi’an Laboratory of Loess and Qu | 1998 | Chinese Science Bulletin1998，43，1： | 3 |
| 18 | Effect of Sr on forming properties of Al- Mg - Si based alloy sheets显示文摘 | LU Guang - xi CHEN Hai - jun GUAN Shao - kang | 2006 | Transactions of Nonferrous Metals Society of China2006，12，： | 1 |
| 19 | Characterization and photocatalytic property of Pd/TiO 2 with the oxidation of gaseous benzene显示文摘 | Jun Bo Zhong Yan Lu Wei Dong Jiang Qing Ming Meng Xi Yang He Jian Zhang Li Yao Qiang Chen | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 20 | Corporate Governance and Market Valuation in China显示文摘 | Bai Chong-En Liu Qiao Lu Joe Song Frank M Zhang Jun xi | | 0，，32： | 1 |
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