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| 1 | A rare Waxy allele coordinately improves rice eating and cooking quality and grain transparency显示文摘In rice(Oryza sativa), amylose content(AC) is the major factor that determines eating and cooking quality(ECQ). The diversity in AC is largely attributed to natural allelic variation at the Waxy(Wx)locus. Here we identified a rare Wx allele, Wx^(mw) ,which combines a favorable AC, improved ECQ and grain transparency. Based on a phylogenetic analysis of Wx genomic sequences from 370 rice accessions, we speculated that Wx^(mw) may have derived from recombination between two important natural Wx alleles, Wx^(in) and Wx^(b). We validated the effects of Wx^(mw) on rice grain quality using both transgenic lines and near-isogenic lines(NILs). When introgressed into the japonica Nipponbare(NIP) background, Wx^(mw) resulted in a moderate AC that was intermediate between that of NILs carrying the Wx^(b)allele and NILs with the Wx^(mp) allele. Notably, mature grains of NILs fixed for Wx^(mw) had an improved transparent endosperm relative to soft rice. Further, we introduced Wx^(mw) into a high-yielding japonica cultivar via molecular marker-assisted selection: the introgressed lines exhibited clear improvements in ECQ and endosperm transparency. Our results suggest that Wx^(mw) is a promising allele to improve grain quality, especially ECQ and grain transparency of high-yielding japonica cultivars, in rice breeding programs. | Changquan Zhang Yong Yang Shengjie Chen Xueju Liu Jihui Zhu Lihui Zhou Yan Lu Qianfeng Li Xiaolei Fan Shuzhu Tang Minghong Gu Qiaoquan Liu | 2021 | Journal of Integrative Plant Biology2021，63，5： | 18 |
| 2 | Down.regulation of E.cadherin enhances prostate cancer chemoresistance via Notch signaling显示文摘Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and metastasis.As a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of chemoresistance.However,the molecular mechanisms underlying PCa chemoresistance remain unclear.The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance.Methods:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were analyzed.PC3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence E-cadherin.Changes of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain reaction.Tumor cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,respectively.The drug sensitivity was evaluated using MTS assay.Results:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 cells.When E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were inhibited.In particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R cells.When E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,particularly,the sensitivity to paclitaxel was decreased.Interestingly,Notch-1 expression was up-regulated in PC3-Tx R and DU145-Tx R cells,whereas the E-cadherin expression was down-regulated in these cells comparing with their parental cells.The use ofγ-secretase inhibitor,a Notch signaling pathway inhibitor,significantly increased the sensitivity of chemoresistant cells to paclitaxel.Conclusion:The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling,and inhibiting the Notch signaling pathway may reverse PCa chemoresistance. | Wenchu Wang Lihui Wang Atsushi Mizokami Junlin Shi Chunlin Zou Jinlu Dai Evan T. Keller Yi Lu Jian Zhang | 2017 | Chinese Journal of Cancer2017，36，3： | 16 |
| 3 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 4 | The Occurrence of Oleananes in the Beibuwan Basin and Its Application to the Study of Maturity and Oil-Source Rock Correlation显示文摘摘要: oleanane 参数,即,在 Beibuwan 盆的二沉积的列的 OP (oleananes/( oleananes+C30hopanes )),华南海,能被用来限定油产生窗户的顶,与在井 M1 的 0.53 的 Ro (/%)并且 0.55 在井 H1/Hd1/Hd2 ,分别地。与 vitrinite 反射(Ro/%) 作比较, OP 展示一个动态范围和罐头更精确显示油产生窗户。由使用 OP 和另外的 geochemical 索引,油来源关联也被进行。它建议在井 M1 和 M2 的油在 situ 从来源岩石被导出。在 Huachang 的 mudstone 高举不是为在这个区域的油的主要来源岩石。OP 也是在一些第三级的湖的盆的一个有用油来源关联参数。 | LI Meijun WANG Tieguan LIU Ju ZHANG Meizhu LU Hong MA Qinglin GAO Lihui | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 9 |
| 5 | Effects of Long-term Creep at Elevated Temperatures on Rupture Ductility in 9Cr-1Mo-V-Nb-N Steel显示文摘Besides the creep strength, creep ductility has also been recognized as an important material parameter, since low ductility is often associated with notch sensitivity and concomitant prema-ture failure, especially brittle fracture. Creep rupture data of 9Cr-1Mo-V-Nb-N show that the creep ductility decreases with decreasing stress at constant temperatures or with decreasing tem-perature at constant stresses. SEM and TEM were used to investigate the mechanism of creep brittleness. The results indicate that the decrease of rupture ductility after long-term creep is related to the decrease of mobile dislocation density, the coarsening and coalescence of carbides and the decrease of shear lip size. | Zhu, Lihui Zhao, Qinxin Gu, Haicheng Lu, Yansun
| 1998 | Journal of Materials Science & Technology1998，14，3： | 3 |
| 6 | No genetic alterations in infants from intracytoplasmic sperm injection in combination with artificial oocyte activation: a pilot study显示文摘The combination of intracytoplasmic sperm injection (ICSI) with artificial oocyte activation has overcome repeated fertilization failure after ICSI due to sperm defects in activating oocyte,resulting in pregnancies and births for many couples.1-3 However,in comparison to the growing data illustrating the effectiveness of artificial oocyte activation in reproductive medicine,the safety of this approach has not been well studied.Previously,we demonstrated that the activated embryos derived from unfertilized oocytes after ICSI could develop to blastocyst stage,similar to normal embryos,as evidenced by dual color fluorescence in situ hybridization (FISH) on sex chromosomes.3 However,before artificial oocyte activation is accepted as a clinical strategy,further safety studies of the offspring need to be carefully evaluated. | Lu Qun Chen Xi Shen Huan Zhang Xiaohong Li Yang Liang Rong Li Sen Wei Lihui | 2014 | Chinese Medical Journal2014，，2： | 2 |
| 7 | Humans Are Not Machines—Anthropocentric Human–Machine Symbiosis for Ultra-Flexible Smart Manufacturing显示文摘1.Introduction The real question is not whether machines think but whether men do.Burrhus Frederic Skineer Dedicated manufacturing systems are fading out as future manufacturing(i.e.,Industry 4.0[1])demands ultra-flexible smart manufacturing systems that can self-adapt to production process changes resulting from the varied batch sizes of personalized products[2–4].The manufacturing shop-floor can become an unstructured environment where manufacturing systems and processes change their configurations dynamically via adaptive near-real-time decision-making.One emerging trend to make manufacturing flexible and reconfigurable is to introduce collaborative machines that work alongside humans with high productivity[5-7]. | Yuqian Lu Juvenal Sastre Adrados Saahil Shivneel Chand Lihui Wang | 2021 | Engineering2021，7，6： | 2 |
| 8 | Characteristics of Oil and Gas Accumulation in Yong'an-Meitai Area of the Fushan Depression,Beibuwan Basin,South China Sea显示文摘The Yong'an-Meitai area is the focus of the present exploration in the Fushan Depression,Beibuwan Basin,South China Sea. All oils from this area are geochemically characterized by higher Pr/Ph ratio,higher proportion of heavy molecular weight hydrocarbons,and higher proportion of C29 regular steranes,which indicate that the organic matter of source rocks might have been deposited in an oxidizing palaeoenvironment and be dominated by higher plant organic matter input. The oil from E3w2 (the second member of Weizhou Fm. of the Oligocene) has a much higher density,relatively higher Pr/nC17 and Ph/nC18 ratios,and a 'UCM-unresolved complex mixture' on gas chromatograms,which indicate that it has been slightly biodegraded. CPI and other terpane and sterane isomer ratios suggest they are all mature oils. The timing of oil charging in E3w2 and E2l1 (the first member of the Liushagang Fm. of the Eocene) determined by the homogenization temperatures of fluid inclusions and thermal evolution history are from 9-3 Ma and 8-3 Ma,respectively. Thus,the interpretation of E3w2 as a secondary reservoir is unlikely. The timing of oil charging is later than that of hydrocarbon generating and expulsion of Liushagang Fm. source rocks and trap formation,which is favorable for oil accumulation in this area. All molecular parameters that are used for tracing oil filling direction decrease with shallower burial depth,which suggests vertical oil migration. The widely occurring faults that penetrate through the source rocks of the Liushagang Fm. may serve as a fine oil charging conduit. | Li Meijun Wang Tieguan Liu Ju Zhang Meizhu Lu Hong Ma Qinglin Gao Lihui | 2007 | Petroleum Science2007，4，4： | 2 |
| 9 | Paleoclimatic evolution indicated by major geochemical elements from aeolian sediments on the east of Qinghai Lake显示文摘As the largest inland lake of China, along with its unique landscape and geographical location, Qinghai Lake has got much atten- tion of the scientists for a long time. The precursors have done substantive researches by using the lake sediment, which deepen our understanding of the climate changes in this region. Although sand dunes and loess sediment are widely distributed around the lake, so far the researches on geochemical elements from aeolian sediment have been less reported. In this paper, we selected a typical aeolian profile on the east of Qinghai Lake. Based on systematic sampling and analysis of seven major geochemical elements, combined with OSL dating and previous researches, this paper discusses climate changes in the Qinghai Lake area since 12.5 ka B.P.. Our conclusions are: (1) Before 12.5 ka B.P., the climate in this region was dry, cold, and accompanied by strong wind-sand activities. (2) During 12.5-11.9 ka B.P., the climate became warm and wet. However, there was an abrupt climate cooling event during 12.2-11.9 ka B.P., which likely corresponded to the Younger Dryas event. (3) During 11.9-8.0 ka B.P., the climate fluctuated greatly and frequently from warm to cold, and three cooling events occurred. (4) During 8.0-2.6 ka B.P., the climate was warm and humid. (5) Since 2.6 ka B.P., similar to the modern climate, the climate was mainly dry and cold. | Yuan Shang RuiJie Lu FeiFei Jia LiHui Tian QingLiang Tang Yuan Chen Chao Zhao WangYang Wu | 2013 | Research in Cold and Arid Regions2013，5，3： | 2 |
| 10 | An optical brain-to-brain interface supports rapid information transmission for precise locomotion control显示文摘Brain-to-brain interfaces(BtBIs) hold exciting potentials for direct communication between individual brains. However,technical challenges often limit their performance in rapid information transfer. Here, we demonstrate an optical brain-to-brain interface that transmits information regarding locomotor speed from one mouse to another and allows precise, real-time control of locomotion across animals with high information transfer rate. We found that the activity of the genetically identified neuromedin B(NMB) neurons within the nucleus incertus(NI) precisely predicts and critically controls locomotor speed. By optically recording Ca2+ signals from the NI of a 'Master' mouse and converting them to patterned optogenetic stimulations of the NI of an 'Avatar' mouse, the Bt BI directed the Avatar mice to closely mimic the locomotion of their Masters with information transfer rate about two orders of magnitude higher than previous Bt BIs. These results thus provide proof-of-concept that optical Bt BIs can rapidly transmit neural information and control dynamic behaviors across individuals. | Lihui Lu Ruiyu Wang Minmin Luo | 2020 | Science China(Life Sciences)2020，63，6： | 2 |
| 11 | Alkyl Naphthalenes and Phenanthrenes:Molecular Markers for Tracing Filling Pathways of Light Oil and Condensate Reservoirs显示文摘冷凝物和轻油被高成熟, sterane 的低集中和 terpane biomarkers 和非烃部分的低内容通常描绘。作为结果,某使用得通常的 sterane, terpane 和 carbazole,在常规油水库的迁居参数可以在煤气的层析团 spectrometry (GCMS ) 为他们的差的信号噪音比率在冷凝物和轻油水库有某个限制。然而,萘,菲和他们的 methylated 取代者在在冷凝物和轻油的重要集中是在场的。拿 Fushan 消沉(在 Beibuwan 盆,北华南海) 作为一个例子,这份报纸第一次试图使用多不的芳香的烃(哼) 跟踪迁居方向的相关参数和为冷凝物和光的充满的小径给水库上油。结果显示出那 TMNr (即 1,3,7-TMN/(1,3,7-TMN + 1,2,5-TMN ) , TMN:trimethylnaphthalene )) , MPI-1 (即 1.5 自从热历史在古生代不能在更低的古生代的继任由于有效热指示物的缺乏客观地被重建。磷灰石和锆石(U-Th )/He thermochronometry 能被用作技术的一种新类型学习热历史并且构造沉积的盆高举。把年龄,磷灰石分裂磁道数据和等价 vitrinite 反射(% EVRo ) 基于测量磷灰石和锆石(U-Th )/He,在 Bachu 的 5 口井的 tectonothermal 历史高举被建模。当模特儿的结果证明有相对高的坡度一吗? | LI Meijun WANG Tieguan LIU Ju ZHANG Meizhu LU Hong MA Qinglin GAO Lihui | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 2 |
| 12 | Inhibition of receptor interacting protein kinases attenuates cardiomyocyte hypertrophy induced by palmitic acid 显示文摘 | ZHAO Mingyue LU Lihui LEI Song | 2016 | Oxid Med Cell Lon gev2016，，14： | 1 |
| 13 | Reusability based on life cycle sustainability assessment:case study on WEEE 显示文摘 | LU Bin LI Bo WANG Lihui | 2014 | Procedia Cirp2014，15，2： | 1 |
| 14 | Activation of hydrogen peroxide by molybdenum disulfide as Fenton-like catalyst and cocatalyst:Phase-dependent catalytic performance and degradation mechanism显示文摘Molybdenum disulfide(Mo S_(2))has attracted great attention in hydrogen peroxide(H_(2)O_(2))activation as a Fenton-like catalyst and cocatalyst,but the distinct mechanism of generating^(·)OH remains unclear.In this paper,the metallic 1T phase and semiconducting 2H phase of Mo S_(2)nanosheets were prepared and applied in MoS_(2)/H_(2)O_(2)and MoS_(2)/Fe^(2+)/H_(2)O_(2)systems with and without light irradiation.Compared with2H-MoS_(2),1T-MoS_(2)exhibited superior removal rates in degrading organic pollutants in the two systems under light irradiation.However,the phase had little effect on activating H_(2)O_(2)in the Mo S_(2)/H_(2)O_(2)system under dark conditions.This is because it was difficult for the surface^(·)OH_(ads)generated in the Mo S_(2)/H_(2)O_(2)system to diffuse into solution,while the^(·)OH_(free)radicals were mainly responsible for degrading organic pollutants.When introducing light irradiation,external energy may accelerate the desorption of^(·)OH_(ads)into^(·)OH_(free.)Interestingly,the conversion between Mo^(4+)and Mo^(5+)triggered the decomposition of H_(2)O_(2)in the Fenton-like reaction,while the cycle of Mo^(4+)/Mo^(6+)promoted the regeneration of Fe^(3+)when employing 1T-MoS_(2)as a cocatalyst.Meanwhile,the 1T-MoS_(2)catalysts exhibited excellent stability and ability to degrade various organics in the two systems.This work offers deeper insight into the Mo S_(2)-based Fenton-like and cocatalytic mechanisms. | Yue Li Bo Yu Huimin Li Bo Liu Xiang Yu Kewei Zhang Gang Qin Jiahao Lu Lihui Zhang Longlu Wang | 2023 | Chinese Chemical Letters2023，34，5： | 1 |
| 15 | Evaluation of effect of number of electrodes in ECT sensors on image quality 显示文摘 | PENG Lihui YE Jiamin LU Geng | 2012 | IEEE Sensors Journal2012，12，5： | 1 |
| 16 | E-cadherin表达下调激活Notch信号通路增强前列腺癌化疗耐药的机制研究显示文摘背景与目的前列腺癌(prostate cancer,PCa)化疗耐药与其侵袭性和转移性密切相关。最新研究显示上皮细胞–间充质转化(epithelial-to-mesenchymal transition,EMT)可能在前列腺癌化疗耐药和转移中发挥重要作用。因此,作为EMT的标志物,E-cadherin被认为有可能与肿瘤化疗耐药有重要关系。然而,PCa化疗耐药的分子机制尚不清楚。本研究旨在探讨EMT与PCa化疗耐药的关系,以及E-cadherin表达变化是否影响PCa化疗耐药。方法以亲代PC3和DU145细胞及其化疗耐药PC3-TxR和DU145-TxR细胞作为研究对象。用E-cadherin过表达的慢病毒感染PC3-TxR和DU145-TxR细胞,使E-cadherin过表达;同时,用小干扰RNA转染PC3和DU145细胞,使E-cadherin表达沉默。采用蛋白免疫印迹和实时定量聚合酶链反应分析EMT相关标志物及信号通路的变化。分别通过划痕、transwell和克隆形成实验检测肿瘤细胞的迁移、侵袭和克隆形成能力。采用MTS法检测细胞对紫杉醇的药物敏感性。结果与亲代PC3和DU145细胞相比,化疗耐药PC3-TxR和DU145-TxR细胞表现出EMT相关的标志物表达改变,包括E-cadherin表达下调和Vimentin、Snail与N-cadherin表达上调。当E-cadherin在PC3-TxR和DU-145-TxR细胞中过表达时,Vimentin和Caldun-1表达下调,肿瘤细胞的迁移和侵袭受到抑制。特别是E-cadherin过表达以后,PC3-TxR和DU145-TxR细胞对紫杉醇的敏感性被重新激活。并且,在亲代PC3和DU145细胞中沉默E-cadherin表达后,Vimentin和Snail表达上调,对紫杉醇的敏感性降低。有趣的是,与亲代PC3和DU145细胞相比,PC3-TxR和DU145-TxR细胞中Notch-1表达上调,而E-cadherin在这些细胞中的表达下调。我们的研究还显示,Notch信号通路抑制剂γ-分泌酶抑制剂可显著增加化疗耐药细胞对紫杉醇的敏感性。结论 E-cadherin下调可以激活Notch信号通路,从而增强PCa化疗耐药,抑制Notch信号通路可能逆转PCa化疗耐药。 | Wenchu Wang Lihui Wang Atsushi Mizokami Junlin Shi Chunlin Zou Jinlu Dai Evan T.Keller Yi Lu Jian Zhang | 2019 | 癌症2019，38，3： | 1 |
| 17 | Morphological,thermal and mechanical properties of ramie crystallites-reinforced plasticized starch biocomposites显示文摘 | Lu Yongshang Weng Lihui Cao Xiaodong | 2006 | Carbohydrate Polymers2006，63，2： | 1 |
| 18 | Ore extensions of multiplier Hopf algebras显示文摘 | Lihui Zhao Diming Lu | 2012 | Comm Algebra2012，40，： | 1 |
| 19 | Synergistic Interfacial and Doping Engineering of Heterostructured NiCo(OH)_(x)-Co_(y)W as an Efficient Alkaline Hydrogen Evolution Electrocatalyst显示文摘To achieve high efficiency of water electrolysis to produce hydrogen(H_(2)),developing non-noble metal-based catalysts with consid-erable performance have been considered as a crucial strategy,which is correlated with both the interphase properties and multi-metal synergistic effects.Herein,as a proof of concept,a delicate NiCo(OH)_(x)-CoyW catalyst with a bush-like heterostructure was realized via gas-template-assisted electrodeposition,followed by an electrochemical etching-growth process,which ensured a high active area and fast gas release kinetics for a superior hydrogen evolution reaction,with an overpotential of 21 and 139 mV at 10 and 500 mA cm^(−2),respectively.Physical and electrochemical analyses demonstrated that the synergistic effect of the NiCo(OH)_(x)-Co_(y)W heteroge-neous interface resulted in favorable electron redistribution and faster electron transfer efficiency.The amorphous NiCo(OH)_(x) strengthened the water dissociation step,and metal phase of CoW provided sufficient sites for moderate H immediate adsorption/H_(2) desorption.In addition,NiCo(OH)_(x)-CoyW exhibited desirable urea oxidation reaction activity for matching H_(2) generation with a low voltage of 1.51 V at 50 mA cm^(−2).More importantly,the synthesis and testing of the NiCo(OH)_(x)-CoyW catalyst in this study were all solar-powered,sug-gesting a promising environmentally friendly process for practical applications. | Ruopeng Li Hao Xu Peixia Yang Dan Wang Yun Li Lihui Xiao Xiangyu Lu Bo Wang Jinqiu Zhang Maozhong An | 2021 | Nano-Micro Letters2021，13，8： | 1 |
| 20 | Simulation of Decoupling Control of Pulsed MIG Welding for Aluminum Alloy 显示文摘 | Ding Fan Jiankang Huang Lihui Lu | 2011 | Lecture Notes in Electrical Engineering2011，88，3： | 1 |
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