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| 1 | Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma显示文摘Tertiary lymphoid structures(TLS)are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis.However,the prognostic value of TLSs in oral squamous cell carcinoma(OSCC)is largely unknown,and the association between tumour infiltrating lymphocytes(TILs)and TLSs has been rarely explored in OSCC.In this study,associated markers of TLS,including peripheral node address(PNAd)in high endothelial venules,CD20 in B cells and CD3 in T cells,were examined in 168 OSCC patients,and survival analysis was performed between TLS-positive and TLS-negative cohorts.We detected the presence of TILs by staining CD8+cytotoxic T cells and CD57+NK cells as well.TLSs appeared as highly organized structures in 45(26.8%)cases.TLSpositive patients had a better 5-year overall survival(OS)rate(88.9%vs.56.1%,P<0.001)and relapse-free survival(RFS)rate(88.9%vs.63.4%,P=0.002).Moreover,the presence of TLS was an independent prognostic factor for both the 5-year OS rate(hazard ratio[HR]=3.784;95%confidence interval[CI],1.498–9.562)and RFS rate(HR=3.296;95%CI,1.279–8.490)in multivariate analysis.Furthermore,a higher density of CD8+T cells and CD57+NK cells was found in TLS-positive sections than in TLS-negative counterparts(P<0.001),and their combination provided a higher predictive accuracy(AUC=0.730;95%CI,0.654–0.805).In conclusion,our results suggest that TLS is an independent positive prognostic factor for OSCC patients.These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment. | Qunxing Li Xiangqi Liu Dikan Wang Yanqiong Wang Huanzi Lu Shuqiong Wen Juan Fang Bin Cheng Zhi Wang | 2020 | International Journal of Oral Science2020，12，3： | 12 |
| 2 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://gffzz3ff3e9d9e9f64aa3hukv0vpfqvqnw6ob0.ffgz.tsg.suse.edu.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 3 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 4 | AOI Techniques for Surface Defect Inspection 显示文摘 | LU Rongsheng SHI Yanqiong LI Qi | 2010 | Applied Mechanics and Materials(S1660-9336)2010，36，： | 1 |
| 5 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang<.--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，： | 1 |
| 6 | Global Structure of Positive Solutions for Second-Order Difference Equation with Nonlinear Boundary Value Condition 显示文摘 | LU Yanqiong MA Ruyun | 2014 | Adv Differ Equ2014，2014，1： | 1 |
| 7 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang< !--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，24： | 1 |
| 8 | Positive period- ic solutions of nonlinear first-order functional difference equa- tions 显示文摘 | Ma Ruyun Chen Tianlan Lu Yanqiong | 2011 | Discrete Dynamics in Nature and Society2011，2011，96： | 1 |
| 9 | Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer显示文摘The therapeutic efficacy of metformin in prostate cancer(PCa)appears uncertain based on various clinical trials.Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation,which leads to drug resistance.However,the underlying mechanism is still unclear.In this study,we found evidences that metformin resistance in PCa cells may be linked to cell cycle reactivation.Super-enhancers(SEs),crucial regulatory elements,have been shown to be associated with drug resistance in various cancers.Our analysis of SEs in metformin-resistant(MetR)PCa cells revealed a correlation with Prostaglandin Reductase 1(PTGR1)expression,which was identified as significantly increased in a cluster of cells with metformin resistance through single-cell transcriptome sequencing.Our functional experiments showed that PTGR1 overexpression accelerated cell cycle progression by promoting progression from the G0/G1 to the S and G2/M phases,resulting in reduced sensitivity to metformin.Additionally,we identified key transcription factors that significantly increase PTGR1 expression,such as SRF and RUNX3,providing potential new targets to address metformin resistance in PCa.In conclusion,our study sheds new light on the cellular mechanism underlying metformin resistance and the regulation of the SE-TFs-PTGR1 axis,offering potential avenues to enhance metformin’s therapeutic efficacy in PCa. | Jianheng Ye Shanghua Cai Yuanfa Feng Jinchuang Li Zhiduan Cai Yulin Deng Ren Liu Xuejin Zhu Jianming Lu Yangjia Zhuo Yingke Liang Jianjiang Xie Yanqiong Zhang Huichan He Zhaodong Han Zhenyu Jia Weide Zhong | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 10 | Analysis of Consumer Behavior in the Context of the Digital Economy显示文摘Under the condition that the digital economy model has penetrated into the consumption field,the consumer market environment is improving,the consumption structure is upgrading,the consumption content is diversified,and the consumer behavior is showing new epoch-making characteristics.But at the same time,there are also some problems,such as consumer privacy disclosure,and price discrimination based on consumer behavior.The future development of consumer economy needs the joint efforts of the government,the market and consumers to establish a new cycle of the economic system from top to bottom. | Yanqiong PENG Fang FANG Fanxin LIU Wenjiao LU Kai GAO Dan LIU Mingquan SHA | 2022 | Asian Agricultural Research2022，14，11： | 0 |
| 11 | Salicylic acid sensitizes cervical cancer cells to radiotherapy by activating AMPK/TSC2/mTOR pathway显示文摘Objective:To investigate the radio-sensitizing effect of salicylic acid(SA)on human cervical cancer cells and its potential molecular mechanism.Methods:Cervical cancer cells were treated with SA and ionizing radiation.The expression ofγ-H2AX was evaluated by immunofluorescence(IF)assay.Cell cycle and apoptosis were analyzed by flow cytometry.Western blot was performed to detect the protein level of AMPK/TSC2/mTOR pathway.Results:SA inhibited basal proliferation of cervical cancer cells in a dose and time dependent manner.In addition,SA increased radiation-induced DNA damage,promoted apoptosis,triggered a redistribution of cell cycle from G2-M phase to G1-S phase of cervical cancer cells,and hence increased cell sensitivity to radiation.Moreover,SA treatment elevated the expression levels of p-AMPKα(t=3.996,P<0.05)and p-TSC2(t=5.308,P<0.05),whereas the level of p-mTOR(t=10.160,P<0.05)was significantly decreased.Conclusion:SA enhances the radiosensitivity of cervical cancer cells by targeting AMPK/TSC2/mTOR signaling pathway,and might serve as a promising therapeutic strategy to improve the efficacy of radiotherapy for cervical cancer. | Shun Lu Wenjing Ye Jie Zhou Guangming Yi Jianming Huang Siyao Deng Minglun Li Yimin Li Yanqiong Song Jiayu Zhang Lichun Wei Guiquan Zhu Jinyi Lang | 2022 | Radiation Medicine and Protection2022，3，1： | 0 |
| 12 | One-Signed Periodic Solutions of First-Order Functional Difference Equations with Parameter显示文摘In this paper,the authors obtain the existence of one-signed periodic solutions of the first-order functional difference equation ?u(n) = a(n)u(n)-λb(n)f(u(n-τ(n))),n ∈ Z by using global bifurcation techniques,where a,b:Z → [0,∞) are T-periodic functions with ∑T n=1 a(n) > 0,∑T n=1 b(n) > 0;τ:Z → Z is T-periodic function,λ > 0 is a parameter;f ∈ C(R,R) and there exist two constants s_2 < 0 < s_1 such that f(s_2) = f(0) = f(s_1) = 0,f(s) > 0 for s ∈(0,s_1) ∪(s_1,∞),and f(s) < 0 for s ∈(-∞,s_2) ∪(s_2,0). | Yanqiong LU Ruyun MA Bo LU | 2018 | Journal of Mathematical Research with Applications2018，38，4： | 0 |
| 13 | EXISTENCE AND MULTIPLICITY OF POSITIVE SOLUTIONS TO NONLINEAR SEMIPOSITONE NEUMANN BOUNDARY VALUE PROBLEM显示文摘In this paper, we study a nonlinear semipositone Neumann boundary value problem. Under some suitable conditions, we prove the existence and multiplicity of positive solutions to the problem, based on Krasnosel'skii's fixed point theorem in cones. | Ruipeng Chen , Yanqiong Lu (Dept. of Math., Northwest Normal University, Lanzhou 730070) | 2012 | Annals of Differential Equations2012，28，2： | 0 |
| 14 | Oscillation Property for the Eigenfunctions of Discrete Clamped Beam Equation and Its Applications显示文摘In this article,we established the structure of all eigenvalues and the oscillation property of corresponding eigenfunctions for discrete clamped beam equation △^(4)u(k-2)=λm(k)u(k),k∈[2,N+1]Z,u(0)=△u(0)=0=u(N+2)=△u(N+2)with the weight function m:[2,N+1]Z→(0,∞),[2,N+1]_(Z)={2,3,...,N+1}.As an application,we obtain the global structure of nodal solutions of the corresponding nonlinear problems based on the nonlinearity satisfying suitable growth conditions at zero and infinity. | Yanqiong LU Rui WANG | 2021 | Journal of Mathematical Research with Applications2021，41，4： | 0 |
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