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| 1 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 2 | Soil organic carbon and nitrogen content of density fractions and effect of meadow degradation to soil carbon and nitrogen of fractions in alpine Kobresia meadow显示文摘This research was conducted on the non-disturbed native alpine Kobresia meadow(YF) and the severely degraded meadow(SDL) of Dari County of Qinghai Province.By a density fractionation approach,each soil sample was divided into two fractions:light fraction(LF) and heavy fraction(HF).The obtained fractions were analyzed for organic carbon(OC) and nitrogen(N) concentrations.The results showed:(1) the OC concentration in HF and LF was 3.84% and 28.63% respectively while the nitrogen concentration in HF and LF was 0.362% and 1.192% respectively in 0-10 cm depth.C:N ratio was 10.6 in HF and 23.8 in LF respectively.(2) As far as the ratio of OC in given fraction to that in gross sample was concerned,dominance of OC in HF was obvious in the whole soil profile.OC in HF increased from 78.95% to 90.33%,while OC in LF decreased from 21.05% to 9.68% with depths.(3) Soil total OC amounted to 47.47 in YF while 17.63 g.kg-1 in SDL,in which the OC content in HF decreased from 37.31 to 16.01 g.kg-1 while OC content in LF decreased from 10.01 to 1.62 g.kg-1.In other words,results of OC and N content show meadow degradation led to the loss of 57% OC in HF and 84% OC in LF from originally native ecosystem on alpine meadow.In addition,meadow degradation led to the loss of 43% N in HF and 79% N in LF from originally native ecosystem on alpine meadow.(4) The main reason for loss of C and N in LF during meadow degradation was not attributed to the decrease of OC and N concentration in LF and LF,but to the decrease in LF dry weight.Loss of N was far lower than loss of C in HF.This may suggest that there is difference in protection mode of C and N in HF. | WANG WenYing WANG QiJi LU ZiYu | 2009 | Science China Earth Sciences2009，52，5： | 10 |
| 3 | Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection显示文摘The ongoing pandemic of coronavirus disease 19(COVID-19)is caused by a newly discoveredβcoronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination.Here we examined,using ELISA,the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6–7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection.All samples were positive for IgGs against the S-and N-proteins of SARS-CoV-2.Notably,14 samples available at 6–7 months post-infection all showed significant neutralizing activities in a pseudovirus assay,with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2.Furthermore,in 10 blood samples from cases at 6–7 months post-infection used for memory T-cell tests,we found that interferonγ-producing CD4+and CD8+cells were increased upon SARS-CoV-2 antigen stimulation.Together,these results indicate that durable anti-SARS-CoV-2 immunity is common in convalescent population,and vaccines developed from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV-2. | Yun Tan Feng Liu Xiaoguang Xu Yun Ling Weijin Huang Zhaoqin Zhu Mingquan Guo Yixiao Lin Ziyu Fu Dongguo Liang Tengfei Zhang Jian Fan Miao Xu Hongzhou Lu Saijuan Chen | 2020 | Frontiers of Medicine2020，14，6： | 6 |
| 4 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 5 | Rapid growth and properties of large-aperture 98%-deuterated DKDP crystals显示文摘In this paper,a highly deuterated potassium dihydrogen phosphate(DKDP)crystal with sizes up to 318 mm×312 mm×265 mm was grown by the rapid-growth method.The synthesis tank device was specially designed to synthesize a higher deuterium concentration and high-purity DKDP solution.The deuterium content of the as-grown crystal,which was 97.9%,was determined by two methods,including infrared(IR)spectroscopy and thermo-gravimetric analysis(TGA)measurements.The performances of the 97.9%DKDP crystal,including transmission,absorption coefficient,and laserinduced damage threshold(LIDT)were measured.The results indicate that,in the near-infrared band,the transmission of the 97.9%DKDP crystal is higher than that of KDP and 70%DKDP crystals,and the absorption coefficient is lower.The LIDT of the crystal reached 23.2 J·cm^-2(R-on-1,1064 nm,3 ns),which meets the engineering requirements for use in optical applications. | Xumin Cai Xiuqing Lin Guohui Li Junye Lu Ziyu Hu Guozong Zheng | 2019 | High Power Laser Science and Engineering2019，7，3： | 4 |
| 6 | Properties and Morphology of TiN Films Deposited by Atomic Layer Deposition显示文摘In this study,TiN films were deposited on SiO2 substrates by Atomic Layer Deposition(ALD) using TiCl4and NH3 as precursors. Properties and morphology of the TiN films were characterized by different methods.Using Grazing Incidence X-Ray Diffraction(GIXRD),TiN films demonstrated polycrystalline structure with(111)preferred orientation. Film thickness was measured by Spectroscopic Ellipsometry(SE) and a stable growth rate of 0.0178 nm/cycle was reached after 500 deposition cycles,which was consistent with the essence of ALD as a surface-saturated self-limiting reaction. Film resistivity measured by a four-point probe continuously decreased with increasing deposition cycles until it reached the minimum value of 300μΩ cm at 5000 deposition cycles with a thickness of 87.04 nm. The surface roughness and morphology of the TiN films at different deposition cycles ranging from 50 to 400 were analyzed by Atomic Force Microscopy(AFM). The AFM results indicated that the initial film growth follows the Stranski-Krastanov mode. | Siyi Xie Jian Cai Qian Wang Lu Wang Ziyu Liu | 2014 | Tsinghua Science and Technology2014，19，2： | 4 |
| 7 | Applications of Deep Learning to MRI Images:A Survey显示文摘Deep learning provides exciting solutions in many fields, such as image analysis, natural language processing, and expert system, and is seen as a key method for various future applications. On account of its non-invasive and good soft tissue contrast, in recent years, Magnetic Resonance Imaging(MRI) has been attracting increasing attention. With the development of deep learning, many innovative deep learning methods have been proposed to improve MRI image processing and analysis performance. The purpose of this article is to provide a comprehensive overview of deep learning-based MRI image processing and analysis. First, a brief introduction of deep learning and imaging modalities of MRI images is given. Then, common deep learning architectures are introduced. Next, deep learning applications of MRI images, such as image detection, image registration, image segmentation, and image classification are discussed. Subsequently, the advantages and weaknesses of several common tools are discussed, and several deep learning tools in the applications of MRI images are presented.Finally, an objective assessment of deep learning in MRI applications is presented, and future developments and trends with regard to deep learning for MRI images are addressed. | Jin Liu Yi Pan Min Li Ziyue Chen Lu Tang Chengqian Lu Jianxin Wang | 2018 | Big Data Mining and Analytics2018，1，1： | 3 |
| 8 | Ultrathin Ni_(x)Co_(y)-silicate nanosheets natively anchored on CNTs films for flexible lithium ion batteries显示文摘The rapid development of portable and wearable electronics has called for novel flexible electrodes with superior performance.The development of flexible electrode materials with excellent mechanical and electrochemical properties has become one of the key factors for this goal.Here,a Ni_(x)Co_(y)-silicate@CNTs film is developed as a flexible anode for lithium ion batteries(LIBs).On this film,Ni_(x)Co_(y)-silicate nanosheets are firmly and intimately anchored on the surface of CNTs,which have a 3D network structure and link the adjacent nanosheets together.Benefitted from this,the composite film is not only sufficient to withstand various deformations due to its excellent flexibility but also has excellent electrochemical properties,in terms of high reversible capacity of 1047 mAh g^(-1) at 0.1 A g^(-1) as well as a high rate and cycling performance(capacity retention up to 78.13% after 140 cycles).The pouch-type full flexible LIB using this material can stably operate under various bending conditions,showing the great potential of this 3 D Ni_(x)Co_(y)-silicate@CNTs film for flexible energy storage devices with high durability. | Wenlei Guo Wenping Si Tao Zhang Yonghuan Han Lei Wang Ziyue Zhou Pengyi Lu Feng Hou Ji Liang | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 9 | A flexible CNT@nickel silicate composite film for high-performance sodium storage显示文摘Due to the sufficient ion diffusion channels provided by the large interlayer spacing, layered silicates are widely considered as potential anode materials for lithium ion and sodium ion batteries. However, due to the poor electronic conductivity, the application of layered silicates for electrochemical energy storage has been greatly limited. Carbon nanotube(CNT) film has excellent electrical conductivity and a unique interconnected network, making it an ideal matrix for composite electrochemical material. We herein report a CNT@nickel silicate composite film(CNT@NiSiO) fabricated by a SiO2-mediated hydrothermal conversion process, for sodium storage with excellent electrochemical properties. The obtained composite possesses a cladding structure with homogeneous nanosheets as the outermost and CNT film as the inner network matrix, providing abundant ion diffusion channels, high electronic conductivity, and good mechanical flexibility. Due to these merits, this material possesses an excellent electrochemical performance for sodium storage, including a high specific capacity up to 390 mAh g-1 at 50 mA g-1, good rate performance up to 205 mAh g-1 at 500 mA g-1, and excellent cycling stability. On this basis, this work would bring a promising material for various energy storage devices and other emerging applications. | Ziyue Zhou Wenping Si Pengyi Lu Wenlei Guo Lei Wang Tao Zhang Feng Hou Ji Liang | 2020 | Journal of Energy Chemistry2020，29，8： | 2 |
| 10 | Photocatalytic decarboxylative coupling between α-oxocarboxylicacids and alkenes显示文摘Photocatalytic decarboxylative cross-coupling which achieves the derivatization of widespread organic acids has become a hot topic in organic synthesis.As special acids,α-oxocarboxylicacids show the great potential in running decarboxylation to construct ketone derivatives.In this article,we have developed a photocatalytic decarboxylative cross-coupling ofα-oxocarboxylic acids and olefins to the synthesis of diverse aryl ketones.Various alkenes andα-oxocarboxylicacids were compatible,generating the desired products in up to 90%yield.Preliminary mechanism studies suggest that a free radical pathway is involved in this process. | Ziyue Chen Fangling Lu Feng Yuan Juanjuan Sun Linyu Du Zhen Li Meng Gao Renyi Shi Aiwen Lei | 2019 | Science China Chemistry2019，62，11： | 2 |
| 11 | Superior resistance to alkali metal potassium of vanadium-based NH_(3)-SCR catalyst promoted by the solid superacid SO_(4)^(2-)-TiO_(2)显示文摘The significant decrease of acid sites caused by alkali metal poisoning is the major factor in the deactivation of commercial V_(2)O_(5)-WO_(3)/TiO_(2)NH_(3)-SCR catalysts.In this work,the solid superacid SO_(4)^(2-)-TiO_(2) modified by sulfate radicals,was selected as the catalyst support,which showed superior potassium resistance.The physicochemical properties and K-poisoning resistance of the V_(2)O_(5)-WO_(3)/SO_(4)^(2-)-TiO_(2)(VWSTi) catalyst were carried out by XRD,BET,H2-TPR,NH3-TPD,XPS,in situ DRIFTS and TG.The results pointed out that the introduction of SO_(4)^(2-)significantly increased the NH3-SCR catalytic activity at high temperatures,with an exceptionally high NO_(x) conversion over 90% between 275℃ and 500℃.When 0.5%(mass) K_(2)O was doped on the catalysts,the catalytic performance of the traditional V_(2)O_(5)-WO_(3)/TiO_(2)(VWTi) catalyst decreased significantly,while the VWSTi catalyst could still maintain a NOxconversion over 90%in the range of 300–500℃.The characterizations suggested that the support of SO_(4)^(2-)-TiO_(2) greatly increased the number of acidic sites,thereby enhancing the adsorption capacity of the reactant NH_(3).The results above demonstrated a potential approach to achieve superior potassium resistance for NH3-SCR catalysts using solid superacid. | Yaoyao Peng Lei Song Siru Lu Ziyu Su Kui Ma Siyang Tang Shan Zhong Hairong Yue Bin Liang | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 1 |
| 12 | Preparation and application of mesoporous core-shell nanosilica using leucine derivative as template in effective drug delivery显示文摘Core-shell structured mesoporous silica nanoparticles have been firstly synthesized with the new template from L-leucine methyl ester hydrochloride(H-Leu-OMe·HCl).LMSNs were characterized by transmission electron microscopy(TEM),nitrogen adsorption/desorption,and small-angle X-ray diffraction(SAXRD),demonstrating a well-ordered mesostructure.After loading doxorubicin hydrochloride(Dox) into pores,considerable loading capacity of 30.5% and favorable cumulative release amount were obtained.MTT assay suggested that Dox-loaded LMSNs demonstrated great promise to anti-tumor.The use of MSNs with the synthesized template,as a drug delivery carrier,will exte nd the pharmaceutical applications of silica materials. | Wei Zhang Qiming Kan Lu Chen Luyao Xie Mingshu Cui Ziyue Xi Yanru Xi Sanming Li Lu Xu | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 13 | A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes显示文摘Dry powder inhalers(DPIs) had been widely used in lung diseases on account of direct pulmonary delivery, good drug stability and satisfactory patient compliance. However, an indistinct understanding of pulmonary delivery processes(PDPs) hindered the development of DPIs. Most current evaluation methods explored the PDPs with over-simplified models, leading to uncompleted investigations of the whole or partial PDPs. In the present research, an innovative modular process analysis platform(MPAP) was applied to investigate the detailed mechanisms of each PDP of DPIs with different carrier particle sizes(CPS). The MPAP was composed of a laser particle size analyzer, an inhaler device,an artificial throat and a pre-separator, to investigate the fluidization and dispersion, transportation,detachment and deposition process of DPIs. The release profiles of drug, drug aggregation and carrier were monitored in real-time. The influence of CPS on PDPs and corresponding mechanisms were explored. The powder properties of the carriers were investigated by the optical profiler and Freeman Technology four powder rheometer. The next generation impactor was employed to explore the aerosolization performance of DPIs. The novel MPAP was successfully applied in exploring the comprehensive mechanism of PDPs, which had enormous potential to be used to investigate and develop DPIs. | Yingtong Cui Ying Huang Xuejuan Zhang Xiangyun Lu Jun Xue Guanlin Wang Ping Hu Xiao Yue Ziyu Zhao Xin Pan Chuanbin Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
| 14 | Advances in post-operative prognostic models for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies and a leading cause of cancer-related death worldwide.Surgery remains the primary and most successful therapy option for the treatment of early-and mid-stage HCCs,but the high heterogeneity of HCC renders prognostic prediction challenging.The construction of relevant prognostic models helps to stratify the prognosis of surgically treated patients and guide personalized clinical decision-making,thereby improving patient survival rates.Currently,the prognostic assessment of HCC is based on several commonly used staging systems,such as Tumor-Node-Metastasis(TNM),Cancer of the Liver Italian Program(CLIP),and Barcelona Clinic Liver Cancer(BCLC).Given the insufficiency of these staging systems and the aim to improve the accuracy of prognostic prediction,researchers have incorporated further prognostic factors,such as microvascular infiltration,and proposed some new prognostic models for HCC.To provide insights into the prospects of clinical oncology research,this review describes the commonly used HCC staging systems and new models proposed in recent years. | Ziqin HE Xiaomin SHE Ziyu LIU Xing GAO Lu LU Julu HUANG Cheng LU Yan LIN Rong LIANG Jiazhou YE | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 1 |
| 15 | Compressibility of epidote up to 20GPa at 298 K显示文摘 | Wu Xiang Liu Jun Liu Jing Wu Ziyu Li Xiaodong Lu Anhuai | 2003 | Chinese Physics Letters2003，20，： | 1 |
| 16 | 3D Printing of Nacre-Inspired Structures with Exceptional Mechanical and Flame-Retardant Properties显示文摘Flame-retardant and thermal management structures have attracted great attention duc to the requirement of high-temperature exposure in industrial,aerospace,and thermal power fields,but the development of protoctive fire-retardant structures with complex shapes to fit arbitrary surfaces is still challenging.Herein,we reported a rotation-blade casting-assisted 3D printing process to fabricate nacre-inspired structures with exceptional mechanical and flame-retardant properties,and the relatedi fundamental mechanisms are studied.3-(Trimethoxysilyl)propyl methacrylate(TMSPMA)modified boron nitride nanoplatelets(BNs)were aligned by rotation-blade casting during the 3D printing process to build the'hrick and mortar'architecture.The 3D printed structures are more lightweight,while having higher fracture toughness than the natural nacre,which is attributed to the crack deflection,aligned BN(a-BNs)bridging,and pull-outs reinforced structures by the covalent bonding between TMSPMA grafted a-BNs and polymer matrix.Thermal conductivity is enhanced by 25.5 times compared with pure polymer and 5.8 times of anisotropy due to the interconnection of a-BNs.3D printed heat-exchange structures with vertically aligned BNs in complex shapes were demonstrated for efficient thermal control of high-power light-emitting diocles.3D printed helmet and armor with a-BNs show exceptional mechanical and fire-retardant properties,demonstrating integrated mechanical and thermal protection. | Yang Yang Ziyu Wang Qingqing He Xiangjia Li Gengxi Lu Laiming Jjiang Yushun Zeng Brandon Bethers Jie Jin Shuang Lin Siqi Xiao Yizhen Zhu Xianke Wu Wenwu Xu Qiming Wang Yong Chen | 2022 | Research2022，，2： | 1 |
| 17 | Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai显示文摘The Omicron family of SARS-CoV-2 variants are currently driving the COVID-19 pandemic.Here we analyzed the clinical laboratory test results of 9911 Omicron BA.2.2 sublineages-infected symptomatic patients without earlier infection histories during a SARS-CoV-2 outbreak in Shanghai in spring 2022.Compared to an earlier patient cohort infected by SARS-CoV-2 prototype strains in 2020,BA.2.2 infection led to distinct fluctuations of pathophysiological markers in the peripheral blood.In particular,severe/critical cases of COVID19 post BA.2.2 infection were associated with less pro-inflammatory macrophage activation and stronger interferon alpha response in the bronchoalveolar microenvironment.Importantly,the abnormal biomarkers were significantly subdued in individuals who had been immunized by 2 or 3 doses of SARS-CoV-2 prototypeinactivated vaccines,supporting the estimation of an overall 96.02% of protection rate against severe/critical disease in the 4854 cases in our BA.2.2 patient cohort with traceable vaccination records.Furthermore,even though age was a critical risk factor of the severity of COVID-19 post BA.2.2 infection,vaccination-elicited protection against severe/critical COVID-19 reached 90.15% in patients aged≥60 years old.Together,our study delineates the pathophysiological features of Omicron BA.2.2 sublineages and demonstrates significant protection conferred by prior prototype-based inactivated vaccines. | Ziyu Fu Dongguo Liang Wei Zhang Dongling Shi Yuhua Ma Dong Wei Junxiang Xi Sizhe Yang Xiaoguang Xu Di Tian Zhaoqing Zhu Mingquan Guo Lu Jiang Shuting Yu Shuai Wang Fangyin Jiang Yun Ling Shengyue Wang Saijuan Chen Feng Liu Yun Tan Xiaohong Fan | 2023 | Frontiers of Medicine2023，17，3： | 1 |
| 18 | Physiological Signals Based Fatigue Prediction Model for Motion Sensing Games显示文摘 | Ziyu Lu Ling Chen Changjun Fan | 2012 | Advances in Computer Entertainment Lecture Notes in Computer Science2012，7624，： | 1 |
| 19 | Optimization and Evaluation of Sputtering Barrier/Seed Layer in Through Silicon Via for 3-D Integration显示文摘The barrier/seed layer is a key issue in Through Silicon Via(TSV) technology for 3-D integration.Sputtering is an important deposition method for via metallization in semiconductor process. However,due to the limitation of sputtering and a 'scallop' profile inside vias,poor step coverage of the barrier/seed layer always occurs in the via metallization process. In this paper,the effects of several sputter parameters(DC power,Ar pressure,deposition time,and substrate temperature) on thin film coverage for TSV applications are investigated.Robust TSVs with aspect ratio 5 1 were obtained with optimized magnetron sputter parameters. In addition,the influences of different sputter parameters are compared and the conclusion could be used as a guideline to select appropriate parameter sets. | Tiwei Wei Jian Cai Qian Wang Yang Hu Lu Wang Ziyu Liu Zijian Wu | 2014 | Tsinghua Science and Technology2014，19，2： | 1 |
| 20 | Management of staghorn stones in special situations显示文摘Staghorn stones have always been a challenge for urologists,especially in some special situations,such as horseshoe kidney,ectopic kidney,paediatric kidney,and solitary kidney.The treatment of these staghorn stones must be aggressive because they can lead to renal function loss and serious complications.The gold-standard management for staghorn stones is surgical treatment with the aim of clearing the stones and preserving renal function.Treatment methods for staghorn stones have developed rapidly,such as extracorporeal shock wave lithotripsy,retrograde intrarenal surgery,percutaneous nephrolithotomy and laparoscopy and open surgery.Whether the standard procedures for staghorn stones can also apply to these stones in special situations is still not agreed upon.The decision should be made individually according to the circumstances of the patient.In this review,we evaluates the previous studies and comments on the management of staghorn stones under special situations in the hope of guiding the optimal choice for urologists. | Xiaofeng Gao Ziyu Fang Chaoyue Lu Rong Shen Hao Dong Yinghao Sun | 2020 | Asian Journal of Urology2020，7，2： | 1 |
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