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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | GAS2-Calpain2 axis contributes to the growth of leukemic cells显示文摘 | LUi Sun Haixia Zhou Hong Liu Yue Ge Xiuyan Zhang Wenjuan Ma Depei Wu Yun Zhao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 2 |
| 3 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 4 | Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma显示文摘 | C.-Y. Hsia T.-I. Huo S.-Y. Chiang M.-F. Lu C.-L. Sun J.-C. Wu P.-C. Lee C.-W. Chi W.-Y. Lui S.-D. Lee | 2006 | European Journal of Surgical Oncology2006，，2： | 1 |
| 5 | Long non-coding RNA expression profiles predict clinical phenotypes in glioma显示文摘 | Xiaoqin Zhang Stella Sun Jenny Kan Suen Pu Anderson Chun On Tsang Derek Lee Venus On Ying Man Wai Man Lui Stanley Thian Sze Wong Gilberto Ka Kit Leung | 2012 | Neurobiology of Disease2012，，1： | 1 |
| 6 | Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma显示文摘 | C.-Y. Hsia T.-I. Huo S.-Y. Chiang M.-F. Lu C.-L. Sun J.-C. Wu P.-C. Lee C.-W. Chi W.-Y. Lui S.-D. Lee | 2006 | European Journal of Surgical Oncology2006，，2： | 1 |
| 7 | Establishment of a metastatic modelof human hepatocellular carcinoma in nude mice via orthotopicimplantation of histologically intact tissues显示文摘 | Sun FX Tang ZY Lui KD | 1996 | Int J Cancer1996，66，2： | 1 |
| 8 | Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues显示文摘 | Tang Z Lui K | 1996 | Int J Cancer1996，66，2： | 1 |
| 9 | Establishment of a metastatic model of human hepatocllular carcinoma in nude mice via orthotopic implantation of histologically intact tissues显示文摘 | Sun F X Tang Z Y Lui K D | 1996 | Int J Cancer1996，66，2： | 1 |
| 10 | Improved treatment outcome in Chinese children and adolescents with Burkitt's lymphoma and large cell lymphoma by using Berlin-Frankfurt-Munster-90 protocol显示文摘 | Zhen ZJ Lui DG | 2006 | Eur J Haematol2006，77，： | 1 |
| 11 | Impact of Diabetes Mellitus and Metformin Use on Oncological Outcomes of Patients Treated With Radical Cystectomy for Urothelial Carcinoma显示文摘 | Malte Rieken Evanguelos Xylinas Luis Kluth Joseph J. Crivelli James Chrystal Talia Faison Yair Lotan Pierre I. Karakiewicz Maxine Sun Harun Fajkovic Marek Babjuk Alexander Bachmann Douglas S. Scherr Shahrokh F. Shariat | 2013 | Urologic Oncology: Seminars and Original Investigations2013，，： | 1 |
| 12 | Distributed Mechanism in Detecting and Defending Against the Low - rate TCP Attack显示文摘 | Sun H Lui J C S Yau D K Y | 2006 | Computer Networks2006，50，13： | 1 |
| 13 | Passive radar using global system for mobile communication signal: theo- ry, implementation and measurements显示文摘 | Tan D K P Sun H Lui Y | 2005 | IEE Pro- ceedings: Radar Sonar and Navigation2005，152，3： | 1 |
| 14 | In-situ formed NiS/Ni coupled interface for efficient oxygen evolution and hydrogen evolution显示文摘High-performance electrocatalysts for water splitting are desired due to the urgent requirement of clean and sustainable hydrogen production.To reduce the energy barrier,herein,we adopt a facile in-situ surface modification strategy to develop a low-cost and efficient electrocatalyst for water splitting.The synthesized mulberry-like NiS/Ni nanoparticles exhibit excellent catalytic performance for water splitting.Small overpotentials of 301 and 161 mV are needed to drive the current density of 10 mA cm^-2 accompanying with remarkably low Tafel slopes of 46 and 74 mV dec^-1 for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER),respectively.Meanwhile,a robust electrochemical stability is demonstrated.Further high-resolution X-ray photoelectron spectroscopy analyses reveal that the intrinsic HER activity improvement is attributed to the electron-enriched S on the strongly coupled NiS and Ni interface,which simultaneously facilitates the important electron transfer,consistent with the electrochemical impedance results.The post characterizations demonstrate that surface reconstructed oxyhydroxide contributes to the OER activity and NiS/Ni is an OER precatalyst.This structure construction with in-situ formation of active interface provides an effective way to design efficient electrocatalysts for energy conversion. | Chaoyi Yan Jianwen Huang Chunyang Wu Yaoyao Li Yuchuan Tan Luying Zhang Yinghui Sun Xiaona Huang Jie Xiong | 2020 | Journal of Materials Science & Technology2020，42，7： | 1 |
| 15 | The effect of maternal cocaine exposure on neonatal rat cardiac function显示文摘 | Sun LS Takuma S Lui R Homma S | 2003 | Anesth Analg2003，97，3： | 1 |
| 16 | Multiparametric MRI reporting using Prostate Imaging Reporting and Data System version 2.0 (PI-RADSv2) retains clinical efficacy in a predominantly post-biopsy patient population显示文摘Objective:To evaluate the efficacy of multiparametric magnetic resonance imaging(mp-MRI)using Prostate Imaging Reporting and Data System version 2.0(PI-RADSv2)definitions in detecting organ-confined prostate cancer.Methods:All patients who underwent radical prostatectomy between January 1,2014 and December 30,2014 were identified.All underwent mp-MRI within 180 days before surgery.Those with prior pelvic irradiation or androgen deprivation therapy were excluded.Fully embedded,whole-mount histopathology was centrally reviewed and correlated with imaging for tumour location,Gleason score(GS)and stage.Results:There were 39 patients included,of which 35(90%)had mp-MRI done post-biopsy.A total of 93 cancer foci were identified on whole-mount pathology,of which mp-MRI detected 63(68%).Of those detected by mp-MRI,14 were PI-RADS 3(n=6 for GS 6,n=8 for GS 7,no GS≥8)and 49 were PI-RADS 4e5(nZ7 for GS 6,nZ33 for GS 7,and nZ9 for GS≥8).There were 30(32%)cancer foci missed by mp-MRI(n=15 for GS 6,n=13 for GS 7 and n=2 for GS≥8).A lesion classified as PI-RADS 4e5 predicted a higher grade cancer on pathology as compared to PI-RADS 3(for GS 7 lesions,odds ratio[OR]=3.53,95%CI:0.93e13.45,p=0.064).The mp-MRI size detection limit was 20 mm2 and 100 mm2 for 50%and 75%probability of cancer,respectively.In associating with radiological and pathologic stage,the weighted Kappa value was 0.69(p<0.0001).The sensitivity and positive predictive values for this study were 68%(95%CI:57%e77%)and 78%(95%CI:67%e86%),respectively.Conclusion:In this predominantly post-biopsy cohort,mp-MRI using PI-RADSv2 reporting has a reasonably high diagnostic accuracy in detecting clinically significant prostate cancer. | Edwin Jonathan Aslim Yan Mee Law Puay Hoon Tan John Carson Allen Jr Lionel Tim-Ee Cheng Viswanath Anand Chidambaram Li Yan Khor Benjamin Yongcheng Tan Ernest Wencong Eu Christopher Wai Sam Cheng John Shyi Peng Yuen Henry Sun Sien Ho Lui Shiong Lee | 2019 | Asian Journal of Urology2019，6，3： | 1 |
| 17 | Combination of carbamazepine and Valproate in different dose proportions in maximal electroshock seizure model in mice显示文摘 | Sun Meizhen Clementina Mvan Rijn Lui Yuxi | 2002 | Epilepsy Research2002，51，： | 1 |
| 18 | Establishment of metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues显示文摘 | Sun FX Tang ZY Lui KD | 1996 | Int J Caneer1996，66，2： | 1 |
| 19 | Inorganic arsenic in Chinese food and its cancer risk显示文摘 | Gang Li Guo-Xin Sun Paul N. Williams Luis Nunes Yong-Guan Zhu | 2011 | Environment International2011，，7： | 1 |
| 20 | Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues 显示文摘 | Tang ZY Lui KD | 1996 | Int J Cancer1996，66，2： | 1 |
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