|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The Role of MicroRNAs in Neural Stem Cells and Neurogenesis显示文摘Neural stem cells give rise to neurons through the process of neurogenesis,which includes neural stem cell proliferation,fate determination of new neurons,as well as the new neuron's migration,maturation and integration.Currently,neurogenesis is divided into two phases:embryonic and adult phases.Embryonic neurogenesis occurs at high levels to form the central nervous system.Adult neurogenesis has been consistently identified only in restricted regions and occurs at low levels.As the basic process for embryonic neurodevelopment and adult brain maintenance,neurogenesis is tightly regulated by many factors and pathways.MicroRNA,short non-coding RNA that regulates gene expression at the post-transcriptional level,appears to be involved in multiple steps of neurogenesis.This review summarizes the emerging role of microRNAs in regulating embryonic and adult neurogenesis,with a particular emphasis on the proliferation and differentiation of neural stem cells. | Fen Ji Xiaohui Lv Jianwei Jiao | 2013 | Journal of Genetics and Genomics2013，40，2： | 11 |
| 3 | A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway显示文摘这研究被设计调查 APJ 受体是否在静态的导致压力的 cardiomyocyte hypertrophyand 充当一个传感器调查 PI3K-autophagy 小径的机制。左室的肥大老鼠模型是腹的主动脉的确定的 bycoarctation。H9c2 老鼠 cardiomyocytes 面对被给 bya 的静态的压力是有教养的定做的压力孵卵器。结果表明 apelin/APJ 系统, PI3K, Akt 和他们的 phosphorylationwere 的表达式显著地在操作组增加了。静态的压力起来调整在 cardiomyocytes 的 APJ 表示, PI3K phosphorylation, Akt phosphorylation, LC3-II/I 和 beclin-1 表示。APJ shRNA pGPU6/Neo-rat-399, PI3K 禁止者 LY294002, Akt 禁止者 1701-1 分别地堵住了 APJ, PI3K phosphorylation, Akt phosphorylation, LC3-II/I 和 beclin-1 表示的起来规定。而且,静态的压力增加了直径,体积,房间的蛋白质内容,和这些能是 reversedwhen 房间分别地与 pGPU6/Neo-rat-399, LY294002,和 autophagy 禁止者 3-methyladenine 被对待。Theseresults 建议了那静态的压力起来调整 APJ 表情由 PI3K-autophagypathway 支持 cardiomyocyte 肥大。 | Feng Xiei Wei Liu Fen Feng Xin Li Li Yang Deguan Lv Xuping Qin Lanfang Li Linxi Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 10 |
| 4 | Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy显示文摘Apelin 高度在左室的肥大 Sprague Dawley 老鼠建模的老鼠被表示,并且它在心血管的系统起一个关键作用。这研究是澄清 apelin-13 是否在 H9c2 老鼠 cardiomyocytes 支持肥大并且调查它的内在的机制的目的。cardiomyocyte 肥大被测量 H9c2 房间的直径,体积,和蛋白质内容观察。autophagy 的激活被由传播电子显微镜学观察 autophagosomes 的形态学评估,观察由轻显微镜学的 LC3 的 subcellular 本地化,并且由西方的污点分析检测 LC3 的联系膜的形式。表明小径的 phosphatidylinositol 3-kinase (PI3K ) 被识别,蛋白质表示用西方的污点分析被检测。结果表明 apelin-13 增加了 H9c2 房间的直径,体积,和蛋白质内容并且支持了 PI3K, Akt, ERK1/2,和 p70S6K 的 phosphorylation。Apelin-13 激活 PI3K-Akt-ERK1/2-p70S6K 小径。PI3K 禁止者 LY294002, Akt 禁止者 1701-1, ERK1/2 禁止者 PD98059 稀释了房间直径的增加,体积,蛋白质内容由 apelin-13 导致了。Apelin-13 增加了 autophagosomes 并且起来调整 beclin 的表情 1 并且 LC3-II/I 短暂地并且稳定地。autophagy 禁止者 3MA 改善了被 apelin-13 导致的房间直径,体积,和蛋白质内容的增加。这些结果建议 apelin-13 经由 PI3K-Akt-ERK1/2-p70S6K 和导致 PI3K 的 autophagy 支持 H9c2 老鼠 cardiomyocyte 肥大。 | Feng Xie Wei Liu Fen Feng Xin Li Lu He Deguan Lv Xuping Qin Lifang Li Lanfang Li Linxi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 9 |
| 5 | Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori显示文摘AIM:To identify genes potentially involved in Helicobacter pylori(H.pylori)-induced gastric carcinogenesis.METHODS:GES-1 cells were co-cultured with H.pylori strains isolated from patients with gastric carcinoma(GC,n = 10) or chronic gastritis(CG,n = 10) for in vitro proliferation and apoptosis assays to identify the most and least virulent strains.These two strains were cagA-genotyped and used for further in vivo carcinogenic virulence assays by infecting Mongolian gerbils for 52 wk,respectively;a broth free of H.pylori was lavaged as control.Genomic profiles of GES-1 cells cocultured with the most and least virulent strains were determined by microarray analysis.The most differentially expressed genes were further verified using quantitative real-time polymerase chain reaction in GES-1cells infected with the most and least virulent strains,and by immunohistochemistry in H.pylori positive CG,precancerous diseases,and GC biopsy specimens in an independent experiment.RESULTS:GC-derived H.pylori strains induced a potent proliferative effect in GES-1 cells in co-culture,whereas CG-derived strains did not.The most(from a GC patient) and least(from a CG patient) virulent strains were cagA-positive and negative,respectively.At week 52,CG,atrophy,metaplasia,dysplasia,and GC were observed in 90.0%,80.0%,80.0%,90%,and 60.0%,respectively,of the animals lavaged with the most virulent strain.However,only mild CG was observed in 90% of the animals lavaged with the least virulent strain.On microarray analysis,800 differentially expressed genes(49 up-and 751 down-regulated),involving those associated with cell cycle regulation,cell apoptosis,cytoskeleton,immune response,and substance and energy metabolisms,were identified in cells co-cultured with the most virulent strain as compared with those co-cultured with the least virulent strain.The six most differentially expressed genes(with a betweenness centrality of 0.1-0.2) were identified among the significant differential gene profile network,including JUN,KRAS,BRCA1,SMAD2,TRAF1,and HDAC6.Quantitative real-time polymerase chain reaction analyses verified that HDAC6 and TRFA1 mRNA expressions were significantly more up-regulated in GES-1 cells cocultured with the most virulent strain than in those cocultured with the least virulent strain.Immunohistochemistry of gastric mucosal specimens from H.pyloripositive patients with CG,intestinal metaplasia(IM),dysplasia,and GC showed that moderately positive and strongly positive HDAC6 expression was detected in 21.7% of CG patients,30.0% of IM patients,54.5% of dysplasia patients,and 77.8% of GC patients(P < 0.001).The up-regulation of TRAF1 expressions was detected in 34.8%,53.3%,72.7%,and 88.9% specimens of CG,IM,dysplasia,and GC,respectively(P < 0.001).CONCLUSION:The overexpression of HDAC6 and TRAF1 in GES-1 cells co-cultured with the GC-derived strain and in H.pylori-positive dysplasia and GC suggests that HDAC6 and TRAF1 may be involved in H.pyloriinduced gastric carcinogenesis. | Fen Wang Li-Dan Luo Jian-Hua Pan Li-Hua Huang Hong-Wei Lv Qin Guo Can-Xia Xu Shou-Rong Shen | 2012 | World Journal of Gastroenterology2012，18，48： | 3 |
| 6 | Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector(GC-ECD)显示文摘 | Shengbing Yu Binghui Zhu Fen Lv | 2012 | Food chemistry2012，134，4： | 1 |
| 7 | Synthesis of 3,4-Dimethoxy-6-aminobenzaldhyde显示文摘 | GUO Wei JIANG Qi-jun Lv Fen YANG Ding-Qiao | 2004 | 合成化学2004，1，： | 1 |
| 8 | Population Structure Analysis and Genome-Wide Association Study of Tea(Camellia sinensis(L.)Kuntze)Germplasm in Qiannan,China,Based on SLAF-Seq Technology显示文摘Duyun Maojian tea is a famous tea in China.In this study,the specific-locus amplified fragment(SLAF)sequencing method was used to analyze the population structure and conduct a genome-wide association study(GWAS)of 2 leaf traits of 123 tea plants in Qiannan,China.A total of 462,019 SLAF tags and 11,362,041 single-nucleotide polymorphism(SNP)loci were obtained.The results of phylogenetic tree analysis,cluster analysis,and principal component analysis showed that 123 tea germplasms were clustered into three groups,and the heterozygosity rates for Groups I,II,and II were 0.206,0.224,and 0.34,respectively.Generally,tea germplasms in a production area are clustered in a group,indicating that tea germplasms in different production areas have certain genetic diversity.The traditional Duyun Maojian tea core production areas,TS and DC-SJ,are clustered into Group I and Group II respectively,while the ZY production area is relatively independent in Group III.Furthermore,based on GWAS analysis,11 candidate genes related to leaf apex and 7 candidate genes related to leaf shape were obtained.This study clarified the genetic relationship among eight Duyun Maojian tea production areas and obtained candidate genes related to leaf apex and leaf shape development.The results showed that population structure and candidate genes are an effective basis for the breeding of Duyun Maojian tea germplasm. | Fen Zhang Weili Tian Lu Cen Litang Lv Xiaofang Zeng Yulu Chen Yichen Zhao Yan Li | 2022 | Phyton-International Journal of Experimental Botany2022，91，4： | 1 |
| 9 | Research on the Contents of Chinese Seabucklthorn Fruit Oil and Its Application to Chloasma Treatments显示文摘 | Hanqing Xu Junfeng Ren Huili Xu Kefeng Sun Ailin Lv Jie Fen | 2005 | Journal of US-China Medical Science2005，2，6： | 1 |
| 10 | Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector (GC-ECD)显示文摘 | YU SHENG-BING ZHU BING-HUI LV FEN | 2012 | Food Chemistry2012，134，4： | 1 |
| 11 | Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector (GC-ECD) 显示文摘 | Yu Shengbing Zhu Binghui Lv Fen | 2012 | Food Chemistry2012，134，4： | 1 |
| 12 | Carbon composite support improving catalytic effect of NbC nanoparticles on the low-temperature hydrogen storage performance of MgH_(2)显示文摘Ultrafine carbon-based transition metal compounds have been widely investigated as efficient catalysts for enhancing the hydrogen storage performance of magnesium hydride.In this work,the carbon ther-mal shock method is applied to synthesize the ultrafine carbon-encapsulated NbC nanoparticles with an average grain size of 17.3 nm.The MgH_(2)-10 wt%NbC/C composites show excellent low-temperature hy-drogen storage performance with the onset dehydrogenation temperature of 196.1℃,which is 92.2℃ and 98℃ lower than that of MgH_(2)-10 wt%NbC and undoped MgH_(2),respectively.Specifically,MgH_(2)-10 wt%NbC/C can absorb 6.71 wt%H_(2) at 100℃ within 30 min around and retain almost 100%reversible hydrogen desorption capacity after 10 cycles.For the catalytic mechanism,the electron transfer process between multi-valence Nb cations of in-situ formed NbH x and Mg,H atoms can greatly improve the cyclic de/rehydrogenation kinetics of MgH_(2)-NbC/C.Besides,the enhancement of dehydrogenation kinetics can also be ascribed to MgH_(2) particle refinement by NbC nanoparticles,and destabilization of the Mg-H bond caused by carbon substrate.This investigation not only proves that carbon-encapsulated NbC nanoparti-cles can greatly enhance the hydrogen storage performance of MgH_(2) but provides an idea of preparing carbon-based transition metal carbides as effective catalysts for magnesium-based hydrogen storage ma-terials. | Yuxiao Jia Xuancheng Wang Leijie Hu Xuezhang Xiao Shuoqing Zhang Jiahuan He Jiacheng Qi Ling Lv Fen Xu Lixian Sun Lixin Chen | 2023 | Journal of Materials Science & Technology2023，，19： | 0 |
| 13 | Robust architecture of 2D nano Mg-based borohydride on graphene with superior reversible hydrogen storage performance显示文摘Efficient technical strategies to synthesize hydrides with high capacity and favorable reversibility are significant for the development of novel energy materials.Herein,nano Mg-based borohydride,Mg(BH_(4))_(2),with robust architecture was designed and prepared by confining on graphene through a solution selfconfinement method.The Mg(BH_(4))_(2) confined on graphene displays a wrinkled 2D nano layer morphology within 8.8 nm thickness.Such 2D nano Mg(BH_(4))_(2) can start dehydrogenation at 67.9℃ with a high capacity of 12.0 wt.%,which is 190.5℃ lower than pristine Mg(BH_(4))_(2).The isothermal dehydrogenation tests and kinetics fitting results indicate the 2D nano Mg(BH_(4))_(2) possesses much-enhanced dehydrogenation kinetics of 31.3 kJ/mol activation energy,which is only half of pristine Mg(BH_(4))_(2).The thermodynamics of the 2D nano Mg(BH_(4))_(2) is also verified by PCT tests,of which Gibbs free energy value for the confined 2D nano Mg(BH_(4))_(2) is estimated to be-18.01 kJ/mol H_(2),lower than-16.36 kJ/mol H_(2) of pristine Mg(BH_(4))_(2).Importantly,the reversibility of the confined 2D nano Mg(BH_(4))_(2) is significantly enhanced to over 90%capacity retention with relatively kinetics stability during 10 cycles.The mechanism analyses manifest that Mg(BH_(4))_(2) exhibits stable 2D nano morphology during 10 cyclic tests,resulting in the greatly reduced H diffusion path and the improved de/rehydrogenation kinetics of the 2D nano Mg(BH_(4))_(2).Based on theoretical calculations of Mg(BH_(4))_(2) and the intermediate MgB12H12 confined on graphene,the charge transfer status of both samples is modified to facilitate de/rehydrogenation,thus leading to the significant thermodynamic improvements of the reversible hydrogen storage performances for 2D nano Mg(BH_(4))_(2).Such investigation of the Mg-based borohydride will illuminate prospective technical research of energy storage materials. | Xuancheng Wang Yuxiao Jia Xuezhang Xiao Panpan Zhou Jiapeng Bi Jiacheng Qi Ling Lv Fen Xu Lixian Sun Lixin Chen | 2023 | Journal of Materials Science & Technology2023，，15： | 0 |
| 14 | Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19显示文摘Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of infection.The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients.Main recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)Healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease control.Changes in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)Healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19. | Wei Song Jie Wei Xiangdong Jian Deren Wang Yanhong Ouyang Yuanshui Liu Xianjin Du Ying Chen Yingqi Zhang Heping Xu Shuming Xianyu Qiong Ning Xiang Li Xiaotong Han Feng Zhan Tao Yu Wenteng Chen Jun Zhang Wenwei Cai Sheng’ang Zhou Shengyang Yi Yu Cao Xiaobei Chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng Yuhong Mi Sisen Zhang Rongjia Yang Shouchun Yan Wenbin Han Yong Lin Chuanyun Qian Wenwu Zhang Yan Xiong Jun Lv Baochi Liu Yan Cao Xiaojun He Xuelian Sun Yufang Cao Tian’en Zhou | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，6： | 0 |
| 15 | High special surface area and“warm light”responsive ZnO:Synthesis mechanism,application and optimization显示文摘In this study,a new series of zinc oxide(ZnO)with high specific surface area and narrow energy band gap are prepared using a facile microwave-induced method.The corresponding formation mechanism is also discussed for the first time.Due to the introduction of C,these ZnO can be excited by long wave temperature light without harmful short wave radiation,and play an efficient photocatalytic activity.This valuable property fundamentally improves the biological safety of its photocatalytic application.Herein,taking teeth whitening as an example,the photocatalytic performance of ZnO is evaluated.The“pure”yellow light-emitting diode(PYLED)with high biological safety is used as the excitation source.It is found that this method could effectively remove pigment on the tooth surface through physical adsorption.In addition,these ZnO could generate active oxygen to degrade the pigment on the tooth surface under the irradiation of yellow light.Some further optimization of these“warm light”responsive ZnO is also discussed in this systematical study,which could open up new opportunities in biomedical field. | Xinxin Miao Fen Yu Kuan Liu Zhongsheng Lv Jianjian Deng Tianlong Wu Xinyan Cheng Wei Zhang Xigao Cheng Xiaolei Wang | 2022 | Bioactive Materials2022，7，1： | 0 |
| 16 | Outcome report of breast massage for lactational mastitis patients in early stage: A protocol for systematic review显示文摘Objective:Lactation mastitis is a kind of disease with high incidence during puerperium.In the early stage,breast massage can effectively eliminate the symptoms.However,the value of breast massage is not fully known to the public,which restricts its promotion and popularization.One important reason is the absence of a multi-dimensional and overall evaluation of outcome.COS is strongly advocated internationally as the outcome in clinical research to promote the transformation of clinical evidence into practice.At present,there is no systematic review of the existing outcome.This protocol aims to provide a set of outcomes and outcome evaluation schemes for developing COS of breast massage in lactation mastitis early stage.Methods:We will search PubMed,Embase,Web of Science,CNKI,Wan-fang,VIP,SinoMed,Grey literature databases(master and doctoral thesis databases and conference literature databases of CNKI,Wan-fang and SinoMed),Clinical Trials Registry Platform portal,the Clinical Trials Registry,Australian,New Zealand Clinical Trials Registry,the Center Watch Registry,before March 1,2021.We will include randomized controlled trials and non-randomized trials,cohort studies,case series,case reports.We will assess the quality of outcome reporting according to the MOMENT,classify all outcomes using the OMERACT Filter 2.0 conceptual framework.Descriptive analysis will be performed for all categorical variables using frequency and mean.Result:This protocol aims to help guide the design of systematic review to summarize the existing outcomes,and comprehensively evaluate existing outcomes,classify outcomes and provide schemes of outcome evaluation for developing COS of breast massage in the early stage of lactation mastitis.Percentage and mean will be used to describe the extracted data.Conclusion:This is the first systematic review protocol to summarize outcomes,measurement instruments,assessment times,measurement frequencies,measurers about breast massage in the early stage of lactational mastitis. | Yun-Peng Lv Xian Wang Fen Zhou | 2021 | TMR Integrative Nursing2021，5，4： | 0 |
| 17 | Heterogeneity of Outcomes Reporting in Trials Evaluating Traditional Chinese Medicine Breast Massage for Stasis Acute Mastitis: A Methodological Review显示文摘Objective To systematically analyze the current status of outcomes reporting in clinical trials on treating stasis acute mastitis with Traditional Chinese Medicine breast massage.Methods We searched CNKI,Wanfang,VIP,Sino Med,Pub Med,Web of Science,Embase,Cochrane library,JBI,CINAHL,Psyc INFO,Clinical Trials Registry Platform portal,Clinical Trials Registry,Australian New Zealand Clinical Trials Registry,Center Watch Registry from inception to May 15,2022 to find randomized controlled trials,non-randomized controlled trials,case series and cohort studies which reported the outcomes of stasis acute mastitis managed with Traditional Chinese Medicine breast massage,with search terms of mastitis,acute mastitis,lactation mastitis,puerperal mastitis,breast problem,breast engorgement,milk stasis,blocked ducked,breast pain,breast massage,and acupoint massage.Outcomes and the measurement schemes(measurement methods,timing of assessing outcome,frequency of assessing outcome,measurers)were extracted from the included studies.We used the Management of Otitis Media with Effusion in Children with Cleft Palate(MOMENT)to assess the quality of each study,then categorized outcomes derived from the included studies into different domains according to the Outcome Measures in Rheumatology Arthritis Clinic Trials(OMERACT)Filter 2.1 framework.Results We identified 85 clinical trials,in which 54 different outcomes were reported.A total of 81.2%(69/85)of studies were assessed as medium quality with a mean score of 2.6,and 18.8%(16/85)as low quality with a mean score of 0.9.These outcomes were organized in three core areas.Lump size(89.4%,76/85)was the most frequently reported outcome,followed by breast pain(69.4%,59/85)and milk excretion(68.2%,58/85).Five methods were used to assess lump size and four methods to assess breast pain.Conclusions The outcomes reported in clinical trials regarding stasis acute mastitis treated by Traditional Chinese Medicine breast massage are heterogeneous.Developing a core outcome set to achieve consistent standards for reporting outcomes and modalities for validation of the outcomes is clearly warranted. | Yun-Peng Lv Ting Yuan Xiao-Ying Mu Ying-Yi Fan Ming-Yang An Fen Zhou | 2023 | Chinese Medical Sciences Journal2023，38，2： | 0 |
| 18 | Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities显示文摘We reported the discovery of six novel coumarins, toddasirins A–F ( 1 – 6 ), each endowed with modified isoprenyl or geranyl side chains, derived from the roots of Toddalia asiatica. Comprehensive structural elucidation was achieved through multispectroscopic analyses, single-crystal X-ray diffraction experiments, and advanced quantum mechanical electronic circular dichroism (ECD) calculations. Furthermore, the anti-inflammatory activity of these compounds was assessed. Notably, compounds 1 – 3 and 6 demonstrated notable inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with 50% inhibitory concentration (IC50) values of 3.22, 4.78, 8.90, and 4.31 μmol·L^(−1), respectively. | HE Haoxuan LI Niping FAN Yunqi HUANG Qian SONG Jianguo LV Lixia LIU Fen WANG Lei WANG Qi GU Jihong | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员