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| 1 | Research progress on silicon/carbon composite anode materials for lithium-ion battery显示文摘Silicon(Si) has been considered as one of the most promising anode material for the next generation lithium-ion batteries(LIBs) with high energy densities, due to its high theoretical capacity, abundant availability and environmental friendliness. However, silicon materials with low intrinsic electric and ionic conductivity suffer from huge volume variation during lithiation/delithiation processes leading to the pulverization of Si and subsequently resulting in severe capacity fading of the electrodes. Coupling of Si with carbon(C) realizes a favorable combination of the two materials properties, such as high lithiation capacity of Si and excellent mechanical and conductive properties of C, making silicon/carbon composite(Si/C) ideal candidates for LIBs anodes. In this review, recent progresses of Si/C materials utilized in LIBs are summarized in terms of structural design principles, material synthesis methods, morphological characteristics and electrochemical performances by highlighting the material structures. The mechanisms behind the performance enhancement are also discussed. Moreover, other factors that affect the performance of Si/C anodes, such as prelithiation, electrolyte additives, and binders, are also discussed. We aim to present a full scope of the Si/C-based anodes, and help understand and design future structures of Si/C anodes in LIBs. | Xiaohui Shen Zhanyuan Tian Ruijuan Fan Le Shao Dapeng Zhang Guolin Cao Liang Kou Yangzhi Bai | 2018 | Journal of Energy Chemistry2018，27，4： | 29 |
| 2 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 3 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 4 | Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer显示文摘AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29(EORTC QLQ-CR29) in Chinese patients with colorectal cancer(CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire(EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale(KPS). The reliability and validity of the questionnaires were assessed by Cronbach's α coefficient, the Spearman correlation test and Wilcoxon rank sum test.RESULTS The EORTC QLQ-CR29 showed satisfactory reliability(α > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability(α = 0.608). The multitrait scaling analyses showed good convergent(r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups(KPS ≤ 80; KPS > 80). body image and most single-item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients. | Jin-bo Lin Lei Zhang Dong-Wen Wu Zhou-Huan xi xue-Jun Wang Yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai Guo Zhen Yang Le Luo Ling-Ya Jiang Qia-Qia Li xue-Ying Zhang Yun-Feng Zhang Hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei | 2017 | World Journal of Gastroenterology2017，23，10： | 12 |
| 5 | SbHKT1;4, a member of the high‐affinity potassium transporter gene family from Sorghum bicolor, functions to maintain optimal Na^+/K^+ balance under Na^+ stress显示文摘In halophytic plants, the high‐affinity potassium transporter HKT gene family can selectively uptake Kt in the presence of toxic concentrations of Nat. This has so far not been well examined in glycophytic crops. Here, we report the characterization of SbHKT1;4, a member of the HKT gene family from Sorghum bicolor. Upon Nat stress, SbHKT1;4 expression was more strongly upregulated in salt‐tolerant sorghum accession, correlating with a better balanced Nat/ Kt ratio and enhanced plant growth. Heterogeneous expression analyses in mutants of Saccharomyces cerevisiae and Arabidopsis thaliana indicated that overexpressing SbHKT1;4 resulted in hypersensitivity to Nat stress, and such hypersensitivity could be alleviated with the supply of elevated levels of Kt, implicating that SbHKT1;4 may mediate Kt uptake in the presence of excessive Nat. Further electrophysiological evidence demonstrated that SbHKT1;4 could transport Nat and Kt when expressed in Xenopus laevis oocytes. The relevance of the finding that SbHKT1;4 functions to maintain optimal Nat/Kt balance under Nat stress to the breeding of salt‐tolerant glycophytic crops is discussed. | Tian‐Tian Wang Zhi‐Jie Ren Zhi‐Quan Liu Xue Feng Rui‐Qi Guo Bao‐Guo Li Le‐Gong Li Hai‐Chun Jing | 2014 | Journal of Integrative Plant Biology2014，56，3： | 11 |
| 6 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 7 | Cellulose synthesis genes CESA6 and CSI1 are important for salt stress tolerance in Arabidopsis显示文摘Soil salinity is a widespread abiotic stress constraint threatening agricultural production,as it severely inhibits growth and development of crops.Several salt stress signaling pathways have been discovered in the model plant Arabidopsis thaliana,which include components for sensing the stress,transmitting the signal and regulating the downstream genes(Deinlein et al.2014;Julkowska | Shuang-Shuang Zhang Le Sun Xinran Dong Sun-Jie Lu Weidong Tian Jian-Xiang Liu | 2016 | Journal of Integrative Plant Biology2016，58，7： | 9 |
| 8 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044s9bocqwbvfp0o60xq.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 9 | A Mini Review on Nanocarbon-Based 1D Macroscopic Fibers:Assembly Strategies and Mechanical Properties显示文摘Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and twodimensional graphene both possess remarkable mechanical properties. In the past years, a large amount of work have been done by using CNTs or graphene as building blocks for constructing novel, macroscopic, mechanically strong fibrous materials. In this review, we summarize the assembly approaches of CNT-based fibers and graphene-based fibers in chronological order, respectively. The mechanical performances of these fibrous materials are compared, and the critical influences on the mechanical properties are discussed. Personal perspectives on the fabrication methods of CNT-and graphene-based fibers are further presented. | Liang Kou Yingjun Liu Cheng Zhang Le Shao Zhanyuan Tian Zengshe Deng Chao Gao | 2017 | Nano-Micro Letters2017，9，4： | 6 |
| 10 | Synthesis and characterization of tungsten and barium co-doped La2Mo2O9 by sol-gel process for solid oxide fuel cells显示文摘Herein,we demonstrate the synthesis of W and Ba co-doped La2Mo2O9(LBMWO)nanocrystalline powder by a sol-gel process.In all the compositions have general formulae La1.9Ba0.1Mo2-xWxO8.95(x=0-0.40).The crystal structure,microstructure and conductivity of LBMWO were characterized by X-ray diffraction,scanning electron microscopy and electrical impedance spectroscopy.In addition,the thermal and decomposition properties of the LBMWO gel were analyzed by differential scanning calorimetry-thermogravimetric.The results reveal that all LBMWO powders calcined at 700℃have a cubic structure;the average crystallite size is about 48 nm.The unit cell parameter of LBMWO powders increases with increase in W content.The as-synthesized nanocrystalline LBMWO samples exhibit excellent sinterability and a relatively lower sintering temperature of 900℃.A high relative density of-96%is achieved after sintering at 900℃which is in good agreeme nt with the re sults of the SEM.Moreover,W and Ba codoping suppresses the phase transition and effectively stabilizes theβ-phase at low temperature.At the same time,La1.9Ba0.1Mo1.85W0.15O8.95 exhibits high ionic conductivity,3.07 x 10^-2 S/cm at 800℃.It is therefore concluded that co-doping can improve the properties of La2MO2O9 electrolytes. | Chang′an Tian Lingbo Shao Dongdong Ji Jie Yang Jinsong Xie Qiyi Yin Huirong Le | 2019 | Journal of Rare Earths2019，37，9： | 5 |
| 11 | Driving Range Parametric Analysis of Electric Vehicles Driven by Interior Permanent Magnet Motors Considering Driving Cycles显示文摘This paper presents parametric analysis of driving range of electric vehicles driven by V-type interior permanent magnet motors aiming at maximum driving range,i.e.,minimal total energy consumption of the motors over a driving cycle.Influence of design parameters including tooth width,slot depth,split ratio(the ratio of inner diameter to outer diameter of the stator),and V-type magnet angle on the energy consumption of the motors and driving range of electric vehicles over a driving cycle is investigated in detail.The investigation is carried out for two typical driving cycles with different characteristics to represent different conditions:One is high-speed,low-torque cycle-Highway Fuel Economy Test and the other is low-speed,high-torque cycle-Artemis Urban Driving Cycle.It shows that for both driving cycles,the same parameters may have different influence on the energy consumption of the motors,as well as driving range of electric vehicles. | Le Tian Lijian Wu Xiaoyan Huang Youtong Fang | 2019 | CES Transactions on Electrical Machines and Systems2019，3，4： | 4 |
| 12 | Experimental research of air-throttling ignition for a scramjet at Ma 6.5显示文摘An experimental investigation on ignition characteristics with air-throttling in an ethylene-fueled scramjet under flight Ma 6.5 conditions was conducted.The dynamic process of air-throttling ignition was explored systematically.The influences of throttling parameters,i.e.,throttling mass rate and duration,were investigated.When the throttling mass rate was 45% of the inflow mass rate,ambient ethylene could be ignited reliably.The delay time from ignition to throttling was about 45–55 ms.There was a threshold of throttling duration under a certain throttling mass rate.It was shorter than 100 ms when the throttling mass rate was 45%.While a 45%throttling mass rate would make the shock train propagate upstream to the isolator entry in about10–15 ms,four lower throttling mass rates were tested,including 30%,25%,20%,and 10%.All of these throttling mass rates could ignite ethylene.However,combustion performances varied with them.A higher throttling mass rate made more ethylene combust and produced higher wall pressure.Through these experiments,some aspects of the relationships between ignition,flame stabilization,combustion efficiency,and air-throttling parameters were brought to light.These results could also be a benchmark for CFD validation. | Weixin DENG Jialing LE Shunhua YANG Wanzhou ZHANG Ye TIAN | 2017 | Chinese Journal of Aeronautics2017，30，3： | 4 |
| 13 | Optimization on the Crosswind Stability of Trains Using Neural Network Surrogate Model显示文摘Under the influence of crosswinds,the running safety of trains will decrease sharply,so it is necessary to optimize the suspension parameters of trains.This paper studies the dynamic performance of high-speed trains under cross-wind conditions,and optimizes the running safety of train.A computational fluid dynamics simulation was used to determine the aerodynamic loads and moments experienced by a train.A series of dynamic models of a train,with different dynamic parameters were constructed,and analyzed,with safety metrics for these being determined.Finally,a surrogate model was built and an optimization algorithm was used upon this surrogate model,to find the minimum possible values for:derailment coefficient,vertical wheel-rail contact force,wheel load reduction ratio,wheel lateral force and overturning coefficient.There were 9 design variables,all associated with the dynamic parameters of the bogie.When the train was running with the speed of 350 km/h,under a crosswind speed of 15 m/s,the benchmark dynamic model performed poorly.The derailment coefficient was 1.31.The vertical wheel-rail contact force was 133.30 kN.The wheel load reduction rate was 0.643.The wheel lateral force was 85.67 kN,and the overturning coefficient was 0.425.After optimization,under the same running conditions,the metrics of the train were 0.268,100.44 kN,0.474,34.36 kN,and 0.421,respectively.This paper show that by combining train aerodynamics,vehicle system dynamics and many-objective optimization theory,a train’s stability can be more comprehensively analyzed,with more safety metrics being considered. | Le Zhang Tian Li Jiye Zhang Ronghuan Piao | 2021 | Chinese Journal of Mechanical Engineering2021，34，4： | 4 |
| 14 | Clinical Outcome of Autologous Hematopoietic Stem Cell Infusion via Hepatic Artery or Portal Vein in Patients with End-stage Liver Diseases显示文摘Objective To investigate the efficacy of hematopoietic stem cell(HSC) transplantation via the hepatic artery vs.the portal vein for end-stage liver disease(ESLD).Methods Patients with hepatic decompensation were prospectively recruited from September 2010 to September 2012 to receive HSC transplantation via the hepatic artery or the portal vein.Liver function was examined at 3,6,and 12 months after transplantation.Liver biopsy results were analyzed using the Knodell score.Results Eighty patients(58 males and 22 females) were enrolled in the study.The Child-Pugh score was grade B in 69 cases,and grade C in the remaining 11 cases.HSC transplantation was performed via the portal vein in 36 patients and via the hepatic artery in 44 patients.ALT levels decreased while serum albumin levels increased significantly in both groups at 6 and 12 months after HSC transplantation(P<0.05 compared with pre-transplantation levels).Total bilirubin levels decreased significantly in both groups at 3,6,and 12 months after HSC transplantation(P<0.05 compared with pre-transplantation levels).Additionally,prothrombin time decreased in both groups at 12 months after HSC transplantation(P<0.05 compared with pre-transplantation level).There were no significant differences in ALT,total bilirubin and prothrombin time between the two groups either before or after transplantation.Moreover,Knodell score decreased significantly at 6 and 12 months.Histological examination showed that liver cell edema,degeneration,necrosis,and inflammation were significantly relieved at 3,6,and 12 months after transplantation.The incidence of portal vein thrombosis,upper gastrointestinal bleeding,and hepatic encephalopathy were 1.25%,3.75%,and 2.5% respectively.The one-year survival rate was 100%.Conclusions Autologous HSC transplantation improves liver function and histology in ESLD patients.The administration route of HSC has no significant impact on the efficacy of transplantation. | Xiao-lun Huang Le Luo Lan-yun Luo Hua Xue Ling-ling Wei Yu-tong Yao Hai-bo Zou Xiao-bing Huang Yi-fan Zhu Tian Zhang Ping Xie Mao-zhu Yang Shao-ping Deng | 2014 | Chinese Medical Sciences Journal2014，29，1： | 4 |
| 15 | Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity显示文摘Berberine,berberrubine,thalifendine,demethyleneberberine,jatrorrhizine,and columbamine are six natural protoberberine alkaloid (PA)compounds that display extensive pharmacological'properties and share the same protoberberine molecular skeleton with only slight substitution differences.The oral delivery of most PAs is hindered by their poor bioavailability,which is largely caused by P-glycoprotein (P-gp)-mediated drug efflux.Meanwhile,P-gp undergoes large-scale conformational changes (from an inward-facing to an outward-facing state)when transporting substrates,and these changes might strongly affect the P-gp-binding specificity.To confirm whether these six compounds are substrates of P-gp,to investigate the differences in efflux capacity caused by their trivial structural differences arid to reveal the key to increasing their binding affinity to P-gp,we conducted a series of in vivo,in vitro,and in silico assays.Here,we first confirmed that all six compounds were substrates of P-gp by comparing the drug concentrations in wild-type and P-gp-knockout mice in vivo.The efflux capacity (net efflux)ranked as berberrubine >berberine > columbamine ~jatrorrhizine >thalifendine >demethyleneberberine based on in vitro transport studies in Caco-2 monolayers. Using molecular dynamics simulation and molecular docking techniques,we determined the transport pathways of the six compounds and their binding affinities to P-gp.The results suggested that at the early binding stage,different hydrophobic and electrostatic interactions collectively differentiate the binding affinities of the compounds to P-gp,whereas electrostatic interactions are the main determinant at the late release stage.In addition to hydrophobic interactions,hydrogen bonds play an important role in discriminating the binding affinities. | Yi-ting Zhang Yu-qi Yu Xiao-xia Yan Wen-jie Wang Xiao-ting Tian Le Wang Wei-liang Zhu Li-kun Gong Guo-yu Pan | 2019 | Acta Pharmacologica Sinica2019，40，1： | 3 |
| 16 | Estimating health damage cost from secondary sulfate particles—a case study of Hunan Province,China显示文摘China’s coal dominated energy pattern has resulted in large amount of SO 2 emissions. Estimate of the sulfur related health damage cost is necessary to help perform systematic cost benefit analysis and set national energy and emissions control priorities. Current researches were confined to gaseous SO 2 in urban areas; however, secondary sulfate (SO 2- 4) particles can exert serious impact in a wider region. Based on the concept of “intake fraction', CALPUFF long range dispersion model and 180 sample emission sources, multiple regression equation was obtained with good correlation( r =0 85), which illustrates that populations were key parameters to determine intake fraction but source characteristics were insignificant. Based on the formula and the population distribution data, county level intake fractions were mapped for Hunan Province(range: 1 1×10 -6 -3 2×10 -6 ) of China. A combination of county level SO 2 emissions with the intake fractions yields a total 1 98 tons of sulfate(SO 2- 4) inhalation, and resulting total health damage cost to be 0 76(willingness to pay approach, WTP) or 0 16(human capital approach, HC) billion USD in 1997, about 2.1% or 0 45% of GDP in Hunan in 1997. Average health damage cost per ton of SO 2 emission is 930(WTP) or 200 USD(HC). The results demonstrated that more stringent regulation should be forced. | HAO Ji ming, LI Ji, YE Xue mei, ZHU Tian le (Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China. ) | 2003 | Journal of Environmental Sciences2003，15，5： | 3 |
| 17 | Neuroprotective effects of Asiaticoside显示文摘In the central nervous system, Asiaticoside has been shown to attenuate in vitro neuronal damage caused by exposure to β-amyloid. In vivo studies demonstrated that Asiaticoside could attenuate neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion animals. In addition, Asiaticoside showed anxiolytic effects in acute and chronic stress animals. However, its potential neuroprotective properties in glutamate-induced excitotoxicity have not been fully studied. We investigated the neuroprotective effects of Asiaticoside in primary cultured mouse cortical neurons exposed to glutamate-induced excitotoxicity invoked by N-methyl-D-aspartate. Pretreatment with Asiaticoside decreased neuronal cell loss in a concentration-dependent manner and restored changes in expression of apoptotic-related proteins Bcl-2 and Bax. Asiaticoside pretreatment also attenuated the upregulation of NR2 B expression, a subunit of N-methyl-D-aspartate receptors, but did not affect expression of NR2 A subunits. Additionally, in cultured neurons, Asiaticoside significantly inhibited Ca2+ influx induced by N-methyl-D-aspartate. These experimental findings provide preliminary evidence that during excitotoxicity induced by N-methyl-D-aspartate exposure in cultured cortical neurons, the neuroprotective effects of Asiaticoside are mediated through inhibition of calcium influx. Aside from its anti-oxidant activity, down-regulation of NR2B-containing N-methyl-D-aspartate receptors may be one of the underlying mechanisms in Asiaticoside neuroprotection. | Feng-yan Qi Le Yang Zhen Tian Ming-gao Zhao Shui-bing Liu Jia-ze An | 2014 | Neural Regeneration Research2014，9，13： | 3 |
| 18 | 先锋氢引燃煤油的超燃燃烧室火焰稳定性研究显示文摘目的:1.在模拟飞行马赫数4.0条件下,通过直连实验研究先锋氢当量比对煤油燃料冲压发动机点火及稳焰的影响;2.通过多种非接触光学测量手段研究超燃冲压发动机内燃烧流场的结构变化和火焰建立等动态过程。创新点:1.通过直连实验发现,适量提高先锋氢当量比有利于发动机点火,且先锋氢的存在是发动机稳燃的前提;2.得到了超燃发动机点火及燃烧不稳定特征的流场。方法:1.通过直连实验,得到监测点压力动态变化数据并对其进行分析(图4和5);2.通过光学测量手段,观测流场及火焰动态变化过程(图6~12)。结论:1.当先锋氢当量比为0.080时,煤油燃料超燃冲压发动机成功点火;当先锋氢当量比为0.040时,点火失败;当先锋氢关闭后,超燃冲压发动机熄火。2.煤油火焰主要集中于凹槽后缘斜坡且结构是非对称的;燃烧是不稳定的且伴随着反复的前后移动。 | Wen SHI Ye TIAN Wan-zhou ZHANG Wei-xin DENG Fu-yu ZHONG Jia-ling LE | 2020 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2020，21，8： | 3 |
| 19 | Impact of migraine attacks on the blood-brain barrier显示文摘背景在动物的外皮的传播消沉罐头原因周期性偏头痛攻击,和起来调整矩阵 metalloproteinase-9 (MMP-9 ) 表示。试图由在周期性偏头痛的尖锐、迟了的阶段在病人测量血浆 MMP-9 层次在血大脑障碍的结构和功能上决定影响的这研究攻击以便阐明我们招募了的病理学的机制 involved.Methods 38 个成年周期性偏头痛病人的一个盒子控制队并且 20 匹配年龄、匹配性健康控制题目。五件毫升血样品在周期性偏头痛(天 1-7 ) 的尖锐、迟了的阶段被收集,并且也从控制使遭到。稳固的阶段两倍抗体三明治连接酶的 immunosorbent 试金被用来决定血浆 MMP-9 层次。统计分析用起始的血浆 MMP-9 周期性偏头痛病人铺平的 9.1 .Results 是的 SAS 版本被执行比那些显著地高控制((12. | GAO Hong-mei LI Le ZHANG Ke-ling CHEN Xu-hui TIAN Shu-qing ZHANG Zhong-ling | 2010 | Chinese Medical Journal2010，，18： | 3 |
| 20 | Relationship between lipidslevelsand right ventricular volume overload in congestive heart failure显示文摘在类脂化合物和冠的动脉疾病之间的 BackgroundThe 关系很好被建立了。然而,这在类脂化合物和心失败之间不是事实。讽刺地,高类脂化合物层次充分在心失败与更好的结果被联系,但是位于现象下面的机制不是理解。这研究被执行到由于静脉的拥挤减少了肠的类脂化合物吸收的假设可以导致的测试低类脂化合物 levels.MethodsWe 与充血的心失败在 442 个 unselected 病人收集了临床的特征, echocardiograph,和类脂化合物侧面的数据。在类脂化合物层次之间的关联[包括的全部的胆固醇( TCL ),高密度的脂蛋白胆固醇(高级数据链路控制),低密度的脂蛋白胆固醇( LDL-C ),和 triglycerides ( TG )]并且正确的室结束心脏舒张的直径( RVEDD ),左室结束心脏舒张的直径( LVEDD ),正确中庭直径( RA ),左中庭直径( LA ),或左室喷射部分( LVEF )用皮尔森关联和部分关联被分析。RVEDD, LVEDD, RA,和 LA 被索引到身体表面 area.ResultsThere 是在 TCL 层次和 RVEDD 之间的显著地反的关联(r =− 0.34, P <0.001 ) 并且 RA (r =− 0.36, P <0.001 ) 。象 LDL-C,高级数据链路控制,和 TG 那样的另外的类脂化合物与 RVEDD 和 RA 有类似的反的关联。在好久调整以后未改变的仍然是的所有这些关联,性,吸烟地位,物理活动层次, comorbidities,和药 use.ConclusionsLipid 层次相反地与充血的心失败在病人被相关到 RVEDD;然而,因为这是观察研究,进一步的调查被需要验证我们的结果以及如果有的话识别一种原因的关系。 | Ying CHEN Xiao-Mei HE Hong MENG Qing-Zhen ZHAO Yu-Zhi ZHEN Li TIAN Le WANG Li-Shuang JI Guo-Ping MA Yu TIAN Gang LIU Zhen-Guo JI Kun-Shen LIU Chao LIU | 2014 | Journal of Geriatric Cardiology2014，11，3： | 3 |
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