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| 1 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 2 | A new species of Megophrys (Amphibia:Anura:Megophryidae) from the northwestern Hunan Province,China显示文摘A new species of Megophrys (Amphibia: Anura: Megophryidae), Megophrys tuberogranulatus Shen, Mo et Li, sp.nov. (Holotype HNUL 03080902, adult male, SVL: 38.2 mm), from Sangzhi County, Hunan Province, is described. Megophrystuberogranulatus is closely related to both Megophrys kuatunensis and Megophrys minor. Characters of the new species that differentiatethis species from close relatives are skin granulated with big tubercles on the dorsal sides of both thigh and tibia, thebigger inner metacarpal tubercle, upper eyelid wider than the interorbital space, hind limbs longer, overlapping of the left andright calcaneal parts. The type specimens are deposited in the Animal Museum of Life Sciences College of Hunan Normal University. | Xiaoyang MO Youhui SHEN Honghui LI Xiushan WU | 2010 | Current Zoology2010，56，4： | 6 |
| 3 | Movement and deformation laws of the overlying strata in paste filling stope显示文摘We combined the similar simulation with numerical simulation to analyze the movement and deforma- tion features of overlying strata caused by paste backfill mining, study the movement and deformation laws of the overlying strata in paste backfill mining, structural movement of the stope strata as well as the stope stress distribution laws. Furthermore, authors also explored the key factors to the movement and deformation of the overlying strata in paste backfill mining. The results indicate that a caving zone existed in the bending zone only in the overlying strata of the paste backfill mining. Compared with the roof caving mining, the degree of stress concentration and area of influence in the paste filling stope were apparently smaller. And the degree of destruction and area of the overlying strata decreased prominently. Also, there was no apparent strata behavior in the working face. Lastly, the filling ratio was the key to control the movement and deformation of the overlying strata. Combined with a specific engineering example, the author proved the reliability of the simulation results and provided a theoretical basis for the further extension of the paste backfill mining. | Xu Ying Chang Qingliang Zhou Huaqiang Cao Zhong Li Xiushan Chen Jianhang | 2011 | Mining Science and Technology2011，21，6： | 5 |
| 4 | Down-Regulation of miR-27a Might Reverse Multidrug Resistance of Esophageal Squamous Cell Carcinoma显示文摘 | Hongwei Zhang Mengbin Li Yu Han Liu Hong Taiqian Gong Li Sun Xiushan Zheng | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 5 | ZNF411, a novel KRAB-containing zinc-finger protein, suppresses MAP kinase signaling pathway显示文摘 | Hui Liu Chuanbing Zhu Jian Luo Yuequn Wang Dali Li Yongqing Li Junmei Zhou Wuzhou Yuan Ying Ou Mingyao Liu Xiushan Wu | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 6 | Precise positioning of underwater static objects without sound speed profile 显示文摘 | YANG Fanlin LU Xiushan LI Jiabiao etal | 2011 | Marine Geodesy ( S0149- 0419 )2011，34，2： | 1 |
| 7 | Precise positioning of underwater static objects without sound speed Profile显示文摘 | YANG Fanlin LU Xiushan LI Jiabiao | 2011 | Marine Geodesy(S0149-0419)2011，34，2： | 1 |
| 8 | A novel six-transmembrane protein hhole functions as a suppressor in MAPK signaling pathways显示文摘 | Junmei Zhou Yongqing Li Pei Liang Wuzhou Yuan Xiangli Ye Chuanbing Zhu Yingduan Cheng Yuequn Wang Guan Li Xiushan Wu Mingyao Liu | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 9 | ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway显示文摘 | Yongqing Li Dan Yang Yan Bai Xiaoyang Mo Wen Huang Wuzhou Yuan Zhaochu Yin Yun Deng Oleg Murashko Yuequn Wang Xiongwei Fan Chuanbing Zhu Karen Ocorr Rolf Bodmer Xiushan Wu | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 10 | Down-Regulation of miR-27a Might Reverse Multidrug Resistance of Esophageal Squamous Cell Carcinoma显示文摘 | Hongwei Zhang Mengbin Li Yu Han Liu Hong Taiqian Gong Li Sun Xiushan Zheng | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 11 | Down-Regulation of miR-27a Might Reverse Multidrug Resistance of Esophageal Squamous Cell Carcinoma显示文摘 | Hongwei Zhang Mengbin Li Yu Han Liu Hong Taiqian Gong Li Sun Xiushan Zheng | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 12 | Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation显示文摘 | Shan Li Kefeng Lu Jian Wang Liguo An Guiwen Yang Hui Chen Yu Cui Xiushan Yin Ping Xie Guichun Xing Fuchu He Lingqiang Zhang | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 13 | Thermochemical decomposition of phosphogypsum with Fe-P slag via a solid-state reaction显示文摘Phosphogypsum is a solid waste sourced from the wet-process phosphoric acid industry,which causes severe environmental damages.Its utilization was limited by its high decomposition temperature and high energy consumption.Herein,an Fe-P slag,which is a solid waste that mainly comprises iron phosphide(FeP)and diiron phosphide(Fe_(2)P),can dramatically decrease the decomposition temperature of phosphogypsum.It was found that the Fe-P slag and CaSO_(4) can react as shown in the following reaction equation:2Fe_(1.5)P+3CaSO_(4)+6CO_(2)→Ca_(3)(PO_(4))_(2)+Fe_(3)O_(4)+3SO_(2)+6CO.Its reaction mechanism was further determined using the thermodynamic method.It was found that CaS was the key intermediate for this reaction.The CaSO_(4) conversion for this method can reach approximately 97%under the optimized roasting conditions:the molar ratio between Fe_(1.5) P and CaSO_(4) of 2:3,roasting temperature of 900℃,a roasting time of 8 h. | Lei Sun Zhongjun Zhao Xiushan Yang Yan Sun Quande Li Chunhui Luo Qiang Zhao | 2022 | Chinese Journal of Chemical Engineering2022，35，7： | 0 |
| 14 | Mapping the transcription repressive domain in the highly conserved human gene hnulp1显示文摘HNULP1,a new member of the basic helixloop-helix transcription factors,contains a DUF654 domain in its C-terminus and is highly conserved from Drosophilae,yeast,zebrafish to mouse.The function of this motif,however,is currently unknown.In this research,we fused five deletion fragments of the DUF654 domain to the GAL4 DNA-binding domain and then co-transfected with plasmids L8G5-Luc and VP-16.The analysis of the GAL4 luciferase reporter gene indicated that fragments from 228 to 407 amino acids in the DUF654 domain had a strong transcription repression activity.Therefore,this study lays a solid foundation for research on the mechanism of hnulp1 transcriptional regulation and the function of the DUF654 domain. | Yuequn WANG Lian LIU Zhenyu CAI Yongqing LI Wuzhou YUAN Chuanbing ZHU Yun DENG Xiaoyang MO Xiushan WU | 2008 | Frontiers in Biology2008，3，2： | 0 |
| 15 | Role of the domains of human gene ZNF569 in MAPK pathway显示文摘Mitogen-activated protein kinase(MAPK)signal pathways are important components in signal transduction connecting cell-surface receptors to critical regulatory targets within cells,mediating multiple intracellular signal cascades and phosphorylating their target proteins,such as transcriptional factors ELK-1,SRE and AP-1,and finally activating the expression of intracellular functional genes.Zinc finger genes are some of the largest gene families in humans,and Zinc finger proteins play an essential role in altering gene expression by acting as transcription factors.Zinc finger proteins are also involved in multiple cell processes,including proliferation,differentiation and development,by interacting with DNA.Here,we reported the transcriptional activities of the domains of zinc finger gene ZNF569 taking advantage of MAPK pathway.Overexpression of ZNF569 in COS-7 cells dramatically inhibited the transcriptional repressor activities of SRE and AP-1,which was also confirmed by subcellular localization analysis.Report assays indicated that the potent repression domains of ZNF569 were the KRAB and ZNF motifs.The results suggested that ZNF569 protein might act as a transcriptional repressor in MAPK signaling pathway to regulate cellular processes. | YUAN Wuzhou HUANG Xinqiong ZHU Chuanbing WANG Yuequn LI Yongqing WU Xiushan | 2006 | Frontiers in Biology2006，1，4： | 0 |
| 16 | Structure of SARS-CoV-2 main protease in the apo state显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has been a global pandemic that severely threatens global health with concordant economic damage.However,there is currently no clinically approved vaccines or drugs against COVID-19(Lu et al.,2020). | Xuelan Zhou Fanglin Zhong Cheng Lin Xiaohui Hu Yan Zhang Bing Xiong Xiushan Yin Jinheng Fu Wei He Jingjing Duan Yang Fu Huan Zhou Peter J.Mc Cormick Qisheng Wang Jian Li Jin Zhang | 2021 | Science China(Life Sciences)2021，64，4： | 0 |
| 17 | Difficulty-aware bi-network with spatial attention constrained graph for axillary lymph node segmentation显示文摘Axillary lymph node(ALN)segmentation in ultrasound images is important for the diagnosis and treatment of breast cancer.Recently,deep learning methods for automatic medical image segmentation have improved significantly.However,two problems arise.(1)A unified model is often employed to segment all images without considering the difficulty diversity.(2)The relationship between elements in the learned class probability map is disregarded.To address these two issues,we propose a novel difficulty-aware binetwork with a spatial attention constrained graph.First,a difficulty grading module(DGM)is developed to learn the difficulty grade of input images.Based on the difficulty grade of images,a novel bi-network architecture is proposed to segment the image adaptively using different branches.In complex branches,a novel spatial attention module(SAM)and graph-based energy with spatial attention constraint are proposed.The learned spatial attention map can provide additional discriminative information.Moreover,the graph-based segmentation framework can capture the relationship between pixels,further improving the segmentation performance for complex images.We conducted an experiment on our ultrasound database using 216 cases.The overall dice similarity coefficient,Jaccard coefficient,volumetric overlap error,and false positive rate are 83.41%,74.4%,12.02%,and 13.36%for ALN segmentation,respectively.The comparison results demonstrated that the proposed method outperforms other deep learning methods. | Qing XU Xiaoming XI Xianjing MENG Zheyun QIN Xiushan NIE Yongjian WU Dongsheng ZHOU Yi QU Chenglong LI Yilong YIN | 2022 | Science China(Information Sciences)2022，65，9： | 0 |
| 18 | Advanced studies on human gene ZNF322显示文摘The human novel gene of ZNF322 is cloned from human fetal cDNA library using the primers on the basis of the ZNF322 sequence analyzed with computer.The gene is located on Chromosome 6p22.1,and encodes a protein con-sisting of 402 amino acid residues and containing nine tandem C_(2)H_(2)-type zinc-finger motifs.Northern blot result shows that the gene is expressed in all examined adult tissues.Sub-cellular location study indicates that ZNF322-EGFP fusion protein is distributed in the nucleus and cytoplasm.Reporter gene assays show that ZNF322 is a potential transcriptional activator. | LI Yongqing WANG Yuequn YUAN Wuzhou DENG Yun ZHU Chuanbing WU Xiushan | 2007 | Frontiers in Biology2007，2，4： | 0 |
| 19 | Geographical Indications and Unique Production Techniques of Tangya Tribute Rice显示文摘Tangya Tribute Rice is a famous and special product in Shandong Province,and it was awarded the National Geographical Indication Certificate trademark in 2011.This paper elaborated the specific production area,unique production environment,rich cultural history and unique product quality of Tangya Tribute Rice.In addition,from the aspects of choice of origin,variety selection,production management,timely harvesting and processing,it summarized the unique production methods of Tangya Tribute Rice.Besides,it discussed its development prospects,in order to maintain the brand quality of Tangya Tribute Rice to the greatest extent,and further improve the brand awareness and market competitiveness of Tangya Tribute Rice in the domestic and international markets. | Yangang LIU Lijuan LIU Guixiu JIN Xiangkui LI Ruihua ZHANG Jing WANG Deyou LIU Xiushan ZHAO | 2020 | Asian Agricultural Research2020，12，5： | 0 |
| 20 | Combining ability for main quality traits in peanut(Arachis hypogaea L.)显示文摘High-oleic peanuts has been recognized by processing sectors,seed sellers and consumers for their longer shelf life,longer seed life and mutiple healthe benefits.High oleate is becoming a requisite for varietal releases in many peanut breeding programs at present.To select desirable parents for high-oleic peanut breeding,the study was conducted to evaluate the combining ability of 5 high-oleic donors from our research team,based on quality of individual single seeds.General combining ability was significant for oleic,linoleic,stearic and palmitic acid,oil and protein,while specific combining ability was significant for the traits except oil.Among them,oil content was found to be conditioned solely by additive gene actions,and for other quality traits,additive gene effects were more important than non-additive gene effects.High-oleic CTW and normal-oleic Xiaojingsheng were selected as the best general combiners for peanut oleic acid improvement.Narrow-sense heritability was high for quality traits other than protein,suggesting that there was high potential for genetic improvement in these traits. | Chuantang Wang Zhiwei Wang Hongwei Han Jiakai Li Hongjv Li Xiushan Sun Guosheng Song | 2021 | Oil Crop Science2021，6，4： | 0 |
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