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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 3 | The origin and geological significance of lunar ridges显示文摘Lunar ridges are a kind of familiar linear structures developed on the lunar surface. The distribution pattern, formation mechanism and research significance of lunar ridges are discussed in this paper. Single lunar ridges are usually distributed in the form of broken lineation, and, as whole, lunar ridges are trapezoidal or annular in shape around the maria. As to the formation mechanism, only volcanism or tectonism was emphasized in the past, but the two processes are seldom taken into combined consideration. On the basis of detailed analyses, the authors thought that tectonism is a prerequisite for the formation of lunar ridges, while volcanism is the key factor controlling their particular shapes. Finally, the authors pointed out that it is very significant in the study of lunar ridges to link the course of lunar structure evolution with the stress state in the lunar crust. | YUE Zongyu OUYANG Ziyuan LI Haobin LIU Jianzhong WU Ganguo | 2007 | Chinese Journal Of Geochemistry2007，26，4： | 11 |
| 4 | Process optimization of neodymium chloride solutions precipitated by magnesium bicarbonate显示文摘Rare earths(REs) are of vital importance for the development of new materials and green energy.Magnesium bicarbonate is one of the most recyclable and environmental-friendly precipitant for REs recovery from leaching solutions. Nd_2(CO_3)_3 has difficulties in industrial production. So in this study,the precipitation of neodymium from chloride solution by magnesium bicarbonate are investigated. The effects of feeding method, [HCO_3^-]/[Nd^(3+)] mole ratio, feeding speed and reaction temperature on yield and impurity(magnesia) content are systematically studied. Results show that the impurity(magnesia)content decreases to 0.010 wt% with a yield approaching to 100% obtained under the conditions of[HCO_3^-]/[Nd^(3+)] = 3.00 by parallel flow addition at 50 ℃. The major impurity(magnesia) in rare earth carbonates mainly presents in the form of physical absorption, which can be easily removed by scrubbing. Therefore, it offers a promising green process that uses magnesium bicarbonate to produce neodymium carbonate due to its cycling of carbon dioxide, magnesium salt and waste water. | Yannan Yan Yang Xu Xiaowei Huang Zongyu Feng Yongke Hou Kai Li Liangshi Wang Yihanna Hu | 2019 | Journal of Rare Earths2019，37，4： | 10 |
| 5 | An Overview of Finite/Fixed-Time Control and Its Application in Engineering Systems显示文摘The finite/fixed-time stabilization and tracking control is currently a hot field in various systems since the faster convergence can be obtained. By contrast to the asymptotic stability,the finite-time stability possesses the better control performance and disturbance rejection property. Different from the finite-time stability, the fixed-time stability has a faster convergence speed and the upper bound of the settling time can be estimated. Moreover, the convergent time does not rely on the initial information.This work aims at presenting an overview of the finite/fixed-time stabilization and tracking control and its applications in engineering systems. Firstly, several fundamental definitions on the finite/fixed-time stability are recalled. Then, the research results on the finite/fixed-time stabilization and tracking control are reviewed in detail and categorized via diverse input signal structures and engineering applications. Finally, some challenging problems needed to be solved are presented. | Yang Liu Hongyi Li Zongyu Zuo Xiaodi Li Renquan Lu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，12： | 6 |
| 6 | Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge显示文摘The gut microbiota is involved in host responses to high altitude.However,the dynamics of intestinal microecology and their association with altitude-related illness are poorly understood.Here,we used a rat model of hypobaric hypoxia challenge to mimic plateau exposure and monitored the gut microbiome,short-chain fatty acids(SCFAs),and bile acids(BAs)over 28 d.We identified weight loss,polycythemia,and pathological cardiac hypertrophy in hypoxic rats,accompanied by a large compositional shift in the gut microbiota,which is mainly driven by the bacterial families of Prevotellaceae,Porphyromonadaceae,and Streptococcaceae.The aberrant gut microbiota was characterized by increased abundance of the Parabacteroides,Alistipes,and Lactococcus genera and a larger Bacteroides to Prevotella ratio.Trans-omics analyses showed that the gut microbiome was significantly correlated with the metabolic abnormalities of SCFAs and BAs in feces,suggesting an interaction network remodeling of the microbiome-metabolome after the hypobaric hypoxia challenge.Interestingly,the transplantation of fecal microbiota significantly increased the diversity of the gut microbiota,partially inhibited the increased abundance of the Bacteroides and Alistipes genera,restored the decrease of plasma propionate,and moderately ameliorated cardiac hypertrophy in hypoxic rats.Our results provide an insight into the longitudinal changes in intestinal microecology during the hypobaric hypoxia challenge.Abnormalities in the gut microbiota and microbial metabolites contribute to the development of high-altitude heart disease in rats. | Zhiyuan Pan Yichen Hu Zongyu Huang Ni Han Yan Li Xiaomei Zhuang Jiye Yin Hui Peng Quansheng Gao Wenpeng Zhang Yong Huang Yujun Cui Yujing Bi Zhenjiang Zech Xu Ruifu Yang | 2022 | Science China(Life Sciences)2022，65，10： | 5 |
| 7 | Ultrafast nonlinear absorption and nonlinear refraction in few-layer oxidized black phosphorus显示文摘We experimentally investigated the nonlinear optical response in few-layer oxidized black phosphorus(OBP) by the femtosecond Z-scan measurement technique, and found that OBP not only possesses strong ultrafast saturable absorption but also a nonlinear self-defocusing effect that is absent in black phosphorus(BP). The saturable absorption property originates mainly from the direct band structure, which is still maintained in OBP. The emergence of self-defocusing might originate from the combined consequences of the oxygen-induced defects in BP. Our experimental findings might constitute the first experimental evidence on how to dynamically tune its nonlinear property, offering an inroad in tailoring its optical properties through chemical modification(oxidation, introducing defects, etc.). The versatile ultrafast nonlinear optical properties(saturable absorption and self-defocusing) imply a significant potential of the layered OBP in the development of unprecedented optoelectronic devices, such as mode lockers, optical switches, laser beam shapers, and wavelength converters. | Shunbin Lu Yanqi Ge Zhengbo Sun Zongyu Huang Rui Cao Chujun Zhao Shuangchun Wen Dianyuan Fan Jianqing Li Han Zhang | 2016 | Photonics Research2016，4，6： | 5 |
| 8 | Investigation on full distribution CNC system based on SERCOS bus显示文摘A full distribution CNC system based on SERCOS bus is studied in accordance with the limitations of traditional PC-based motion card. The conventional PC-based motion control card is dispersed into several autonomous intelligent servo-control units with the function of servo driver. The autonomous intelligent servo-control units realize the loop control of position, velocity and current. Interpolation computation is completed in PC and the computational results are transferred to every autonomous intelligent servo-control unit by high speed SERCOS bus. Software or hardware synchronization technology is used to ensure all servomotors are successive and synchronously running. The communication and synchronization technology of SERCOS are also researched and the autonomous intelligent servo-control card is developed byself. Finally, the experiment of circle contour process on a prototype system proves the feasibility. | Guo Wei Chen Zongyu Li Congxin | 2008 | Journal of Systems Engineering and Electronics2008，19，1： | 4 |
| 9 | Synthesis of lanthanum oxide nanosheets by a green carbonation process显示文摘Two-dimensional metal oxide nanostructures,such as nanoplates,nanowalls,and nanosheets,have received further attentions in recent years,due to their outstanding properties resulted from the small thickness and quantum size effects.In this work,lanthanum oxide nanosheets with the thickness of 56 nm had been successfully prepared by an originally simple method of carbon dioxide carbonation;the preparation process was green without using surfactants and detergent.The X-ray diffraction,transmission electron microscopy,and scanning electron microscopy were used to characterize the products.Thermogravimetric-differential thermal analysis and FT-IR were introduced to prove that the lanthanum oxide precursor with lamellar morphology was La2(CO3)3 3H2O.The carbon dioxide carbonation method would provide significant benefits containing mild reaction conditions,high efficiency,low cost,and easy to realize large-scale production. | Yanfei Xiao Zongyu Feng Xiaowei Huang Li Huang Zhiqi Long Qiang Wang Yongke Hou | 2014 | Chinese Science Bulletin2014，59，16： | 4 |
| 10 | Toxicity assessment and histopathological analysis of nano-ZnO against marine fish(Mugilogobius chulae) embryos显示文摘The toxicity of nano-materials has received increasing attention in recent years.Nevertheless,relatively few studies have focused on their oceanic distributions and toxicities.In this study,we assessed nano-ZnO toxicity in marine organisms using the yellowstriped goby(Mugilogobius chulae).The relative differences in nano-ZnO dissolution and dispersal in seawater and fresh water were also investigated.The effects of nano-ZnO on embryonic development,deformity,hatching,mortality,and histopathology were analyzed.In addition,the effects of the Zn^(2+) concentration on M.chulae hatching and mortality were compared.The results showed that nano-ZnO had higher solubility in seawater than in fresh water.Nano-ZnO significantly inhibited hatching.By the fifth day of exposure,the LC_(50) of nano-ZnO was 45.40 mg/L,and the mortality rate spiked.Hatching inhibition and lethality were dose-dependent over a range of1–25 mg/L nano-ZnO.Zn^(2+) inhibited hatching and increased lethality,but its effects were weaker than those of nano-ZnO at the same concentrations.Nano-ZnO also induced spinal bending,oedema,hypoplasia,and other deformities in M.chulae embryos and larvae.Histopathology revealed vacuolar degeneration,hepatocyte and enterocyte enlargement,and morphological abnormalities of the vertebrae.Therefore,nano-ZnO caused malformations in M.chulae by affecting embryonic growth and development.We conclude that nano-ZnO toxicity in seawater was significantly positively correlated with the associated Zn^(2+) concentration and sedimentary behaviour.The toxicity of nano-ZnO was cumulative and showed a critical point,beyond which embryonic and developmental toxicity in marine fish was observed. | Jianjun Li Zhanming Chen Ren Huang Zongyu Miao Lei Cai Qingping Du | 2018 | Journal of Environmental Sciences2018，30，11： | 4 |
| 11 | Landing site topographic mapping and rover localization for Chang’e-4 mission显示文摘This paper presents the techniques and results of landing-site topographic mapping and rover localization using orbital,descent and rover images in the Chang’e-4 mission.High-resolution maps of the landing site are generated from orbital and descent images.Local digital elevation models and digital orthophoto maps with 0.02 m resolution are generated at each waypoint.The location of the lander is determined as(177.588?E,45.457?S)using festure-matching techniques.The cross-site visual localization method is routinely used to localize the rover at each waypoint to reduce error accumulation from wheel slippage and IMU drift in dead reckoning.After the first five lunar days,the rover travels 186.66 m from the lander,according to the cross-site visual localization.The developed methods and results have been directly utilized to support the mission’s operations.The maps and localization information are also valuable for supporting multiple scientific explorations of the landing site. | Zhaoqin LIU Kaichang DI Jian LI Jianfeng XIE Xiaofeng CUI Luhua XI Wenhui WAN Man PENG Bin LIU Yexin WANG Sheng GOU Zongyu YUE Tianyi YU Lichun LI Jia WANG Chuankai LIU Xin XIN Mengna JIA Zheng BO Jia LIU Runzhi WANG Shengli NIU Kuan ZHANG Yi YOU Bing LIU Jiangang LIU | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 12 | The Study of Configurationstyle CNC System Based on CANBUS显示文摘 | Chen Zongyu Wang L F Li C X | 2006 | International Journal of Advanced Manufacturing Technology2006，28，1112： | 1 |
| 13 | Platoon control of connected vehicles with heterogeneous model structuresconsidering external disturbances显示文摘This article studies the distributed cooperative control problem with the heterogeneous model structures and external disturbances for the connected vehicle(CV)platoon.We propose a hierarchical framework to separate information flow topology from local dynamics control,which aims to deal with the heterogeneous model structures of CV platoon.This hierarchical framework splits the control scheme into two layers,which include an observer in the upper-level layer and an integral sliding mode(ISM)controller in the lower-level layer.Then,the conditions for the asymptotic stability of the CV platoon are derived and the effectiveness of the ISM controller is demonstrated through the Lyapunov method.The research shows that compared with the traditional methods,the hierarchical framework does not need to specify the topology structure as a commonly used topology.Finally,numerical simulation results are performed to test the effectiveness and superiority of the developed controller. | Yongfu Li Zongyu Qin Hao Zhu Srinivas Peeta Xinbo Gao | 2022 | Green Energy and Intelligent Transportation2022，1，3： | 1 |
| 14 | Computer Simulation of the Slab Reheating Furnace 显示文摘 | Li Zongyu Barr P V Brimaeombe J K | 1988 | Canadian Metallurgical Quarterly1988，27，3： | 1 |
| 15 | Physical, Antioxidant and Thermal Shock Properties of Cu/Ti_2AlC Conductive Composites显示文摘Cu/Ti2AlC composites were fabricated by vacuum hot-pressing technique. Phase composition was analyzed by XRD and morphology of fracture was observed by SEM. Physical performance such as density, resistivity, hardness and friction coefficient with different volume fraction of Cu/Ti2AlC composites were studied. When the content of Ti2AlC increased from 10% to 70%, the relative density reduced from 99.38% to 90.56% and the resistivity increased significantly. Hardness reached the maximum value when Ti2AlC was at 60% and friction coefficient declined with the increasing of Ti2AlC. Cu/Ti2AlC composites, showing good conductivity properties and friction performance. Oxidation resistance enhanced obviously with the content of Ti2AlC increasing. Cu-60%Ti2AlC sample possessed optimum thermal shock resistance, and no cracking was found at 600 ℃ cycled for 10 times and 900 ℃ cycled for 1 time. | 严明 ZENG Chengwen LI Zongyu LI Xuefeng 陈艳林 | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，3： | 1 |
| 16 | rransmembrane domain dependent inhibitory unction of FcyRIIB显示文摘FcyRIIB,the only inhibitory IgG Fc receptor,functions to suppress the hyper-activation of immune cells.Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcyRIIB. However,later studies revealed that in addition to the ITIiVI,the transmembrane (TM)domain of FcyRIIB is also indispensable for its inhibitory function.Indeed,recent epidemiological studies revealed that a non-synonymous single nucleotide polymorphism (rs1050501) within the TM domain of FcyRIIB,responsible for the 1232T substitution,is associated with the susceptibility to systemic lupus erythematosus (SLE).In this review, we will summarize these epidemiological and functional studies of FcyRIIB-1232T in the past few years,and will further discuss the mechanisms accounting for the functional loss of FcyRIIB-1232T.Our review will help the reader gain a deeper understanding of the importance of the TM domain in mediating the inhibitory function of FcyRIIB and may provide insights to a new therapeutic target for the associated diseases. | Junyi Wang Zongyu Li Liling Xu Hengwen Yang Wanli Liu | 2018 | Protein & Cell2018，9，12： | 1 |
| 17 | R158Q and G212S,novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome显示文摘The dysfunction of Na^(+)-Cl^(−)cotransporter(NCC)caused by mutations in solute carrier family12,member 3 gene(SLC12A3)primarily causes Gitelman syndrome(GS).In identifying the pathogenicity of R158Q and G212S variants of SLC12A3,we evaluated the pathogenicity by bioinformatic,expression,and localization analysis of two variants from a patient in our cohort.The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensional structure.Western blot showed a decrease of mutant Ncc.Immunofluorescence of the two mutations revealed a diffuse positive staining below the plasma membrane.Meanwhile,we conducted a compound heterozygous model—Ncc^(R156Q/G210S)mice corresponding to human NCC R158Q/G212S.Ncc^(R156Q/G210S)mice clearly exhibited typical GS features,including hypokalemia,hypomagnesemia,and increased fractional excretion of K^(+)and Mg^(2+)with a normal blood pressure level,which made Ncc^(R156Q/G210S)mice an optimal mouse model for further study of GS.A dramatic decrease and abnormal localization of the mutant Ncc in distal convoluted tubules contributed to the phenotype.The hydrochlorothiazide test showed a loss of function of mutant Ncc in Ncc^(R156Q/G210S)mice.These findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of GS. | Zongyue Li Huixiao Wu Shuoshuo Wei Moke Liu Yingzhou Shi Mengzhu Li Ning Wang Li Fang Bo Xiang Ling Gao Chao Xu Jiajun Zhao | 2022 | Frontiers of Medicine2022，16，6： | 1 |
| 18 | NAO-1:Lunar Highland Soil Simulant Developed in China显示文摘 | Li Yongquan Liu Jianzhong Yue Zongyu | 2009 | Journal of Aerospace Engineering2009，21，1： | 1 |
| 19 | Assessment of Geological Security and Integrated Assessment Geo-environmental Suitability in Worst-hit Areas in Wenchuan Quake显示文摘在 2008 的 Wenchuan 地震和地震触发的 geo 危险为象建设,交通和电一样的基础结构引起了大损害和死亡以及破坏损坏。为与高大小地震在高多山的区域构造的镇区和城市选择相对安全的区域是迫切的。这篇论文与高大小地震在高山和沟壑为重建论述基本想法,评估索引和地质的安全评估,水和陆地资源安全示范和对 geo 环境的适用性的综合评价的评估方法,它在最糟点击的区域(12 个县) 被使用。综合评价显示出那:(1 ) 在 Longmenshan 差错地区定位了,评估区域具有差的地区性的外壳稳定性,在哪个不稳定并且第二个不稳定的区域说明 79% 总数;(2 )geo 危险危险性在评估区域高。地震触发的 geo 危险的点主要在中等、高的山区与更高的分发沿着活跃差错地区被散布,在哪个为 40.1% 总数的高、中等的危险性 zoning 报道的区域;(3 ) 地质的安全在评估区域是差的,在哪个区域不合适,建设分别地为 8.3% 评估区域, 9.3% 和 9.3% 在合适的构造区域,地质的安全的区域,第二安全和紧张 zoning 报道占据 73.1% ;(4 )geo 环境的适用性在评估区域,适用性的区域和基本适用性 zoning 在说明 3.5% 整个评估区域和 7.3% 是差的。 | LI Wenpeng WEN Dongguang ZHOU Aiguo SUN Xiaoming MENG Hui SHI Jusong CHEN Zongyu ZHANG Liqin FENG Xiaoming LIU Changli ZHOU Jianwei | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 1 |
| 20 | Identification of two potential glycogen synthase kinase 3β inhibitors for the treatment of osteosarcoma显示文摘Osteosarcoma 是在与高死亡率世界范围的青少年之中的最普通的主要恶意的骨头肿瘤。肝糖 synthase kinase (GSK3 ) 3 是 serine/threonine kinase 并且在 osteosarcoma 被看作一个验证目标治疗。因此, GSK3 禁止者的学习是在 anti-osteosarcoma 药开发的最流行的领域之一。这里,生物信息学的工具被用来从锌药数据库屏蔽 GSK3 的新奇有效禁止者。分子的停靠、分子的动态模拟, MM/GBSA,和精力分解分析被执行识别禁止者。最后, ZINC08383479 和 ZINC08441251 作为潜在的 GSK3 禁止者被选择。这二个禁止者被 GSK3 kinase 抑制试金在 vitro 评估。房间增长的抑制在 vitro 在 osteosarcoma 房间线 U2OS 和 MG63 被测试。结果显示出那 ZINC08383479, ZINC08441251 对 GSK3 举办了高抑制活动。我们发现 CHIR99021 (一个已知的 GSK3 禁止者) , ZINC08383479,和 ZINC08441251 在 U2OS 房间和 MG63 房间举办了重要抑制活动。这些调查结果可以为 osteosarcoma 为更多的有势力 GSK3 禁止者和治疗学的目标的设计提供新想法。 | Kaimin Lu Xin Wang Yuyu Chen Danfeng Liang Hao Luo Li Long Zongyue Hu Jinku Bao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 0 |
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