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| 1 | Strengthening FCC-CoCrFeMnNi high entropy alloys by Mo addition显示文摘In order to strengthen the face-centered-cubic(FCC) type CoCrFeMnNi high entropy alloys(HEAs), different contents of Mo(0–16 at.%, similarly hereinafter) were alloyed. Phase evolution, microstructure,mechanical properties and related mechanism of these HEAs were systematically studied. The results show that sigma phase is appeared with addition of Mo, and the volume fraction of it increases gradually from 0 to 66% with increasing Mo content. It is found that Mo is enriched in sigma phase, which indicates that Mo element is beneficial to form sigma phase. Compressive testing shows that the yield strength of the alloys increases gradually from 216 to 765 MPa, while the fracture strain decreases from 50%(no fracture) to 19% with increasing of Mo. The alloy exhibits the best compressive performance when Mo content reaches 11%, the yield strength, fracture strength and fracture strain are 547 MPa, 2672 MPa and44% respectively. The increased volume fraction of sigma phase plays an important role in improving the compressive strength of(CoCrFeMnNi)_(100-x)Mo_xHEAs. | Gang Qin Ruirun Chen Huiting Zheng Hongze Fang Liang Wang Yanqing Su Jingjie Guo Hengzhi Fu | 2019 | Journal of Materials Science & Technology2019，35，4： | 11 |
| 2 | Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria显示文摘Infections caused by drug-resistant“superbugs”pose an urgent public health threat due to the lack of effective drugs;however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors VII, IX and X, three proteins with well-established roles in initiation of the coagulation cascade. These factors exert antibacterial function via their light chains (LCs). Unlike many antibacterial agents that target cell metabolism or the cytoplasmic membrane, the LCs act by hydrolyzing the major components of bacterial outer membrane, lipopolysaccharides, which are crucial for the survival of Gram-negative bacteria. The LC of factor VII exhibits in vitro efficacy towards all Gram-negative bacteria tested, including extensively drug-resistant (XDR) pathogens, at nanomolar concentrations. It is also highly effective in combating XDR Pseudomonas aeruginosa and Acinetobacter baumannii infections in vivo. Through decoding a unique mechanism whereby factors VII, IX and X behave as antimicrobial proteins, this study advances our understanding of the coagulation system in host defense, and suggests that these factors may participate in the pathogenesis of coagulation disorder-related diseases such as sepsis via their dual functions in blood coagulation and resistance to infection. Furthermore, this study may offer new strategies for combating Gram-negative “superbugs”. | Jinwu Chen Xiaojie Li Ling Li Ting Zhang Qing Zhang Fangming Wu Diyue Wang Hongze Hu Changlin Tian Dongsheng Liao Liang Zhao Danxia Song Yongyun Zhao Chuanfang Wu Xu Song | 2019 | Cell Research2019，29，9： | 6 |
| 3 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 4 | Alcohols controlled selective radical cyclization of 1,6-dienes under mild conditions显示文摘An efficient procedure for the selective preparation of hydroxy-,carbonyl-and acetal-containing 2-pyrrolidinones has been developed through radical cyclization of 1,6-dienes initiated byα-C(sp3)-H functionalization of alcohols.This protocol could be conducted at catalyst-free conditions at relatively low temperature(80℃)by employing commercially available tert-butyl peroxybenzoate(TBPB)as the oxidant. | Fu-Hua Qin Xun-jie Huang Yi Liu Hongze Liang Qiang Li Zhong Cao Wen-Ting Wei Wei-Min He | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 5 | Distributed Beamforming for Energy-Harvesting Relaying in Vehicular Networks显示文摘Recently,battery capacity and charging speed have been the bottlenecks of mobile communication networks.Energy harvesting(EH)relaying has become a promising solution for green 5th generation mobile communication with the advancement of wireless power transfer technology.In this paper,we investigate EH relaying in vehicular networks and adopt distributed beamforming(DB)to enhance the reliability and capacity of EH relaying.To be more specific,we propose a DB solution based on the joint optimization of power-splitting(PS)factors.For amplify-and-forward relaying,to transform the optimization problem into a quasi-convex one,we apply the semidefinite relaxation(SDR)method so that we can effectively attain the global optimal solution,while the suboptimal DB solution with distributed optimal PS factor which only requires local channel state information is also proposed.For decode-and-forward relaying,to get the optimal PS factors,we set a signal-to-noise ratio threshold at the relays,which can reduce the system error rate caused by the poor transmission link.Simulation results demonstrate the efficiency of our proposed DB-based EH relaying scheme in vehicular networks. | Yuxiang Liang Bing Li Rongqing Zhang Hongze Li Shengjie Zhao | 2020 | Journal of Communications and Information Networks2020，5，2： | 0 |
| 6 | Indirubin-30 -monoxime-loaded PLGA-PEG nanoparticles for potential Alzheimer's disease treatment显示文摘Alzheimer's disease(AD)is an irreversible neurodegenerative disorder,which is pathologically characterized by the deposits of β-amyloid(Aβ),and plays an important role in neuronal death.Indirubin-30-monoxime(I3M)showed neuroprotective effects against Aβ-induced neuronal apoptosis.However,the use of I3M in AD treatment is limited due to its low bioavailability.Herein,PLGA-PEG nanoparticles were synthesized for I3M loading.I3M could release sustainedly sustain release from the I3M-loaded PLGA-PEG nanoparticles(PLGA-PEG-I3M NPs)without obvious burst release.What's more,the PLGA-PEG-I3M NPs could significantly promote the uptake of I3M by PC12 cells through nanoparticle-mediated transport,and improve the efficacy of I3M on the inhibition of Aβfibrillization and oligomerization as well as the neuroprotective activity of I3M on Aβoligomers-induced neuronal death.Thus,the PLGA-PEG-I3M NPs may be a promising platform for AD therapy. | Lingli Jin Qiyao Wang Mengxiang Yang Jiaying Zhang Hongze Liang Hui Tan Zhenjiang Liang Xiaopeng Ma Junying Liu Haiyan Li Xiaodong Cai Wei Cui Lingling Zhao | 2022 | Medicine in Novel Technology and Devices2022，，3： | 0 |
| 7 | Synthesis and Crystal Structure of Rare Earth Metal Chlorides Bearing Bridged-lndenyl Ancillary Ligand显示文摘二新稀土元素金属氯化物建筑群由 bridged-indenyl 支持了辅助 ligand,[C9H6SiMe2-(CH2 ) 2SiMe2C9H6 ] 行(-Cl)2Li(TMEDA)[Ln=Y (1 ) ,陆(2 )] ,经由盐换位反应被综合。有 2 equiv 的 C9H7SiMe2 (CH2 ) 2SiMe2C9H7 的反应。在在空间的己的 n-butyllithium,温度负担得起[C9H6SiMe2-(CH2 ) 2SiMe2C9H6 ] 在 95% 孤立的产量的 Li2 同样白的粉末。进一步的处理[C9H6SiMe2 (CH2 )2SiMe2- C9H6 ] 有在 1:1 的无水的 LnCl3 的 Li2 在在房间温度的 THF/TMEDA 的臼齿的比率提供了 1 和 2 在孤立的 86%89% 产出的 bridged-indenyl 稀土元素金属氯化物。两建筑群被英尺红外光谱学, NMR 光谱学,元素的分析,和 X 光检查单身者描绘水晶结构分析。在两建筑群的中央金属由在 5 时尚,和二个氯原子的二 indenyl ligands 是八坐标的采用弄歪的有四面的几何学。 | Wang Yibin Feng Xiaoying Luo Yunjie Zhang Yong Liang Hongze | 2011 | Chinese Journal of Chemistry2011，29，2： | 0 |
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