|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 2 | Chemistry and pharmacology of Siraitia grosvenorii: A review显示文摘Siraitia grosvenorii is a perennial herb endemic to Guangxi province of China. Its fruit, commonly known as Luo hanguo, and has been used for hundreds of years as a natural sweetener and as a traditional medicine for the treatment of pharyngitis, pharyngeal pain, as well as an anti-tussive remedy in China. Based on ninety-three literary sources, this review summarized the advances in chemistry, biological effects, and toxicity research of S. grosvenorii during the past 30 years. Several different classes of compounds have been isolated or detected from various parts of S. grosvenorii, mainly triterpenoids, flavonoids, polysaccharides, amino acids, and essential oils. Various types of extracts or individual compounds derived from this species exhibited a wide array of biological effects e.g. anti-tussive, phlegm-relieving, anti-oxidant, immunomodulatory, liver-protecting, glucose-lowering, and anti-microbial. The existing research has shown that extracts and individual compounds from S. grosvenorii are basically non-toxic. Finally, some suggestions for further research on specific chemical and pharmacological properties of S. grosvenorii are proposed in this review. | LI Chun LIN Li-Mei SUI Feng WANG Zhi-Min HUO Hai-Ru DAI Li JIANG Ting-Liang | 2014 | Chinese Journal of Natural Medicines2014，12，2： | 28 |
| 3 | Comparsion analysis of data mining models applied to clinical research in Traditional Chinese Medicine显示文摘OBJECTIVE: To help researchers selecting appropriate data mining models to provide better evidence for the clinical practice of Traditional Chinese Medicine(TCM) diagnosis and therapy.METHODS: Clinical issues based on data mining models were comprehensively summarized from four significant elements of the clinical studies:symptoms, symptom patterns, herbs, and efficacy.Existing problems were further generalized to determine the relevant factors of the performance of data mining models, e.g. data type, samples, parameters, variable labels. Combining these relevant factors, the TCM clinical data features were compared with regards to statistical characters and informatics properties. Data models were compared simultaneously from the view of applied conditions and suitable scopes.RESULTS: The main application problems were the inconsistent data type and the small samples for the used data mining models, which caused the inappropriate results, even the mistake results. These features, i.e. advantages, disadvantages, satisfied data types, tasks of data mining, and the TCM issues, were summarized and compared.CONCLUSION: By aiming at the special features of different data mining models, the clinical doctors could select the suitable data mining models to resolve the TCM problem. | Yufeng Zhao Qi Xie Liyun He Baoyan Liu Kun Li Xiang Zhang Wenjing Bai Lin Luo Xianghong Jing Ruili Huo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 14 |
| 4 | Effects of dietary alfalfa flavonoids extraction on growth performance,organ development and blood biochemical indexes of Yangzhou geese aged from 28 to 70 days显示文摘This experiment was conducted to study the effects of dietary alfalfa flavonoids extraction supplemental level on growth performance, organ development and blood biochemical indexes of Yangzhou geese at the age of 28 to 70 days. Two hundred and forty 21-day-old healthy male geese with similar body weight were randomly distributed into 4 groups with 6 replicates per group and 10 geese per replicate. Geese in the control group were fed a basal diet and the others in the experimental groups(groups 1,2, and 3) were fed experimental diets supplemented with 150, 300 and 450 mg/kg alfalfa flavonoids extraction(the concentration of it was 81%), respectively. The experiment had 7 days for pre-test and 42 days for formal test.The results showed that the final body weight and average daily intake of group 2 were significantly higher than those of other groups(P < 0.05). The average daily gain of group 2 was significantly higher than that in the control group and group 1(P < 0.05). There was no significant difference in feed-to-gain ratio between each group(P > 0.05). Pre-slaughter live weight, carcass weight, slaughter rate, semieviscerated weight, semi-eviscerated rate, eviscerated weight, eviscerated rate, leg muscle weight and leg muscle rate had no significant difference between each group(P > 0.05). The breast muscle weight and ratio of each test group were significantly higher than those in the control group(P < 0.05) and the group2 was the best. The abdominal fat weight and ratio in the group 1 were significantly higher than those in the control group and group 3(P < 0.05) and the tibia weight in the group 2 was significantly higher than that in the control group and group 1(P < 0.05); There were no significant differences in heart weight,liver weight and the gland stomach weight among all groups(P > 0.05). Spleen weight in test groups was significantly higher than that in the control group(P < 0.05). The bursa weight and muscular stomach weight in the group 2 were significantly higher than those in the control group and group 1(P < 0.05). In serum, total cholesterol, triglycerides, low-density lipoprotein and urea nitrogen in the group 2 were significantly lower comparing with those in the control group(P < 0.05). High-density lipoprotein in the group 2 was significantly higher than that in other groups(P < 0.05). There were no significant differences in total serum protein, albumin, globulin and albumin/globulin among all groups(P > 0.05). Alanine aminotransferase and aspartate transaminase(AST) in groups 2 and 3 were higher than those in the group1 and control group but not obvious(P > 0.05) and alkaline phosphatase(ALP) in groups 1 and 2 was higher than that in the control group and group 3(P > 0.05). It is concluded that alfalfa flavonoids extraction added in dietary feed improve the growth performance, organ development and blood biochemical indexes of Yangzhou geese. It is concluded that 300 mg/kg supplemental level of the dietary alfalfa flavonoids extraction is optimal in this experiment. | Yinyin Chen Xiaoxiao Gong Guodong Li Miao Lin Yongjiu Huo Shengli Li Guoqi Zhao | 2016 | Animal Nutrition2016，，4： | 14 |
| 5 | Detection of lung adenocarcinoma using magnetic beads based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry serum protein profiling显示文摘背景由于 proteomic 技术的快速的发展,最近,大进展在许多科学的地里被做了。我们试图使用基于的磁性的祷告(液体薄片)为肺腺癌( adCA )屏蔽特殊 biomarkers 的帮助矩阵的激光解吸附作用/电离 time-of-flight 团 spectrometry ( MALDI-TOF-MS )技术,并且交换磁性的祷告( MB-WCX )用弱阳离子建立诊断蛋白质 profiles.Methods 从 35 肺 adCA , 46 良性的肺疾病( BLD )和 44 个健康个人的 sera 孤立并且净化低分子的重量蛋白质。锚 chip-MALDI-TOF-MS 获得的产生系列被 ClinProTools 和模式识别分析基因算法(GA ) 。在工作的团中的结果 800-10 变化 000 Da, 99 座特殊山峰在肺 adCA 对 BLD 被解决,当 101 座山峰在肺 adCA 对健康的人被解决时。能把 adCA 与 BLD 区分开来的 GA 获得的侧面与 80% 的敏感由 4053.88, 4209.57 和 3883.33 Da 组成, 93% 的特性当那能把 adCA 与健康控制分开时与 94% 的敏感由 2951.83 Da 和 4209.73 Da 组成, 95% 的特性。carcinoembryonic 抗原(CEA ) 在这个实验提供的敏感比我们的差别对待的侧面显著地低(P < 0.005 ) 。我们进一步识别了一个真核细胞的肽链版本因素 GTP 有约束力的子单元(eRF3b )(4209 Da ) 和可以为肺 adCA 用作候选人 biomarkers 的补充 C3f (1865 Da ) 。基于的 MALDI-TOF-MS 技术能很快并且有效地屏蔽的结论磁性的祷告从肺 adCA 病人和控制的 sera 的特殊蛋白质 / 多肽,它有潜力为为肺 adCA 建立一个新诊断方法珍视。 | LIN Xiu-li YANG Shuan-ying DU Jie TIAN Ying-xuan BU Li-na HUO Shu-fen WANG Feng-peng NAN Yan-dong | 2010 | Chinese Medical Journal2010，，1： | 13 |
| 6 | Classification of Complex Reservoirs in Superimposed Basins of Western China显示文摘许多通过重叠在西方的中国的沉积的盆被形成并且混合至少二以前开发了沉积的盆,一般来说,他们能作为复杂的附加的盆被称为。这些盆和单型盆之间的不同差别是他们在地质的历史上的不连续的 stratigraphic 沉积, stratigraphic 结构和 stratigraphic 压力紧张行动。在结构的节上基于按年代先后的年龄的关联,附加的盆能在这研究被划分成五种类型:(1 ) 连续沉积类型附加了盆,(2 ) 中间、迟了的 stratigraphic 附加了盆,(3 ) 早、迟了的 stratigraphic 附加了盆,(4 ) 早、中间的 stratigraphic 附加了盆,并且(5 ) 长期的暴露的附加的盆。多重 source-reservoir-caprock 集合在如此的盆发展了。另外,多级式的烃产生和逐出,多重来源,多不的烃累积和多重类型的烃水库调整,改革和破坏发生在这些盆。在附加的盆广泛地被发现了到日期的复杂水库从这的原因正在合拢的主要水库,和根有显著地不同的地质的特征,剥光和破裂效果象联系渗出物一样在附加的盆由多相的构造事件引起了,散开,掉下,氧化,降级并且裂开。基于他们的开始特征,复杂水库被划分成五个范畴:(1 ) 主要水库,(2 ) 套住调整类型水库,(3 ) 部件变体水库,(4 ) 分阶段执行变换类型水库并且(5 ) 改革规模的水库。 | PANG Xiongqi ZHOU Xinyuan LIN Changsong HUO Zhipeng LUO Xiaorong PANG Hong | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 11 |
| 7 | Changes of Vertical Groundwater Recharge with Increase in Thickness of Vadose Zone Simulated by One-Dimensional Variably Saturated Flow Model显示文摘The thickness of vadose zone plays a critical role in vertical groundwater recharge. The decline of water table since the past decades due to long-term groundwater over-exploitation has resulted in deep vadose zone in North China Plain. One-dimensional variably saturated flow models were established by Hydrus-1D software and simulations were run under steady and continuous declining water table respectively to estimate the impact of increase in thickness of vadose zone on recharge process, quantity and recharge time. Luancheng area was selected to estimate recharge quantity considering steady and continuous declining water table. The simulation results show that the increase in thickness of vadose zone delays recharge process to water table. The recharge quantity decreases first and then remains stable with the decline of water table. Under the condition of declining water table, the evaluation of recharge by the flux at water table overestimates the recharge quantity. The average annual recharge rate of Luancheng area is 134 mm/a. | Siyuan Huo Menggui Jin Xing Liang Dan Lin | 2014 | Journal of Earth Science2014，25，6： | 10 |
| 8 | Effects of Nitrogen Application Levels on Ammonia Volatilization and Nitrogen Utilization during Rice Growing Season显示文摘We conducted field trials of rice grown in sandy soil and clay soil to determine the effects of nitrogen application levels on the concentration of NH4+-N in surface water,loss of ammonia through volatilization from paddy fields,rice production,nitrogen-use efficiency,and nitrogen content in the soil profile.The concentration of NH4+-N in surface water and the amount of ammonia lost through volatilization increased with increasing nitrogen application level,and peaked at 1-3 d after nitrogen application.Less ammonia was lost via volatilization from clay soil than from sandy soil.The amounts of ammonia lost via volatilization after nitrogen application differed depending on the stage when it was applied,from the highest loss to the lowest:N application to promote tillering > the first N topdressing to promote panicle initiation(applied at the last 4-leaf stage) > basal fertilizer > the second N topdressing to promote panicle initiation(applied at the last 2-leaf stage).The total loss of ammonia via volatilization from clay soil was 10.49-87.06 kg/hm2,equivalent to 10.92%-21.76% of the nitrogen applied.The total loss of ammonia via volatilization from sandy soil was 11.32?102.43 kg/hm2,equivalent to 11.32%-25.61% of the nitrogen applied.The amount of ammonia lost via volatilization and the concentration of NH4+-N in surface water peaked simultaneously after nitrogen application;both showed maxima at the tillering stage with the ratio between them ranging from 23.76% to 33.65%.With the increase in nitrogen application level,rice production and nitrogen accumulation in plants increased,but nitrogen-use efficiency decreased.Rice production and nitrogen accumulation in plants were slightly higher in clay soil than in sandy soil.In the soil,the nitrogen content was the lowest at a depth of 40-50 cm.In any specific soil layer,the soil nitrogen content increased with increasing nitrogen application level,and the soil nitrogen content was higher in clay soil than in sandy soil.In terms of ammonia volatilization,the amount of ammonia lost via volatilization increased markedly when the nitrogen application level exceeded 250 kg/hm2 in the rice growing season.However,for rice production,a suitable nitrogen application level is approximately 300 kg/hm2.Therefore,taking the needs for high crop yields and environmental protection into account,the appropriate nitrogen application level was 250-300 kg/hm2 in these conditions. | LIN Zhong-cheng DAI Qi-gen YE Shi-chao WU Fu-guan JIA Yu-shu CHEN Jing-dou XU Lu-sheng ZHANG Hong-cheng Huo Zhong-yang Xu Ke WEt Hai-yan | 2012 | Rice science2012，19，2： | 9 |
| 9 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 10 | Optical properties of NaY(MoO4)2:Eu3+ nanophosphors prepared by molten salt method显示文摘We synthesized NaY(MoO4)2:Eu3+phosphors of different doping concentrations by a molten salt method.This facile way possesses advantages such as simple process,lower calcination temperature(350℃)and small particle size(70 nm).The crystal system is tetragonal phase and crystal lattice is body centered.The photo luminescence measurements including emission spectra,excitation spectra and fluorescence decay curves were carried out,elucidating that NaY(MoO4)2:Eu3+can be effectively excited by near UV and blue light.Moreover,it can be concluded that Eu3+energy transfer type is exchange interaction.Huang-Rhys factor and the critical energy transfer distance(Rc)were calculated to be 0.043 and 0.995 nm,respectively.Auzel’s model was used to obtain the intrinsic radiative transition lifetime of5 D0 level(τ0=0.923 ms).Furthermore,a calculation method was used to calculate refractive index n of nontransparent NaY(MoO4)2:1 mol%Eu3+phosphor,and n was obtained to be 1.86. | Lin Bai Qingyu Meng Mingxue Huo Yu Sui | 2019 | Journal of Rare Earths2019，37，12： | 8 |
| 11 | Effects of surfactants on graphene oxide nanoparticles transport in saturated porous media显示文摘Transport behaviors of graphene oxide nanoparticles(GONPs) in saturated porous media were examined as a function of the presence and concentration of anionic surfactant(SDBS)and non-ionic surfactant(Triton X-100) under different ionic strength(IS). The results showed that the GONPs were retained obviously in the sand columns at both IS of 50 and200 mmol/L, and they were more mobile at lower IS. The presence and concentration of surfactants could enhance the GONP transport, particularly as observed at higher IS. It was interesting to see that the GONP transport was surfactant type dependent, and SDBS was more effective to facilitate GONP transport than Triton X-100 in our experimental conditions. The advection–dispersion–retention numerical modeling followed this trend and depicted the difference quantitatively. Derjaguin–Landau–Verwey–Overbeek(DLVO)interaction calculations also were performed to interpret these effects, indicating that secondary minimum deposition was critical in this study. | Wei Fan Xuehui Jiang Ying Lu Mingxin Huo Shanshan Lin Zhi Geng | 2015 | Journal of Environmental Sciences2015，27，9： | 6 |
| 12 | Efficacy of Yiqigubiao pill on chronic obstructive pulmonary disease in rats with the disease induced by lipopolysaccharide and cigarette-smoke fumigation显示文摘OBJECTIVE:To investigate the efficacy of Yiqigubiao pill(YQGB)on chronic obstructive pulmonary disease(COPD)in rats with the COPD induced by lipopolysaccharide(LPS)and cigarettesmoke fumigation.METHODS:In this study,six groups of rats were set up,including control group,model group,positive control group(aminophylline)and YQGB(high,medium and low doses)groups.Tracheal injection of lipopolysaccharide(LPS)and cigarette-smoke fumigation induced COPD in rats.The general condition,incubation period and coughing times,lung function,level of inflammatory factors,leukocyte condition and pathological changes of bronchus and lung tissue were observed in rats of each group.RESULTS:In the COPD rats,the latent period of coughing was shortened and the cough frequency was increased significantly;the pulmonary function was significantly decreased,which was manifested by the increased lung tissue resistance and respiratory system resistance,and the decreasing percentage of forced expiratory volume and forced expiratory volume in the 0.3 s(FEV0.3/FVC);the contents of tumor necrosis factor-alpha(TNF-α)and interleukin-4 in serum were obviously increased,and the NEUT%in bronchoalveolar lavage fluid was significantly increase.YQGB could obviously prolong the latent period of cough,and reduce the cough frequency and the content of TNF-αin serum.YQGB can also significantly reduce respiratory resistance and increase FEV0.3/FVC value.The results of histopathology showed that YQGB significantly reduced the pathological changes of tracheal mucosa and lung caused by COPD.YQGB obviously increased level of AQP1,which was down-regulated in the COPD rats.CONCLUSION:YQGB could significantly improve the pulmonary function,reduce inflammation and alleviate lung and bronchial diseases in the COPD rats. | Jiang Lin Li Fengsen Sun Jianhui Huo Hairu Li Xiaoqin Li Hongmei | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 6 |
| 13 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 14 | Simultaneous Determination of Hexoestrol, Diethylstilbestrol, Estrone and 17-Beta-estradiol in Feed by Gas Chromatography-mass Spectrometry显示文摘A method was developed for the simultaneous determination of four kinds of estrogens(hexoestrol, diethylstilbestrol, estrone, and 17-beta-estradiol) in feed by gas chromatography-mass spectrometry(GC-MS). After the sample was extracted by ethyl ether and cleaned-up on HLB phase extraction column, four kinds of estrogens were derived and quantified in gas chromatographymass spectrometry. The results showed that the linear detectable ranged from 2.5 ng·mL^(-1) to 250 ng·mL^(-1) for hexoestrol and from 5 ng·mL^(-1) to 500 ng·mL^(-1) for three other estrogens with the correlation coefficients(R^2) were no less than 0.990. The recoveries were in the range of 76.34%-96.33% and the relative standard deviation was no more than 22.7%. The limits of quantitation(LOQ) for all analytics were between 10 ug·kg^(-1) and 20 ug·kg^(-1).The method was accurate and sensitive and could meet the actual requirements for the analyses of feed samples. | Huo Feng Li Ning Lin Xiao-Li | 2016 | Journal of Northeast Agricultural University(English Edition)2016，23，1： | 6 |
| 15 | A three-microRNA panel in serum as novel biomarker for papillary thyroid carcinoma diagnosis显示文摘Background:Accumulating evidence has revealed that circulating microRNAs(miRNAs)can serve as non-invasive biomarkers for cancer diagnosis.This study aimed to identify differentially expressed miRNAs in serum which might become potential biomarkers for non-invasive diagnosis of papillary thyroid carcinoma(PTC).Methods:The experiment was carried out between 2015 and 2017.In the screening stage,the Exiqon miRNA quantitative real-time polymerase chain reaction(qPCR)panel was applied to select candidate miRNAs.In the following training,testing,and external validation stages,the serum samples of 100 patients and 96 healthy controls(HCs)were analyzed to compare the expression levels of the identified miRNAs.The areas under the receiver operating characteristic curves(AUCs)were calculated to assess the diagnostic value of the identified signature.Results:Three miRNAs(miR-25-3p,miR-296-5p,and miR-92a-3p)in serum were consistently up-regulated in PTC patients compared with HCs.A three-miRNA panel was constructed by logistic regression analysis and showed better diagnostic performance than a single miRNA for PTC detection.The AUCs of the panel were 0.727,0.771,and 0.862 for the training,testing,and external validation stage,respectively.Meanwhile,the panel showed stable capability in differentiating PTC patients from patients with benign goiters,with an AUC as high as 0.969.For further exploration,the three identified miRNAs were analyzed in tissue samples(23 PTC vs.23 HCs)and serum-derived exosomes samples(24 PTC vs.24 HCs),and the altered expression in the tumor also indicated their close relationship with PTC disease.Conclusion:We identify a three-miRNA panel in serum which might serve as a promising biomarker for PTC diagnosis. | Xuan Zou Feng Gao Zhi-Yan Wang Huo Zhang Qing-Xie Liu Lin Jiang Xin Zhou Wei Zhu | 2020 | Chinese Medical Journal2020，，21： | 6 |
| 16 | Application of Artificial Intelligence in Medicine: An Overview显示文摘Artificial intelligence(AI)is a new technical discipline that uses computer technology to research and develop the theory,method,technique,and application system for the simulation,extension,and expansion of human intelligence.With the assistance of new AI technology,the traditional medical environment has changed a lot.For example,a patient’s diagnosis based on radiological,pathological,endoscopic,ultrasonographic,and biochemical examinations has been effectively promoted with a higher accuracy and a lower human workload.The medical treatments during the perioperative period,including the preoperative preparation,surgical period,and postoperative recovery period,have been significantly enhanced with better surgical effects.In addition,AI technology has also played a crucial role in medical drug production,medical management,and medical education,taking them into a new direction.The purpose of this review is to introduce the application of AI in medicine and to provide an outiook of future trends. | Peng-ran LIU Lin LU Jia-yao ZHANG Tong-tong HUO Song-xiang LIU Zhe-wei YE | 2021 | Current Medical Science2021，41，6： | 5 |
| 17 | The role of ezrin-associated protein network in human sperm capacitation显示文摘在精子房间的膜修正在精子 capacitation 代表关键步;然而,这些修正的分子的基础充分没被理解。Ezrin 是 ezrin/radixin/merlin 家庭的学习最好的成员。作为在外皮的细胞骨架和血浆膜蛋白质之间的 cross-linker, ezrin 贡献膜表面结构改变。而且,激活 ezrin 和 Rho 分离禁止者, RhoGDI,通过 Rho 激活支持外皮的 cytoskeleton-polymerized 肌动朊的形成。因此, ezrin,肌动朊, RhoGDI, Rho 和血浆膜蛋白质在 vivo 形成一个复杂网络,它贡献膜表面的结构的集会。以前,我们证明 ezrin 和 RhoGDI1 在人的睾丸被表示。因此,我们寻求了决定 ezrin 鈥揜h oGDI1 鈥揳c 听鈥搈e mbrane 蛋白质网络是否在人的精子 capacitation 有一个角色。我们由西方的污点的结果显示 ezrin 被 threonine567 残余的 phosphorylation 在 capacitation 期间激活。Co-immunoprecipitation 研究表明在精子 capacitation 期间,在 ezrin 和 RhoGDI1 之间的相互作用增加,并且二维的电气泳动胶化的 phosphostaining 证明 RhoGDI1 是 phosphorylated,建议 RhoGDI1 从 RhoA 分裂并且导致精子头上的肌动朊聚合。我们推测那激活的 ezrin 在 capacitation 以后与 polymerized 肌动朊和 glycosylated 膜蛋白质 cd44 交往。用 ezrin 特定或肌动朊特定的 monoclonal 抗体堵住精子 capacitation 减少他们的 acrosome 反应(AR ) 率,但是没独自在 AR 上有效果。一起拿,我们的结果证明由 ezrin, RhoGDI1, RhoA, F 肌动朊和膜蛋白质组成的一个网络工作影响在人的精子 capacitation 期间发生在精子头的膜上的修正。 | Lei Wang Wen Chen Chun Zhao Ran Huo Xue-Jiang Guo Min Lin Xiao-Yan Huang Yun-Dong Mao Zuo-Min Zhou Jia-Hao Sha | 2010 | Asian Journal of Andrology2010，12，5： | 4 |
| 18 | A highly selective dual-channel Hg^(2+) chemosensor based on an easy to prepare double naphthalene Schiff base显示文摘A non-sulfur chemosensor based on an easy to prepare double naphthalene Schiff base is reported for the colorimetric and fluorometric dual-channel sensing of Hg2+ ions by taking advantage of the twisted intramolecular charge transfer (TICT) mechanism. This work provides a novel approach for the selective recognition of mercury ions. Moreover, this sensor serves as a potential recyclable component in sensing materials and the complex L-Hg2+ (L = 1-[(2-naphthalenylimino)methyl]-2-naphthalenol) can therefore be used as a fluorescent sensor for iodine anions. Notably, the color changes are very significant and all the recognition and recycling processes can be observed by the naked eye. | ZHANG YouMing SHI BingBing ZHANG Peng HUO JianQiang CHEN Pei LIN Qi LIU Jun WEI TaiBao | 2013 | Science China Chemistry2013，56，5： | 4 |
| 19 | Effect of high temperature annealing on the performance of MANOS charge trapping memory显示文摘We have investigated the effect of post deposition annealing (PDA) temperature of Al2O3 blocking layer on the performance of charge trapping memory capacitors. Two splits of PDA were performed in N2 ambient at 850°C/60 s and 1050°C/60 s, respectively. The 1050°C annealed capacitor could be programmed and erased normally by using Fowler-Nordheim (FN) injection. In contrast, the 850°C annealed device could not be erased, even though it could be programmed properly. By measuring the gate leakage current and the flatband voltage shift, we found the erase failure in the 850°C annealed device was due to a larger gate back-injection leakage current at Vg<0. The trend of gate leakage current was further verified in two Al/Al2O3/SiO2/p-Si control capacitors with the same PDA splits. In addition, constant voltage stress measurements on control capacitors in the FN regime showed that the change of gate leakage current followed an empirical Curie-von Schweidler law at Vg<0. The data pointed out the importance to further study the relation between PDA conditions and the defect generation properties in Al2O3 blocking layer. | JIN Lin ZHANG ManHong HUO ZongLiang YU ZhaoAn JIANG DanDan WANG Yong BAI Jie CHEN JunNing LIU Ming | 2012 | Science China(Technological Sciences)2012，55，4： | 4 |
| 20 | Simulation of stray grain formation in Ni-base single crystal turbine blades fabricated by HRS and LMC techniques显示文摘The simulation models of the thermal and macrostructural evolutions during directional solidification of Ni-base single crystal(SX) turbine blades under high rate solidification(HRS) and liquid metal cooling(LMC) have been constructed using Pro CAST software, coupled with a 3D Cellular Automaton Finite Element(CAFE) model. The models were used to investigate the tendencies of stray grain(SG) formation in the platform region of turbine blades fabricated by HRS and LMC techniques. The results reveal that the LMC technique can prohibit SG formation by smoothing the concaved isotherm and in turn alleviating the undercooling in the platform ends to let the dendrites fill up the undercooled zone before SG nucleation. The simulation results agreed well with the experimental results, indicating that these models could be used to analyze the macrostructural evolution or to optimize process parameters to suppress SG formation. Using these models, the critical withdrawal rate for casting SX turbine blades without SG formation were determined to be around 75 μm·s^(-1) and 100 μm·s^(-1) for HRS and LMC respectively, suggesting that LMC can be used as an efficient technique in fabricating SX turbine blades without any SG defect formation. | Ya-feng Li Lin Liu Tai-wen Huang Miao Huo Jun-sheng He Jun Zhang Heng-zhi Fu | 2017 | China Foundry2017，14，2： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员