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| 1 | The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury显示文摘Sentrin-specific protease 3(SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion(MIR) injury is unclear. Here, we observed that SENP3 was expressed and upregulated in the mouse heart depending on reactive oxygen species(ROS) production in response to MIR injury. By utilizing si RNA-mediated cardiac specific gene silencing, SENP3 knockdown was demonstrated to significantly reduce MIR-induced infarct size and improve cardiac function. Mechanistic studies indicated that SENP3 silencing ameliorated myocardial apoptosis mainly via suppression of endoplasmic reticulum(ER) stress and mitochondrial-mediated apoptosis pathways. By contrast, adenovirusmediated cardiac SENP3 overexpression significantly exaggerated MIR injury. Further molecular analysis revealed that SENP3 promoted mitochondrial translocation of dynamin-related protein 1(Drp1) in reperfused myocardium. In addition, mitochondrial division inhibitor-1(Mdivi-1), a pharmacological inhibitor of Drp1, significantly attenuated the exaggerated mitochondrial abnormality and cardiac injury by SENP3 overexpression after MIR injury. Taken together, we provide the first direct evidence that SENP3 upregulation pivotally contributes to MIR injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury. | Lingchen Gao Yichao Zhao Jie He Yang Yan Longwei Xu Nan Lin Qingqi Ji Renyang Tong Yanan Fu Yu Gao Yuanyuan Su Ancai Yuan Ben He Jun Pu | 2018 | Journal of Genetics and Genomics2018，45，3： | 5 |
| 2 | Morphological control of SnTe nanostructures by tuning catalyst composition显示文摘A method of controlling the morphology of SnTe nanostructures produced by a simple chemical vapor deposition is presented, in which Au-containing catalysts with different Au concentrations are used to induce specific growth behavior. Triangular SnTe nanoplates with a {100} dominated surface and {100}, {111} and {120} side facets were induced by AuSn catalysts, whereas 〈010〉 SnTe nanowires with four nonpolar {100} side-facets were produced using AusSn catalysts. Through detailed structural and chemical characterization, coupled with surface energy calculations, it is found that nanowire growth is thermodynamically controlled via a vapor-solid-solid growth mechanism, whereas nanoplate growth is kinetically controlled via a vapor-liquid-solid growth mechanism. Therefore, this study provides a fundamental understanding of the catalyst's role in the growth of IV-VI compound nanostructures. | Yichao Zou Zhigang Chen Jing Lin Xiaohao Zhou Wei Lu John Drennan Jin Zou | 2015 | Nano Research2015，8，9： | 4 |
| 3 | Severity of early allograft dysfunction following donation after circulatory death liver transplantation:a multicentre study显示文摘Background:Early allograft dysfunction(EAD)is associated with decreased graft and patient survival rates.This study aimed to identify the severity of EAD and develop a predictive model for EAD after donation after circulatory death(DCD)liver transplantation(LT).Furthermore,the influence of operative time on EAD incidence was also evaluated.Methods:In this retrospective,multicentre cohort study,nomograms were established based on a single-centre training cohort(n=321)and validated in a 3-center validation cohort(n=501).Results:The incidence rate of EAD was 46.4%(149/321)in the training cohort and 40.5%(203/501)in the validation cohort.Of the 149 EAD patients in the training cohort,77 patients with either elevated alanine aminotransferase(ALT)or aspartate aminotransferase(AST)were classified as having EAD type A,and the rest of the EAD patients were classified as having EAD type B.Recipients with EAD type B had lower graft and patient survival rates than recipients with EAD type A(P=0.043 and 0.044,respectively).We further developed a nomogram to predict EAD(graft weight,cold ischemia time,donor age,model for end-stage liver disease(MELD)score)and another nomogram to predict EAD type B(graft weight,cold ischemia time,MELD score).The nomograms for the prediction of EAD and EAD type B had good discrimination[concordance index(C-index)=0.712(0.666-0.758),0.707(0.641-0.773)]and calibration[Hosmer-Lemeshow(HL)P=0.384,P=0.425]in the validation cohort.An increased operative time(>6 h)was associated with increased EAD and EAD type B incidence in the high-risk group(P=0.005,P=0.020,respectively).Conclusions:EAD type B was associated with decreased graft and patient survival rates.The novel nomograms effectively predicted the incidence of EAD and EAD type B in DCD LT patients. | Kun Wang Di Lu Yuhui Liu Wangyao Li Li Zhuang Zhenyu Ma Qinfen Xie Binhua Pan Yichao Wu Junli Chen Lidan Lin Xiaowen Feng Qiang Wei Xuyong Wei Haiyang Xie Zhengxin Wang Shusen Zheng Xiao Xu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 4 |
| 4 | Fe-Based Metal-Organic Framework and Its Derivatives for Reversible Lithium Storage显示文摘The use of a Fe-based metal organic framework(MOF), namely MIL-88B(Fe), as active material for lithium ion batteries(LIBs) is reported for the first time in the present work. Fe-based MOF demonstrated high capacity, excellent cycling stability and rate performance when used as anode. A highly reversible capacity of 680 mAhg^(-1) after 500 cycles at a current density of 200 m A g^(-1) was obtained. In addition, Fe_2O_3 and Fe_3O_4/C composites were obtained from Fe-based MOFs through thermal treatment. Both Fe_2O_3 and Fe_3O_4/C composites demonstrated high capacity and excellent cycling stability. | Yan Jin Chongchong Zhao Yichao Lin Deyu Wang Liang Chen Cai Shen | 2017 | Journal of Materials Science & Technology2017，33，8： | 3 |
| 5 | Synthesis of diverse well-defined functional polymers based on hydrozirconation and subsequent anti-markovnikov halogenation of 1,2-polybutadiene 显示文摘 | Zheng Jun Liu Feng Lin Yichao | 2012 | Macromolecules2012，45，3： | 1 |
| 6 | Ultrafine RuO_(2) nanoparticles/MWCNTs cathodes for rechargeable Na-CO_(2) batteries with accelerated kinetics of Na_(2)CO_(3) decomposition显示文摘Na-CO_(2) batteries have attracted extensive attention due to their high theoretical energy density(1125 Wh/kg),efficient utilization of CO_(2),and abundant sodium resources.However,they are trapped by the sluggish decomposition kinetic of discharge products (mainly Na_(2)CO_(3)) on cathode side during the charging process.Here we prepared a series of nano-composites composed of RuO_(2) nanoparticles in situ loaded on activated multi-walled carbon nanotubes (RuO_(2)@a-MWCNTs) through hydrolyzing reaction followed by calcination method and used them as cathode catalysts to accelerate the decomposition of Na_(2)CO_(3).Among all catalysts,the RuO_(2)@a-MWCNTs with appropriate ratio of RuO_(2)(49.7 wt%) demonstrated best stability and rate performance in Na-CO_(2) batteries,benefiting from both high specific surface area (160.3 m^(2)/g) and highly dispersed RuO_(2) with ultrafine nanostructures (~2 nm).At a limited capacity of 500 mAh/g,Na-CO_(2) batteries could afford the operation of over 120 cycles at 100 mA/g,and even at the current density to 500 mA/g,the charge voltage was still lower than 4.0 V after 40 cycles.Further theoretical calculations proved that RuO_(2) was the catalytically active center and contributed to the decomposition of Na_(2)CO_(3) by weakening the C=O bond.The synergetic functions of high specific surface(CNTs) and high catalytic activity (RuO_(2)) will inspire more progress on metal-CO_(2) batteries. | Zhenzhen Wang Yichao Cai Youxuan Ni Yong Lu Liu Lin Haoxiang Sun Haixia Li Zhenhua Yan Qing Zhao Jun Chen | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
| 7 | Evaluation and Quantitative Attribution Analysis of Water Yield Services in the Peak-cluster Depression Basins in Southwest of Guangxi,China显示文摘Karst environmental issues have become one of the hot spots in contemporary international geological research. The same problem of water shortage is one of the hot spots of global concern. The peak-cluster depression basins in southwest of Guangxi is an important water connotation and ecological barrier areas in the Pearl River Basin of China. Thus, studying the spatial and temporal variations and the influencing factors of its water yield services is critical to achieve the sustainable development of water resources and ecological environmental protection in this region. As such, this paper uses the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST) model to assess the spatial and temporal variabilities of water yield services and its trends in the peak-cluster depression basins in southwest of Guangxi from 2000 to 2020. This work also integrates precipitation(Pre), reference evapotranspiration(ET), temperature(Tem), digital elevation model(DEM), slope, normalized difference vegetation index(NDVI), land use/land cover(LULC) and soil type to reveal the main factors that influence water yield services with the help of Geodetector. Results show that: 1) in time scale,the total annual water yield in the study area show a fluctuating and increasing trend from 2000 to 2020, with a growth rate of 7.3753 × 10^(8)m^(3)/yr, and its multi-year average water yield was 538.07 mm;2) in spatial pattern, with high yield areas mainly distributed in the south of the study area(mainly including Shangsi County, Pingxiang City, Ningming County, Longzhou County and Jingxi County), and low yield areas mainly distributed in Baise City and Nanning City;3) the dominant factor of water yield within karst and non-karst landforms is not necessarily controlled by precipitation, and the explanation degree of DEM factors in karst areas is significantly higher than that in non-karst areas;4) amongst the climatic factors, Pre, ET and Tem are dominant in the spatial pattern of region water yield capacity. among which Pre has the highest explanatory power for the spatial heterogeneity of annual water production, with q values above0.8, and each driver showed a significant interaction on the spatial distribution of water yield, with Pre exhibiting the strongest interaction with LULC. | WANG Donghua TIAN Yichao ZHANG Yali HUANG Liangliang TAO Jin YANG Yongwei LIN Junliang ZHANG Qiang | 2023 | Chinese Geographical Science2023，33，1： | 0 |
| 8 | Improved Antiproliferative Activities of a New Series of 1,3,4-Thiadiazole Derivatives Against Human Leukemia and Breast Cancer Cell Lines显示文摘 | LIU Tingting WAN Yichao LIU Renshuai MA Lin LI Minyong FANG Hao | 2016 | Chemical Research in Chinese Universities2016，32，5： | 0 |
| 9 | A comprehensive study on Li_(4)Si_(1-x)Ti_(x)O_(4) ceramics for advanced tritium breeders显示文摘Hetero-element doped lithium orthosilicates have been considered as advanced tritium breeders due to the superior performances.In this work,Li_(4)Si_(1-x)Ti_(x)O_(4) ceramics were prepared by proprietary hydrothermal process and multistage reactive sintering.The reaction mechanism of Li_(4)Si_(1-x)Ti_(x)O_(4) was put forward.XRD and SEM analyses indicate that insertion of Ti leads to lattice expansion,which promotes the grain growth and changes the fracture mode.The compressive tests show that the crush load increases almost four times by increasing x from 0 to 0.2.However,the thermal conductivity and ionic conductivity are the best when x=0.05 and x=0.1,respectively.Thermal cycling stability of Li_(4)Si_(1-x)Ti_(x)O_(4) pebbles was further appraised through investigating the changes of microstructure and crush load.After undergoing thermal cycling,the Li_(4)Si_(1-x)Ti_(x)O_(4) still show higher crush load compared with Li_(4)SiO_(4),despite Ti segregation in some samples.The x=0.05 sample exhibits excellent thermal cycling stability.In summary,proper amount of Ti doping can improve the crush load,thermal and ionic conductivity,and thermal cycling stability of Li_(4)SiO_(4). | Yichao GONG Lin LIU Jianqi QI Mao YANG Junjie LI Hailiang WANG Hao GUO Guojun ZHANG Tiecheng LU | 2020 | Journal of Advanced Ceramics2020，9，5： | 0 |
| 10 | Global energy transition revolution and the connotation and pathway of the green and intelligent energy system显示文摘The essence of energy system transition is the'energy revolution':The development of the'resource-dominated'energy system with fossil energy as the mainstay has promoted human progress,but it has also triggered energy crisis and ecological environment crisis,which is not compatible with the new demands of the new round of scientific and technological revolution,industrial transformation,and sustainable human development.It is in urgent need to research and develop a new-type energy system in the context of carbon neutrality.In the framework of'technique-dominated'new green and intelligent energy system with'three new'of new energy,new power and new energy storage as the mainstay,the'super energy basin'concepts with the Ordos Basin,Nw China as a representative will reshape the concept and model of future energy exploration and development.In view of the'six inequalities'in global energy and the resource conditions of'abundant coal,insufficient oil and gas and infinite new energy'in China,it is suggested to deeply boost'China energy revolution',sticking to the six principles of independent energy production,green energy supply,secure energy reserve,efficient energy consumption,intelligent energy management,economical energy cost;enhance'energy scientific and technological innovation'by implementing technique-dominated'four major science and technology innovation projects',namely,clean coal project,oil production stabilization and gas production increasing project,new energy acceleration project,and green-intelligent energy project;implement'energy transition'by accelerating the green-dominated'four-modernization development',namely,fossil energy cleaning,large-scale new energy,coordinated centralized energy distribution,intelligent multi-energy management,so as to promote the exchange of two 80%s'in China's energy structure and construct the new green and intelligent energy system. | ZOU Caineng MA Feng PAN Songqi ZHAO Qun FU Guoyou ZHANG Guosheng YANG Yichao YU Hao LIANG Yingbo LIN Minjie WANG Ying XIONG Bo LIU Hanlin | 2023 | Petroleum Exploration and Development2023，50，3： | 0 |
| 11 | The Tianlai Cylinder Pathfinder array: System functions and basic performance analysis显示文摘The Tianlai Cylinder Pathfinder is a radio interferometer array designed to test techniques for 21 cm intensity mapping in the post-reionization Universe,with the ultimate aim of mapping the large scale structure and measuring cosmological parameters such as the dark energy equation of state.Each of its three parallel cylinder reflectors is oriented in the north-south direction,and the array has a large field of view.As the Earth rotates,the northern sky is observed by drift scanning.The array is located in Hongliuxia,a radio-quiet site in Xinjiang,and saw its first light in September 2016.In this first data analysis paper for the Tianlai cylinder array,we discuss the sub-system qualification tests,and present basic system performance obtained from preliminary analysis of the commissioning observations during 2016-2018.We show typical interferometric visibility data,from which we derive the actual beam profile in the east-west direction and the frequency band-pass response.We describe also the calibration process to determine the complex gains for the array elements,either using bright astronomical point sources,or an artificial on site calibrator source,and discuss the instrument response stability,crucial for transit interferometry.Based on this analysis,we find a system temperature of about 90 K,and we also estimate the sensitivity of the array. | JiXia Li ShiFan Zuo FengQuan Wu YouGang Wang JuYong Zhang ShiJie Sun YiDong Xu ZiJie Yu Reza Ansari YiChao Li Albert Stebbins Peter Timbie YanPing Cong JingChao Geng Jie Hao QiZhi Huang JianBin Li Rui Li DongHao Liu YingFeng Liu Tao Liu John PMarriner ChenHui Niu Ue-Li Pen Jeffery BPeterson HuLi Shi Lin Shu YaFang Song HaiJun Tian GuiSong Wang QunXiong Wang RongLi Wang WeiXia Wang Xin Wang KaiFeng Yu Jiao Zhang BoQin Zhu JiaLu Zhu XueLei Chen | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，12： | 0 |
| 12 | In situ rapid versatile method for the preparation of zirconium metal-organic framework filters显示文摘The development of the rapid preparation of highly stable metal-organic framework(MOF)-based devices provides the possibility of meeting the increasing demands of MOF in industrial applications.However,MOFs experience poor processability and stable high-valence-metal(Ⅳ)-based MOFs favor forming either thermodynamically stable metal hydroxides or oxides during their growth and nucleation,which hinders their practical applications.Herein,we present a versatile deep eutectic solvent(DES)-assisted hot pressing method to in situ rapidly prepare six distinct zirconium-based MOF nanocrystals on fibers(denoted as Zr-MOFilters)within 20 min.A small amount of DES promotes MOF precursor contact and accelerates Zr-MOF growth.Temperature and pressure facilitate the formation of Zr-MOFs onto desired substrates.In situ1H nuclear magnetic resonance spectra and time-dependent Fourier-transform infrared spectra were conducted to elucidate the growth of Zr-MOF nanocrystals.As a proof-of-concept,the abilities of Zr-MOFilters for Cr_(2)O_(7)^(2−) and micro(nano)plastics removal have been demonstrated.This strategy paves the way for the rapid fabrication of highly stable MOF-based devices and brings MOFs a step closer to practical application. | Hang Wang Xingmao Zhang Ruxin Yao Shuang Zhao Pengfei Zhao Ruile Yang Lin Wang Yichao Huang Tong Wei Xiang Li Zhuangjun Fan Bo Wang | 2022 | Science China Chemistry2022，65，12： | 0 |
| 13 | Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway显示文摘Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC. | TIANYING CAI JUNJIE BAI PENG TAN ZHIWEI HUANG CHEN LIU ZIMING WU YONGLANG CHENG TONGXI LI YIFAN CHEN JIAN RUAN LIN GAO YICHAO DU WENGUANG FU | 2023 | Oncology Research2023，31，5： | 0 |
| 14 | Study on Winter Operation Process of the Surface Flow Constructed Wetland in Tianjin Area显示文摘[Objective] The research aimed to study winter operation process of the surface flow constructed wetland in Tianjin area.[Method] In view of climate characteristics in Tianjin,by the way of running under the ice,winter operation experiment of the surface flow constructed wetland in Tianjin was conducted,with the expectation to get some useful process parameters to run such systems in North China in winter.[Result] Although purification effect of the sewage by surface flow constructed wetland in winter was worse than that in other seasons(average reduction of about 20%),surface flow constructed wetland running under the ice was feasible in Tianjin area.When surface flow constructed wetland in North China ran under ice in winter,it was suggested that the outlet must be located in a low position to prevent to be completely frozen,and running water depth should not be less than 50-60 cm.The hydraulic load could be raised on the basis of reflux,and hydraulic retention time should maintain less than 4 d to keep water-soil interface not freezing.Inlet water depth should be increased as much as possible to improve temperature in the system.[Conclusion] The research could provide reference for promotion and application of the surface flow constructed wetland in North China. | Xiaodan Qin Yichao Sun Li Li Xiaolong Shao Dan Yu Qiongqiong Liu Honglei Liu Lin Han | 2013 | Meteorological and Environmental Research2013，4，7： | 0 |
| 15 | The highly selective catalytic hydrogenation of CO_(2)to CO over transition metal nitrides显示文摘Three transition metal-like facet centered cubic structured transition metal nitrides,γ-Mo_(2)N,β-W_(2)N andδ-NbN,are synthesized and applied in the reaction of CO_(2)hydrogenation to CO.Among the three nitride catalysts,theγ-Mo_(2)N exhibits superior activity to target product CO,which is 4.6 and 76 times higher than the other two counterparts ofβ-W_(2)N andδ-NbN at 600℃,respectively.Additionally,γ-Mo_(2)N exhibits excellent stability on both cyclic heating-cooling and high space velocity steady state operation.The deactivation degree of cyclic heating-cooling evaluation after 5 cycles and long-term stability performance at 773 and 873 K in 50 h are all less than 10%.In-situ XRD and kinetic studies suggest that theγ-Mo_(2)N itself is able to activate both of the reactants CO_(2)and H_(2).Below 400℃,the reaction mainly occurs at the surface ofγ-Mo_(2)N catalyst.CO_(2)and H_(2)competitively adsorbe on the surface of catalyst and CO_(2)is the relatively stronger surface adsorbate.At a higher temperature,the interstitial vacancies of theγ-Mo_(2)N can be reversibly filled with the oxygen from CO_(2)dissociation.Both of the surface and bulk phase sites ofγ-Mo_(2)N participate in the high temperature CO_(2)hydrogenation pathway. | Yichao Wu Zhiwei Xie Xiaofeng Gao Xian Zhou Yangzhi Xu Shurui Fan Siyu Yao Xiaonian Li Lili Lin | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 0 |
| 16 | Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2显示文摘Cancer is a predominant culprit behind worldwide death and accounts for up to 10 million deaths every year.Chemotherapy is the primary therapeutic method employed for cancer in clinical settings and is essential in controlling tumor progression.Despite the advances in this field,tumor invasion and metastasis during treatment remain a significant cause of treatment failure.Nevertheless,the underlying mechanisms involving such a disappointing phenomenon are still not fully elucidated.Vinorelbine(VNB)extends the lifespan of many cancer patients in the clinic as an emerging chemotherapy drug approved by Food and Drug Administration(FDA).However,VNB-induced tumor metastasis is still an intractable problem,which may be closely related to the abnormal oxidative stress generated during VNB-mediated treatment.Hence,the study aims to construct a reductive nanosystem loaded with VNB,called VNB-VNP,to improve cancer cure rates and reduce tumor metastasis.With the reductive component vitamin E,VNB-VNP can effectively reduce oxidative stress and significantly outperform free VNB in preventing tumor progression.The transcriptome analysis shows that VNB-VNP can alleviate the over-expression of ectonucleotide pyrophosphatase/phosphodiesterase 2(ENPP2),which may be the main reason why VNB-VNP can inhibit tumor invasion and metastasis.Overall,the research designs a new platform for VNB treatment,which demonstrates promising efficacy in inhibiting neoplastic progression and identifies a new mechanism associated with VNB-induced tumor metastasis,which may offer several valuable references for enhancing chemotherapy efficacy in clinical anti-tumor therapy. | Xiaoqi Zhao Xuemeng Guo Mei Pang Weigen Qiu Zhenyu Luo Qing Lin Yichao Lu Hang Yin Sijie Wang Huihui Liu Junlei Zhang Lihua Luo Jian You | 2024 | Nano Research2024，17，4： | 0 |
| 17 | Remarkable enhancement of gas selectivity on organosilica hybrid membranes using urea-modulated metal-organic framework nanoparticles显示文摘Metal-organic framework/organosilica hybrid membranes on tubular ceramic substrates have shown great potential for the implementation of membrane technology in practical gas separation projects due to their higher permeance compared to commercial polymers.However,the selectivities of the reported membranes are moderate.Here,we have incorporated urea-modulated metal-organic frameworks into organosilica membranes to greatly enhance its separation performance.The urea-modulated metal-organic frameworks exhibit less-defined edges of crystallographic facets and high defect density.They can be well-dispersed in the organosilica layer,which substantially suppresses the interfacial defects between metal-organic frameworks and organosilica,which is beneficial for improving the selectivity of membranes for gas separation.The results have shown that the enhanced ideal selectivity of H_(2)/CH_(4) was 165 and that of CO_(2)/CH_(4) was 43,with H_(2) permeance of about 1.25×10^(−6) mol·m^(−2)·s^(−1)·Pa^(−1) and CO_(2) permeance of 3.27×10^(−7) mol·m^(−2)·s^(−1)·Pa^(−1) at 0.2 MPa and 25℃.In conclusion,the high level of hybrid membranes can be used to separate H_(2)(or CO_(2))from the binary gas mixture H_(2)/CH_(4)(or CO_(2)/CH_(4)),which is important for gas separation in practical applications.Moreover,the simple and feasible modulation of metal-organic framework is a promising strategy to tune different metal-organic frameworks for membranes according to the actual demands. | Yayun Zhao Dechuan Zhao Chunlong Kong Yichao Lin Xuezhen Wang Liang Chen | 2024 | Frontiers of Chemical Science and Engineering2024，18，2： | 0 |
| 18 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
| 19 | Enhanced ORR performance of Pt catalysts in acidic media by coupling with topological C defects显示文摘Defect engineering is a promising strategy for supported catalysts to improve the catalytic activity and durability.Here,we selected the Cmatrix enriched with topological defects to serve as the substrate material,in which the topological defects can act as anchoring centers to trapPt nanoparticles for driving the O_(2) reduction reactions(ORRs).Both experimental characterizations and theoretical simulations revealed the strong Ptdefect interaction with enhanced charge transfer on the interface.Despite a low Pt loading,the supported catalyst can still achieve a remarkable 55 mV positive shift of half-wave potential toward ORR in O_(2)-saturated 0.1 M HClO_(4) electrolyte compared with the commercial Pt catalyst on graphitized C.Moreover,the degeneration after 5,000 voltage cycles was negligible.This finding indicates that the presence of strong interaction between Pt and topological C defects can not only stabilize Pt nanoparticles but also optimize the electronic structures of Pt/C catalysts toward ORR. | Yan Dong Yuan Wang Ziqi Tian Kemin Jiang Yanle Li Yichao Lin Colin W.Oloman Elod L.Gyenge Jianwei Su Liang Chen | 2021 | The Innovation2021，2，4： | 0 |
| 20 | Global multifaceted biodiversity patterns,centers,and conservation needs in angiosperms显示文摘The Convention on Biological Diversity seeks to conserve at least 30%of global land and water areas by 2030,which is a challenge but also an opportunity to better preserve biodiversity,including flowering plants(angiosperms).Herein,we compiled a large database on distributions of over 300,000 angiosperm species and the key functional traits of 67,024 species.Using this database,we constructed biodiversity-environment models to predict global patterns of taxonomic,phylogenetic,and functional diversity in terrestrial angiosperms and provide a comprehensive mapping of the three diversity facets.We further evaluated the current protection status of the biodiversity centers of these diversity facets.Our results showed that geographical patterns of the three facets of plant diversity exhibited substantial spatial mismatches and nonoverlapping conservation priorities.Idiosyncratic centers of functional diversity,particularly of herbaceous species,were primarily distributed in temperate regions and under weaker protection compared with other biodiversity centers of taxonomic and phylogenetic facets.Our global assessment of multifaceted biodiversity patterns and centers highlights the insufficiency and unbalanced conservation among the three diversity facets and the two growth forms(woody vs.herbaceous),thus providing directions for guiding the future conservation of global plant diversity. | Ao Luo Yaoqi Li Nawal Shrestha Xiaoting Xu Xiangyan Su Yichao Li Tong Lyu Kilara Waris Zhiyao Tang Xiaojuan Liu Luxiang Lin Yongsheng Chen Kuiling Zu Wenqi Song Shijia Peng Niklaus E.Zimmermann Loïc Pellissier Zhiheng Wang | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
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