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| 1 | Bio-Inspired Controller for a Robot Cheetah with a Neural Mechanism Controlling Leg Muscles显示文摘 | Xin Wang Mantian Li Pengfei Wang Wei Guo Lining Sun | 2012 | Journal of Bionic Engineering2012，9，3： | 18 |
| 2 | CPG Control for Biped Hopping Robot in Unpredictable Environment显示文摘 | Tingting Wang Wei Guo Mantian Li Fusheng Zha Lining Sun | 2012 | Journal of Bionic Engineering2012，9，1： | 17 |
| 3 | Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage显示文摘The microglia-mediated inflammatory reaction promotes neuronal damage under cerebral ischemia/hypoxia conditions. We therefore speculated that inhibition of hypoxia-induced microglial activation may alleviate neuronal damage. To test this hypothesis, we co-cultured ginsenoside Rb1, an active component of ginseng, and cortical neurons. Ginsenoside Rb1 protected neuronal morphology and structure in a single hypoxic culture system and in a hypoxic co-culture system with microglia, and reduced neuronal apoptosis and caspase-3 production. The protective effect was observable prior to placing in co-culture. Additionally, ginsenoside Rb1 inhibited levels of tumor necrosis factor-α in a co-culture system containing activated N9 microglial cells. Ginsenoside Rb1 also significantly decreased nitric oxide and superoxide production induced by N9 microglia. Our findings indicate that ginsenoside Rb1 attenuates damage to cerebral cortex neurons by downregulation of nitric oxide, superoxide, and tumor necrosis factor-α expression in hypoxia-activated microglia. | Lining Ke Wei Guo Jianwen Xu Guodong Zhang Wei Wang Wenhua Huang | 2014 | Neural Regeneration Research2014，9，3： | 11 |
| 4 | Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 prototypic 自体免疫的疾病。天生、适应的免疫合作地贡献 SLE 的发展。介绍抗原的房间(APC ) 被建议了连接天生、适应的免疫。T 房间 immunoglobulin-domain-containing 和 mucin-domain-containing molecule-4 (Tim-4;另外作为 Timd4 知道) ,首先在 APC 的表面上表示了,是 TIM 家庭,的一个成员作为免疫系统的潜在的管理者收到了许多注意的分子的一个最近描述的组。在这研究,我们使用了量的即时反向的抄写聚合酶链反应从 SLE 病人在外部血 mononuclear 房间( PBMC )检验 Tim-4 的 mRNA 表示并且进一步在 PBMC 和浆液肿瘤坏死因素( TNF )分析了在 Tim-4 和 Tim-1 (为 Tim-4 的潜在的 ligand )的表示之间的关联-伪层次。结果证明在 PBMC 的那个 Tim-4 mRNA 表达式比在健康控制在 SLE 病人是显著地更高的,特别在疾病的活跃阶段的那些病人。而且, Tim-4 mRNA 层次密切在 SLE 病人然而并非在控制组在 PBMC 并且与浆液 TNF- 伪层次与 Tim-1 mRNA 层次被相关。一起拿,这些结果证明 Tim-4 可以涉及 SLE 的致病。 | Peiqing Zhao Liyun Xu Piming Wang Xiaohong Liang Jianni Qi Peng Liu Chun Guo Lining Zhang Chunhong Ma Lifen Gao | 2010 | Cellular & Molecular Immunology2010，7，2： | 11 |
| 5 | Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice显示文摘可观的证据显示那种类型 1 个 T 助手(Th1 )- 并且当时,调停 Th17 的有免疫力的回答支持动脉粥样硬化患者匾的形成那 CD4 + CD25 + 规章的 T 房间(Tregs ) 有的 Foxp3 + 保护的效果。然而,因为令人满意的匾破裂模型的缺乏,在匾破裂遗体的多样的 CD4 + 淋巴细胞子集的功能糟糕理解。这里,我们在颈动脉动脉上用一本高脂肪的食谱和领子放置建立了动脉粥样硬化患者匾破裂的一个鼠科的模型,并且在 apolipoprotein 电子大美人与 lipopolysaccharide, phenylephrine 注射和寒冷的联合由短期的刺激触发了匾破裂(ApoE −/−) 老鼠。我们由 PCR,流动 cytometry, ELISA 和 immunohistochemistry 调查了在 Th1 房间, Th17 房间和 Tregs 和匾破裂之间的协会。总共, 75 %(18/24 ) 脆弱的匾,而是没有稳定的匾,显示出的破裂特征。Th17 房间的比例在处理以后在 splenocytes 之中被增加,但是在 Th1 房间和 Tregs 的层次的变化不与破裂有关。而且,处理在浆液并且在匾破裂的区域导致了 interleukin-17 (IL-17 ) 的高水平。在 vitro, IL-17 增加了 apoptosis 的水平,与匾破裂联系的一个主要因素,在有教养的鼠科的脉管的光滑的肌肉房间。Th17 房间和 IL-17 可以涉及短期的刺激在 ApoE −/− 老鼠。 | Tian Ma Qi Gao Faliang Zhu Chun Guo Qun Wang Fei Gao Lining Zhang | 2013 | Cellular & Molecular Immunology2013，10，4： | 9 |
| 6 | Metabolomic Profiling in Selaginella lepidophylla at Various Hydration States Provides New Insights into the Mechanistic Basis of Desiccation Tolerance显示文摘Selaginella lepidophylla 是仅仅一些之一发展了干燥忍耐(DT ) 或从一个 air-dried 状态复兴的能力的尖铁苔藓(Selaginellaceae ) 的种类。以便理解 DT 的新陈代谢的基础, S。lepidophylla 受到一五阶段, rehydration/dehydration 周期,然后分析了使用基于 GC/MS 和 UHLC/MS/MS2 平台介绍技术的非偏导的、全球 metabolomics。包括 167 说出的 251 代谢物(66.5%) 的一个总数并且 84 (33.4%) 未命名的混合物被描绘。仅仅 42 (16.7%) 并且(29.5%) 74 混合物显示出显著地增加或减少的丰富分别地,显示大多数混合物组成地被生产包括高度丰富的 trehalose,蔗糖,和葡萄糖。几 glycolysis/gluconeogenesis 和 tricarboxylic 酸(TCA ) 周期中介在 100% 亲戚水内容(RWC ) 和 50% RWC 显示出增加的丰富。Vanillate,一种有势力抗氧化剂,也更充满含水的状态。许多不同的糖白酒和糖酸更充满含水的状态。这些 polyols 多半速度率在水和期间在弄干的过程以及慢水吸收期间浇损失,稳定蛋白质,并且清除反应的氧种类(ROS ) 。相反,充满氮并且 -glutamyl 氨基酸,瓜氨酸,和核苷酸分解代谢产品(例如 allantoin ) 更充满干燥状态,建议这些混合物可能在水和期间或在清除的 ROS 在氮动员起重要作用。紫外保护的混合物象 3-(3-hydroxyphenyl ) 那样 propionate, apigenin,和 naringenin,更充满干燥状态。大多数类脂化合物组成地被生产,与胆碱磷酸盐的例外,它更充满干燥状态并且多半在膜水和和稳定起一个作用。相反,几多元不堡和丰满的酸更充满含水的状态,建议这些混合物多半帮助在脱水期间维持膜流动性。最后, S。lepidophylla 包含了显示了双重或更大的丰富在的七未命名的混合物干燥或 rehydrating 状态,建议这些混合物可能在 DT 起适应作用。 | Abou Yobi Bernard W.M. Wone Wenxin Xu Danny C. Alexander Lining Guo John A. Ryals Melvin J. Oliver John C. Cushman | 2013 | Molecular Plant2013，6，2： | 9 |
| 7 | 在由巨噬细胞并且从而的增加的 IL-10 表示的规划房间死亡 4 结果的缺乏在 hyperlipidemic 鼠标稀释动脉粥样硬化显示文摘(Pdcd4 ) 规划房间死亡 4 是抄写和翻译和肿瘤 suppressor 的一个最新定义的禁止者。最近的研究建议了 Pdcd4 可以也涉及一些煽动性的疾病。然而,它在动脉粥样硬化的角色,动脉的墙的长期的发炎,尚待被调查。这里,我们发现在老鼠的那 Pdcd4 缺乏在巨噬细胞增加了 IL-10 的表示并且减少在 T 房间的 IL-17 的表示面对在 vitro 并且在高导致脂肪的动脉粥样硬化患者匾的一个联系动脉粥样硬化的激发器。重要地,击倒 Pdcd4 在喂的 Apoe −/− 老鼠在动脉粥样硬化患者损害导致了减少一本高胖的食谱。这效果能被与抵销的抗体堵住 IL-10 然而并非由外长的 IL-17 的申请部分颠倒。进一步机械学的研究表明 Pdcd4 否定地以一种 ERK1/2 依赖、 p38 依赖的方式调整了 IL-10 的表示。这些结果证明那 Pdcd4 缺乏通过反煽动性的 cytokine IL-10 的 upregulation 部分地在 hyperlipidemic 老鼠稀释动脉粥样硬化。这显示内长的 Pdcd4 支持动脉粥样硬化因此与动脉粥样硬化为病人代表一个潜在的治疗学的目标。 | Yang Jiang Qi Gao Liyang Wang Chun Guo Faliang Zhu Bo Wang Qun Wang Fei Gao Youhai Chen Lining Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 8 | Key Problems in Microforming Processes of Microparts显示文摘从生产工程的观点, microforming 被看作 aneffective 过程在 microforming processeswere investigated.A 制作各种各样的 microparts.Several 钥匙问题有高僵硬的新 microforming 仪器 thepunch 司机被开发生产 microparts.To 的压电的致动器改进形成的能力并且定位 thebillets ,漂浮的 microdie 是营舍的 designed.The 尺寸效果并且死 themicroforming 能力上的洞与 upsetti | Chunju WANG Debin SHAN Bin GUO Jian ZHOU Lining SUN | 2007 | Journal of Materials Science & Technology2007，23，2： | 6 |
| 9 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 10 | Study of an inchworm-like micro-robot显示文摘 | 李满天 Guo Wei Sun Lining | 2006 | High Technology Letters2006，12，2： | 3 |
| 11 | Velocity Control of a Bounding Quadruped via Energy Control and Vestibular Reflexes显示文摘 | Xin Wang Mantian Li Wei Guo Pengfei Wang Lining Sun | 2014 | Journal of Bionic Engineering2014，11，4： | 3 |
| 12 | Corrosion of Cr Bearing Low Alloy Pipeline Steel in CO2 Environment at Static and Flowing Conditions 显示文摘 | Xu Lining Guo Shaoqiang Chang Wei | 2013 | Applied Surface Science2013，270，4： | 1 |
| 13 | Dietary Exposure to Benzyl Butyl Phthalate in China显示文摘Objective Benzyl butyl phthalate(BBP) is a plasticizer used in food contact materials. Dietary exposure to BBP might lead to reproduction and developmental damages to human. The present paper was aimed to assess the health risk of BBP dietary exposure in Chinese population. Methods The BBP contents were detected in 7409 food samples from 25 food categories by gas chromatography-mass spectrometry operated in selected ion monitoring(SIM) mode. The dietary exposures of BBP in different age and sex groups were estimated by combining the content data with food consumption data derived from 2002 China National Nutrient and Health Survey, and evaluated according to the tolerable daily intake(TDI) of BBP established by European Food safety Agency. Results It was found that BBP was undetectable in most samples and the highest level was 1.69 mg/kg detected in a vegetable oil sample. The average dietary exposure of BBP in people aged ≥2 years was 1.03 μg/kg bw per day and the highest average exposure was found in 2-6 years old children(1.98 μg/kg bw per day). The BBP exposure in 7-12 months old children excessed 10% of tolerable daily intake(TDI) in worst scenario. Conclusion The health risk of BBP dietary exposure in Chinese population is low and, considering BBP alone, there is no safety concern. | ZHANG Lei JIANG Ding Guo SUIHaiXia WU Ping Gu LIU Ai Dong YANG Da Jin LIU Zhao Ping SONG Yan LINing | 2016 | Biomedical and Environmental Sciences2016，29，5： | 1 |
| 14 | Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus显示文摘 | Di Li Lijun Song Yuchen Fan Xia Li Yingjie Li Jie Chen Faliang Zhu Chun Guo Yongyu Shi Lining Zhang | 2009 | Clinical Immunology2009，，： | 1 |
| 15 | Force-controlled Compensation Scheme for P-Q Valve-controlled Asymmetric Cylinder used on Hydraulic Quadruped Robots显示文摘Under the requirement of the force controller of hydraulic quadruped robots,the goal of this work is to accurately track the force commands at the level of the hydraulic drive unit.The main contribution focuses on the development of a force-controlled compensation scheme,which is specifically aimed at the key issues affecting the hydraulic quadrupedal locomotion.With this idea,based on a P-Q valve-controlled asymmetric cylinder,we first establish a mathematical model for the hydraulic drive unit force control system.With the desired force commands,a force feed-forward algorithm is presented to improve the dynamic performance of the system.Meanwhile,we propose a disturbance compensation algorithm to reduce the influence induced by external disturbances due to foot-ground impacts.Afterwards,combining with a variable gain PI controller,a series of experiments are implemented on a force control performance test platform to verify the proposed scheme.The results demonstrate that the force-controlled compensation scheme has the ability to notably improve the force tracking accuracy,reduce the response time and redundant force. | Yapeng Shi Mantian Li Fusheng Zha Lining Sun Wei Guo Cong Ma Zhibin Li | 2020 | Journal of Bionic Engineering2020，17，6： | 1 |
| 16 | A multi-degree-of-freedom ultrasonic motor using in-plane deformation of planar piezoelectric elements显示文摘 | Minghui Zhang Wei Guo Lining Sun | 2008 | Sensors and actuators2008，148，： | 1 |
| 17 | Corrosion of alloy steelscontaining 2% chromium in C02 environments显示文摘 | Shaoqiang Guo Lining Xu Lei Zhang | 2012 | Corrosion Science2012，63，： | 1 |
| 18 | Plasma metabolomic profile in nonalcoholic fatty liver disease显示文摘 | Satish C. Kalhan Lining Guo John Edmison Srinivasan Dasarathy Arthur J. McCullough Richard W. Hanson Mike Milburn | 2011 | Metabolism2011，，3： | 1 |
| 19 | PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice显示文摘 | Liyang Wang Mingsheng Zhao Chun Guo Guannan Wang Faliang Zhu Jianing Wang Xiaoyan Wang Qun Wang Wei Zhao Yongyu Shi Youhai H. Chen Lining Zhang | 2016 | Inflammatory Bowel Diseases2016，，： | 1 |
| 20 | Development of a Porcine cDNA Microarray:Analysis of Clenbuterol Responding Genes in Pig(Sus scrofa) Internal Organs显示文摘Pig(Sus scrofa) fat accumulation can be reduced by feeding with high dosages of clenbuterol,but the molecular mechanism has not yet been explained.In our study,a porcine cDNA microarray representing 3 358 pig genes was successfully developed.This microarray is the first porcine DNA microarray in China and its false positive rate is 0.98%,which means the microarray platform is reliable.The microarray can be used to study gene expression profiles in multiple pig tissues because the present genes percentage of adipose,skeletal muscle,heart,liver,lung,kidney,and spleen were all more than 60%.This microarray was used to identify the genes responding to clenbuterol stimulation in pig internal organs,including heart,liver,lung,spleen,and kidney.Many genes were identified including enzymes involved in lipids metabolism(lipoprotein lipase up-regulated in liver,heart and lung,ATP-citrate lyase and carnitine palmitoyltransferase II precursor up-regulated in liver,succinyl-CoA up-regulated in lung,mitochondrial malate dehydrogenase down-regulated in spleen),and signaling pathway genes(cAMP-protein kinase A signaling pathway was found up-regulated in liver,heart,lung,and kidney as reported previously,while transforming growth factor was found down-regulated in heart and lung).However,no common gene responding to clenbuterol administration was found in all tissues.The expression levels of 14 genes were analyzed using real-time PCR with 82.1% of them induced to express similar magnitudes as in the microarray analyses.This work offers some understanding of how clenbuterol so effectively reduces pig adipose accumulation on the molecular level. | ZHANG Jin GUO Wei SHEN Liang-cai LILT Qiu-yue DENG Xue-mei HU Xiao-xiang LINing | 2012 | Journal of Integrative Agriculture2012，11，11： | 1 |
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