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| 1 | Individualized prediction of perineural invasion in colorectal cancer: development and validation of a radiomics prediction model显示文摘Objective: To develop and validate a radiomics prediction model for individualized prediction of perineural invasion(PNI) in colorectal cancer(CRC).Methods: After computed tomography(CT) radiomics features extraction, a radiomics signature was constructed in derivation cohort(346 CRC patients). A prediction model was developed to integrate the radiomics signature and clinical candidate predictors [age, sex, tumor location, and carcinoembryonic antigen(CEA) level]. Apparent prediction performance was assessed. After internal validation, independent temporal validation(separate from the cohort used to build the model) was then conducted in 217 CRC patients. The final model was converted to an easy-to-use nomogram.Results: The developed radiomics nomogram that integrated the radiomics signature and CEA level showed good calibration and discrimination performance [Harrell's concordance index(c-index): 0.817; 95% confidence interval(95% CI): 0.811–0.823]. Application of the nomogram in validation cohort gave a comparable calibration and discrimination(c-index: 0.803; 95% CI: 0.794–0.812).Conclusions: Integrating the radiomics signature and CEA level into a radiomics prediction model enables easy and effective risk assessment of PNI in CRC. This stratification of patients according to their PNI status may provide a basis for individualized auxiliary treatment. | Yanqi Huang Lan He Di Dong Caiyun Yang Cuishan Liang Xin Chen Zelan Ma Xiaomei Huang Su Yao Changhong Liang Jie Tian Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 23 |
| 2 | GC-MS, GC-O and OAV analyses of key aroma compounds in Jiaozi Steamed Bread显示文摘Jiaozi Steamed Bread(JSB)has a unique aroma as a traditional staple food in China.The volatile compounds in JSBwere extracted by simultaneous distillation and extraction(SDE)and headspace solid-phasemicroextraction(HS-SPME).These volatile substances were analyzed by gas chromatography-mass spectrometry(GC-MS)and gas chromatographyolfactometry-mass spectrometry(GC-O-MS).The results demonstrated that 61 volatile compounds were identified totally in samples,of which 15 were confirmed as potent aroma compounds with odor active values(OAVs)>1.The 15 potent aroma compounds were ethanol,1-butanol,1-pentanol,1-hexanol,heptanol,1-octen-3-ol,3-methyl-1-butanol,hexanal,heptanal,nonanal,(E)-2-heptenal,benzaldehyde,(E,E)-2,4-decadienal,2-pentylfuran and naphthalene.The SDEmethod had better linearity with coefficients of determination(R2)equal to or higher than 0.9991.Furthermore,the SDE method also achieved lower sensitivity and better repeatability and recovery than HS-SPME.This work provides reference method and parameters for future research on the flavor of JSB for commercial products. | Yuanhui Wang Jingwen Zhao Fei Xu Xiaoyun Wu Wenxuan Hu Yongfeng Chang Lanlan Zhang Jie Chen Changhong Liu | 2020 | Grain & Oil Science and Technology2020，3，1： | 17 |
| 3 | Chemical and optical properties of aerosols and their interrelationship in winter in the megacity Shanghai of China显示文摘A field campaign on air quality was carried out in Shanghai in winter of 2012. The concentrations of NO, NO2, NOx, SO2, CO, and PM2.5increased during haze formation. The average masses of SO42-, NO3-and NH4+were 10.3, 11.7 and 6.7 μg/m3 during the haze episodes, which exceeded the average(9.2, 7.9, and 3.4 μg/m3) of these components in the non-haze days. The mean values for the aerosol scattering coefficient(b sp), aerosol absorption coefficient(b ap) and single scattering albedo(SSA) were 288.7, 27.7 and0.91 Mm-1, respectively. A bi-peak distribution was observed for the mass concentrations of CO, NO, NO2, and NOx. More sulfate was produced during daytime than that in the evening due to photochemical reactions. The mass concentration of NH4+achieved a small peak at noontime. NO3-showed lower concentrations in the afternoon and higher concentrations in the early morning. There were obvious bi-peak diurnal patterns for b sp and b ap as well as SSA. b sp and b ap showed a positive correlation with PM2.5mass concentration.(NH4)2SO4, NH4NO3, organic mass, elemental carbon and coarse mass accounted for 21.7%, 19.3%, 31.0%, 9.3% and 12.3% of the total extinction coefficient during non-haze days, and 25.6%, 24.3%, 30.1%, 8.1% and 8.2% during hazy days. Organic matter was the largest contributor to light extinction. The contribution proportions of ammonium sulfate and ammonium nitrate to light extinction were significantly higher during the hazy time than during the non-haze days. | Tingting Han Liping Qiao Min Zhou Yu Qu Jianfei Du Xingang Liu Shengrong Lou Changhong Chen Hongli Wang Fang Zhang Qing Yu Qiong Wu | 2015 | Journal of Environmental Sciences2015，27，1： | 14 |
| 4 | Radiomics approach for preoperative identification of stages Ⅰ-Ⅱand Ⅲ-Ⅳ of esophageal cancer显示文摘Objective: To predict preoperative staging using a radiomics approach based on computed tomography(CT)images of patients with esophageal squamous cell carcinoma(ESCC).Methods: This retrospective study included 154 patients(primary cohort: n=114; validation cohort: n=40) with pathologically confirmed ESCC. All patients underwent a preoperative CT scan from the neck to abdomen. High throughput and quantitative radiomics features were extracted from the CT images for each patient. A radiomics signature was constructed using the least absolute shrinkage and selection operator(Lasso). Associations between radiomics signature, tumor volume and ESCC staging were explored. Diagnostic performance of radiomics approach and tumor volume for discriminating between stages Ⅰ-Ⅱ and Ⅲ-Ⅳ was evaluated and compared using the receiver operating characteristics(ROC) curves and net reclassification improvement(NRI).Results: A total of 9,790 radiomics features were extracted. Ten features were selected to build a radiomics signature after feature dimension reduction. The radiomics signature was significantly associated with ESCC staging(P<0.001), and yielded a better performance for discrimination of early and advanced stage ESCC compared to tumor volume in both the primary [area under the receiver operating characteristic curve(AUC): 0.795 vs. 0.694,P=0.003; NRI=0.424)] and validation cohorts(AUC: 0.762 vs. 0.624, P=0.035; NRI=0.834).Conclusions: The quantitative approach has the potential to identify stage Ⅰ-Ⅱ and Ⅲ-Ⅳ ESCC before treatment. | Lei WU Cong Wang Xianzheng Tan Zixuan Cheng Ke Zhao Lifen Yan Yanli Liang Zaiyi Liu Changhong Liang | 2018 | Chinese Journal of Cancer Research2018，30，4： | 14 |
| 5 | Expression and Function of Zinc-α2-Glycoprotein显示文摘Zinc-α2-glycoprotein(ZAG), encoded by the AZGP1 gene, is a major histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been demonstrated to promote lipid metabolism and glucose utilization, and to regulate insulin sensitivity. Apart from adipose tissue, skeletal muscle, liver, and kidney, ZAG also occurs in brain tissue, but its distribution in brain is debatable. Only a few studies have investigated ZAG in the brain. It has been found in the brains of patients with Krabbe disease and epilepsy, and in the cerebrospinal fluid of patients with Alzheimer disease, frontotemporal lobe dementia, and amyotrophic lateral sclerosis. Both ZAG protein and AZGP1 m RNA are decreased in epilepsy patients and animal models, while overexpression of ZAG suppresses seizure and epileptic discharges in animal models of epilepsy, but knowledge of the specific mechanism of ZAG in epilepsy is limited. In this review, we summarize the known roles and molecular mechanisms of ZAG in lipid metabolism and glucose metabolism, and in the regulation of insulin sensitivity, and discuss the possible mechanisms by which it suppresses epilepsy. | Xin Wei Xi Liu Changhong Tan Lijuan Mo Hui Wang Xi Peng Fen Deng Lifen Chen | 2019 | Neuroscience Bulletin2019，35，3： | 14 |
| 6 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 7 | Radiomics-based predictive risk score: A scoring system for preoperatively predicting risk of lymph node metastasis in patients with resectable non-small cell lung cancer显示文摘Objective: To develop and validate a radiomics-based predictive risk score(RPRS) for preoperative prediction of lymph node(LN) metastasis in patients with resectable non-small cell lung cancer(NSCLC).Methods: We retrospectively analyzed 717 who underwent surgical resection for primary NSCLC with systematic mediastinal lymphadenectomy from October 2007 to July 2016. By using the method of radiomics analysis, 591 computed tomography(CT)-based radiomics features were extracted, and the radiomics-based classifier was constructed. Then, using multivariable logistic regression analysis, a weighted score RPRS was derived to identify LN metastasis. Apparent prediction performance of RPRS was assessed with its calibration,discrimination, and clinical usefulness.Results: The radiomics-based classifier was constructed, which consisted of 13 selected radiomics features.Multivariate models demonstrated that radiomics-based classifier, age group, tumor diameter, tumor location, and CT-based LN status were independent predictors. When we assigned the corresponding score to each variable,patients with RPRSs of 0-3, 4-5, 6, 7-8, and 9 had distinctly very low(0%-20%), low(21%-40%), intermediate(41%-60%), high(61%-80%), and very high(81%-100%) risks of LN involvement, respectively. The developed RPRS showed good discrimination and satisfactory calibration (C-index: 0.785, 95% confidence interval(95% CI):0.780-0.790)Additionally, RPRS outperformed the clinicopathologic-based characteristics model with net reclassification index(NRI) of 0.711(95% CI: 0.555-0.867).Conclusions: The novel clinical scoring system developed as RPRS can serve as an easy-to-use tool to facilitate the preoperatively individualized prediction of LN metastasis in patients with resectable NSCLC. This stratification of patients according to their LN status may provide a basis for individualized treatment. | Lan He Yanqi Huang Lixu Yan Junhui Zheng Changhong Liang Zaiyi Liu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 7 |
| 8 | Progress on design and related R&D activities for the water-cooled breeder blanket for CFETR显示文摘The water-cooled ceramic breeder (WCCB) blanket is one of the blanket candidates for Chinese fusion engineering testing reactor (CFETR) and is being developed at the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP). This paper reviews design and evolution of the WCCB blanket for CFETR, and presents a new WCCB blanket design according to the latest CFETR core parameters (major and minor radii are R = 7.2 m and a = 2.2 m, respectively) and missions. This new design is expected to satisfy multiple CFETR operation modes of 0.2, 0.5, 1.0, and 1.5 GW fusion power and achieve tritium self-sufficiency. The feasibility of the updated blanket design is evaluated from the aspects of neutronics and thermo-hydraulics. Furthermore, the research and development (R&D) activities supporting to the WCCB blanket for CFETR are reported, including the design code, the water loop experiments, the pebble bed modeling and experiments, and the components fabrication technology. | Songlin Liu Xiaoman Cheng Xuebin Ma Lei Chen Kecheng Jiang Xia Li Hui Bao Jichao Wang Wanjing Wang Changhong Peng Peng Lu Min Li Kai Huang | 2019 | Theoretical & Applied Mechanics Letters2019，9，3： | 6 |
| 9 | Numerical and experimental investigation of three-dimensionality in the dam-break flow against a vertical wall显示文摘The three-dimensionality extent of the dam break flow over a vertical wall is investigated numerically and experimentally in this paper. The numerical method is based on Reynolds averaged Navier-Stokes(RANS) equation that describes the three-dimensional incompressible turbulent flow. The free surface is captured by using the unstructured multi-dimensional interface capturing(UMTHINC) scheme. The equations are discretized on 2-D and 3-D unstructured grids using finite volume method. The numerical simulations are compared with newly conducted experiment with emphasis on the effect of three-dimensionality on both free surface and impact pressure. The comparison between the numerical and experimental results shows good agreement. Furthermore, the results also show that 3-D motion of the flow originates at the moment of impact at the lower corners of the impact wall and propagates to the inner region as time advances. The origin of the three-dimensionality is found to be the turbulence development as well as the relative velocity between the side wall region and the inner region of the wave front at the moment of impact. | Mohamed M.Kamra Nik Mohd Cheng Liu Makoto Sueyoshi Changhong Hu | 2018 | Journal of Hydrodynamics2018，30，4： | 5 |
| 10 | Studies on the influence of spar position on aeroelastic optimization of a large aircraft wing显示文摘Aeroelastic problems are encountered at the preliminary design stage of flexible wings for large aircraft.A three-dimensional finite element model of a high-aspect-ratio wing was built,and the influence of the front and rear spar positions on the results of the aeroelastic analysis and optimization was studied to improve the wing structure desgin.The most feasible and optimal solutions were effectively obtained by aeroelastic optimization.In particular,the position parameter of the front spar has a greater influence on the aeroelastic analysis and optimization than the rear spar.In addition,some key constraints became re-strictive leading to a rapid increase in the structural weight.Therefore,reasonable constraints were necessary for the oprimiza-tion of results. | WAN ZhiQiang LIU DongYue TANG ChangHong YANG Chao | 2012 | Science China(Technological Sciences)2012，55，1： | 5 |
| 11 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
| 12 | Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features显示文摘Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. | Xiaojun Yang Lei Wu Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang | 2020 | Chinese Journal of Cancer Research2020，32，2： | 4 |
| 13 | Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p显示文摘Background:Angiogenesis constitutes a major mechanism responsible for exercise-induced beneficial effects.Our previous study identified a cluster of differentially expressed extracellular vesicle microRNAs(miRNAs)after exercise and found that some of them act as exerkines.However,whether these extracellular vesicle miRNAs mediate the exercise-induced angiogenesis remains unknown.Methods:A 9-day treadmill training was used as an exercise model in C57BL/6 mice.Liver-specific adeno-associated virus 8 was used to knock down microRNA-122-5p(miR-122-5p).Human umbilical vein endothelial cells were used in vitro.Results:Among these differentially expressed extracellular vesicle miRNAs,miR-122-5p was identified as a potent pro-angiogenic factor that activated vascular endothelial growth factor signaling and promoted angiogenesis both in vivo and in vitro.Exercise increased circulating levels of miR-122-5p,which was produced mainly by the liver and shuttled by extracellular vesicles in mice.Inhibition of circulating miR-122-5p or liver-specific knockdown of miR-122-5p significantly abolished the exercise-induced pro-angiogenic effect in skeletal muscles,and exerciseimproved muscle performance in mice.Mechanistically,miR-122-5p promoted angiogenesis through shifting substrate preference to fatty acids in endothelial cells,and miR-122-5p upregulated endothelial cell fatty-acid utilization by targeting 1-acyl-sn-glycerol-3-phosphate acyltransferase(AGPAT1).In addition,miR-122-5p increased capillary density in perilesional skin tissues and accelerated wound healing in mice.Conclusion:These findings demonstrated that exercise promotes angiogenesis through upregulation of liver-derived extracellular vesicle miR-122-5p,which enhances fatty acid utilization by targeting AGPAT1 in endothelial cells,highlighting the therapeutic potential of miR-122-5p in tissue repair. | Jing Lou Jie Wu Mengya Feng Xue Dang Guiling Wu Hongyan Yang Yan Wang Jia Li Yong Zhao Changhong Shi Jiankang Liu Lin Zhao Xing Zhang Feng Gao | 2022 | Journal of Sport and Health Science2022，11，4： | 4 |
| 14 | Evolution of Residual Stresses in Micro-arc Oxidation Ceramic Coatings on 6061 Al Alloy显示文摘Most researches on micro-arc oxidation mainly focus on the application rather than discovering the evolution of residual stresses.However,residual stresses in the surface coatings of structural components have adverse effects on their properties,such as fatigue life,dimensional stability and corrosion resistance,etc.The micro-arc oxidation ceramic coatings are produced on the surfaces of6061 aluminum alloy by a homemade asymmetric AC type of micro-arc oxidation equipment of 20 kW.A constant current density of4.4 0.1 A/dm2and a self-regulated composite electrolyte are used.The micro-arc oxidation treatment period ranges from 10 min to 40min,and the thickness of the ceramic coatings is more than 20μm.Residual stresses attributed toγ-Al2O3constituent in the coatings at different micro-arc oxidation periods are analyzed by an X-ray diffractometer using the sin2ψmethod.The analysis results show that the residual stress in the ceramic coatings is compressive in nature,and it increases first and then decreases with micro-arc oxidation time increase.The maximum stress value is 1667±20 MPa for period of 20 min.Through analyzing the coating thickness,surface morphology and phase composition,it is found that the residual stress in the ceramic coatings is linked closely with the coating growth,the phase composition and the micro cracks formed.It is also found that both the heat treatment and the ultrasonic action release remarkably the residual compressive stress.The heat treatment makes the residual compressive stress value decrease 1 378 MPa.The ultrasonic action even alters the nature of the residual stress,making the residual compressive stress change into a residual tensile stress. | SHEN Dejiu CAI Jingrui GUO Changhong LIU Peiyu | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 4 |
| 15 | Effects of Normalized Difference Vegetation Index and Related Wavebands′ Characteristics on Detecting Spatial Heterogeneity Using Variogram-based Analysis显示文摘Spatial heterogeneity is widely used in diverse applications, such as recognizing ecological process, guiding ecological restoration, managing land use, etc. Many researches have focused on the inherent scale multiplicity of spatial heterogeneity by using various environmental variables. How these variables affect their corresponding spatial heterogeneities, however, have received little attention. In this paper, we examined the effects of characteristics of normalized difference vegetation index (NDVI) and its related bands variable images, namely red and near infrared (NIR), on their corresponding spatial heterogeneity detection based on variogram models. In a coastal wetland region, two groups of study sites with distinct fractal vegetation cover were tested and analyzed. The results show that: 1) in high fractal vegetation cover (H-FVC) area, NDVI and NIR variables display a similar ability in detecting the spatial heterogeneity caused by vegetation growing status structure; 2) in low fractal vegetation cover (L-FVC) area, the NIR and red variables outperform NDVI in the survey of soil spatial heterogeneity; and 3) generally, NIR variable is ubiquitously applicable for vegetation spatial heterogeneity investigation in different fractal vegetation covers. Moreover, as variable selection for remote sensing applications should fully take the characteristics of variables and the study object into account, the proposed variogram analysis method can make the variable selection objectively and scientifically, especially in studies related to spatial heterogeneity using remotely sensed data. | WEN Zhaofei ZHANG Ce ZHANG Shuqing DING Changhong LIU Chunyue PAN Xin LI Huapeng SUN Yan | 2012 | Chinese Geographical Science2012，22，2： | 4 |
| 16 | Comparison of human face matching behavior and computational image similarity measure显示文摘Computational similarity measures have been evaluated in a variety of ways,but few of the validated computational measures are based on a high-level,cognitive criterion of objective similarity. In this paper,we evaluate two popular objective similarity measures by comparing them with face matching performance in human observers. The results suggest that these measures are still limited in predicting human behavior,especially in rejection behavior,but objective measure taking advantage of global and local face characteristics may improve the prediction. It is also suggested that human may set different criterions for 'hit' and 'rejection' and this may provide implications for biologically-inspired computational systems. | CHEN WenFeng LIU ChangHong LANDER Karen FU XiaoLan | 2009 | Science in China(Series F)2009，52，2： | 3 |
| 17 | Knowledge-Domain Semantic Searching and Recommendation Based on Improved Ant Colony Algorithm显示文摘 | Mingyang Liu Shufen Liu Xiaoyan Wang Ming Qu Changhong Hu | 2013 | Journal of Bionic Engineering2013，10，4： | 3 |
| 18 | Development and validation of a CT-based radiomics nomogram for preoperative prediction of tumor histologic grade in gastric adenocarcinoma显示文摘Objectives:To develop and validate a radiomics nomogram for preoperative prediction of tumor histologic grade in gastric adenocarcinoma(GA).Methods:This retrospective study enrolled 592 patients with clinicopathologically confirmed GA(low-grade:n=154;high-grade:n=438)from January 2008 to March 2018 who were divided into training(n=450)and validation(n=142)sets according to the time of computed tomography(CT)examination.Radiomic features were extracted from the portal venous phase CT images.The Mann-Whitney U test and the least absolute shrinkage and selection operator(LASSO)regression model were used for feature selection,data dimension reduction and radiomics signature construction.Multivariable logistic regression analysis was applied to develop the prediction model.The radiomics signature and independent clinicopathologic risk factors were incorporated and presented as a radiomics nomogram.The performance of the nomogram was assessed with respect to its calibration and discrimination.Results:A radiomics signature containing 12 selected features was significantly associated with the histologic grade of GA(P<0.001 for both training and validation sets).A nomogram including the radiomics signature and tumor location as predictors was developed.The model showed both good calibration and good discrimination,in which C-index in the training set,0.752[95%confidence interval(95%CI):0.701-0.803];C-index in the validation set,0.793(95%CI:0.711-0.874).Conclusions:This study developed a radiomics nomogram that incorporates tumor location and radiomics signatures,which can be useful in facilitating preoperative individualized prediction of histologic grade of GA. | Jia Huang Huasheng Yao Yexing Li Mengyi Dong Chu Han Lan He Xiaomei Huang Ting Xia Zongjian Yi Huihui Wang Yuan Zhang Jian He Changhong Liang Zaiyi Liu | 2021 | Chinese Journal of Cancer Research2021，33，1： | 3 |
| 19 | The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations. | Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 20 | Effect of fatigue loading-confining stress unloading rate on marble mechanical behaviors: An insight into fracture evolution analyses显示文摘Rocks in underground works usually experience rather complex stress disturbance.For this,their fracture mechanism is significantly different from rocks subjected to conventional triaxial compression conditions.The effects of stress disturbances on rock geomechanical behaviors under fatigue loading conditions and triaxial unloading conditions have been reported in previous studies.However,little is known about the dependence of the unloading rate on fatigue loading and confining stress unloading(FL-CSU)conditions that influence rock failure.In this paper,we aimed at investigating the fracture behaviors of marble under FL-CSU conditions using the post-test X-ray computed tomography(CT)scanning technique and the GCTS RTR 2000 rock mechanics system.Results show that damage accumulation at the fatigue stage can influence the final fracture behaviors of marble.The stored elastic energy for rock samples under FL-CSU tests is relatively larger compared to those under conventional triaxial tests,and the dissipated energy used to drive damage evolution and crack propagation is larger for FL-CSU tests.In FL-CSU tests,as the unloading rate increases,the dissipated energy grows and elastic energy reduces.CT scanning after the test reveals the impacts of the unloading rate on the crack pattern and a fracture degree index is therein defined in this context to represent the crack dimension.It shows that the crack pattern after FL-CSU tests depends on the unloading rate,and the fracture degree is in agreement with the analysis of both the energy dissipation and the amount of energy released.The effect of unloading rate on fracture evolution characteristics of marble is revealed by a series of FL-CSU tests. | Yu Wang Dongqiao Liu Jianqiang Han Changhong Li Hao Liu | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，6： | 3 |
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