|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Top-emitting thermally activated delayed fluorescence organic light-emitting devices with weak light-matter coupling显示文摘Resonance interaction between a molecular transition and a confined electromagnetic field can lead to weak or strong light-matter coupling.Considering the substantial exciton–phonon coupling in thermally activated delayed fluorescence(TADF)materials,it is thus interesting to explore whether weak light-matter coupling can be used to redistribute optical density of states and to change the rate of radiative decay.Here,we demonstrate that the emission distribution of TADF emitters can be reshaped and narrowed in a top-emitting organic light-emitting device(OLED)with a weakly coupled microcavity.The Purcell effect of weak microcavity is found to be different for TADF emitters with different molecular orientations.We demonstrate that radiative rates of the TADF emitters with vertical orientation can be substantial increased in weakly coupled organic microcavity.These observations can enhance external quantum efficiencies,reduce efficiency roll-off,and improve color-purities of TADF OLEDs,especially for emitters without highly horizontal orientation. | Chunxiu Zang Shihao Liu Mengxin Xu Ruifang Wang Chen Cao Zelin Zhu Jiaming Zhang Hui Wang Letian Zhang Wenfa Xie Chun-Sing Lee | 2021 | Light(Science & Applications)2021，10，7： | 7 |
| 2 | Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency显示文摘In this study, arsenic trioxide(ATO) was encapsulated in liposomes via copper acetate(Cu(OAc)2) gradients and high entrapment efficiency of over 80% was obtained. The average particle size and the zeta-potential of the liposomes were detected to be 115.1 ± 29.1 nm and-21.97 ± 0.6 m V, respectively. The TEM images showed rod-like precipitates in the inner aqueous phase, which was supposed be due to the formation of insoluble ATO–Cu complex.The in vitro drug release of ATO–Cu liposomes exhibited a sustained release over 72 h, and the release rates decreased with the increase of the p H of release media. Pharmacokinetic and tissue distribution studies of ATO liposomes showed significantly reduced plasma clearance rate, increased AUC0–12h and T1/2, and improved tumor distribution of As compared to iv administration of ATO solution. The anti-tumor effect of ATO loaded liposomes to S180 tumor-bearing mice was significantly improved with a tumor inhibition rate of 61.2%,meanwhile the toxicity of encapsulated ATO was greatly decreased. In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients;the co-administration of ATO and Cu(Ⅱ) via liposomal formulation may find wide applications in the treatment of various tumors. | Shaoning Wang Chunxiu Liu Cunyang Wang Jia Ma Hui Xu Jianbo Guo Yihui Deng | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 6 |
| 3 | Small-volume solution current-time behavior study for application in reverse iontophoresis-based non-invasive blood glucose monitoring显示文摘The reverse iontophoresis-based glucose monitoring circumstance is similar to the small-volume solution in which mass diffusion controls the current response of the electrochemical biosensors.In this study,the law of mass transfer in this type of solution was analyzed and a mathematic model was established to depict the current-time behavior of the fabricated planar electrode used in the non-invasive meter designed by ourselves.A small-volume glucose solution was directly constructed on the electrode to simulate the reverse iontophoresis-based sensing condition.The correctness of the model was demonstrated by chronoamperometry.Animal assay was subsequently carried out to verify the practicality of the model in determination of blood glucose.The results processed by the new method accurately traced the authentic value,confirming the advantage of the new method and the potential in clinical analysis. | CHANG LingQian LIU ChunXiu HE YinZeng XIAO HongHui CAI XinXia | 2011 | Science China Chemistry2011，54，1： | 4 |
| 4 | Efficacy of miacalcic in treating a hypercalcemia crisis caused by Williams-Beuren syndrome显示文摘Williams-Beuren syndrome (WBS) is a hereditary disease involving multiple systems due to microdeletion of chromosome 7q11.23.The deleted region in most patients is approximately 1.55 Mb,including 26-28 genes.The incidence of WBS in live-born children is roughly 1/7 500-1/25 000.1 The majority of WBS cases are sporadic;inheritance is autosomal dominant.The clinical manifestations of WBS include aortic valve stenosis alone or combined with other cardiovascular malformations,characteristic facies (full peri-orbital region,flat and short nose,upward pointingnose,long philtrum,wide mouth thick lips,and disorders of the teeth),temporary hypercalcemia,developmental retardation associated with mild-to-moderate dysgnosia,and personality changes.Salmon calcitonin (miacalcic) is widely used in the treatment of adult hypercalcemia crisis. | Gu Yi Gong Chunxiu Shen Ying Wu Di Liang Xuejun Chang Bo Liu Ying Wang Yi | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 5 | Air-Stable Ultrabright Inverted Organic Light-Emitting Devices with Metal Ion-Chelated Polymer Injection Layer显示文摘Here,this work presents an air-stable ultrabright inverted organic lightemitting device(OLED)by using zinc ionchelated polyethylenimine(PEI)as electron injection layer.The zinc chelation is demonstrated to increase the conductivity of the PEI by three orders of magnitude and passivate the polar amine groups.With these physicochemical properties,the inverted OLED shows a record-high external quantum efficiency of 10.0% at a high brightness of 45,610 cd m^(-2) and can deliver a maximum brightness of 121,865 cd m^(-2).Besides,the inverted OLED is also demonstrated to possess an excellent air stability(humidity,35%)with a half-brightness operating time of 541 h@1000 cd m^(-2) without any protection nor encapsulation. | Shihao Liu Chunxiu Zang Jiaming Zhang Shuang Tian Yan Wu Dong Shen Letian Zhang Wenfa Xie Chun-Sing Lee | 2022 | Nano-Micro Letters2022，14，1： | 3 |
| 6 | Clinical features and predictors of remission in children under the age of 7 years with Graves’disease显示文摘Importance:Graves’disease(GD)is rare in children under the age of 7 years.Children with this disease exhibit greater thyrotoxicity at diagnosis and require a longer course of medical therapy,compared with pubertal and postpubertal children and adults.Objective:To investigate the clinical features and identify predictors of remission in children under the age of 7 years with GD.Methods:This retrospective study included 77 children who were diagnosed with GD under the age of 7 years and were treated in the Department of Endocrinology,Beijing Children’s Hospital from 2010 to 2018.Clinical manifestations,laboratory data,and follow-up records were collected for all patients.Children who achieved remission of treatment with methimazole were compared with those who had persistent disease to identify which variables were associated with remission;multiple logistic regression and Cox regression analyses were used to evaluate interactions among predictive variables.Results:Sixty-three boys and 14 girls were included;the median age at diagnosis was 4.2 years(interquartile range:3.2-5.3 years).Forty-six(56.7%)patients had no family history of thyroid disease,17 patients had family history of thyroid disease and 14 patients with unknown family history.Of the 77 patients,18(23.4%)patients achieved remission of treatment with methimazole and 59 patients did not;moreover,51(66.2%)had Graves’ophthalmopathy.Univariate analyses revealed no significant differences between the remission group and non-remission group in terms of age at diagnosis,sex,initial goiter size,or initial thyroid hormone concentration.However,there were a trend of correlation between the initial level of thyroid peroxidase antibody(TPOAb)and remission status(univariate analysis OR 1.002,P=0.038;multivariate analysis OR 1.004,P=0.019).Similar results were observed in univariate analysis of the initial thyrotropin receptor antibody(TRAb)level,but this association was not significant in multivariate analysis.Cox regression analyses revealed that children with high TRAb level required longer duration of remission,compared with low TRAb level(OR 0.950,95%CI 0.904-0.997,P=0.037).Interpretation:Initial TRAb level was an independent predictor of remission outcome in young children under the age of 7 years with GD.Initial TRAb level may predict the likelihood of remission in patients with young-age-of-onset GD. | Yi Gu Xuejun Liang Ming Liu Di Wu Wenjing Li Bingyan Cao Yuchuan Li Chang Su Jiajia Chen Chunxiu Gong | 2020 | Pediatric Investigation2020，4，3： | 3 |
| 7 | Exploring the efficacy of testosterone undecanoate in male children with 5α-reductase deficiency显示文摘Importance:Children with 5-alpha-reductase deficiency(5α-RD)and hypospadias present with micropenis,which makes it difficult to obtain sufficient tissue for urethral reconstruction.Objective:We investigated the therapeutic effects of oral testosterone undecanoate and established a standard androgen treatment protocol for patients with 5α-RD with micropenis.Methods:Patients with 5α-RD were treated with oral testosterone undecanoate for 3 months as a course.All patients were treated with no more than 3 courses.If the penile length(PL)reached 2.5 cm(the minimum criterion for surgery)or greater than or equal to−2.5 standard deviations(SDs)(lower limit of normal),testosterone undecanoate was considered to be effective.Results:The median age of 90 patients with 5α-RD was 1.7 years(0.9,3.1 years).The baseline PL was 1.9±0.6 cm before treatment.At the end of the first course,the PL of 63 patients(70%)reached 2.5 cm,and 49 patients(54%)reached greater than or equal to−2.5 SDs.After two treatment courses,the PL of 81 patients(90%)reached 2.5 cm,and 90 patients(100%)reached greater than or equal to−2.5 SDs.After three courses,the PL of all patients reached 2.5 cm,and all patients reached a PL greater than or equal to−2.5 SDs.No abnormal increase was observed in height-SD score,weight-SD score,or ratio of bone age to chronological age during the 1-3-year follow-up.Interpretation:After 3-9 months of treatment,PL increased to the target length.No severe adverse reactions were observed during follow-up.Testosterone undecanoate was safe and effective in children with 5α-RD with micropenis. | Ying Liu Lijun Fan Xiaoling Wang Chunxiu Gong | 2021 | Pediatric Investigation2021，5，4： | 3 |
| 8 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 9 | Wearable and flexible electrochemical sensors for sweat analysis:a review显示文摘Flexible wearable sweat sensors allow continuous,real-time,noninvasive detection of sweat analytes,provide insight into human physiology at the molecular level,and have received significant attention for their promising applications in personalized health monitoring.Electrochemical sensors are the best choice for wearable sweat sensors due to their high performance,low cost,miniaturization,and wide applicability.Recent developments in soft microfluidics,multiplexed biosensing,energy harvesting devices,and materials have advanced the compatibility of wearable electrochemical sweat-sensing platforms.In this review,we summarize the potential of sweat for medical detection and methods for sweat stimulation and collection.This paper provides an overview of the components of wearable sweat sensors and recent developments in materials and power supply technologies and highlights some typical sensing platforms for different types of analytes.Finally,the paper ends with a discussion of the challenges and a view of the prospective development of this exciting field. | Fupeng Gao Chunxiu Liu Lichao Zhang Tiezhu Liu Zheng Wang Zixuan Song Haoyuan Cai Zhen Fang Jiamin Chen Junbo Wang Mengdi Han Jun Wang Kai Lin Ruoyong Wang Mingxiao Li Qian Mei Xibo Ma Shuli Liang Guangyang Gou Ning Xue | 2023 | Microsystems & Nanoengineering2023，9，1： | 2 |
| 10 | Supramolecular vesicles of cationic gemini surfactants modulated by p-sulfonatocalix[4]arene显示文摘Supramolecular binary vesicles were constructed by host-guest complex formation between p-sulfonatocalix[4]arene and three cationic gemini surfactants, which were identified by UV-vis, dynamic laser scattering, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, and surface tension experiments. The critical aggregation concentration of gemini surfactants decreased pronouncedly by a factor of ca. 1000 owing to the complexation of p-sulfonato-calix[4]arene. | LI ZhenQuan HU ChunXiu CHENG YuQiao XU Hui CAO XuLong SONG XinWang ZHANG HengYi LIU Yu | 2012 | Science China Chemistry2012，55，10： | 2 |
| 11 | Adsorptive removal of copper ions with highly porous chitosan/cellulose acetate blends hollow fiber membranes 显示文摘 | Liu Chunxiu Bai Renbi | 2006 | Journal of Membrane Science2006，284，12： | 1 |
| 12 | A novel method to prepare high chitosan content blend hollow fiber membranes using a non- acidic dope solvent for highly enhanced adsorptive performance 显示文摘 | Han Wei Liu Chunxiu Bai Renbi | 2007 | Journal of Membrane Science2007，302，12： | 1 |
| 13 | Adsorptive removal of copper ions with highly po- rous chitosan/cellulose acetate blend hollow fiber membranes显示文摘 | Chunxiu Liu R B | 2006 | Journal of Membrane Science2006，284，12： | 1 |
| 14 | Preparing highly porous ehitosan/cellulose acetate blend hollow fibers as adsorptive membranes: Effeet of polymer eoncentra- tions and coagulant compositions显示文摘 | Chunxiu Liu R B | 2006 | Journal of Membrane Seienee2006，279，12： | 1 |
| 15 | An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites显示文摘 | Wentao Shi Chunxiu Liu Yilin Song Nansen Lin Shuai Zhou Xinxia Cai | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 16 | A novel method to prepare high chitosan content blend hollow fiber membranes using a non-acidic dope solvent for highly enhanced adsorptive performance显示文摘 | HAN Wei LIU Chunxiu BAI Renbi | 2007 | Journal of Membrane Science2007，302，12： | 1 |
| 17 | Preparing highly porous chitosan/cellulose acetate blend hollow fibers as adsorptive membranes:Effect of polymer concentrations and coagulant compositions显示文摘 | LIU Chunxiu BAI Renbi | 2006 | Journal of Membrane Science2006，279，12： | 1 |
| 18 | Preparation of chitosan/cellulose acetate blend hollow fibers for adsorptive performance显示文摘 | LIU Chunxiu BAI Renbi | 2005 | Journal of Membrane Science2005，267，12： | 1 |
| 19 | Adsorptive removal of copper ions with highly porous chitosan/cellulose acetate blend hollow fiber membranes显示文摘 | LIU Chunxiu BAI Renbi | 2006 | Journal of Membrane Science2006，284，12： | 1 |
| 20 | Preparation of chitosan/cellulose acetate blend hollow fibers for adsorptive performance显示文摘 | Chunxiu Liu Renbi Bai | | 0，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员