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| 1 | In vitro derivation of functional insulin-producing cells from human embryonic stem cells显示文摘为人的胚胎的茎(ES ) 的自强和区别的能力细胞为对待类型 Idiabetes mellitus 为胰腺的贝它细胞的产生使他们成为潜在的来源。这里,我们报导一最新发展了并且有效方法,在aserum免费的系统执行了,区分进生产胰岛素的 cells.Activin A 的导致的人的 ES 房间它在起始的阶段被使用从人的 EScells 导致权威的内胚叶区别,是由权威的内胚叶标记 Sox17 和 Brachyury.Further 的表示检测了, all-trans retinoic 酸( RA )被用来支持胰腺的区别,由早胰腺的抄写因素 pdx1 和 hlxb9 的表示显示了。在成熟 inDMEM/F12 以后有 bFGF 和菸碱的没有浆液的媒介,区分的房间表示了小岛特定的标记象 C 肽,胰岛素,胰高血糖素和 glut2 那样。百分比 ofC-peptide-positive 房间超过了 15% 。由这些房间的胰岛素和 C 肽的分泌物在葡萄糖层次对应于变化。当移植了进肾的囊时, ofStreptozotocin (STZ ) 对待裸体老鼠,这些区分的人的 ES 房间熬过并且维持贝它房间标记基因的表示包括 C 肽, pdx1, glucokinase, nkx6.1, IAPP, pax6and Tcf1。百分之三十只移植裸体老鼠展出了 stableeuglycemia 的明显的恢复;并且改正的显型被支撑超过六个星期。我们的新方法为学习人的胰开发的机制提供一个有希望的试管内区别模特儿并且说明为类型 Idiabetes mellitus 的处理使用人的 ES 房间的潜力。 | Wei Jiang Yan Shi Dongxin Zhao Song Chen Jun Yong Jing Zhang Tingting Qing Xiaoning Sun Peng Zhang Mingxiao Ding Dongsheng Li Hongkui Deng | 2007 | Cell Research2007，17，4： | 38 |
| 2 | Mechanism of electroacupuncture on inflammatory pain: neural-immune-endocrine interactions显示文摘Nociceptive signals are transmitted by peripheral afferents to the central nervous system under pain condition, a process that involves various neurotransmitters and pathways. Electroacupuncture (EA) has been widely used as a pain management technique in clinical practice. Emerging studies have shown that EA can inhibit the induction and transmission of pain signals and, consequently, mediate anti-nociceptive and anti-inflammatory effects by rebalancing the neural-immune-endocrine interactions. This review summarizes the neural-immune- endocrine circuit including peripheral afferent and central efferent, contributing to EA-induced neuroimmune and neuroendocrine modulation in inflammatory pain models. The peripheral afferent circuit includes crosstalk among immune cells, inflammatory cytokines, peripheral nociceptors. In central efferent primarily involves the neuroinflammatory interactions between spinal nociceptive neurons and glial cells. Furthermore, the hypothalamic- pituitary-adrenal axis, sympathetic and vagal nervous may serve as an essential pathway involved in the mechanism of acupuncture-mediated analgesia within the interactions of the central, immune and endocrine systems. Overall, this review focuses on the interactions of neural-immune-endocrine in inflammatory pain, which may be underlying the mechanism of EA-induced anti-inflammatory and antinociceptive effect. | Li Yuan Yang Mingxiao Wu Fan Cheng Ke Chen Haiyong Shen Xueyong Lao Lixing | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 20 |
| 3 | Prognostic implications of epidermal growth factor receptor variant Ⅲ expression and nuclear translocation in Chinese human gliomas显示文摘Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We retrospectively examined EGFRvⅢ expression and EGFRvⅢ nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization(WHO) II gliomas, 84 WHO Ⅲ gliomas and 72 glioblastomas(WHO IV). Factors that correlated with EGFRvⅢ and EGFRvⅢ nuclear translocation expression were analyzed by the Chi-square test. Kaplan-Meier methodology and Cox regression were used for the survival analysis.Results: Log-rank tests showed that patient age, Karnofsky performance scale(KPS) score, tumor grade,EGFRvⅢ expression, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, isocitrate dehydrogenase(IDH)mutation, Ki-67 labeling index and O6-methylguanine-DNA methyltransferase(MGMT) status(P<0.05) were significantly correlated with overall survival(OS) time. Multivariate Cox regression analysis revealed that patient age, tumor grade, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, and IDH mutation(P<0.05) were significantly correlated with OS. Patients with a high level of EGFRvⅢ nuclear translocation(≥7%) had both significantly shorter OS [hazard ratio(HR): 1.920, 95% confidence interval(95% CI): 1.228-3.003, P=0.004] and progression-free survival(PFS) times(HR: 1.661, 95% CI: 1.116-2.471, P=0.012) than those with a low level of EGFRvⅢ nuclear translocation(<7%).Conclusions: A high level of EGFRvⅢ nuclear translocation in glioma is an independent factor indicating a poor prognosis, but EGFRvⅢ expression is not an independent clinical prognostic factor. The level of EGFRvⅢ nuclear translocation maybe a novel and crucial prognostic biomarker in glioma. | Kaiyuan Yang Xiaohui Ren Liyuan Tao Peipei Wang Haihui Jiang Li Shen Yiming Zhao Yong Cui Mingxiao Li Song Lin | 2019 | Chinese Journal of Cancer Research2019，31，1： | 8 |
| 4 | Review of interface tailoring techniques and applications to improve insulation performance显示文摘Interfaces between different materials,for instance,electrode-dielectrics and vacuum/air/SF6‐insulators and oilpaper,are universal in high‐voltage insulation systems.Targeted tailoring of the interfacial properties,e.g.chemical structures,micro‐/nanoscale morphology,the charge injection barrier,trap states,and surface conductivity,is thought to be an effective approach to improve insulation properties such as breakdown and flashover strength,corona/tracking resistance,and wettability.In this article,the authors review recent progress in interface tailoring methods and their application to improve various insulation properties.The potential application scenarios of interface tailoring in different facilities are first summarised,and the desired insulation properties of various applications are highlighted.Interface tailoring methods are classified as physical/chemical surface modification and surface coating(inorganic,organic and composite),and the features of different techniques are described in detail.The structure-property relationships between interfacial states and various microscopic parameters such as charge injection barrier,trap distribution and surface conductivity are discussed together with the tailoring mechanisms for different insulation properties.Finally,the future development prospects of interface tailoring methods and their applications,e.g.multi-functional coating and stimuli-response smart coating,are presented. | Mingxiao Zhu Jianyi Xue Yanhui Wei Guochang Li Guanjun Zhang | 2022 | High Voltage2022，7，1： | 4 |
| 5 | Analysis for remedial alternatives of unregulated municipal solid waste landfills leachate-contaminated groundwater显示文摘地下水流动和溶质运输模型为预报沾染物运输并且基于 unregulated 垃圾堆的案例研究估计补救选择的效果用视觉 Modflow 被开发在东方中国的污染 leachate 的地下水。结果证明那根砷羽毛是到达在八年,和砷羽毛的最长侧面、纵的距离以后在下游的农田抽很好是分别地到达 200 m 和 260 m。但是砷羽毛的区域是不显然从八年增加到十年和羽毛的高集中的区域是在 20 年以后传播到下游的河和农田区域;当垃圾堆磨擦了时被变硬,羽毛是不在八年以后到达下游的农田区域;当抽的井下游地在羽毛被安装,分泌物率是 200m ^ 时,啜 3 ^/d,羽毛将有效地被制止;为防漏的障碍,它可能有效地在一个程度时间范围以内保护敏感目标的地下水。要不是连续的点来源,羽毛仍然是防漏的障碍到圆;当排水阴沟的分泌物率是 170.26 m ^ 时,啜 3 ^/d,羽毛有效地被控制;有排水阴沟的联合地面变硬能在控制沾染物散开给最好的效果的全面方法,和分泌物率将被归结为 111.43 m ^ 啜 3 ^/d。因此,当 leachate 漏发生在 unregulated 垃圾堆时,有排水阴沟的全面补救其他的联合地面变硬将为阻止地下水污染被推荐[出版摘要] | Da AN Yonghai JIANG Beidou XI Zhifei MA Yu YANG Queping YANG Mingxiao LI Jinbao ZHANG Shunguo BAI Lei JIANG | 2013 | Frontiers of Earth Science2013，7，3： | 3 |
| 6 | Relation between the characteristics of strong earthquake activities in Chinese mainland and the Wenchuan earthquake显示文摘This paper studies the relations between the great Wenchuan earthquake and the active-quiet periodic characteristics of strong earthquakes,the rhythmic feature of great earthquakes,and the grouped spatial distribution of MS8.0 earthquakes in Chinese mainland.We also studied the relation between the Wenchuan earthquake and the stepwise migration characteristics of MS≥7.0 earthquakes on the North-South seismic belt,the features of the energy releasing acceleration in the active crustal blocks related to the Wenchuan earthquake and the relation between the Wenchuan earthquake and the so called secondarc fault zone.The results can be summarized as follows:1 the occurrence of the Wenchuan earthquake was consistent with the active-quiet periodic characteristics of strong earthquakes;2 its occurrence is consistent with the features of grouped occurrence of MS8.0 earthquakes and follows the 25 years rhythm(each circulation experiences the same time) of great earthquakes;3 the Wenchuan MS8.0 earthquake follows the well known stepwise migration feature of strong earthquakes on the North-South seismic belt;4 the location where the Wenchuan MS8.0 earthquake took place has an obvious consistency with the temporal and spatial characteristic of grouped activity of MS≥7.0 strong earthquakes on the secondarc fault zone;5 the second-arc fault zone is not only the lower boundary for earthquakes with more than 30 km focal depth,but also looks like a lower boundary for deep substance movement;and 6 there are obvious seismic accelerations nearby the Qaidam and Qiangtang active crustal blocks(the northern and southern neighbors of the Bayan Har active block,respectively),which agrees with the GPS observation data. | Xiaodong Zhang Guohua Yang Xian Lu Mingxiao Li Zhigao Yang | 2009 | Earthquake Science2009，22，5： | 3 |
| 7 | Corrosion Behavior of 316L Stainless Steels Exposed to Salt Lake Atmosphere of Western China for 8 years显示文摘The evolution of corrosion behavior of 316 L stainless steels exposed to salt lake atmosphere for 8 years was investigated.The results showed that the stainless steel in salt lake atmosphere had a greater corrosion rate during the initial exposure time and relatively lower corrosion rate during the subsequent exposure time.Dust depositions accumulated on the downward surface caused severe local corrosion of stainless steel.As exposure time prolonged,the relative amount of Croxide and Feoxidein the corrosion products gradually increased,which may directly affect the corrosion rate of stainless steels.Moreover,the maximum pit depth followed a power function with respect to exposure time. | Mingxiao Guo Junrong Tang Tianzhen Gu Can Peng Qiaoxia Li Chen Pan Zhenyao Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，4： | 3 |
| 8 | Seismic comprehensive forecast based on modified project pursuit regression显示文摘In the research of projection pursuit for seismic comprehensive forecast,the algorithm of projection pursuit regression(PPR) is one of most applicable methods.But generally,the algorithm structure of the PPR is very complicated.By partial smooth regressions for many times,it has a large amount of calculation and complicated extrapolation,so it is easily trapped in partial solution.On the basis of the algorithm features of the PPR method,some solutions are given as below to aim at some shortcomings in the PPR calculation:to optimize project direction by using particle swarm optimization instead of Gauss-Newton algorithm,to simplify the optimal process with fitting ridge function by using Hermitian polynomial instead of piecewise linear regression.The overall optimal ridge function can be obtained without grouping the parameter optimization.The modeling capability and calculating accuracy of projection pursuit method are tested by means of numerical emulation technique on the basis of particle swarm optimization and Hermitian polynomial,and then applied to the seismic comprehensive forecasting models of polydimensional seismic time series and general disorder seismic samples.The calculation and analysis show that the projection pursuit model in this paper is characterized by simplicity,celerity and effectiveness.And this model is approved to have satisfactory effects in the real seismic comprehensive forecasting,which can be regarded as a comprehensive analysis method in seismic comprehensive forecast. | Anxu Wu Xiangdong Lin Changsheng Jiang Yongxian Zhang Xiaodong Zhang Mingxiao Li Ping'an Li | 2009 | Earthquake Science2009，22，5： | 3 |
| 9 | Advances in Fe(Ⅲ)bioreduction and its application prospect for groundwater remediation:A review显示文摘Microbial Fe(Ⅲ)reduction is a significant driving force for the biogeochemical cycles of C,O,P,S,N,and dominates the natural bio-purification of contaminants in groundwater(e.g.,petroleum hydrocarbons,chlorinated ethane,and chromium).In this review,the mechanisms and environmental significance of Fe(Ⅲ)(hydro)oxides bioreduction are summarized.Compared with crystalline Fe(Ⅲ)(hydro)oxides,amorphous Fe(m)(hydro)oxides are more bioavailable.Ligand and electron shuttle both play an important role in microbial Fe(Ⅲ)reduction.The restrictive factors of Fe(Ⅲ)(hydro)oxides bioreduction should be further investigated to reveal the characteristics and mechanisms of the process.It will improve the bioavailability of crystalline Fe(Ⅲ)(hydro)oxides and accelerate the anaerobic oxidation efficiency of the reduction state pollutants.Furthermore,the approach to extract,culture,and incubate the functional Fe(Ⅲ)reducing bacteria from actual complicated environment,and applying it to the bioremediation of organic,ammonia,and heavy metals contaminated groundwater will become a research topic in the future.There are a broad application prospects of Fe(Ⅲ)(hydro)oxides bioreduction to groundwater bioremediation,which includes the in situ injection and permeable reactive barriers and the innovative Kariz wells system.The study provides an important reference for the treatment of reduced pollutants in contaminated groundwater. | Yu Jiang Beidou Xi Rui Li Mingxiao Li Zheng Xu Yuning Yang Shaobo Gao | 2019 | Frontiers of Environmental Science & Engineering2019，13，6： | 3 |
| 10 | The starch grafted poly( l -lactide) and the physical properties of its blending composites显示文摘 | Li Chen Xueyu Qiu Mingxiao Deng Zhongkui Hong Rui Luo Xuesi Chen Xiabin Jing | 2005 | Polymer2005，，15： | 2 |
| 11 | Immune responses of pigs inoculated with a recombinant fowlpox virus coexpressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL-18显示文摘 | Guoshun Shen Ningyi Jin Mingxiao Ma Kuoshi Jin Min Zheng Tianzhong Zhuang Huijun Lu Guangze Zhu Hongtao Jin Minglan Jin Xiaowei Huo Xiaoguang Qin Ronglan Yin Chang Li Hongwen Li Yang Li Zhenzhen Han Yifeng Chen Miaomiao Jin | 2007 | Vaccine2007，，21： | 2 |
| 12 | Seabed deposition and erosion change and influence factors in the Yangshan Deepwater Port over the years显示文摘The seabed scouring and silting are very important to the construction of port and waterway engineering.Seabed deposition and erosion change is complicated due to the influence of sediment supply,human activities and other factors.The Yangshan Deepwater Port is the new deep water harbor,which is an important part of the Shanghai International Shipping Service Center.Its construction has received much attention.At present,the water depth from the 1st to the 3rd harbor district is currently suitable under regular dredging and tidal current action.The fourth harbor district will be built in the world’s largest fully-automated deep water wharf.In the study,bathymetry change of the entire sea area of the Yangshan Deepwater Port and the 4th harbor district(i.e.,PhaseⅣproject)waters were analyzed quantitatively using multiyear bathymetric,hydrological and sediment data.The results show that from 1998 to 2010,seabed changes are characterized by large volumes of erosion and sedimentation,which the southern part was deposited and the northern part was eroded in the inner harbor waters,but the seabed of the Kezhushan inlet was eroded.Seabed changes of PhaseⅣproject waters generally show a scour tendency in recent few years with the annual scour rate about 0.7 m.Among the many factors,the existence of Kezhushan inlet and its influence of the western water flow play an important positive role in water depth changes under the ebb tide action. | Shuhua Zuo Hualiang Xie Xiaoming Ying Cheng Cui Yuxin Huang Huaiyuan Li Mingxiao Xie | 2019 | Acta Oceanologica Sinica2019，38，7： | 2 |
| 13 | Wearable and flexible electrochemical sensors for sweat analysis:a review显示文摘Flexible wearable sweat sensors allow continuous,real-time,noninvasive detection of sweat analytes,provide insight into human physiology at the molecular level,and have received significant attention for their promising applications in personalized health monitoring.Electrochemical sensors are the best choice for wearable sweat sensors due to their high performance,low cost,miniaturization,and wide applicability.Recent developments in soft microfluidics,multiplexed biosensing,energy harvesting devices,and materials have advanced the compatibility of wearable electrochemical sweat-sensing platforms.In this review,we summarize the potential of sweat for medical detection and methods for sweat stimulation and collection.This paper provides an overview of the components of wearable sweat sensors and recent developments in materials and power supply technologies and highlights some typical sensing platforms for different types of analytes.Finally,the paper ends with a discussion of the challenges and a view of the prospective development of this exciting field. | Fupeng Gao Chunxiu Liu Lichao Zhang Tiezhu Liu Zheng Wang Zixuan Song Haoyuan Cai Zhen Fang Jiamin Chen Junbo Wang Mengdi Han Jun Wang Kai Lin Ruoyong Wang Mingxiao Li Qian Mei Xibo Ma Shuli Liang Guangyang Gou Ning Xue | 2023 | Microsystems & Nanoengineering2023，9，1： | 2 |
| 14 | Effects of UV on the Corrosion Behavior of Pure Aluminum 1060 in Simulated Nansha Marine Atmosphere显示文摘The corrosion behavior of pure aluminum 1060 subjected to a wet-dry cyclic accelerated test in simulated Nansha marine atmosphere in the dark and under UV illumination has been investigated by means of scanning electron microscopy(SEM),electrochemical impedance spectroscopy(EIS),and Mott–Schottky measurements in this work.The results show that under the two conditions,the native oxide films are constantly destroyed and the thicknesses of the oxide films continuously decrease in the first 24 days of the corrosion test.In particular,UV illumination can diminish the pitting corrosion susceptibility of the native oxide films to an extent in terms of a photo-induced modifi cation of the native oxide film on the pure aluminum surfaces.Besides,UV illumination can also reduce the carrier concentration in the oxide films,thus reducing the conductivity and the corrosion rate. | Can Peng Mingxiao Guo Tianzhen Gu Xiaohan Li Chuan Wang Zhenyao Wang Cheng Sun | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，7： | 1 |
| 15 | Hmited fluid re- suscitation attenuates lung and intestine injury caused by hemorrhagic shock in rats 显示文摘 | Yousheng Li Mingxiao Guo Jing | 2014 | Journal of investigative surgery : the official journal of the Academy of Surgical Research2014，27，2： | 1 |
| 16 | The starch grafted poly(L-lactide) and the physical properties of its blending composites显示文摘 | Chen li Qiu xueyu Deng mingxiao | 2005 | Polymer2005，46，15： | 1 |
| 17 | Spectroscopic characterization of water extractable organic matter during composting of municipal solid waste显示文摘 | Xiaosong He Beidou Xi Zimin Wei Xujing Guo Mingxiao Li Da An Hongliang Liu | 2010 | Chemosphere2010，，4： | 1 |
| 18 | Si nanowire Bio-FET for electrical and label-free detection of cancer cell-derived exosomes显示文摘Exosomes are highly important in clinical diagnosis due to their high homology with their parental cells.However,conventional exosome detection methods still face the challenges of expensive equipment,low sensitivity,and complex procedures.Field effect transistors(FETs)are not only the most essential electronic component in the modern microelectronics industry but also show great potential for biomolecule detection owing to the advantages of rapid response,high sensitivity,and label-free detection.In this study,we proposed a Si nanowire field-effect transistor(Si-NW Bio-FET)device chemically modified with specific antibodies for the electrical and label-free detection of exosomes.The Si-NW FETs were fabricated by standard microelectronic processes with 45 nm width nanowires and packaged in a polydimethylsiloxane(PDMS)microfluidic channel.The nanowires were further modified with the specific CD63 antibody to form a Si-NW Bio-FET.The use of the developed Si-NW Bio-FET for the electrical and labelfree detection of exosomes was successfully demonstrated with a limit of detection(LOD)of 2159 particles/mL.In contrast to other technologies,in this study,Si-NW Bio-FET provides a unique strategy for directly quantifying and realtime detecting exosomes without labeling,indicating its potential as a tool for the early diagnosis of cancer. | Wenjie Zhao Jiawei Hu Jinlong Liu Xin Li Sheng Sun Xiaofeng Luan Yang Zhao Shuhua Wei Mingxiao Li Qingzhu Zhang Chengjun Huang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 19 | The starch grafted poly (L-lactide) and the physical properties of its blending composites显示文摘 | Li Chen Xueyu Qiu Mingxiao Deng | 2005 | Polymer2005，46，： | 1 |
| 20 | Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts显示文摘 | Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou Honggang Li Wei Jiang Jun Cai Meng Liu Kai Cui Xiuxia Qu Tingting Xiang Danyu Lu Xiaochun Chi Ge Gao Weizhi Ji Mingxiao Ding Hongkui Deng | 2008 | Cell Stem Cell2008，，6： | 1 |
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