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| 1 | Gain-of-function mutant p53 in cancer progression and therapy显示文摘p53 is a key tumor suppressor,and loss of p53 function is frequently a prerequisite for cancer development.The p53 gene is the most frequently mutated gene in human cancers;p53 mutations occur in>50%of all human cancers and in almost every type of human cancers.Most of p53 mutations in cancers are missense mutations,which produce the full-length mutant p53(mutp53)protein with only one amino acid difference from wild-type p53 protein.In addition to loss of the tumor-suppressive function of wild-type p53,many mutp53 proteins acquire new oncogenic activities independently of wild-type p53 to promote cancer progression,termed gain-of-function(GOF).Mutp53 protein often accumulates to very high levels in cancer cells,which is critical for its GOF.Given the high mutation frequency of the p53 gene and the GOF activities of mutp53 in cancer,therapies targeting mutp53 have attracted great interest.Further understanding the mechanisms underlying mutp53 protein accumulation and GOF will help develop effective therapies treating human cancers containing mutp53.In this review,we summarize the recent advances in the studies on mutp53 regulation and GOF as well as therapies targeting mutp53 in human cancers. | Cen Zhang Juan Liu Dandan Xu Tianliang Zhang Wenwei Hu Zhaohui Feng | 2020 | Journal of Molecular Cell Biology2020，12，9： | 18 |
| 2 | Adjunctive treatment with high frequency repetitive transcranial magnetic stimulation for the behavioral and psychological symptoms of patients with Alzheimer's disease: a randomized, double-blind, sham-controlled study显示文摘 | Yue WU Wenwei XU Xiaowei LIU Qing XU Li TANG Shuyan WU | 2015 | 上海精神医学2015，27，5： | 15 |
| 3 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 4 | Responses of Patients with Disorders of Consciousness to Habit Stimulation:A Quantitative EEG Study显示文摘Whether habit stimulation is effective in DOC patient arousal has not been reported. In this paper, we analyzed the responses of DOC patients to habit stimulation. Nineteen DOC patients with alcohol consumption or smoking habits were recruited and 64-channel EEG signals were acquired both at the resting state and at three stimulation states. Wavelet transformation and nonlinear dynamics were used to extract the features of EEG signals and four brain lobes were selected to investigate the degree of EEG response to habit stimulation. Results showed that the highest degree of EEG response was from the callname stimulation, followed by habit and music stimulations. Significant differences in EEG wavelet energy and response coefficient were found both between habit and music stimulation, and between habit and call-name stimulation. These findings prove that habit stimulation induces relatively more intense EEG responses in DOC patients than music stimulation, suggesting that it may be a relevant additional method for eliciting patient arousal. | Jingqi Li Jiamin Shen Shiqin Liu Maelig Chauvel Wenwei Yang Jian Mei Ling Lei Li Wu Jian Gao Yong Yang | 2018 | Neuroscience Bulletin2018，34，4： | 8 |
| 5 | Advanced chemical strategies for lithium-sulfur batteries: A review显示文摘Lithium-sulfur(Li-S) battery has been considered as one of the most promising rechargeable batteries among various energy storage devices owing to the attractive ultrahigh theoretical capacity and low cost. However, the performance of Li-S batteries is still far from theoretical prediction because of the inherent insulation of sulfur, shuttling of soluble polysulfides, swelling of cathode volume and the formation of lithium dendrites. Significant efforts have been made to trap polysulfides via physical strategies using carbon based materials, but the interactions between polysulfides and carbon are so weak that the device performance is limited. Chemical strategies provide the relatively complemented routes for improving the batteries' electrochemical properties by introducing strong interactions between functional groups and lithium polysulfides. Therefore, this review mainly discusses the recent advances in chemical absorption for improving the performance of Li-S batteries by introducing functional groups(oxygen, nitrogen, and boron, etc.) and chemical additives(metal, polymers, etc.) to the carbon structures, and how these foreign guests immobilize the dissolved polysulfides. | Xiaojing Fan Wenwei Sun Fancheng Meng Aiming Xing Jiehua Liu | 2018 | Green Energy & Environment2018，3，1： | 7 |
| 6 | Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection显示文摘Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy donors.Taken together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses. | Yuan Liu Jian Zheng Yinping Liu Liyan Wen Lei Huang Zheng Xiang Kwok-Tai Lam Aizhen Lv Huawei Mao Yu-Lung Lau Wenwei Tu | 2018 | Cellular & Molecular Immunology2018，15，9： | 6 |
| 7 | Dominant Gene cplsr1 Corresponding to Premature Leaf Senescence Resistance in Cotton (Gossypium hirsutum L.)显示文摘Cotton (Gossypium hirsutum L.) premature leaf senescence-resistant inbred XLZ33 and senescence-susceptible inbred lines XLZ13 were selected and crossed to produce F1, F1-reciprocal, F2 and BC1 generations for evaluation of leaf senescence process and inheritance. The results showed that leaf senescence processes for XLZ13 and XLZ33 were obviously different and leaf senescence traits could be distinguished between the two parents at particular periods of cotton growth. Inheritance anlysis for the cotton premature leaf senescence resistant trait further showed that the segregation in the F2 fit a 3:1 ratio inheritance pattern, with resistance being dominant. The backcross of F1 to the susceptible parent produced a 1:1 ratio, confirming that cotton premature leaf senescence resistant trait was from a single gene. The single dominant gene controlling cotton premature leaf senescence resistance in XLZ33 was named as cotton premature leaf senescence resistance 1, with the symbol cplsr1. | Jingqing Zhao Tengfei Jiang Zhi Liu Wenwei Zhang Guiliang Jian Fanfljun Qi | 2012 | Journal of Integrative Plant Biology2012，54，8： | 6 |
| 8 | yδ-T cells: an unpolished sword in human anti-infection immunity显示文摘γ δ -T 房间代表有免疫力的房间的一张小人口,但是对外长的病原体,内长的致病的有免疫力的监视甚至免疫系统的动态平衡在主人防卫起一个不可缺少的作用。γ 的激活和扩大; δ -T 房间通常与他们的前进和预后在多样的人的传染疾病和相互关联被观察。γ δ -T 房间有两 ‘ innate’并且 ‘ adaptive’在有免疫力的反应的特征,和他们的反感染活动被在由另外的有免疫力的部件的精致的规定下面的多重小径调停。在这评论,我们在 γ 总结文学和最近的前进的当前的状态; δ -T 对普通人的传染病原体的调停房间的有免疫力的回答。尽管进一步的调查被需要改进我们不同 γ 的特征的理解; δ在特定的条件下面的 -T 房间 subpopulations, γ δ -T 基于房间的治疗为传染疾病的治疗有大潜力。 | Jian Zheng Yinping Liu Yu-Lung Lau Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，1： | 6 |
| 9 | CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD41 regulatory T cells显示文摘CD4^(+)regulatory T cells(Tregs)play an important role in maintaining immune tolerance by suppressing pathologic immune responses.,The generation of large numbers of antigen-specific Tregs ex vivo is critical for the development of clinical immunotherapy based on the adoptive transfer of Tregs.Both CD40-activated B cells(CD40-B)and immature dendritic cells(imDCs)have been used as professional antigen-presenting cells(APCs)to generate antigen-specific Tregs.However,the efficiencies of CD40-B and imDCs to generate CD4^(+)Tregs have not been compared directly and the mechanism driving the generation of these Tregs remains largely unknown.In this study,we found that CD40-B exhibited mature phenotypes and were more able to induce and expand CD4^(high)'CD25^(+)Tregs than imDCs.Moreover,Tregs induced by CD40-B had greater suppressive capacity than those induced by imDCs.The generation of CD4^(high)CD25^(+)Tregs by CD40-B and imDCs is cell-cell contact dependent and partially relies on the expression of human leukocyte antigen(HLA)-DR and CD80/86.Differences in CD4^(high)CD25^(+)Treg generation efficiency were largely explained by the production of endogenous IL-2 by CD40-B.Our results suggest that CD40-B is better able to generate large numbers of antigen-specific Tregs than imDCs.Additionally,using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection,graft versus host disease(GVHD)and autoimmune diseases. | Jian Zheng Yinping Liu Yu-Lung Lau Wenwei Tu | 2010 | Cellular & Molecular Immunology2010，7，1： | 5 |
| 10 | GOLM1 exacerbates CD8^(+)T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages显示文摘The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses.Golgi membrane protein 1(GOLM1)is correlated to hepatocellular carcinoma(HCC)progression and metastasis.However,little is known about the role of GOLM1 in regulating the immunosuppressive environment and its impact on immunotherapeutic efficacy in HCC.In this study,GOLM1 was positively correlated with infiltrating tumor-associated macrophages(TAMs)expressed high levels of programmed death-ligand 1(PD-L1)and CD8^(+)T cell suppression in HCC tissues.Both gain-and loss-of-function studies determined a close correlation between GOLM1 and immunosuppression.In the mechanism,GOLM1 promoted COP9 signalosome 5-mediated PD-L1 deubiquitination in HCC cells and increased the transport of PD-L1 into exosomes via suppression of Rab27b expression.Furthermore,co-culture with exosomes derived from HCC cells upregulated the expression of PD-L1 on macrophages.Zoledronic acid in combination with anti-PD-L1 therapy reduced PD-L1^(+)TAMs infiltration and alleviated CD8^(+)T cell suppression,resulting in tumor growth inhibition in the mouse HCC model.Together,our study unveils a mechanism by which GOLM1 induces CD8^(+)T cells suppression through promoting PD-L1 stabilization and transporting PD-L1 into TAMs with exosome dependent.Targeting PD-L1^(+)TAM could be a novel strategy to enhance the efficacy of anti-PD-L1 therapy in HCC. | Jinhong Chen Zhifei Lin Lu Liu Rui Zhang Yan Geng Minghao Fan Wenwei Zhu Ming Lu Lu Lu Huliang Jia Jubo Zhang Lun-Xiu Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 5 |
| 11 | Tumor suppressor p53 cross-talks with TRIM family proteins显示文摘p53 is a key tumor suppressor.As a transcription factor,p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor suppression.In addition to tumor suppression,p53 is also involved in many other physiological and pathological processes,e.g.anti-infection,immune response,development,reproduction,neurodegeneration and aging.To maintain its proper function,p53 is under tight and delicate regulation through different mechanisms,particularly the posttranslational modifications.The tripartite motif(TRIM)family proteins are a large group of proteins characterized by the RING,B-Box and coiled-coil(RBCC)domains at the N-terminus.TRIM proteins play important roles in regulation of many fundamental biological processes,including cell proliferation and death,DNA repair,transcription,and immune response.Alterations of TRIM proteins have been linked to many diseases including cancer,infectious diseases,developmental disorders,and neurodegenera-tion.Interestingly,recent studies have revealed that many TRIM proteins are involved in the regulation of p53,and at the same time,many TRIM proteins are also regulated by p53.Here,we review the cross-talk between p53 and TRIM proteins,and its impact upon cellular biological processes as well as cancer and other diseases. | Juan Liu Cen Zhang Xue Wang Wenwei Hu Zhaohui Feng | 2021 | Genes & Diseases2021，8，4： | 5 |
| 12 | Tumor suppressor p53 and metabolism显示文摘p53 plays a key role in tumor suppression. The tumor suppressive function of p53 has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence in cells. However, recent studies suggest that other functions of p53 also contribute to its role as a tumor suppressor, such as its function in metabolic regulation. p53 regulates various metabolic pathways to maintain the metabolic homeostasis of cells and adapt cells to stress. In addition, recent studies have also shown that gain-offunction (GOF) mutant p53 proteins drive metabolic reprogramming in cancer cells, contributing to cancer progression. Further understanding of p53 and its GOF mutants in metabolism will provide new opportunities for cancer therapy. | Juan Liu Cen Zhang Wenwei Hu Zhaohui Feng | 2019 | Journal of Molecular Cell Biology2019，11，4： | 5 |
| 13 | Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity. | Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu | 2017 | Virologica Sinica2017，32，2： | 4 |
| 14 | Hierarchical structures hydrogel evaporator and superhydrophilic water collect device for efficient solar steam evaporation显示文摘Efficient light absorption and trapping are of vital importance for the solar water evaporation by hydrogel-based photothermal conversion materials.Conventional strategies are focused on the development of the composition and structure of the hydrogers internal network.In our point of view,the importance of the surface structure of hydrogel has usually been underestimated or ignored.Here inspired by the excellent absorbance and water transportation ability of biological surface structure,the hierarchical structured hydrogel evaporators(HSEs)increased the light absorption,trapping,water transportation and water-air interface,which is the beneficial photothermal conversion and water evaporation.The HSEs showed a rapid evaporation rate of 1.77 kg·m^(-2)·h^(-1)at about 92%energy efficiency under one sun(1 kW·m^(-2)).Furthermore,the superhydrophilic window device was used in this work to collect the condensed water,which avoids the light-blocking caused by the water mist formed by the small droplets and the problem of the droplets stick on the device dropping back to the bulk water.Integrated with the excellent photothermal conversion hydrogel and superhydrophilic window equipment,this work provides efficient evaporation and desalination of hydrogel-based solar evaporators in practical large-scale applications. | Wenwei Lei Sovann Khan Lie Chen Norihiro Suzuki Chiaki Terashima Kesong Liu Akira Fujishima Mingjie Liu | 2021 | Nano Research2021，14，4： | 4 |
| 15 | HYSYS Automation and Its Application on Evaluation of Plate Heat Exchanger显示文摘当为 multicomponent 混合物模仿或设计板热 exchangers 时,大多数设计者经常与怎么选择或估计物理性质参数和希望有能被采用的一个可靠数据库上的问题被困惑。商业代码 HYSYS 供应为 them.This 工作的超过 1500 种纯物质和超过 16 000 个二进制系数上的物理性质包裹简短基于在内部板热 exchanger 模拟代码和 HYSYS 包裹之间的微软部件对象模型(COM ) 介绍了一个有效通讯接口。一个定做的 HYSYS-COM 接口的应用程序显示出高效率,例如为评估每条过程溪流的性质需要的时间的重要减小。这个自动化方法能方便地被扩大为象热转移,列,和另外的设备那样的任何特定的操作设备推进优化学习。 | Dai Yuqiang Liu Wenwei Wang Shaomin Hu Dapeng | 2008 | China Petroleum Processing & Petrochemical Technology2008，10，3： | 3 |
| 16 | Human Vγ9Vδ2-T cells efficiently kill influenzavirus-infected lung alveolar epithelial cells显示文摘 | Hong Li Zheng Xiang Ting Feng Jinrong Li Yinping Liu Yingying Fan Qiao Lu Zhongwei Yin Meixing Yu Chongyang Shen Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 17 | Plasma Levels of Interleukin 18, Interleukin 10, and Matrix Metalloproteinase-9 and -137G/C Polymorphism of Interleukin 18 Are Associated with Incidence of In-stent Restenosis After Percutaneous Coronary Intervention显示文摘 | Wenwei Liu Yongsheng Liu Hua Jiang Xiangwu Ding Rui Zhu Bin Li Yuqin Zhao | 2013 | Inflammation2013，，： | 2 |
| 18 | Few-layer metasurfaces with arbitrary scattering properties显示文摘Metasurfaces,which are planar arrays of subwavelength artificial structures,have emerged as excellent platforms for the integration and miniaturization of electromagnetic devices and provided ample possibilities for single-dimensional and multi-dimensional manipulations of electromagnetic waves.However,owing to the limited interactions between planar thin metallic nanostructures and electromagnetic waves as well as intrinsic losses in metals,metasurfaces exhibit disadvantages in terms of efficiency,controllability,and functionality.Recent advances in this field show that few-layer metasurfaces can overcome these drawbacks.Few-layer metasurfaces composed of more than one functional layer enable more degrees of design freedom.Hence,they possess unprecedented capabilities for electromagnetic wave manipulation,which have considerable impact in the area of nanophotonics.This article reviews recent advances in few-layer metasurfaces from the viewpoint of their scattering properties.The scattering matrix theory is briefly introduced,and the advantages and drawbacks of few-layer metasurfaces for the realization of arbitrary scattering properties are discussed.Then,a detailed overview of typical few-layer metasurfaces with various scattering properties and their design principles is provided.Finally,an outlook on the future directions and challenges in this promising research area is presented. | Zhancheng Li Wenwei Liu Hua Cheng Shuqi Chen | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，8： | 2 |
| 19 | Dynamic tensile behavior of AZ31B magnesium alloy at ultra-high strain rates显示文摘The samples having {0001} parallel to extruding direction(ED) present a typical true stress–true strain curve with concave-down shape under tension at low strain rate. Ultra-rapid tensile tests were conducted at room temperature on a textured AZ31 B magnesium alloy. The dynamic tensile behavior was investigated. The results show that at ultra-high strain rates of 1.93 · 102 s 1and 1.70 · 103 s 1, the alloy behaves with a linear stress–strain response in most strain range and exhibits a brittle fracture. In this case, {10-12} < 10-11> extension twinning is basic deformation mode. The brittleness is due to the macroscopic viscosity at ultra-high strain rate, for which the external critical shear stress rapidly gets high to result in a cleavage fracture before large amounts of dislocations are activated. Because {10-12} tension twinning, {10-11} compressive twinning,basal slip, prismatic slip and pyramidal slip have different critical shear stresses(CRSS), their contributions to the degree of deformation are very differential. In addition,Schmid factor plays an important role in the activity of various deformation modes and it is the key factor for the samples with different strain rates exhibit various mechanical behavior under dynamic tensile loading. | Geng Changjian Wu Baolin Liu Fang Tong Wenwei Han Zhenyu | 2015 | Chinese Journal of Aeronautics2015，28，2： | 2 |
| 20 | Non-covalent glycosylated gold nanoparticles/peptides nanovaccine as potential cancer vaccines显示文摘Herein,we firstly developed a non-covalent glycosylated gold nanoparticles/peptides nanovaccine which is assembled byβ-cyclodextrin(β-CD)based host-guest recognitions.This nanovaccine can generate significant titers of antibodies and improve the therapeutic effect against melanoma,suggesting the immunogenicity of peptide antigens can be improved by loading with this carrier.The novel vaccine carrier provides a platform for the transport of various antigens especially T cell-independent antigens. | Liming Zeng Zonglang Liao Wenwei Li Qijuan Yuan Peng Wu Zhipeng Gu Zhongqiu Liu Guochao Liao | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
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