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| 1 | Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells显示文摘Cholesterol represents one of the key constituents of small,dynamic,sterol-and sphingolipid-enriched domains on the plasma membrane.It has been reported that many viruses depend on plasma membrane cholesterol for efficient infection.In this study,the role of the plasma membrane cholesterol in porcine reproductive and respiratory syndrome virus(PRRSV) infection of MARC-145 cells was investigated.Pretreatment of MARC-145 cells with methyl-β-cyclodextrin(MβCD),a drug used to deplete cholesterol from cellular membrane,significantly reduced PRRSV infection in a dose-dependent manner.This inhibition was partially reversed by supplementing exogenous cholesterol following MβCD treatment,suggesting that the inhibition of PRRSV infection was specifically mediated by removal of cellular cholesterol.Further detailed studies showed that depletion of cellular membrane cholesterol significantly inhibited virus entry,especially virus attachment and release.These results indicate that the presence of cholesterol in the cellular membrane is a key component of PRRSV infection. | SUN Ying XIAO ShaoBo WANG Dang LUO Rui LI Bin CHEN HuanChun FANG LiuRong | 2011 | Science China(Life Sciences)2011，54，11： | 3 |
| 2 | Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway显示文摘 | Rui Luo Shaobo Xiao Yunbo Jiang Hui Jin Dang Wang Manli Liu Huanchun Chen Liurong Fang | 2008 | Molecular Immunology2008，，10： | 2 |
| 3 | Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus (PRRSV)显示文摘 | Rui Luo Liurong Fang Hui Jin Yunbo Jiang Dang Wang Huanchun Chen Shaobo Xiao | 2011 | Antiviral Research2011，，2： | 1 |
| 4 | Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-λ1 pathway显示文摘 | Dang Wang Liurong Fang Lizhi Liu Huijuan Zhong Quangang Chen Rui Luo Xiangtao Liu Zhongming Zhang Huanchun Chen Shaobo Xiao | 2011 | Molecular Immunology2011，，1： | 1 |
| 5 | Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1 β Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages显示文摘 | Jing Bi Shuang Song Liurong Fang Dang Wang Huiyuan Jing Li Gao Yidong Cai Rui Luo Huanchun Chen Shaobo Xiao Vera L. Petricevich | 2014 | Mediators of Inflammation2014，，： | 1 |
| 6 | Molecular cloning, expression and antiviral activity of porcine interleukin-29 (poIL-29)显示文摘 | Dang Wang Liurong Fang Fuwei Zhao Rui Luo Huanchun Chen Shaobo Xiao | 2010 | Developmental and Comparative Immunology2010，，3： | 1 |
| 7 | Induction of autophagy enhances porcine reproductive and respiratory syndrome virus replication显示文摘 | Quangang Chen Liurong Fang Dang Wang Shaohua Wang Ping Li Mao Li Rui Luo Huanchun Chen Shaobo Xiao | 2011 | Virus Research2011，，2： | 1 |
| 8 | Immunogenicity and Protective Efficacy of Recombinant Pseudorabies Virus Expressing the Two Major Membrane - Associated Proteins of porcine Reproductive and Respiratory Syndrome Virus显示文摘 | Jiang Yunbo Fang Liurong Xiao Shaobo | 2007 | Vaccine2007，，25： | 1 |
| 9 | Construction and lmmunogenicity of Pseudotype Baculovirus Expressing GP5 and M Protein of Porcine Reproductive and Respiratory Syndrome Virus 显示文摘 | Wang Shengping Fang Liurong Fan Huiying | 2007 | Vaccine2007，，25： | 1 |
| 10 | Hypodermin A, a potential agent for prevention of allogeneic acute rejection显示文摘 | Quangang Chen Renjin Chen Jing Liu Honghua Yuan Peng Liu Ankang Hu Lianlian Wu Liurong Fang Shaobo Xiao Xiaorong Zhu | 2015 | Transplant Immunology2015，，3： | 1 |
| 11 | Pathogenesis of nonsuppurative encephalitis caused by highly pathogenic Porcine reproductive and respiratory syndrome virus显示文摘 | Cao J B Li Bin Fang Liurong | | 0，，04： | 1 |
| 12 | DNA vaccines co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV) display enhanced immunogenieity显示文摘 | Jiang Yunbo Xiao Shaobo Fang Liurong | 2006 | Vaccine2006，24，： | 1 |
| 13 | Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells显示文摘 | Yanwei Wang Rui Luo Liurong Fang Dang Wang Jing Bi Huanchun Chen Shaobo Xiao | 2010 | Molecular Immunology2010，，4： | 1 |
| 14 | Porcine reproductive and respiratory syndrome virus infection activates NOD2–RIP2 signal pathway in MARC-145 cells显示文摘 | Huiyuan Jing Liurong Fang Dang Wang Zhen Ding Rui Luo Huanchun Chen Shaobo Xiao | 2014 | Virology2014，，： | 1 |
| 15 | Epidemiology and evolutionary characteristics of the porcine reproductive and re- spiratory syndrome virus in China between 2006 and 2010显示文摘 | Li Bin Fang Liurong Guo Xueliang | 2011 | J Clin Microbial2011，49，9： | 1 |
| 16 | Construction and characterization of a live, attenuated apxIICA inactivation mutant of Actinobacillus pleuropneumoniae lacking a drug resistance marker显示文摘 | Weicheng Bei Qigai He Lin Yan Liurong Fang Yadi Tan Shaobo Xiao Rui Zhou Meilin Jin Aizhen Guo Jianqiang Lv Hongliang Huang Huanchun Chen | 2004 | FEMS Microbiology Letters2004，，1： | 1 |
| 17 | Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus ( PRRSV ) 显示文摘 | Rui Luo Liurong Fang Hui Jin | 2011 | Antiviral Research2011，91，： | 1 |
| 18 | Complete coding sequences and phylogenetic analysis of porcine bo- cavirus显示文摘 | Zeng Songlin Wang Dang Fang Liurong | 2011 | The Journal of General Virology2011，92，4： | 1 |
| 19 | DNA vaccines co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV) display enhanced immunogenicity显示文摘 | Yunbo Jiang Shaobo Xiao Liurong Fang | 2006 | Vaceine2006，24，： | 1 |
| 20 | Induction of autophagy enhances porcine reproductive and respiratory syndrome virus replication显示文摘 | Quangang Chen Liurong Fang Dang Wang Shaohua Wang Ping Li Mao Li Rui Luo Huanchun Chen Shaobo Xiao | 2011 | Virus Research2011，，2： | 1 |
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