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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Regulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia显示文摘Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute brain ischemia. We hypothesized that activated extracellular signal-regulated kinase 1/2 can protect hippocampal neurons from injury in a diabetic model after cerebral ischemia/reperfusion. In this study, transient whole-brain ischemia was induced by four-vessel occlusion in normal and diabetic rats, and extracellular signal-regulated kinase 1/2 inhibitor(U0126) was administered into diabetic rats 30 minutes before ischemia as a pretreatment. Results showed that the number of surviving neurons in the hippocampal CA1 region was reduced, extracellular signal-regulated kinase 1/2 phosphorylation and Ku70 activity were decreased, and pro-apoptotic Bax expression was upregulated after intervention using U0126. These findings demonstrate that inhibition of extracellular signal-regulated kinase 1/2 activity aggravated neuronal loss in the hippocampus in a diabetic rat after cerebral ischemia/reperfusion, further decreased DNA repairing ability and accelerated apoptosis in hippocampal neurons. Extracellular signal-regulated kinase 1/2 activation plays a neuroprotective role in hippocampal neurons in a diabetic rat after cerebral ischemia/ reperfusion. | Yaning Zhao Jianmin Li Qiqun Tang Pan Zhang Liwei Jing Changxiang Chen Shuxing Li | 2014 | Neural Regeneration Research2014，9，7： | 10 |
| 3 | Climate change and its effect on reference crop evapotranspiration in central and western Inner Mongolia during 1961-2009显示文摘水资源是到在中央、西方的内部蒙古的农业生产的主要限制之一,在的地方由干旱、半干旱的气候是特征的。参考庄稼土壤水分蒸发蒸腾损失总量(et 0 ) 是在农业生态系统的水周期的重要部分,它在庄稼生长和产量上有直接效果。et 0 上的气候变化的含意具有为关于安排的水管理和灌溉的农业的高重要性。这研究的目的是在时期上在在中央、西方的内部蒙古的 et 0 上在气候和它的效果分析变化 1961 ~ 2009。为这个目的,在越过学习区域的十个气象学的车站的数据被收集, FAO Penman-Monteith 56 方法被使用。结果证明平均温度,最大的温度和最小的温度由 0.49 莬增加了吗?? | Di HE Yaling LIU Zhihua PAN Pingli AN Liwei WANG Zhiqiang DONG Jingting ZHANG Xuebiao PAN Peiyi ZHAO | 2013 | Frontiers of Earth Science2013，7，4： | 8 |
| 4 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 5 | Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells显示文摘Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Unfortunately, it is impossible to obtain normal tissue for DIPG because of the vital functions of the pons.Here we report the human fetal hindbrain-derived neural progenitor cells(pontine progenitor cells, PPCs) as normal control cells for DIPG. The PPCs not only harbored similar cell biological and molecular signatures as DIPG glioma stem cells, but also had the potential to be immortalized by the DIPG-specific mutation H3 K27 M in vitro. These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG. | Yu Sun Cheng Xu Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng Zhang Wenhao Wu Yu Wang Deling Li Zhen Wu Junting Zhang Qiaoran Xi Liwei Zhang | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 6 | Deviation-Rectifying Control of Carbon Fiber Prepreg Slitting and Winding Machine显示文摘With the growing needs of prepreg tapes for the automated fiber placement(AFP),the deviation-rectifying of prepreg in slitting process was investigated on a self-developed 16-tow prepreg slitting and winding machine.The process of slitting and rewinding of prepreg tape was introduced,and the reason of prepreg tape deviation in slitting process was analyzed.In order to ensure the quality of the narrow prepreg slits,the application of the fuzzy PID algorithm in a closed-loop control system was discussed.A fuzzy PID algorithm was designed by combining fuzzy rules and PID controller.By applying it to precise deviation-rectifying control strategy,the automatic control of rectification could be achieved with accuracy of 0.1 mm,which satisfies the requirement of the prepreg tape both in slitting quality and layup quality for AFP. | Wen Liwei Zhu Tengfei Qin Lihua Wang Xianfeng Pan Jie Feng Qiaoqiao | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，3： | 2 |
| 7 | An Expedient Method for Regioselective Methylation of Catechol Coumarins显示文摘 | LU Junxia WANG Ping HOU Jie ZOU Liwei CUI Pan YANG Ling GE Guangbo GONG Xiaojie | 2016 | Chemical Research in Chinese Universities2016，32，5： | 1 |
| 8 | Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang显示文摘 | Huaxu Zhu Zhilei Qian Huan Li Liwei Guo Linmei Pan Qichun Zhang Yuping Tang | 2012 | Journal of Ethnopharmacology2012，，1： | 1 |
| 9 | Construction of Regular Rate-Compatible LDPC Convolutional Codes显示文摘In this paper, we propose a new method to derive a family of regular rate-compatible low-density parity-check(RC-LDPC) convolutional codes from RC-LDPC block codes. In the RC-LDPC convolutional family, each extended sub-matrix of each extended code is obtained by choosing specified elements from two fixed matrices HE1K and HE1K, which are derived by modifying the extended matrices HE1 and HE2 of a systematic RC-LDPC block code. The proposed method which is based on graph extension simplifies the design, and prevent the defects caused by the puncturing method. It can be used to generate both regular and irregular RC-LDPC convolutional codes. All resulted codes in the family are systematic which simplify the encoder structure and have maximum encoding memories which ensure the property. Simulation results show the family collectively offer a steady improvement in performance with code compatibility over binary-input additive white Gaussian noise channel(BI-AWGNC). | Liwei Mu Chulong Liang Zhiyong Liu Daru Pan | 2016 | China Communications2016，13，8： | 1 |
| 10 | 显示文摘 | Pan Liwei Wang Shudong | 2005 | International Journal of Hydro-gen Energy2005，30，9： | 1 |
| 11 | Apolipoprotein E mimetic peptide protects against diffuse brain injury显示文摘Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apolipoprotein E mimetic peptide significantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental findings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mitochondrial apoptotic pathway. | Yaning Zhao Jianmin Li Qiqun Tang Junling Gao Changxiang Chen Liwei Jing Pan Zhang Shuxing Li | 2014 | Neural Regeneration Research2014，9，5： | 1 |
| 12 | A compact integrated fuel processing system for proton exchange membrane fuel cells显示文摘 | PAN Liwei WANG Shudong | 2006 | International Journal of Hydrogen Energy2006，31，4： | 1 |
| 13 | Methanol steam reforming in a compact plate-? n reformer for fuel-cell systerns显示文摘 | Shudong Wang | 2005 | International Journal of Hydrogen Energy2005，30，： | 1 |
| 14 | Ordered cone-structured tin directly grown on carbon paper as efficient electrocatalyst for CO_(2) electrochemical reduction to formate显示文摘The conversion of carbon dioxide to chemicals by the electrochemical reactions(ERC)is an efficient solution to the current energy crisis and excess CO_(2) emissions.It is still a great challenge and of significance to synthesize a highly selective,efficient,and non-noble metal electrocatalyst that facilitates the ERC reaction.A novel triton X-100(C_(14)H_(22)O(C_(2)H_(4)O)n)assisted electrodeposition method was developed to synthesize the ordered cone-structured tin(OCSn)electrocatalysts with controllable morphology and structure.The results suggest that Triton X-100 plays an important role in directing the structure of the Sn electrocatalysts during the electrodeposition process.The OCSn synthesized at 60 m A cm^(-2) achieves the best performances.It selectively catalyzes the ERC on the onset potential about 110 m V lower than Sn synthesized without Triton X-100.In 0.5 M Na HCO_(3),high faradaic efficiency(92%)for formate product on OCSn has been achieved.More prominently,the catalyst presents excellent stability,showing no performance deterioration during 30 h electrolysis.This work provides an efficient,green,and scalable synthesis method of the electrocatalyst for CO_(2) reduction to formate. | Hexiang Zhong Yanling Qiu Xianfeng Li Liwei Pan Huamin Zhang | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 15 | ,Study on a compat methanol reformer for a miniatare fuel cell 显示文摘 | Liwei Pan Changjun Ni Xuebin Zhang etc | 2011 | Internatioual Journal of Hydrogen Energy2011，36，1： | 1 |
| 16 | The Characteristics of Pressure Drop in Microchannels 显示文摘 | Su Hongjiu Niu Haining Pan Liwei | 2010 | Ind Eng Chem Res2010，49，： | 1 |
| 17 | Modeling of a compact plate-fin reformer for methanol steam reforming in fuel cell system显示文摘 | Liwei Pan | 2005 | Power sources2005，108，： | 1 |
| 18 | Mechanistic study of ammonium-induced corrosion of AZ31 magnesium alloy in sulfate solution显示文摘The influence of NH4+ions on the corrosion behavior of AZ31 magnesium alloy was investigated by immersion test,hydrogen evolution,electrochemical methods and morphology observation.The results demonstrate the acceleration effect of NH4+on corrosion of AZ31 magnesium alloy due to the disruption of protective MgO film in NH4+-containing solution.The loose and cracked corrosion products of AZ31 magnesium alloy in NH4+-containing solutions are mainly composed of(Mg0.833Al0.167)(OH)2(CO3)0.083·0.75H2O and Mg5(CO3)4(OH)2·5H2O.When the NH4+concentration is lower than 0.01 M,knife-cut like corrosion occurs in some active area of the surface due to the partial dissolution of MgO layer.As the NH4+concentration is increased to 0.1 M,the MgO layer is completely disrupted,resulting in the occurrence of uniform corrosion.Both cathodic and anodic reactions are accelerated by NH4+ions,while the effect of original pH values on the reaction kinetics can be neglected in NH4+-containing solutions. | Hui Pan Liwei Wang Yi Lin Feng Ge Kang Zhao Xin Wang Zhongyu Cui | 2020 | Journal of Materials Science & Technology2020，54，19： | 1 |
| 19 | Research of a configurability framework of MES for mechanical processing enterprise显示文摘 | Qi Lei Liwei Pan | | 0，，10： | 1 |
| 20 | Anisotropic MOF-on-MOF Growth of Isostructural Multilayer Metal–Organic Framework Heterostructures显示文摘Isostructural MOFs with similar crystallographic parameter are easily available for MOF-on-MOF growth and possible to form core–shell structure by isotropic growth.However,due to well-matched cell lattice,selective growth in isostructural MOF heterostructures remains a great challenge for engineering atypical MOF heterostructures.Herein,an anisotropic MOF-onMOF growth strategy was developed to structure a range of multilayer sandwich-like ZIF-L heterostructures via stacking isostructural ZIF-L-Zn and ZIF-L-Co alternately with three-,five-,seven-,and more layer structures.Moreover,these heterostructures with highly designable feature were fantastic precursors for fabricating derivatives with tunable magnetic and catalytic properties.Such strategy explores a novel way of achieving anisotropic MOF-on-MOF growth between isostructural MOFs and opens up new horizons for regulating the properties by MOF modular assembly in versatile functional nanocomposites. | Zhida Gu Wenlei Zhang Ting Pan Yu Shen Peishan Qin Peng Zhang Xiaohan Li Liwei Liu Linjie Li Yu Fu Weina Zhang Fengwei Huo | 2021 | Research2021，，1： | 1 |
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